Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance

Journal of Biochemistry

Volumn 147, Issue 4, 2010, Pages 601-609

  Dinitto, Jonathan P ^a   Deshmukh, Gayatri D ^a   Zhang, Yan ^a   Jacques, Suzanne L ^a   Coli, Rocco ^a   Worrall, Joseph W ^a   Diehl, Wade ^a   English, Jessie M ^a,b   Wu, Joe C ^a  

^a PFIZER INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

A loop; Autophosphorylation; C Kit; Imatinib; Sunitinib; Tyrosine kinase

Indexed keywords

IMATINIB; PHOSPHOPEPTIDE; STEM CELL FACTOR RECEPTOR; SUNITINIB;

ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INDOLES; KINETICS; MICROCHEMISTRY; MODELS, BIOLOGICAL; MUTANT PROTEINS; PEPTIDE MAPPING; PHOSPHORYLATION; PHOSPHOTYROSINE; PIPERAZINES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; PYRROLES; RECOMBINANT FUSION PROTEINS;

EID: 77950617070     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvq015     Document Type: Article

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