A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Nature Cell Biology

Volumn 6, Issue 4, 2004, Pages 308-318

  Yeh, Elizabeth ^a   Cunningham, Melissa ^b   Arnold, Hugh ^b   Chasse, Dawn ^a   Monteith, Teresa ^a   Ivaldi, Giovanni ^a   Hahn, William C ^c   Stukenberg, P Todd ^d   Shenolikar, Shirish ^a   Uchida, Takafumi ^e   Counter, Christopher M ^a   Nevins, Joseph R ^a   Means, Anthony R ^a   Sears, Rosalie ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ISOMERASE; MUTANT PROTEIN; MYC PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; RAS PROTEIN; SERINE; VIRUS SMALL T ANTIGEN;

ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; GENES, MYC; HUMANS; MICE; MUTATION; NEOPLASMS; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RNA STABILITY; SERINE; SIGNAL TRANSDUCTION; THREONINE;

ANIMALIA; SIMIAE; SIMIAN VIRUS 40;

EID: 2342526543     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1110     Document Type: Article

References (38)

1. Charron, J. et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 6, 2248-2257 (1992).
2. Davis, A. C., Wims, M., Spotts, G. D., Hann, S. R. & Bradley, A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7, 671-682 (1993).
3. de Alboran, I. M. et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14, 45-55 (2001).
4. Trumpp, A. et al. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 766 (2001).
5. Coppola, J. A. & Cole, M. D. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment. Nature 320, 760-763 (1986).
6. Evan, G. L. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128 (1992).
7. Cole, M. D. The myc oncogene: its role in transformation and differentiation. Ann. Rev. Genet. 20, 361-384 (1986).
8. Nesbit, C. E., Tersak, J. M. & Prochownik, E. V. MYC oncogenes and human neoplastic disease. Oncogene 18, 3004-3016 (1999).
9. Spencer, C. A. & Groudine, M. Control of c-myc regulation in normal and neoplastic cells. Adv. Canc. Res. 56, 1-48 (1991).
10. Sears, R., Leone, G., DeGregori, J. & Nevins, J. R. Ras enhances Myc protein stability. Mol. Cell 3, 169-179 (1999).
11. Sears, R. et al. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514 (2000).
12. Pulverer, B. J. et al. Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene 9, 59-70 (1994).
13. Henriksson, M., Bakardjiev, A., Klein, G. & Luscher, B. Phosphorylation sites mapping in the N-terminal domain of c-Myc modulate its transforming potential. Oncogene 8, 3199-3209 (1993).
14. Lutterbach, B. & Hann, S. R. Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol. Cell. Biol. 14, 5510-5522 (1994).
15. Cross, D. A. E., Alessi, D. R., Cohen, P,, Andejelkovich, M. & Hemmings, B. A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789 (1995).
16. Salghetti, S. E., Kim, S. Y. & Tansey, W. P. Destruction of Myc by ubiquitin-mediated proteolysis: cancer associated and transforming muations stabilize Myc. EMBO J. 18, 717-726 (1999).
17. Gregory, M. A. & Hann, S. R. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell. Biol. 20, 2423-2435 (2000).
18. Zhou, X. Z. et al. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol. Cell 6, 873-883 (2000).
19. Stukenberg, P. T. & Kirschner, M. W. Pin1 acts catalytically to promote a conformational change in Cdc25. Mol. Cell 7, 1071-1083 (2001).
20. Sontag, E. et al. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell 75, 887-897 (1993).
21. Myers, J. K., Morris, D. P., Greenleaf, A. L. & Oas, T. G. Phosphorylation of RNA polymerase II CTD fragments results in tight binding to the WW domain from the yeast prolyl isomerase Ess1. Biochemistry 40, 8479-8486 (2001).
22. Lu, P. J., Zhou, X. Z., Shen, M. & Lu, K. P. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-1328 (1999).
23. Atchison, F. W., Capel, B. & Means, A. R. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development 130, 3579-3586 (2003).
24. Sears, R., Ohtani, K. & Nevins, J. R. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol. 17, 5227-5235 (1997).
25. Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464-468 (1999).
26. Hahn, W. C. et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell. Biol. 22, 2111-2123 (2002).
27. Papas, T. S. & Lautenberger, J. A. Sequence curiosity in v-myc oncogenes. Nature 318, 237 (1985).
28. Bhatia, K. et al. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nature Genet. 5, 56-61 (1993).
29. Chang, D. W., Claassen, G. F., Hann, S. R. & Cole, M. D. The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals. 20, 4309-4319 (2000).
30. Winkler, K. E., Swenson, K. I., Kornbluth, S. & Means, A. R. Requirement of the Prolyl isomerase Pin1 for the replication checkpoint. Science 287, 1644-1647 (2000).
31. Nevins, J. R., DeGregori, J., Jakoi, L. & Leone, G. Functional analysis of E2F. Meth.. Enzymol. 283, 205-219 (1997).
32. DeGregori, J., Leone, G., Ohtani, K., Miron, A. & Nevins, J. R. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9, 2873-2887 (1995).
33. Cook, J. G. et al. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc. Natl Acad. Sci. USA 99, 1347-1352 (2002).
34. He, T.-C. et al. A simplified system for generating recombinant adenoviruses. Biochem. Biophys. Res. Comm. 95, 2509-2514 (1998).
35. Fujimori, F., Takahashi, K., Uchida, C. & Uchida, T. Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest. 265, 658-663 (1999).
36. Robertson, E. J. in Teratocarcinomas and Embryonic Stem Cells: A Practical Approach (ed. Robertson, E. J.) 104-108 (IRL Press, Oxford, 1987).
37. Hann, S., Dixit, M., Sears, R. & Sealy, L. The alternatively initiated c-Myc proteins differentially regulated transcription through a noncanonical DNA binding site. Genes Dev. 8, 2441-2452 (1994).
38. Cifone, M. A. & Fidler, I. J. Correlation of patterns of anchorage independent growth with in vivo behavior of cells from a murine fibrosarcoma. Proc. Natl Acad. Sci. USA 77, 1039-1043 (1980).