Analysis of c-kit receptor dimerization by flourescence resonance energy transfer

Blood

Volumn 91, Issue 3, 1998, Pages 898-906

  Broudy, Virginia C ^a   Lin, Nancy L ^b   Bühring, Hans Jörg ^b   Komatsu, Norio ^b   Kavanagh, Terrance J ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

STEM CELL FACTOR RECEPTOR;

ARTICLE; BURST FORMING UNIT; CELL PROLIFERATION; DIMERIZATION; ENERGY TRANSFER; EPITHELIUM CELL; FLUORESCENCE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0032006690     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.3.898.898_898_906     Document Type: Article

References (65)

1. Broudy VC: Stem cell factor and hematopoiesis. Blood 90:1345, 1997
2. Arakawa T, Yphantis DA, Lary JW, Narhi LO, Lu HS, Prestrelski SJ, Clogston CL, Zsebo ICM, Mendiaz EA, Wypych J, Langley KE: Glycosylated and unglycosylated recombinant-derived human stem cell factors are dimeric and have extensive regular secondary structure. J Biol Chem 266:18942, 1991
3. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu R-Y, Birkett NC, Okino KH, Murdock DC, Jacobsen FW, Langley KE, Smith KA, Takeishi T, Cattanach BM, Galli SJ, Suggs SV: Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63:213, 1990
4. Huang E, Nocka K, Beier DR, Chu T-Y, Buck J, Lahm H-W, Wellner D, Leder P, Besmer P: The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63:225, 1990
5. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
6. 42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science 247:209, 1990
7. Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A: W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 4:390, 1990
8. 41 and W. EMBO J 9:1805, 1990
9. W42 minigene in transgenic mice: Recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Genes Dev 5:2265, 1991
10. Blume-Jensen P, Claesson-Welsh L, Siegbahn A, Zsebo KM, Westermark B, Heldin C-H: Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J 10:4121, 1991
11. Lev S, Yarden Y, Givol D: A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. J Biol Chem 267:10866, 1992
12. Broudy VC, Morgan DA, Lin N, Zsebo KM, Jacobsen FW, Papayannopoulou T: Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor. Blood 82:436, 1993
13. Philo JS, Wen J, Wypych J, Schwartz MG, Mendiaz EA, Langley KE: Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, kit. J Biol Chem 271:6895, 1996
14. Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J: Kit receptor dimerization is driven by bivalent binding of stem cell factor. J Biol Chem 272:6311, 1997
15. Heldin C-H: Dimerization of cell surface receptors in signal transduction. Cell 80:213, 1995
16. Pawson T: Protein modules and signalling networks. Nature 373:573, 1995
17. Stryer L, Haugland RP: Energy transfer: A spectroscopic ruler. Proc Natl Acad Sci USA 58:719, 1967
18. Dos Remedios CG, Moens PDJ: Fluorescence resonance energy transfer spectroscopy is a reliable "ruler" for measuring structural changes in proteins. J Struct Biol 115:175, 1995
19. Chuck RS, Cantor CR, Tse DB: CD4-T-cell antigen receptor complexes on human leukemia T cells. Proc Natl Acad Sci USA 87:5021, 1990
20. Vignali DAA, Carson RT, Chang B, Mittler RS. Strominger JL: The two membrane proximal domains of CD4 interact with the T cell receptor. J Exp Med 183:2097, 1996
21. Guo C, Dower SK, Holowka D, Baird B: Fluorescence resonance energy transfer reveals interleukin (IL)-1-dependent aggregation of IL-1 Type 1 receptors that correlates with receptor activation. J Biol Chem 270:27562, 1995
22. Carraway III KL, Cerione RA: Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain. J Biol Chem 268: 23860, 1993
23. Gadella Jr TWJ, Jovin TM: Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation. J Cell Biol 129:1543, 1995
24. Selvin PR: Fluorescence resonance energy transfer. Methods Enzymol 246:300, 1995
25. Wu H, Klingmüller U, Besmer P, Lodish HF: Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377:242, 1995
26. Wu H, Klingmüller U, Acurio A, Hsiao JG, Lodish HF: Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci USA 94:1806, 1997
27. Jacobs-Helber SM, Penta K, Sun Z, Lawson A, Sawyer ST: Distinct signaling from stem cell factor and erythropoietin in HCD57 cells. J Biol Chem 272:6850, 1997
28. Avanzi GC, Lista P, Giovinazzo B, Miniero R, Saglio G, Benetton G, Coda R, Cattoretti G, Pegoraro L: Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. Br J Haematol 69:359, 1988
29. Kuriu A, Ikeda H, Kanakura Y, Griffin JD, Druker B, Yagura H, Kitayama H, Ishikawa J, Nishiura T, Kanayama Y, Yonezawa T, Tarui S: Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product. Blood 78:2834, 1991
30. Komatsu N, Yamamoto M, Fujita H, Miwa A, Hatake K, Endo T, Okano H, Katsube T, Fukumaki Y, Sassa S, Miura Y: Establishment and characterization of an erythropoietin-dependent subline UT-7/Epo, derived from human leukemia cell line, UT-7. Blood 82:456, 1993
31. Broudy VC, Tait JF, Powell JS: Recombinant human erythropoietin: Purification and analysis of carbohydrate linkage. Arch Biochem Biophys 265:329, 1988
32. Komatsu N, Kunitama M, Yamada M, Hagiwara T, Kato T, Miyazaki H, Eguchi M, Yamamoto M, Miura Y: Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. Blood 87:4552, 1996
33. Broudy VC, Lin N, Brice M, Nakamoto B, Papayannopoulou T: Erythropoietin receptor characteristics on primary human erythroid cells. Blood 77:2583, 1991
34. Broudy VC, Lin NL, Sabath DF, Papayannopoulou T, Kaushansky K: Human platelets display high-affinity receptors for thrombopoietin. Blood 89:1896, 1997
35. Rappold I, Ziegler BL, Kohler I, Marchetto S, Rosnet O, Birnbaum D, Simmons PJ, Zannettino ACW, Hill B, Neu S, Knapp W, Alitato R, Alitalo K, Ullrich A, Kanz L, Bühring H-J: Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood 90:111, 1997
36. Ashman LK, Cambareri AC, Nguyen L, Bühring H-J: Summary report: CD117 (c-kit), in Kishimoto T (ed): Leucocyte Typing VI. New York, NY, Garland, 1997 (in press)
37. Ashman LK, Bühring H-J, Aylett GW, Broudy VC, Müller C: Epitope mapping and functional studies with three monoclonal antibodies to the C-KIT receptor tyrosine kinase, YB5.B8, 17F11, and SR-1. J Cell Physiol 158:545, 1994
38. Broudy VC, Lin N, Zsebo KM, Birkett NC, Smith KA, Bernstein ID, Papayannopoulou T: Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor. Blood 79:338, 1992
39. Kuijpers TW, Raleigh M, Kavanagh T, Janssen H, Calafat J, Roos D, Harlan JM: Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape. A tubulin-driven process. J Immunol 152:5060, 1994
40. Fraser JK, Lin F-K, Berridge MV: Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL. Exp Hematol 16:836, 1988
41. Yee NS, Hsiau C-WM, Serve H, Vosseller K, Besmer P: Mechanism of down-regulation of c-kit receptor. J Biol Chem 269: 31991, 1994
42. Miyazawa K, Toyama K, Gotoh A, Hendrie PC, Broxmeyer HE: Ligand-dependent polyubiquitination of c-kit gene product: A possible mechanism of receptor down modulation in MO7e cells. Blood 83:137, 1994
43. Mayeux P, Lacombe C, Casadevall N, Chretien S, Dusanter I, Gisselbrecht S: Structure of the murine erythropoietin receptor complex. J Biol Chem 266:23380, 1991
44. Sawyer ST, Hankins WD: The functional form of the erythropoietin receptor is a 78-kDa protein: Correlation with cell surface expression, endocytosis, and phosphorylation. Proc Natl Acad Sci USA 90:6849, 1993
45. Massagué J, Czech MP: Affinity cross-linking of receptors for insulin and the insulin-like growth factors I and II. Methods Enzymol 109:179, 1985
46. Massagué J: Identification of receptor proteins for Type-α transforming growth factor. Methods Enzymol 146:143, 1987
47. Turner AM, Bennett LG, Lin NL, Wypych J, Bartley TD, Hunt RW, Atkins HL, Langley KE, Parker V, Martin F, Broudy VC: Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines. Blood 85:2052, 1995
48. Sorkin A, Carpenter G: Dimerization of internalized epidermal growth factor receptors. J Biol Chem 266:23453, 1991
49. Sorkin A, Eriksson A, Heldin C-H, Westermark B, Claesson-Welsh L: Pool of ligand-bound platelet-derived growth factor β-receptors remain activated and tyrosine phosphorylated after internalization. J Cell Physiol 156:373, 1993
50. Vieira AV, Lamaze C, Schmid SL: Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274:2086, 1996
51. Simons K, Ikonen E: Functional rafts in cell membranes. Nature 387:569, 1997
52. Reich Z, Boniface JJ, Lyons DS, Borochov N, Wachtel EJ, Davis MM: Ligand-specific oligomerization of T-cell receptor molecules. Nature 387:617, 1997
53. Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, Besmer P: Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice. Genes Dev 3:816, 1989
54. Russell ES: Hereditary anemias of the mouse: A review for geneticists. Adv Genet 20:357, 1979
55. Lin C-S, Lim S-K, D'Agati V, Costantini F: Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev 10:154, 1996
56. Wu H, Liu X, Jaenisch R, Lodish HF: Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:59, 1995
57. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg Jr LA, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
58. Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
59. Kaushansky K, Broudy VC, Grossman A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
60. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494, 1995
61. Vigon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
62. Kieran MW, Perkins AC, Orkin SH, Zon LI: Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci USA 93:9126, 1996
63. Sorkin A, Waters CM: Endocytosis of growth factor receptors. BioEssays 15:375, 1993
64. Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, Toyama K: Membrane-bound steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85:641, 1995
65. Bagley CJ, Woodcock JM, Stomski FC, Lopez AF: The structural and functional basis of cytokine receptor activation: Lessons from the common β subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood 89:1471, 1997