Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential

Blood

Volumn 96, Issue 12, 2000, Pages 3734-3742

  Gommerman, J L ^a   Sittaro, D ^a   Klebasz, N Z ^a   Williams, D A ^a   Berger, S A ^a  

^a Arthritis and Immune Disorder Research Centre   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; NEOMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN P85; STEEL FACTOR; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL STRAIN 3T3; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; LEUKEMOGENESIS; MITOGENESIS; MONOCYTE; MOUSE; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0034548829     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.12.3734     Document Type: Article

References (71)

1. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
2. The murine W/c-kit and Steel loci and the control of hematopoiesis
3. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
4. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
5. Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
6. Identification of a ligand for the c-kit proto-oncogene
7. The mouse W/c-kit locus: A mammalian gene that controls the development of three distinct cell lineages
8. Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells
9. Chymase cleavage of stem cell factor yields a bioactive, soluble product
10. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant
11. Characterization of the gene-product of the Steel locus
12. Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein
13. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor
14. Role of the stem cell factor (SCF) receptor and the alternative forms of its ligand (SCF) in the induction of long-term growth by stroma cells
15. Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF)
16. The role of soluble growth factors in inducing transient growth and clonal extinction of stroma cell dependent erythroblastic leukemia cells
17. The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow
18. Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: Genetic evidence for a differential role in erythropoiesis
19. Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains
20. The majority of stem cell factor exists as a monomer under physiological conditions
21. Signal transduction by receptors with tyrosine kinase activity
22. Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-kit receptor
23. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
24. Steel factor-induced tyrosine phosphorylation in murine mast cells: Common elements with IL-3-induced signal transduction pathways
25. Phosphatidylinositol 3-kinase
26. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking
27. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
28. PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes
29. HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase
30. Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events
31. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
32. A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen
33. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
34. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
35. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
36. Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin
37. Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
38. Second messengers derived from inositol lipids
39. Phospholipase C-gamma1: Regulation of enzyme function and role in growth factor-dependent signal transduction
40. PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells
41. Parthenogenetic activation of mouse eggs by microinjection of a truncated c-kit tyrosine kinase present in spermatozoa
42. Protection from apoptosis by Steel factor but not interleukin-3 is reversed through blockade of calcium influx
43. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signals
44. Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
45. Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase
46. An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase C
47. c-Kit expression enhances the leukemogenic potential of 32D cells
48. Enrichment and characterization of murine hematopoietic stem cells that express the c-kit molecule
49. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase
50. Mechanism of down-regulation of c-kit receptor: Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C
51. SH2 domains recognize specific phosphopeptide sequences
52. Specificity in recognition of phosphopeptides by src-homology 2 domains
53. The Steel/W transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
54. Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells
55. Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE
56. Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis
57. Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2)
58. Spontaneous [Ca2+]i fluctuations in rat chromaffin cells do not require inositol 1,4,5-trisphosphate elevations but are generated by a caffeine- and ryanodine-sensitive intracellular Ca2+ store
59. Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle
60. Neomycin inhibits PDGF-induced IP3 formation and DNA synthesis but not PDGF-stimulated uptake of inorganic phosphate in C3H/10T1/2 fibroblasts
61. Neomycin inhibits angiogenin-induced angiogenesis
62. Immobilized anti-KIT monoclonal antibody induces ligand-independent dimerization and activation of Steel factor receptor: Biologic similarity with membrane-bound form of Steel factor rather than its soluble form
63. Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation
64. SI/SId hematopoietic progenitors are deficient in situ
65. Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction
66. Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin
67. Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophils
68. Phosphoinositide 3-kinase regulates phospholipase C gamma-mediated calcium signaling
69. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
70. p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
71. Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C