C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Phung, Bengt ^a   Sun, Jianmin ^a   Schepsky, Alexander ^b   Steingrimsson, Eirikur ^b   Rönnstrand, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MEK; PROTEIN TYROSINE KINASE; RAS PROTEIN; STEM CELL FACTOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; MITF PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STEM CELL FACTOR RECEPTOR;

ARTICLE; BINDING SITE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE; CELL LINE; CYTOLOGY; GENETICS; MELANOCYTE; METABOLISM; MISSENSE MUTATION; PATHOLOGY; PHOSPHORYLATION;

CELL LINE; CELL PROLIFERATION; HUMANS; MELANOCYTES; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION, MISSENSE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION;

EID: 80051981588     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024064     Document Type: Article

References (59)

1. Kasamatsu S, Hachiya A, Higuchi K, Ohuchi A, Kitahara T, et al. (2008) Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes. J Invest Dermatol 128: 1763-1772.
2. Okayama Y, Kawakami T, (2006) Development, Migration, and Survival of Mast Cells. Immunol Res 34: 97-115.
3. Wehrle-Haller B, (2003) The Role of Kit-Ligand in Melanocyte Development and Epidermal Homeostasis. Pigment Cell Res 16: 287-296.
4. Vincent S, Segretain D, Nishikawa S, Nishikawa SI, Sage J, et al. (1998) Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse:a Kit-KL interaction critical for meiosis. Development 125: 4585-4593.
5. Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, et al. (2010) ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature 467: 846-853.
6. Alexeev V, Yoon K, (2006) Distinctive Role of the cKit Receptor Tyrosine Kinase Signaling in Mammalian Melanocyte. J Invest Dermatol pp. 1102-1110.
7. Hachiya A, Sriwiriyanont P, Kobayashi T, Nagasawa A, Yoshida H, et al. (2009) Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair. J Pathol 219: 30-39.
8. Wang ZQ, Si L, Tang Q, Lin D, Fu Z, et al. (2009) Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation. Am J Hum Genet 84: 672-677.
9. Taylor ML, Dastych J, Sehgal D, Sundstrom M, Nilsson G, et al. (2001) The Kit-activating mutation D816V enhances stem cell factor--dependent chemotaxis. Blood 98.
10. Fritsche-Polanz R, Jordan JH, Feix A, Sperr WR, Sunder-Plassmann G, et al. (2001) Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis. Br J Haematol 113: 357-364.
11. Kissel H, Timokhina I, Hardy MP, Rothschild G, Tajima Y, et al. (2000) Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J 19: 1312-1326.
12. Blume-Jensen P, Jiang G, Hyman R, Lee KF, O'Gorman S, et al. (2000) Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility. Nat Genet 24: 157-162.
13. Ward SM, Sanders KM, (2001) Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol Gastrointest Liver Physiol 281: G602-611.
14. Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, et al. (1999) Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction. Oncogene 18: 5546-5553.
15. Roskoski R, (2005) Signaling by Kit protein-tyrosine kinase- The stem cell factor receptor. Biochem Biophys Res Commun 337: 1-13.
16. Ueda S, Mizuki M, Ikeda H, Tsujimura T, Matsumura I, et al. (2002) Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood 99: 3342-3349.
17. Serve H, Hsu YC, Besmer P, (1994) Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells. J Biol Chem 269: 6026-6030.
18. Lev S, Givol D, Yarden Y, (1992) Interkinase domain of kit contains the binding site for phosphatidylinositol 3′ kinase. Proc Natl Acad Sci U S A 89: 678-682.
19. Sun J, Pedersen M, Rönnstrand L, (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem 283: 27444-27451.
20. Tachibana M, (1999) A cascade of genes related to Waardenburg syndrome. J Investig Dermatol Symp Proc 4: 126-129.
21. Fleischman RA, Saltman DL, Stastny V, Zneimer S, (1991) Deletion of the c-kit protooncogene in the human developmental defect piebald trait. Proc Natl Acad Sci U S A 88: 10885-10889.
22. Hou L, Pavan WJ, (2008) Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf? Cell Res 18: 1163-1176.
23. Witte ON, (1990) Steel locus defines new multipotent growth factor. Cell 65: 5-6.
24. Russell ES, (1979) Hereditary anemias of the mouse: a review for geneticists. Adv Genet 20: 357-459.
25. Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, et al. (2007) MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem 282: 15921-15929.
26. Lu SY, Li M, Lin YL, Mitf induction by RANKL is critical for osteoclastogenesis. Mol Biol Cell 21: 1763-1771.
27. Nechushtan H, Razin E, (2002) The function of MITF and associated proteins in mast cells. Mol Immunol 38: 1177-1180.
28. Kitamura Y, Morii E, Jippo T, Ito A, (2002) Regulation of mast cell phenotype by MITF. Int Arch Allergy Immunol 127: 106-109.
29. Steingrimsson E, Copeland NG, Jenkins NA, (2004) Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet 38: 365-411.
30. Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, et al. (2004) Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 6: 565-576.
31. McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109: 707-718.
32. Carreira S, Goodall J, Aksan I, La Rocca SA, Galibert MD, et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433: 764-769.
33. Loercher AE, Tank EM, Delston RB, Harbour JW, (2005) MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol 168: 35-40.
34. Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, et al. (2000) c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 14: 301-312.
35. Xu W, Gong L, Haddad MM, Bischof O, Campisi J, et al. (2000) Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res 255: 135-143.
36. Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE, (1998) MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391: 298-301.
37. Bauer GL, Praetorius C, Bergsteinsdottir K, Hallsson JH, Gisladottir BK, et al. (2009) The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue. Genetics 183: 581-594.
38. Bismuth K, Skuntz S, Hallsson JH, Pak E, Dutra AS, et al. (2008) An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate. Genetics 178: 259-272.
39. Blume-Jensen P, Siegbahn A, Stabel S, Heldin CH, Rönnstrand L, (1993) Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C. Embo J 12: 4199-4209.
40. Molina DM, Grewal S, Bardwell L, (2005) Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation. J Biol Chem 280: 42051-42060.
41. Wellbrock C, Rana S, Paterson H, Pickersgill H, Brummelkamp T, et al. (2008) Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. PLoS One 3: e2734.
42. Oka M, Kageyama A, Fukunaga M, Bito T, Nagai H, et al. (2004) Phosphatidylinositol 3-kinase/Akt-dependent and-independent protection against apoptosis in normal human melanocytes. J Invest Dermatol 123: 930-936.
43. Kim DS, Park SH, Kwon SB, Kwon NS, Park KC, Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. J Pharm Pharmacol 62: 181-187.
44. Lee JH, Jang JY, Park C, Kim BW, Choi YH, et al. Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells. Int J Mol Med 26: 101-106.
45. Saha B, Singh SK, Sarkar C, Bera R, Ratha J, et al. (2006) Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB. Pigment Cell Res 19: 595-605.
46. Mizutani Y, Hayashi N, Kawashima M, Imokawa GA, single UVB, exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38/CREB. Arch Dermatol Res 302: 283-294.
47. Carreira S, Goodall J, Denat L, Rodriguez M, Nuciforo P, et al. (2006) Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev 20: 3426-3439.
48. Dynek JN, Chan SM, Liu J, Zha J, Fairbrother WJ, et al. (2008) Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas. Cancer Res 68: 3124-3132.
49. Rönnstrand L, (2004) Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci 61: 2535-2548.
50. Wellbrock C, Weisser C, Geissinger E, Troppmair J, Schartl M, (2002) Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling. J Biol Chem 277: 6443-6454.
51. Horst B, Gruvberger-Saal SK, Hopkins BD, Bordone L, Yang Y, et al. (2009) Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol 174: 1524-1533.
52. Akavia UD, Litvin O, Kim J, Sanchez-Garcia F, Kotliar D, et al. An integrated approach to uncover drivers of cancer Cell 143: 1005-1017.
53. Boisvert-Adamo K, Aplin AE, (2006) B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis. Oncogene 25: 4848-4856.
54. Khaled M, Larribere L, Bille K, Ortonne JP, Ballotti R, et al. (2003) Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway. J Invest Dermatol 121: 831-836.
55. Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, et al. (1997) Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J Biol Chem 272: 5915-5920.
56. Price DJ, Rivnay B, Avraham H, (1999) CHK down-regulates SCF/KL-activated Lyn kinase activity in Mo7e megakaryocytic cells. Biochem Biophys Res Commun 259: 611-616.
57. Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, et al. (1998) SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol 18: 2089-2099.
58. Masson K, Heiss E, Band H, Ronnstrand L, (2006) Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J 399: 59-67.
59. Sun J, Pedersen M, Bengtsson S, Ronnstrand L, (2007) Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res 313: 3935-3942.