Transcriptional and ERK1/2-dependent synergistic upregulation of p21cip1/waf1associated with steel factor synergy in MO7e

Biochemical and Biophysical Research Communications

Volumn 280, Issue 3, 2001, Pages 675-683

  Lee, Y ^b   Mantel, C ^b   Anzai, N ^b   Braun, S E ^b   Broxmeyer, H E ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WALTHER CANCER INSTITUTE   (United States)

Author keywords

GM CSF; MAP kinase; P21cip1 waf1; Steel factor; Synergy; Transcriptional regulation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN P21; STAT5 PROTEIN; STEEL FACTOR; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL LEVEL; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN INDUCTION; RIBONUCLEASE PROTECTION ASSAY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034816719     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4215     Document Type: Article

References (29)

1. Selective growth response to IL-3 of a human leukemic cell line with megakaryocytic features
2. Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of the human factor-dependent cell line, MO7e
3. The kit receptor and its ligand, steel factor, as regulators of hemopoiesis
4. Signal transduction of steel factor and granulocyte-macrophage colony-stimulating factor: Differential regulation of transcription factor and G1 cyclin gene expression, and of proliferation in the human factor-dependent cell line MO7
5. c-kit expression in human megakaryoblastic leukemia cell lines
6. Early signaling pathways activated by c-Kit in hematopoietic cells
7. Involvement of immediate-early gene expression in the synergistic effects of steel factor in combination with granulocyte-macrophage colony-stimulating factor or interleukin-3 on proliferation of a human factor-dependent cell line
8. Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo
9. CDK inhibitors: Positive and negative regulators of G1-phase progression
10. WAF1, a potential mediator of p53 tumor suppression
11. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
12. Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5
13. Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity
14. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway
15. Ras- and mitogen-activated protein kinase kinase-dependent and -independent pathways in p21Cip1/Wafl induction by fibroblast growth factor-2, platelet-derived growth factor, and transforming growth factor-beta1
16. Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: Possible involvement of protein tyrosine kinase and phospholipase C-gamma
17. Regulation of the cdk inhibitor p27 and its deregulation in cancer
18. Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines
19. Activation of p90RSK and cAMP response element binding protein in stimulated neutrophils: Novel effects of the pyridinyl imidazole SB 203580 on activation of the extracellular signal-regulated kinase cascade
20. Inhibition of p38 MAP kinase activity Up-regulates multiple MAP kinase pathways and potentiates 1, 25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells
21. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
22. A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer
23. The combination of steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line
24. Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites
25. c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1
26. Sp1 phosphorylation by Erk 2 stimulates DNA binding
27. The Jak-Stat pathway in normal and perturbed hematopoiesis
28. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
29. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1