Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 25, 1996, Pages 14665-14669

  Piao, Xianhua ^a,b   Paulson, Robert ^a   Van Der Geer, Peter ^a   Pawson, Tony ^a,b   Bernstein, Alan ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Mastocytosis; Oncogenes; Signal transduction; Ubiquitin

Indexed keywords

ASPARTIC ACID; PHOSPHOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TYROSINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE C KIT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-KIT; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

ANIMALIA; MURINAE; RODENTIA;

EID: 0029907089     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.25.14665     Document Type: Article

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