Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation

Biochemical Journal

Volumn 399, Issue 1, 2006, Pages 59-67

  Masson, Kristina ^a   Heiss, Elke ^a,c   Band, Hamid ^b   Rönnstrand, Lars ^a,d  

^a LUND UNIVERSITY   (Sweden)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

^d Malmö University Hospital   (Sweden)

Author keywords

Cbl; Degradation; Receptor tyrosine kinase; Src family kinase; Stem cell factor receptor c Kit; Ubiquitin ligase

Indexed keywords

AMINO ACIDS; BIOCHEMICAL ENGINEERING; CARCINOGENS; DEGRADATION; ENZYMES; ONCOLOGY;

CBL; RECEPTOR TYROSINE KINASE; SRC FAMILY KINASE; STEM CELL FACTOR RECEPTOR/C-KIT; UBIQUITIN LIGASE;

CELLS;

CBL PROTEIN; ISOLEUCINE; LEUCINE; PROTEIN TYROSINE KINASE; STEM CELL FACTOR RECEPTOR; TYROSINE; UBIQUITIN PROTEIN LIGASE E3;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; ENDOCYTOSIS; HUMANS; LIGANDS; MICE; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-KIT; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SIGNAL TRANSDUCTION; SWINE; TYROSINE; UBIQUITIN;

EID: 33749390318     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060464     Document Type: Article

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