SKAR is a specific target of S6 kinase 1 in cell growth control

Current Biology

Volumn 14, Issue 17, 2004, Pages 1540-1549

  Richardson, Celeste J ^a   Bröenstrup, Mark ^a,b   Fingar, Diane C ^a   Jülich, Kristina ^a,c   Ballif, Bryan A ^a   Gygi, Steven ^a   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; MESSENGER RNA; NUCLEAR PROTEIN; RNA BINDING PROTEIN; S6 KINASE; SKAR PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; CELL DIVISION; CELL SIZE; COMPARATIVE STUDY; DNA SEQUENCE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOPRECIPITATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; NORTHERN BLOTTING; PEPTIDE MAPPING; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIVISION; CELL SIZE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEIN BINDING; RIBOSOMAL PROTEIN S6 KINASES; RNA INTERFERENCE; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 4644303065     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2004.08.061     Document Type: Article

References (38)

1. Neufeld T.P., de la Cruz A.F., Johnston L.A., Edgar B.A. Coordination of growth and cell division in the Drosophila wing. Cell. 93:1998;1183-1193
2. Shamji A.F., Nghiem P., Schreiber S.L. Integration of growth factor and nutrient signaling. implications for cancer biology Mol. Cell. 12:2003;271-280
3. Richardson C.J., Schalm S.S., Blenis J. PI3-kinase and TOR. PIKTORing cell growth Semin. Cell Dev. Biol. 15:2004;147-159
4. Huang S., Houghton P.J. Targeting mTOR signaling for cancer therapy. Curr. Opin. Pharmacol. 3:2003;371-377
5. Montagne J., Stewart M.J., Stocker H., Hafen E., Kozma S.C., Thomas G. Drosophila S6 kinase. a regulator of cell size Science. 285:1999;2126-2129
6. Shima H., Pende M., Chen Y., Fumagalli S., Thomas G., Kozma S.C. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17:1998;6649-6659
7. Pende M., Kozma S.C., Jaquet M., Oorschot V., Burcelin R., Le Marchand-Brustel Y., Klumperman J., Thorens B., Thomas G. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature. 408:2000;994-997
8. Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:2002;1472-1487
9. Rommel C., Bodine S.C., Clarke B.A., Rossman R., Nunez L., Stitt T.N., Yancopoulos G.D., Glass D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat. Cell Biol. 3:2001;1009-1013
10. Martin K.A., Blenis J. Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv. Cancer Res. 86:2002;1-39
11. Jefferies H.B., Fumagalli S., Dennis P.B., Reinhard C., Pearson R.B., Thomas G. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16:1997;3693-3704
12. Tang H., Hornstein E., Stolovich M., Levy G., Livingstone M., Templeton D., Avruch J., Meyuhas O. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol. Cell. Biol. 21:2001;8671-8683
13. Stolovich M., Tang H., Hornstein E., Levy G., Cohen R., Bae S.S., Birnbaum M.J., Meyuhas O. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol. Cell. Biol. 22:2002;8101-8113
14. Pende M., Um S.H., Mieulet V., Sticker M., Goss V.L., Mestan J., Mueller M., Fumagalli S., Kozma S.C., Thomas G. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24:2004;3112-3124
15. Maniatis T., Reed R. An extensive network of coupling among gene expression machines. Nature. 416:2002;499-506
16. Vojtek A.B., Hollenberg S.M., Cooper J.A. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 74:1993;205-214
17. Cheatham L., Monfar M., Chou M.M., Blenis J. Structural and functional analysis of pp70S6k. Proc. Natl. Acad. Sci. USA. 92:1995;11696-11700
18. Liu L., Rodriguez-Belmonte E.M., Mazloum N., Xie B., Lee M.Y. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J. Biol. Chem. 278:2003;10041-10047
19. Burd C.G., Dreyfuss G. Conserved structures and diversity of functions of RNA-binding proteins. Science. 265:1994;615-621
20. Strasser K., Hurt E. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature. 413:2001;648-652
21. Schalm S.S., Blenis J. Identification of a conserved motif required for mTOR signaling. Curr. Biol. 12:2002;632-639
22. Weng Q.P., Andrabi K., Kozlowski M.T., Grove J.R., Avruch J. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15:1995;2333-2340
23. Weng Q.P., Kozlowski M., Belham C., Zhang A., Comb M.J., Avruch J. Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies. J. Biol. Chem. 273:1998;16621-16629
24. Gerber S.A., Rush J., Stemman O., Kirschner M.W., Gygi S.P. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc. Natl. Acad. Sci. USA. 100:2003;6940-6945
25. Biondi R.M., Nebreda A.R. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem. J. 372:2003;1-13
26. Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826
27. Edgar B.A. From small flies come big discoveries about size control. Nat. Cell Biol. 1:1999;E191-E193
28. Wang X., Li W., Williams M., Terada N., Alessi D.R., Proud C.G. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 20:2001;4370-4379
29. Raught B., Peiretti F., Gingras A.C., Livingstone M., Shahbazian D., Mayeur G.L., Polakiewicz R.D., Sonenberg N., Hershey J.W. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J. 23:2004;1761-1769
30. Miron M., Verdu J., Lachance P.E., Birnbaum M.J., Lasko P.F., Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat. Cell Biol. 3:2001;596-601
31. Lachance P.E., Miron M., Raught B., Sonenberg N., Lasko P. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol. Cell. Biol. 22:2002;1656-1663
32. Sonenberg N., Gingras A.C. The mRNA 5′ cap-binding protein eIF4E and control of cell growth. Curr. Opin. Cell Biol. 10:1998;268-275
33. Romanelli A., Martin K.A., Toker A., Blenis J. p70 S6 kinase is regulated by protein kinase C zeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol. Cell. Biol. 19:1999;2921-2928
34. Chou M.M., Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell. 85:1996;573-583
35. Chen R.H., Blenis J. Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells. phosphorylation and activation during initiation of cell proliferation Mol. Cell. Biol. 10:1990;3204-3215
36. Boyle W.J., van der Geer P., Hunter T. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:1991;110-149
37. Sui G., Soohoo C., Affar el B., Gay F., Shi Y., Forrester W.C. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA. 99:2002;5515-5520
38. Martin K.A., Schalm S.S., Richardson C., Romanelli A., Keon K.L., Blenis J. Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. J. Biol. Chem. 276:2001;7884-7891