-
1
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-436 (Pubitemid 38745528)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.6
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
2
-
-
20844458056
-
Chemistry and biology of wortmannin
-
DOI 10.1039/b504418a
-
Wipf P, Halter Robert J. Chemistry and biology of wortmannin. Org Biomol Chem 2005;3:2053-2061 (Pubitemid 40859876)
-
(2005)
Organic and Biomolecular Chemistry
, vol.3
, Issue.11
, pp. 2053-2061
-
-
Wipf, P.1
Halter, R.J.2
-
3
-
-
0029346877
-
The viridin family of steroidal antibiotics
-
Hanson JR. The viridin family of steroidal antibiotics. Nat Prod Rep 1995;12:381-384
-
(1995)
Nat Prod Rep
, vol.12
, pp. 381-384
-
-
Hanson, J.R.1
-
4
-
-
0029965452
-
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
-
Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, et al. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 1996; 16:1722-1733 (Pubitemid 26095645)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.4
, pp. 1722-1733
-
-
Wymann, M.P.1
Bulgarelli-Leva, G.2
Zvelebil, M.J.3
Pirola, L.4
Vanhaesebroeck, B.5
Waterfield, M.D.6
Panayotou, G.7
-
5
-
-
33947218937
-
Covalent Reactions of Wortmannin under Physiological Conditions
-
DOI 10.1016/j.chembiol.2007.02.007, PII S1074552107000749
-
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L. Covalent reactions of wortmannin under physiological conditions. Chem Biol 2007; 14:321-328 (Pubitemid 46428147)
-
(2007)
Chemistry and Biology
, vol.14
, Issue.3
, pp. 321-328
-
-
Yuan, H.1
Barnes, K.R.2
Weissleder, R.3
Cantley, L.4
Josephson, L.5
-
6
-
-
13344276592
-
Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs
-
DOI 10.1021/jm950619p
-
Norman BH, Shih C, Toth JE, et al. Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs. J Med Chem 1996;39:1106-1111 (Pubitemid 26082943)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.5
, pp. 1106-1111
-
-
Norman, B.H.1
Shih, C.2
Toth, J.E.3
Ray, J.E.4
Dodge, J.A.5
Johnson, D.W.6
Rutherford, P.G.7
Schultz, R.M.8
Worzalla, J.F.9
Vlahos, C.J.10
-
7
-
-
0029774179
-
Synthesis and in vitro evaluation of new wortmannin esters: Potent inhibitors of phosphatidylinositol 3-kinase
-
DOI 10.1021/jm960283z
-
Creemer LC, Kirst HA, Vlahos CJ, Schultz RM. Synthesis and in vitro evaluation of new wortmannin esters: potent inhibitors of phosphatidylinositol 3-kinase. J Med Chem 1996;39:5021-5024 (Pubitemid 26422519)
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, Issue.25
, pp. 5021-5024
-
-
Creemer, L.C.1
Kirst, H.A.2
Vlahos, C.J.3
Schultz, R.M.4
-
8
-
-
0029156587
-
In vitro and in vivo antitumor activity of the phosphatidylinositol-3- kinase inhibitor, wortmannin
-
Schultz RM, Merriman RL, Andis SL, et al. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin. Anticancer Res 1995;15:1135-1139
-
(1995)
Anticancer Res
, vol.15
, pp. 1135-1139
-
-
Schultz, R.M.1
Merriman, R.L.2
Andis, S.L.3
-
9
-
-
49449099537
-
Slow self-activation enhances the potency of viridin prodrugs
-
Blois J, Yuan H, Smith A, et al. Slow self-activation enhances the potency of viridin prodrugs. J Med Chem 2008;51:4699-4707
-
(2008)
J Med Chem
, vol.51
, pp. 4699-4707
-
-
Blois, J.1
Yuan, H.2
Smith, A.3
-
10
-
-
31544478032
-
Wortmannin- C20 conjugates generate wortmannin
-
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin- C20 conjugates generate wortmannin. J Med Chem 2006;49:740-747
-
(2006)
J Med Chem
, vol.49
, pp. 740-747
-
-
Yuan, H.1
Luo, J.2
Weissleder, R.3
Cantley, L.4
Josephson, L.5
-
12
-
-
38949214348
-
Fate of a bioactive fluorescent wortmannin derivative in cells
-
DOI 10.1021/bc7002204
-
Barnes KR, Blois J, Smith A, et al. Fate of a bioactive fluorescent wortmannin derivative in cells. Bioconjug Chem 2008;19:130-137 (Pubitemid 351213843)
-
(2008)
Bioconjugate Chemistry
, vol.19
, Issue.1
, pp. 130-137
-
-
Barnes, K.R.1
Blois, J.2
Smith, A.3
Yuan, H.4
Reynolds, F.5
Weissleder, R.6
Cantley, L.C.7
Josephson, L.8
-
14
-
-
33746885455
-
phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
-
DOI 10.1084/jem.20052069
-
Ellson CD, Davidson K, Ferguson GJ, O'Connor R, Stephens LR, Hawkins PT. Neutrophils from p40phox./. mice exhibit severe defects in NADPHoxidas e regulation and oxidant-dependent bacterial killing. J Exp Med 2006;203:1927-1937 (Pubitemid 44188467)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.8
, pp. 1927-1937
-
-
Ellson, C.D.1
Davidson, K.2
Ferguson, G.J.3
O'Connor, R.4
Stephens, L.R.5
Hawkins, P.T.6
-
15
-
-
41649109390
-
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: Potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy
-
Zask A, Kaplan J, Toral-Barza L, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem 2008;51:1319-1323
-
(2008)
J Med Chem
, vol.51
, pp. 1319-1323
-
-
Zask, A.1
Kaplan, J.2
Toral-Barza, L.3
-
16
-
-
4444223702
-
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
-
Ihle NT, Williams R, Chow S, et al. Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3- kinase signaling. Mol Cancer Ther 2004;3:763-772 (Pubitemid 39193758)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.7
, pp. 763-772
-
-
Ihle, N.T.1
Williams, R.2
Chow, S.3
Chew, W.4
Berggren, M.I.5
Paine-Mrrieta, G.6
Minion, D.J.7
Halter, R.J.8
Wipf, P.9
Abraham, R.10
Kirkpatrick, L.11
Powis, G.12
-
17
-
-
33744816775
-
Practicalities of drugging the phosphatidylinositol-3-kinase/Akt cell survival signaling pathway
-
DOI 10.1158/1078-0432.CCR-06-0617
-
Powis G, Ihle N, Kirkpatrick DL. Practicalities of drugging the phosphatidylinositol- 3-kinase/Akt cell survival signaling pathway. Clin Cancer Res 2006;12:2964-2966 (Pubitemid 43837339)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.10
, pp. 2964-2966
-
-
Powis, G.1
Ihle, N.2
Kirkpatrick, D.L.3
-
18
-
-
0023150655
-
Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues
-
DOI 10.1016/0014-4827(87)90201-1
-
Baggiolini M, Dewald B, Schnyder J, Ruch W, Cooper PH, Payne TG. Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues. Exp Cell Res 1987;169: 408-418 (Pubitemid 17056606)
-
(1987)
Experimental Cell Research
, vol.169
, Issue.2
, pp. 408-418
-
-
Baggiolini, M.1
Dewald, B.2
Schnyder, J.3
-
19
-
-
0027432424
-
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses
-
Arcaro A, Wymann MP. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses. Biochem J 1993;296:297-301.
-
(1993)
Biochem J
, vol.296
, pp. 297-301
-
-
Arcaro, A.1
Wymann, M.P.2
-
20
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
-
Knight ZA, Gonzalez B, Feldman ME, et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 2006;125:733-747
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
-
21
-
-
33750525089
-
PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?
-
Ruckle T, Schwarz MK, Rommel C. PI3Kγ inhibition: towards an 'aspirin of the 21st century'? Nat Rev Drug Discov 2006;5:903-918
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 903-918
-
-
Ruckle, T.1
Schwarz, M.K.2
Rommel, C.3
-
22
-
-
0031002529
-
Polysaccharides as drug carriers: Biodisposition of fluorescein-labeled dextrans in mice
-
Kaneo Y, Uemura T, Tanaka T, Kanoh S. Polysaccharides as drug carriers: biodisposition of fluorescein-labeled dextrans in mice. Biol Pharm Bull 1997;20:181-187 (Pubitemid 27123170)
-
(1997)
Biological and Pharmaceutical Bulletin
, vol.20
, Issue.2
, pp. 181-187
-
-
Kaneo, Y.1
Uemura, T.2
Tanaka, T.3
Kanoh, S.4
-
23
-
-
33644772618
-
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
-
DOI 10.1093/jnci/djj070
-
Dreher MR, Liu W, Michelich CR, Dewhirst MW, Yuan F, Chilkoti A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J Natl Cancer Inst 2006;98:335-344 (Pubitemid 43338213)
-
(2006)
Journal of the National Cancer Institute
, vol.98
, Issue.5
, pp. 335-344
-
-
Dreher, M.R.1
Liu, W.2
Michelich, C.R.3
Dewhirst, M.W.4
Yuan, F.5
Chilkoti, A.6
-
25
-
-
0030604280
-
Potent inhibition of angiogenesis by wortmannin, a fungal metabolite
-
DOI 10.1016/S0014-2999(96)00864-3, PII S0014299996008643
-
Oikawa T, Shimamura M. Potent inhibition of angiogenesis by wortmannin, a fungal metabolite. Eur J Pharmacol 1996;318:93-96 (Pubitemid 27033209)
-
(1996)
European Journal of Pharmacology
, vol.318
, Issue.1
, pp. 93-96
-
-
Oikawa, T.1
Shimamura, M.2
|