Activating SRC mutation in a subset of advanced human colon cancers

Nature Genetics

Volumn 21, Issue 2, 1999, Pages 187-190

  Irby, Rosalyn B ^a   Mao, Weiguang ^a   Coppola, Domenico ^a   Kang, Jimmy ^a   Loubeau, Jean Marc ^a   Trudeau, Walter ^a   Karl, Richard ^a   Fujita, Donald J ^b   Jove, Richard ^a   Yeatman, Timothy J ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLON CANCER; GENE ACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; ROUS SARCOMA ONCOVIRUS;

3T3 CELLS; ANIMALS; CELL LINE; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, SRC; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUTATION; NEOPLASM TRANSPLANTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RATS; TRANSFECTION;

EID: 0032932248     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/5971     Document Type: Article

References (28)

1. Stehelin, D., Varmus, H.E., Bishop, J.M. & Vogt, P.K. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260, 170-173 (1976).
2. Brugge, J.S. & Erikson, R.L. Identification of a transformation-specific antigen induced by an avian sarcoma virus. Nature 269, 346-348 (1977).
3. Jove, R. & Hanafusa, H. Cell transformation by the viral src oncogene. Annu. Rev. Cell Biol. 3, 31-56 (1987).
4. Thomas, S.M. & Brugge, J.S. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13, 513-609 (1997).
5. Rosen, N. et al. Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. J. Biol. Chem. 261, 13754-13759 (1986).
6. Bolen, J., Veillette, A., Schwartz, A., DeSeau, V. & Rosen, N. Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc. Natl Acad. Sci. USA 84, 2251-2255 (1987).
7. Cartwright, C., Kamps, M., Meisler, A., Pipas, J. & Eckhart, W. pp60c-src activation in human colon carcinoma. J. Clin. Invest. 83, 2025-2033 (1989).
8. Talamonti, M.A., Roh, M.S., Curley, S.A. & Gallick, G.E. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J. Clin. Invest. 91, 53-60 (1991).
9. Cartwright, C., Coad, C. & Egbert, B. Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis. J. Clin. Invest. 93, 509-515 (1994).
10. Termuhlen, P.M., Curley, S.A., Talamonti, M.S., Saboorian, M.H. & Gallick, G.E. Site-specific differences in pp60c-src activity in human colorectal metastases. J. Surg. Res. 54, 293-298 (1993).
11. Mao, W. et al. Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene 15, 3083-3090 (1997).
12. Cooper, J., Gould, K., Cartwright, C. & Hunter, T. Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science 231, 1431-1434 (1986).
13. Cartwright, C., Eckhart, W., Simon, S. & Kaplan, P. Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell 49, 83-91 (1987).
14. Kmiecik, T. & Shalloway, D. Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49, 65-73 (1987).
15. Piwnica-Worms, H., Saunders, K.B., Roberts, T.M., Smith, A.E. & Cheng, S.H. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell 49, 75-82 (1987).
16. Reynolds, A.B. et al. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J. 6, 2359-2364 (1987).
17. c-src mutants. Oncogene Res. 5, 49-60 (1989).
18. Bjorge, J. et al. Characterization of two activated mutants of human pp60c-src that escape c-Src kinase regulation by distinct mechanisms. J. Biol. Chem. 270, 24222-24228 (1995).
19. Guo, Z., Liu, Q. & Smith, L.M. Enhanced discrimination of single nucleotide polymorphisms by artificial mismatch hybridization. Nature Biotechnol. 15, 331-335 (1997).
20. Cooper, J.A. & Howell, B. The when and how of src regulation. Cell 73, 1051-1054 (1993).
21. Tanaka, A. et al. DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes. Mol. Cell. Biol. 7, 1978-1983 (1987).
22. Tanaka, A. & Fujita, D.J. Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vector. Mol. Cell. Biol. 6, 3900-3909 (1986).
23. Jove, R., Kornbluth, S. & Hanafusa, H. Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. Cell 50, 937-943 (1987).
24. Xu, W., Harrison, S.C. & Eck, M.J. Three-dimensional structure of the tyrosine kinase c-Src (see comments). Nature 385, 595-602 (1997).
25. Snyder, M.A., Bishop, J.M., Colby, W.W. & Levinson, A.D. Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src. Cell 32, 891-901 (1983).
26. Hamaguchi, M. et al. Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src. Oncogene 10, 1037-1043 (1995).
27. Egan, S. et al. Transformation by oncogenes encoding protein kinases induces the metastatic phenotype. Science 238, 202-205 (1987).
28. Tatsuka, M. et al. Different metastatic potentials of ras- and src-transformed BALB/c 3T3 A31 variant cells. Mol. Carcinog. 15, 300-308 (1996).