Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 18811-18816

  Ley, Rebecca ^a   Balmanno, Kathryn ^a   Hadfield, Kathryn ^a   Weston, Claire ^a,b   Cook, Simon J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; RNA;

PHOSPHORYLATION;

PROTEINS;

BH3 PROTEIN; BIM PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN; PROTEIN BCL 2; UBIQUITIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; CARRIER PROTEIN; CYSTEINE PROTEINASE; ENZYME INHIBITOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MULTIENZYME COMPLEX; ONCOPROTEIN; PROTEINASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONJUGATION; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TEMPERATURE SENSITIVE MUTANT; ANIMAL; BLOOD; CELL LINE; CHO CELL; DRUG ANTAGONISM; GENETICS; HAMSTER; HEAT; METABOLISM; MUTATION; PHOSPHORYLATION;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BLOOD; CARRIER PROTEINS; CELL LINE; CHO CELLS; CRICETINAE; CULTURE MEDIA, SERUM-FREE; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME INHIBITORS; HEAT; HUMANS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; MUTATION; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 0038482050     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301010200     Document Type: Article

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