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Volumn 2, Issue 5, 2000, Pages 249-256

FAK integrates growth-factor and integrin signals to promote cell migration

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; INTEGRIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

EID: 0033772308     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35010517     Document Type: Article
Times cited : (1105)

References (40)
  • 8
    • 0033539801 scopus 로고    scopus 로고
    • Binding of paxillin to alpha 4 integrins modifies integrin-dependent biological responses
    • (1999) Nature , vol.402 , pp. 676-681
    • Liu, S.1
  • 9
    • 0029046858 scopus 로고
    • Interaction of focal adhesion kinase with cytoskeletal protein talin
    • (1995) J. Biol. Chem. , vol.270 , pp. 16995-16999
    • Chen, H.C.1
  • 10
    • 0029834447 scopus 로고    scopus 로고
    • Evidence for in vivo phosphorylation of the Grb 2 SH 2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5623-5633
    • Schlaepfer, D.D.1    Hunter, T.2
  • 12
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1
  • 13
    • 0033606767 scopus 로고    scopus 로고
    • Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
    • (1999) J. Cell Biol. , vol.146 , pp. 389-404
    • Gu, J.1
  • 14
    • 0032531732 scopus 로고    scopus 로고
    • Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK cell migration
    • (1998) EMBO J. , vol.17 , pp. 5933-5947
    • Sieg, D.J.1
  • 16
    • 0033002997 scopus 로고    scopus 로고
    • Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk 2
    • (1999) Mol. Cell Biol. , vol.19 , pp. 4806-4818
    • Owen, J.D.1    Ruest, P.J.2    Fry, D.W.3    Hanks, S.K.4
  • 20
    • 0028783271 scopus 로고
    • Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK
    • (1995) Oncogene , vol.11 , pp. 1989-1995
    • Furuta, Y.1
  • 21
    • 0029120440 scopus 로고
    • Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
    • (1995) Nature , vol.377 , pp. 539-544
    • Ilic, D.1
  • 22
    • 0030046955 scopus 로고    scopus 로고
    • The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor
    • (1996) Eur. J. Biochem. , vol.235 , pp. 495-500
    • Chen, H.C.1    Guan, J.L.2
  • 23
    • 0033214460 scopus 로고    scopus 로고
    • Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells
    • (1999) J. Biol. Chem. , vol.274 , pp. 28371-28378
    • Salazar, E.P.1    Rozengurt, E.2
  • 24
    • 0031921101 scopus 로고    scopus 로고
    • Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK 2/mitogen-activated protein kinase: Summation of both c-Src and FAK-initiated tyrosine phosphorylation events
    • (1998) Mol. Cell Biol. , vol.18 , pp. 2571-2585
    • Schlaepfer, D.D.1    Jones, K.C.2    Hunter, T.3
  • 26
    • 0039441744 scopus 로고    scopus 로고
    • Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility
    • (1999) Mol. Cell Biol. , vol.19 , pp. 3125-3135
    • Manes, S.1
  • 31
    • 0032981482 scopus 로고    scopus 로고
    • Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2278-2288
    • Lev, S.1
  • 33
    • 0033168542 scopus 로고    scopus 로고
    • Induction of phosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope
    • (1999) J. Immunol. , vol.163 , pp. 420-426
    • Cicala, C.1
  • 35
    • 0032472411 scopus 로고    scopus 로고
    • The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
    • (1998) EMBO J. , vol.17 , pp. 81-92
    • Fincham, V.J.1    Frame, M.C.2
  • 37
    • 0029039421 scopus 로고
    • Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
    • (1995) Cancer Res. , vol.55 , pp. 2752-2788
    • Owens, L.V.1
  • 38
    • 0031657454 scopus 로고    scopus 로고
    • Focal adhesion kinase and its potential involvement in tumor invasion and metastasis
    • (1998) Head Neck , vol.20 , pp. 745-752
    • Kornberg, L.J.1
  • 39
    • 0033533746 scopus 로고    scopus 로고
    • Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
    • (1999) Oncogene , vol.18 , pp. 5646-5653
    • Agochiya, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.