-
1
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
2
-
-
38649116056
-
Selective versus total insulin resistance: A pathogenic paradox
-
Brown MS, Goldstein JL (2008) Selective versus total insulin resistance: A pathogenic paradox. Cell Metab 7:95-96.
-
(2008)
Cell Metab
, vol.7
, pp. 95-96
-
-
Brown, M.S.1
Goldstein, J.L.2
-
3
-
-
77649264504
-
-
Li S, Brown MS, Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not gluconeogenesis. Proc Natl Acad Sci USA 107:3441-3446.
-
Li S, Brown MS, Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not gluconeogenesis. Proc Natl Acad Sci USA 107:3441-3446.
-
-
-
-
4
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC (2007) AKT/PKB signaling: Navigating downstream. Cell 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
6
-
-
34347406521
-
SREBP-1c transcription factor and lipid homeostasis: Clinical perspective
-
Ferre P, Foufelle F (2007) SREBP-1c transcription factor and lipid homeostasis: Clinical perspective. Horm Res 68:72-82.
-
(2007)
Horm Res
, vol.68
, pp. 72-82
-
-
Ferre, P.1
Foufelle, F.2
-
7
-
-
0033570119
-
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
-
Shimomura I, Bashmakov Y, Horton JD (1999) Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-30032.
-
(1999)
J Biol Chem
, vol.274
, pp. 30028-30032
-
-
Shimomura, I.1
Bashmakov, Y.2
Horton, J.D.3
-
8
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante M, Sabatini DM (2009) mTOR signaling at a glance. J Cell Sci 122:3589-3594.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
9
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
Laplante M, Sabatini DM (2009) An emerging role of mTOR in lipid biosynthesis. Curr Biol 19:R1046-R1052.
-
(2009)
Curr Biol
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
10
-
-
35248816945
-
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
-
Brown NF, Stefanovic-Racic M, Sipula IJ, Perdomo G (2007) The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes. Metabolism 56:1500-1507.
-
(2007)
Metabolism
, vol.56
, pp. 1500-1507
-
-
Brown, N.F.1
Stefanovic-Racic, M.2
Sipula, I.J.3
Perdomo, G.4
-
11
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng T, Golub TR, Sabatini DM (2002) The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 22:5575-5584.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
12
-
-
66249090283
-
Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
-
Mauvoisin D, et al. (2007) Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver. J Cell Commun Signal 1:113-125.
-
(2007)
J Cell Commun Signal
, vol.1
, pp. 113-125
-
-
Mauvoisin, D.1
-
13
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann T, et al. (2008) SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8:224-236.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
-
14
-
-
3843061127
-
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
-
Chen G, Liang G, Ou J, Goldstein JL, Brown MS (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci USA 101:11245-11250.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 11245-11250
-
-
Chen, G.1
Liang, G.2
Ou, J.3
Goldstein, J.L.4
Brown, M.S.5
-
15
-
-
62649093597
-
AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
-
LiuZM
-
Yang J, Craddock L,Hong S, LiuZM(2009)AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. J Cell Biochem 106:414-426.
-
(2009)
J Cell Biochem
, vol.106
, pp. 414-426
-
-
Yang, J.1
Craddock, L.2
Hong, S.3
-
16
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y, et al. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
-
17
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
Newgard CB, et al. (2009) A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9:311-326.
-
(2009)
Cell Metab
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
-
18
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um SH, et al. (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
-
19
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
-
Khamzina L, Veilleux A, Bergeron S, Marette A (2005) Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance. Endocrinology 146:1473-1481.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
20
-
-
40649104735
-
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
-
Ozcan U, et al. (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29:541-551.
-
(2008)
Mol Cell
, vol.29
, pp. 541-551
-
-
Ozcan, U.1
-
21
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun HL, et al. (2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119: 1201-1215.
-
(2009)
J Clin Invest
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
|