메뉴 건너뛰기




Volumn 36, Issue 3, 2008, Pages 301-308

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Author keywords

[No Author keywords available]

Indexed keywords

P85 ALPHA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE IALPHA; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; STEM CELL FACTOR RECEPTOR;

EID: 39149093030     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.11.008     Document Type: Article
Times cited : (12)

References (31)
  • 1
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S., Isozaki K., Moriyama Y., et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279 (1998) 577-580
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 2
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm
    • Longley B.J., Tyrrell L., Lu S.Z., et al. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 12 (1996) 312-314
    • (1996) Nat Genet , vol.12 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3
  • 3
    • 0034650957 scopus 로고    scopus 로고
    • C-kit mutations in core binding factor leukemias
    • Beghini A., Peterlongo P., Ripamonti C.B., et al. C-kit mutations in core binding factor leukemias. Blood 95 (2000) 726-727
    • (2000) Blood , vol.95 , pp. 726-727
    • Beghini, A.1    Peterlongo, P.2    Ripamonti, C.B.3
  • 4
  • 5
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H., Worobec A.S., Oh C.K., et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 92 (1995) 10560-10564
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3
  • 6
    • 0036207241 scopus 로고    scopus 로고
    • Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts
    • Feger F., Ribadeau Dumas A., Leriche L., Valent P., and Arock M. Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts. Int Arch Allergy Immunol 127 (2002) 110-114
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 110-114
    • Feger, F.1    Ribadeau Dumas, A.2    Leriche, L.3    Valent, P.4    Arock, M.5
  • 7
    • 0038170400 scopus 로고    scopus 로고
    • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
    • Care R.S., Valk P.J., Goodeve A.C., et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol 121 (2003) 775-777
    • (2003) Br J Haematol , vol.121 , pp. 775-777
    • Care, R.S.1    Valk, P.J.2    Goodeve, A.C.3
  • 8
    • 26944457435 scopus 로고    scopus 로고
    • Imatinib mesylate for refractory acute myeloblastic leukemia harboring inv(16) and a C-KIT exon 8 mutation
    • Nanri T., Matsuno N., Kawakita T., Mitsuya H., and Asou B. Imatinib mesylate for refractory acute myeloblastic leukemia harboring inv(16) and a C-KIT exon 8 mutation. Leukemia 19 (2005) 1673-1675
    • (2005) Leukemia , vol.19 , pp. 1673-1675
    • Nanri, T.1    Matsuno, N.2    Kawakita, T.3    Mitsuya, H.4    Asou, B.5
  • 9
    • 33344465478 scopus 로고    scopus 로고
    • KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
    • Schnittger S., Kohl T.M., Haferlach T., et al. KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood 107 (2006) 1791-1799
    • (2006) Blood , vol.107 , pp. 1791-1799
    • Schnittger, S.1    Kohl, T.M.2    Haferlach, T.3
  • 10
    • 33646432204 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study
    • Cairoli R., Beghini A., Grillo G., et al. Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study. Blood 107 (2006) 3463-3468
    • (2006) Blood , vol.107 , pp. 3463-3468
    • Cairoli, R.1    Beghini, A.2    Grillo, G.3
  • 11
    • 33344471932 scopus 로고    scopus 로고
    • KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group
    • Shimada A., Taki T., Tabuchi K., et al. KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group. Blood 107 (2006) 1806-1809
    • (2006) Blood , vol.107 , pp. 1806-1809
    • Shimada, A.1    Taki, T.2    Tabuchi, K.3
  • 12
    • 0043169405 scopus 로고    scopus 로고
    • Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
    • Akin C., Brockow K., D'Ambrosio C., et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hematol 31 (2003) 686-692
    • (2003) Exp Hematol , vol.31 , pp. 686-692
    • Akin, C.1    Brockow, K.2    D'Ambrosio, C.3
  • 13
    • 0041656424 scopus 로고    scopus 로고
    • Imatinib for systemic mast-cell disease
    • Pardanani A., Elliott M., Reeder T., et al. Imatinib for systemic mast-cell disease. Lancet 362 (2003) 535-536
    • (2003) Lancet , vol.362 , pp. 535-536
    • Pardanani, A.1    Elliott, M.2    Reeder, T.3
  • 14
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y., Zeng S., Metcalfe D.D., et al. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 99 (2002) 1741-1744
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3
  • 15
    • 0029907089 scopus 로고    scopus 로고
    • Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1
    • Piao X., Paulson R., van der Geer P., Pawson T., and Bernstein A. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A 93 (1996) 14665-14669
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14665-14669
    • Piao, X.1    Paulson, R.2    van der Geer, P.3    Pawson, T.4    Bernstein, A.5
  • 16
    • 0035383812 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells
    • Ning Z.Q., Li J., and Arceci R.J. Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. Blood 97 (2001) 3559-3567
    • (2001) Blood , vol.97 , pp. 3559-3567
    • Ning, Z.Q.1    Li, J.2    Arceci, R.J.3
  • 17
    • 0035958555 scopus 로고    scopus 로고
    • STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity
    • Ning Z.Q., Li J., McGuinness M., and Arceci R.J. STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity. Oncogene 20 (2001) 4528-4536
    • (2001) Oncogene , vol.20 , pp. 4528-4536
    • Ning, Z.Q.1    Li, J.2    McGuinness, M.3    Arceci, R.J.4
  • 18
    • 0035469886 scopus 로고    scopus 로고
    • Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
    • Chian R., Young S., Danilkovitch-Miagkova A., et al. Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant. Blood 98 (2001) 1365-1373
    • (2001) Blood , vol.98 , pp. 1365-1373
    • Chian, R.1    Young, S.2    Danilkovitch-Miagkova, A.3
  • 19
    • 0042591430 scopus 로고    scopus 로고
    • Phosphatidylinositol 3 kinase is required for growth of mast cells expressing the kit catalytic domain mutant
    • Shivakrupa R., Bernstein A., Watring N., and Linnekin D. Phosphatidylinositol 3 kinase is required for growth of mast cells expressing the kit catalytic domain mutant. Cancer Res 63 (2003) 4412-4419
    • (2003) Cancer Res , vol.63 , pp. 4412-4419
    • Shivakrupa, R.1    Bernstein, A.2    Watring, N.3    Linnekin, D.4
  • 20
    • 0037305583 scopus 로고    scopus 로고
    • Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation
    • Hashimoto K., Matsumura I., Tsujimura T., et al. Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation. Blood 101 (2003) 1094-1102
    • (2003) Blood , vol.101 , pp. 1094-1102
    • Hashimoto, K.1    Matsumura, I.2    Tsujimura, T.3
  • 21
    • 28844501416 scopus 로고    scopus 로고
    • Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice
    • Kosmider O., Denis N., Lacout C., Vainchenker W., Dubreuil P., and Moreau-Gachelin F. Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice. Cancer Cell 8 (2005) 467-478
    • (2005) Cancer Cell , vol.8 , pp. 467-478
    • Kosmider, O.1    Denis, N.2    Lacout, C.3    Vainchenker, W.4    Dubreuil, P.5    Moreau-Gachelin, F.6
  • 22
    • 0042734621 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling-which way to target?
    • Wymann M.P., Zvelebil M., and Laffargue M. Phosphoinositide 3-kinase signalling-which way to target?. Trends Pharmacol Sci 24 (2003) 366-376
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 366-376
    • Wymann, M.P.1    Zvelebil, M.2    Laffargue, M.3
  • 24
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., Wang Z., Bardelli A., Silliman N., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 (2004) 554
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4
  • 25
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader A.G., Kang S., Zhao L., and Vogt P.K. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5 (2005) 921-929
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 26
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    • Terauchi Y., Tsuji Y., Satoh S., et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21 (1999) 230-235
    • (1999) Nat Genet , vol.21 , pp. 230-235
    • Terauchi, Y.1    Tsuji, Y.2    Satoh, S.3
  • 27
    • 0034283717 scopus 로고    scopus 로고
    • Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency
    • Williams D.A., Tao W., Yang F., et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood 96 (2000) 1646-1654
    • (2000) Blood , vol.96 , pp. 1646-1654
    • Williams, D.A.1    Tao, W.2    Yang, F.3
  • 28
    • 34548856481 scopus 로고    scopus 로고
    • Genetic and pharmacologic evidence implicating the p85{α}, but not p85{β}, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
    • Munugalavadla V., Sims E.C., Borneo J., Chan R.J., and Kapur R. Genetic and pharmacologic evidence implicating the p85{α}, but not p85{β}, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis. Blood 110 (2007) 1612-1620
    • (2007) Blood , vol.110 , pp. 1612-1620
    • Munugalavadla, V.1    Sims, E.C.2    Borneo, J.3    Chan, R.J.4    Kapur, R.5
  • 29
    • 10144261890 scopus 로고    scopus 로고
    • Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase
    • Kitayama H., Tsujimura T., Matsumura I., et al. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase. Blood 88 (1996) 995-1004
    • (1996) Blood , vol.88 , pp. 995-1004
    • Kitayama, H.1    Tsujimura, T.2    Matsumura, I.3
  • 30
    • 33845751024 scopus 로고    scopus 로고
    • Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling
    • Xiang Z., Kreisel F., Cain J., Colson A., and Tomasson M.H. Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling. Mol Cell Biol 27 (2007) 267-282
    • (2007) Mol Cell Biol , vol.27 , pp. 267-282
    • Xiang, Z.1    Kreisel, F.2    Cain, J.3    Colson, A.4    Tomasson, M.H.5
  • 31
    • 9144221383 scopus 로고    scopus 로고
    • Sequence-based design of kinase inhibitors applicable for therapeutics and target identification
    • Niv M.Y., Rubin H., Cohen J., et al. Sequence-based design of kinase inhibitors applicable for therapeutics and target identification. J Biol Chem 279 (2004) 1242-1255
    • (2004) J Biol Chem , vol.279 , pp. 1242-1255
    • Niv, M.Y.1    Rubin, H.2    Cohen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.