Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 480-490

  Zadjali, Fahad ^a,b   Pike, Ashley C W ^c   Vesterlund, Mattias ^a   Sun, Jianmin ^d   Wu, Chenggang ^e   Li, Shawn S C ^e   Rönnstrand, Lars ^d   Knapp, Stefan ^c,f   Bullock, Alex N ^c   Flores Morales, Amilcar ^g  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SULTAN QABOOS UNIVERSITY   (Oman)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d LUND UNIVERSITY   (Sweden)

^e WESTERN UNIVERSITY   (Canada)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; CELLULAR RESPONSE; DATA SUPPORT; E3 UBIQUITIN LIGASES; GERM CELLS; HEMATOPOIETIC CELL; HIGH AFFINITY; HUMAN TUMORS; IN-CELL; MOLECULAR DATA; MOLECULAR MECHANISM; PHOSPHOPEPTIDES; PROTEIN TURNOVERS; RECEPTOR TYROSINE KINASE; SH2 DOMAIN; SPECIFIC INTERFACE; STEM CELL FACTOR; STRUCTURAL BASIS; SUBSTRATE INTERACTION; SUBSTRATE PEPTIDES; SUBSTRATE RECOGNITION; SUPPRESSOR OF CYTOKINE SIGNALING; UBIQUITIN LIGASES;

AMINO ACIDS; CRYSTAL STRUCTURE; ENZYMES; SIGNALING; STEM CELLS;

SUBSTRATES;

ELONGIN B; ELONGIN C; PHOSPHOPEPTIDE; PROTEIN TYROSINE PHOSPHATASE SHP 2; STEM CELL FACTOR RECEPTOR; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 6; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROGEN BOND; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPEPTIDES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STEM CELL FACTOR; SUBSTRATE SPECIFICITY; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; UBIQUITINATION;

EID: 78650938219     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.173526     Document Type: Article

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