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Volumn 12, Issue 5, 2012, Pages 598-612

Neuroprotective strategies for the treatment of inherited photoreceptor degeneration

Author keywords

Apoptosis; Calpain; Calpastatin; CGK; Epigenetics; HDAC; PARP; PKG

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GUANYLATE CYCLASE; NERVE GROWTH FACTOR; NEUROTROPHIN; PIGMENT EPITHELIUM DERIVED FACTOR; THIOCTIC ACID; XANTHOPHYLL; ZEAXANTHIN;

EID: 84861003107     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652412800620048     Document Type: Review
Times cited : (65)

References (246)
  • 1
    • 0018595710 scopus 로고
    • Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments
    • Baehr W, Devlin MJ, Applebury ML. Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments. J Biol Chem 1979; 254: 11669-11677.
    • (1979) J Biol Chem , vol.254 , pp. 11669-11677
    • Baehr, W.1    Devlin, M.J.2    Applebury, M.L.3
  • 2
    • 33645535034 scopus 로고    scopus 로고
    • G protein-coupled receptor rhodopsin
    • Palczewski K. G protein-coupled receptor rhodopsin. Annu Rev Biochem 2006; 75: 743-767.
    • (2006) Annu Rev Biochem , vol.75 , pp. 743-767
    • Palczewski, K.1
  • 4
    • 0034622122 scopus 로고    scopus 로고
    • A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes
    • Phelan JK, Bok D. A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes. Mol Vis 2000; 6:116-124.
    • (2000) Mol Vis , vol.6 , pp. 116-124
    • Phelan, J.K.1    Bok, D.2
  • 5
    • 0036500230 scopus 로고    scopus 로고
    • On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention
    • Farrar GJ, Kenna PF, Humphries P. On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention. EMBO J 2002; 21: 857-864.
    • (2002) EMBO J , vol.21 , pp. 857-864
    • Farrar, G.J.1    Kenna, P.F.2    Humphries, P.3
  • 7
    • 27444437192 scopus 로고    scopus 로고
    • Mouse mutants as models for congenital retinal disorders
    • Dalke C, Graw J. Mouse mutants as models for congenital retinal disorders. Exp Eye Res 2005; 81: 503-512.
    • (2005) Exp Eye Res , vol.81 , pp. 503-512
    • Dalke, C.1    Graw, J.2
  • 8
    • 0024990758 scopus 로고
    • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase
    • Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature 1990; 347: 677-680.
    • (1990) Nature , vol.347 , pp. 677-680
    • Bowes, C.1    Li, T.2    Danciger, M.3    Baxter, L.C.4    Applebury, M.L.5    Farber, D.B.6
  • 10
    • 0017866791 scopus 로고
    • Differential effect of the rd mutation on rods and cones in the mouse retina
    • Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 1978; 17: 489-498.
    • (1978) Invest Ophthalmol Vis Sci , vol.17 , pp. 489-498
    • Carter-Dawson, L.D.1    Lavail, M.M.2    Sidman, R.L.3
  • 11
    • 0035161831 scopus 로고    scopus 로고
    • A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants
    • Caffe AR, Soderpalm AK, Holmqvist I, van Veen T. A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants. Invest Ophthalmol Vis Sci 2000; 42: 275-282.
    • (2000) Invest Ophthalmol Vis Sci , vol.42 , pp. 275-282
    • Caffe, A.R.1    Soderpalm, A.K.2    Holmqvist, I.3    van Veen, T.4
  • 12
    • 33947543601 scopus 로고    scopus 로고
    • Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration
    • Miranda-Sanz M, Johnson LE, Ahuja S, Ekstrom PA, Romero J, van Veen T. Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration. Neuroscience 2007; 145: 1120-1129.
    • (2007) Neuroscience , vol.145 , pp. 1120-1129
    • Miranda-Sanz, M.1    Johnson, L.E.2    Ahuja, S.3    Ekstrom, P.A.4    Romero, J.5    van Veen, T.6
  • 13
    • 33747505724 scopus 로고    scopus 로고
    • BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice
    • Zencak D, Crippa SV, Tekaya M, et al. BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 2006; 572: 209-215.
    • (2006) Adv Exp Med Biol , vol.572 , pp. 209-215
    • Zencak, D.1    Crippa, S.V.2    Tekaya, M.3
  • 14
    • 77950532428 scopus 로고    scopus 로고
    • Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
    • Gorbatyuk MS, Knox T, LaVail MM, et al. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci USA 2010; 107: 5961-5966.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5961-5966
    • Gorbatyuk, M.S.1    Knox, T.2    Lavail, M.M.3
  • 15
    • 44249085878 scopus 로고    scopus 로고
    • Safety and efficacy of gene transfer for Leber's congenital amaurosis
    • Maguire AM, Simonelli F, Pierce EA, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008; 358: 2240-2248.
    • (2008) N Engl J Med , vol.358 , pp. 2240-2248
    • Maguire, A.M.1    Simonelli, F.2    Pierce, E.A.3
  • 16
    • 77649242176 scopus 로고    scopus 로고
    • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration
    • Simonelli F, Maguire AM, Testa F, et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 2010; 18: 643-650.
    • (2010) Mol Ther , vol.18 , pp. 643-650
    • Simonelli, F.1    Maguire, A.M.2    Testa, F.3
  • 17
    • 44249120315 scopus 로고    scopus 로고
    • Effect of gene therapy on visual function in Leber's congenital amaurosis
    • Bainbridge JW, Smith AJ, Barker SS, et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med 2008; 358: 2231-2239.
    • (2008) N Engl J Med , vol.358 , pp. 2231-2239
    • Bainbridge, J.W.1    Smith, A.J.2    Barker, S.S.3
  • 18
    • 54449085219 scopus 로고    scopus 로고
    • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
    • Cideciyan AV, Aleman TS, Boye SL, et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc Natl Acad Sci USA 2008; 105: 15112-15117.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15112-15117
    • Cideciyan, A.V.1    Aleman, T.S.2    Boye, S.L.3
  • 19
    • 33644853775 scopus 로고    scopus 로고
    • Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors
    • Akimoto M, Cheng H, Zhu D, et al. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Proc Natl Acad Sci USA 2006; 103: 3890-3895.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3890-3895
    • Akimoto, M.1    Cheng, H.2    Zhu, D.3
  • 20
    • 0034708051 scopus 로고    scopus 로고
    • Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat
    • Chacko DM, Rogers JA, Turner JE, Ahmad I. Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. Biochem Biophys Res Commun 2000; 268: 842-846.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 842-846
    • Chacko, D.M.1    Rogers, J.A.2    Turner, J.E.3    Ahmad, I.4
  • 21
    • 77951268630 scopus 로고    scopus 로고
    • Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa
    • Wang NK, Tosi J, Kasanuki JM, et al. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation 2010; 89: 911-919.
    • (2010) Transplantation , vol.89 , pp. 911-919
    • Wang, N.K.1    Tosi, J.2    Kasanuki, J.M.3
  • 22
    • 33750861299 scopus 로고    scopus 로고
    • Retinal repair by transplantation of photoreceptor precursors
    • MacLaren RE, Pearson RA, MacNeil A, et al. Retinal repair by transplantation of photoreceptor precursors. Nature 2006; 444: 203-207.
    • (2006) Nature , vol.444 , pp. 203-207
    • Maclaren, R.E.1    Pearson, R.A.2    Macneil, A.3
  • 23
    • 58049200677 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice
    • Lamba DA, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell 2009; 4: 73-79.
    • (2009) Cell Stem Cell , vol.4 , pp. 73-79
    • Lamba, D.A.1    Gust, J.2    Reh, T.A.3
  • 24
    • 0037039812 scopus 로고    scopus 로고
    • Will retinal implants restore vision?
    • Zrenner E. Will retinal implants restore vision? Science 2002; 295: 1022-1025.
    • (2002) Science , vol.295 , pp. 1022-1025
    • Zrenner, E.1
  • 25
    • 53649104645 scopus 로고    scopus 로고
    • Extraocular surgery for implantation of an active sub retinal visual prosthesis with external connections: Feasibility and outcome in seven patients
    • Besch D, Sachs H, Szurman P, et al. Extraocular surgery for implantation of an active sub retinal visual prosthesis with external connections: feasibility and outcome in seven patients. Br J Ophthalmol 2008; 92: 1361-1368.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1361-1368
    • Besch, D.1    Sachs, H.2    Szurman, P.3
  • 26
    • 79952692042 scopus 로고    scopus 로고
    • Subretinal electronic chips allow blind patients to read letters and combine them to words
    • Zrenner E, Bartz-Schmidt KU, Benav H, et al. Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc R Soc B 2011; 278: 1489-1497.
    • (2011) Proc R Soc B , vol.278 , pp. 1489-1497
    • Zrenner, E.1    Bartz-Schmidt, K.U.2    Benav, H.3
  • 27
    • 79952988118 scopus 로고    scopus 로고
    • Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task
    • Ahuja AK, Dorn JD, Caspi A, et al. Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task. Br J Ophthalmol 2011; 95: 539-54
    • (2011) Br J Ophthalmol , vol.95 , pp. 539-554
    • Ahuja, A.K.1    Dorn, J.D.2    Caspi, A.3
  • 28
    • 44349103098 scopus 로고    scopus 로고
    • Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration
    • Lagali PS, Balya D, Awatramani GB, et al. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci 2008; 11: 667-675.
    • (2008) Nat Neurosci , vol.11 , pp. 667-675
    • Lagali, P.S.1    Balya, D.2    Awatramani, G.B.3
  • 29
    • 57349113014 scopus 로고    scopus 로고
    • Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin
    • Lin B, Koizumi A, Tanaka N, Panda S, Masland RH. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci USA 2008; 105: 16009-160014.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16009-160014
    • Lin, B.1    Koizumi, A.2    Tanaka, N.3    Panda, S.4    Masland, R.H.5
  • 30
    • 77954847711 scopus 로고    scopus 로고
    • Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
    • Busskamp V, Duebel J, Balya D, et al. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 2010; 329: 413-417
    • (2010) Science , vol.329 , pp. 413-417
    • Busskamp, V.1    Duebel, J.2    Balya, D.3
  • 32
    • 1342312503 scopus 로고    scopus 로고
    • Neuro protection in ophthalmology: A review
    • Barkana Y, Belkin M. Neuro protection in ophthalmology: a review. Brain Res Bull 2004; 62: 447-453.
    • (2004) Brain Res Bull , vol.62 , pp. 447-453
    • Barkana, Y.1    Belkin, M.2
  • 33
    • 0037214277 scopus 로고    scopus 로고
    • Retinal neuro protection by growth factors: A mechanistic perspective
    • Chaum E. Retinal neuro protection by growth factors: a mechanistic perspective. J Cell Biochem 2003; 88: 57-75.
    • (2003) J Cell Biochem , vol.88 , pp. 57-75
    • Chaum, E.1
  • 34
    • 33746773660 scopus 로고    scopus 로고
    • Antioxidants reduce cone cell death in a model of retinitis pigmentosa
    • Komeima K, Rogers BS, Lu L, Campochiaro PA. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci USA 2006; 103: 11300-11305.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11300-11305
    • Komeima, K.1    Rogers, B.S.2    Lu, L.3    Campochiaro, P.A.4
  • 35
    • 80052373259 scopus 로고    scopus 로고
    • Transcorneal electrical stimulation for patients with retinitis pigmentosa: A prospective, randomized, sham-controlled exploratory study
    • Schatz A, Rock T, Naycheva L, et al. Transcorneal electrical stimulation for patients with retinitis pigmentosa: a prospective, randomized, sham-controlled exploratory study. Invest Ophthalmol Vis Sci 2011; 52: 4485-4496.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 4485-4496
    • Schatz, A.1    Rock, T.2    Naycheva, L.3
  • 37
    • 0027521914 scopus 로고
    • Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice
    • Chang GQ, Hao Y, Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 1993; 11: 595-605.
    • (1993) Neuron , vol.11 , pp. 595-605
    • Chang, G.Q.1    Hao, Y.2    Wong, F.3
  • 39
    • 79960192809 scopus 로고    scopus 로고
    • Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats
    • Kaur J, Mencl S, Sahaboglu A, et al. Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats. PLoS ONE 2011; 6: e22181.
    • (2011) PLoS ONE , vol.6
    • Kaur, J.1    Mencl, S.2    Sahaboglu, A.3
  • 40
    • 58149333254 scopus 로고    scopus 로고
    • PKG activity causes photoreceptor cell death in two retinitis pigmentosa models
    • Paquet-Durand F, Hauck SM, van Veen T, Ueffing M, Ekstrom P. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neuro chem 2009; 108: 796-810.
    • (2009) J Neuro Chem , vol.108 , pp. 796-810
    • Paquet-Durand, F.1    Hauck, S.M.2    van Veen, T.3    Ueffing, M.4    Ekstrom, P.5
  • 41
    • 77958558027 scopus 로고    scopus 로고
    • Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse
    • Sancho-Pelluz J, Alavi M, Sahaboglu A, et al. Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death & Disease 2010; 1(e24): 1-9.
    • (2010) Cell Death & Disease , vol.1 , Issue.e24 , pp. 1-9
    • Sancho-Pelluz, J.1    Alavi, M.2    Sahaboglu, A.3
  • 42
    • 79551602686 scopus 로고    scopus 로고
    • A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa
    • Paquet-Durand F, Beck S, Michalakis S, et al. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 2011; 20: 941-947.
    • (2011) Hum Mol Genet , vol.20 , pp. 941-947
    • Paquet-Durand, F.1    Beck, S.2    Michalakis, S.3
  • 44
    • 3042705879 scopus 로고    scopus 로고
    • Rita Levi-Montalcini: The discovery of nerve growthfactor and modern neurobiology
    • Aloe L. Rita Levi-Montalcini: the discovery of nerve growthfactor and modern neurobiology. Trends Cell Biol 2004; 14: 395-399.
    • (2004) Trends Cell Biol , vol.14 , pp. 395-399
    • Aloe, L.1
  • 45
    • 0014782231 scopus 로고
    • Oxygen-induced visual cell degeneration in the rabbit
    • Bresnick GH. Oxygen-induced visual cell degeneration in the rabbit. Invest Ophthalmol 1970; 9: 372-387.
    • (1970) Invest Ophthalmol , vol.9 , pp. 372-387
    • Bresnick, G.H.1
  • 46
    • 53249147453 scopus 로고    scopus 로고
    • NT-501: An ophthalmic implant of polymer-encapsulated ciliary neurotrophic factor-producing cells
    • Emerich DF, Thanos CG. NT-501: an ophthalmic implant of polymer-encapsulated ciliary neurotrophic factor-producing cells. Curr Opin Mol Ther 2008; 10: 506-515.
    • (2008) Curr Opin Mol Ther , vol.10 , pp. 506-515
    • Emerich, D.F.1    Thanos, C.G.2
  • 47
    • 33644872951 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants
    • Sieving PA, Caruso RC, Tao W, et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci USA 2006; 103: 3896-3901.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3896-3901
    • Sieving, P.A.1    Caruso, R.C.2    Tao, W.3
  • 48
    • 77149141784 scopus 로고    scopus 로고
    • Biodegradable intraocular therapies for retinal disorders: Progress to date
    • Kuno N, Fujii S. Biodegradable intraocular therapies for retinal disorders: progress to date. Drugs Aging 2010; 27: 117-134.
    • (2010) Drugs Aging , vol.27 , pp. 117-134
    • Kuno, N.1    Fujii, S.2
  • 49
    • 0001716873 scopus 로고
    • A nerve growth-stimulating factor isolated from snake venom
    • Cohen S, Levi-Montalcini R. A nerve growth-stimulating factor isolated from snake venom. Proc Natl Acad Sci USA 1956; 42: 571-574.
    • (1956) Proc Natl Acad Sci USA , vol.42 , pp. 571-574
    • Cohen, S.1    Levi-Montalcini, R.2
  • 50
    • 0000050472 scopus 로고
    • A nerve growth stimulating factor isolated from sarcom AS 37 and 180
    • Cohen S, Levi-Montalcini R, Hamburger V. A nerve growth stimulating factor isolated from sarcom AS 37 and 180. Proc Natl Acad Sci USA 1954; 40: 1014-1018.
    • (1954) Proc Natl Acad Sci USA , vol.40 , pp. 1014-1018
    • Cohen, S.1    Levi-Montalcini, R.2    Hamburger, V.3
  • 51
    • 0001047311 scopus 로고
    • Purification of a nerve-growth promoting proteinfrom the mouse salivary gland and its neuro-cytotoxic antiserum
    • Cohen S. Purification of a nerve-growth promoting proteinfrom the mouse salivary gland and its neuro-cytotoxic antiserum. Proc Natl Acad Sci USA 1960; 46: 302-311.
    • (1960) Proc Natl Acad Sci USA , vol.46 , pp. 302-311
    • Cohen, S.1
  • 52
    • 0014584518 scopus 로고
    • The nerve growth factor: Purification as a 30,000-molecular-weight protein
    • Bocchini V, Angeletti PU. The nerve growth factor: purification as a 30,000-molecular-weight protein. Proc NatlAcad Sci USA 1969; 64: 787-794.
    • (1969) Proc NatlAcad Sci USA , vol.64 , pp. 787-794
    • Bocchini, V.1    Angeletti, P.U.2
  • 53
    • 0012315645 scopus 로고    scopus 로고
    • Neurotrophin secretion: Current facts and future prospects
    • Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 2003; 69: 341-374.
    • (2003) Prog Neurobiol , vol.69 , pp. 341-374
    • Lessmann, V.1    Gottmann, K.2    Malcangio, M.3
  • 54
    • 0036850873 scopus 로고    scopus 로고
    • Micro glia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration
    • Harada T, Harada C, Kohsaka S, et al. Micro glia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci 2002; 22: 9228-9236.
    • (2002) J Neurosci , vol.22 , pp. 9228-9236
    • Harada, T.1    Harada, C.2    Kohsaka, S.3
  • 55
    • 0028889346 scopus 로고
    • Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina
    • Wen R, Song Y, Cheng T, et al. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J Neurosci 1995; 15: 7377-7385.
    • (1995) J Neurosci , vol.15 , pp. 7377-7385
    • Wen, R.1    Song, Y.2    Cheng, T.3
  • 56
    • 3042526482 scopus 로고    scopus 로고
    • Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat
    • Yu DY, Cringle S, Valter K, Walsh N, Lee D, Stone J. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci 2004; 45: 2013-2019.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2013-2019
    • Yu, D.Y.1    Cringle, S.2    Valter, K.3    Walsh, N.4    Lee, D.5    Stone, J.6
  • 57
    • 38949092959 scopus 로고    scopus 로고
    • Regulation of neurotrophin expression and activity in the retina
    • Hackam AS. Regulation of neurotrophin expression and activity in the retina. Adv Exp Med Biol 2008; 613: 343-349.
    • (2008) Adv Exp Med Biol , vol.613 , pp. 343-349
    • Hackam, A.S.1
  • 58
    • 0042786843 scopus 로고    scopus 로고
    • Neuro trophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury
    • Boyd JG, Gordon T. Neuro trophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol 2003; 27: 277-324.
    • (2003) Mol Neurobiol , vol.27 , pp. 277-324
    • Boyd, J.G.1    Gordon, T.2
  • 59
    • 33744929368 scopus 로고    scopus 로고
    • Optimizing neurotrophic factor combinations for neurite outgrowth
    • Deister C, Schmidt CE. Optimizing neurotrophic factor combinations for neurite outgrowth. J Neural Eng 2006; 3:172-179.
    • (2006) J Neural Eng , vol.3 , pp. 172-179
    • Deister, C.1    Schmidt, C.E.2
  • 60
    • 33747410191 scopus 로고    scopus 로고
    • Molecular mechanisms of neuroprotection in the eye
    • Barnstable CJ, Tombran-Tink J. Molecular mechanisms of neuroprotection in the eye. Adv Exp Med Biol 2006; 572: 291-295.
    • (2006) Adv Exp Med Biol , vol.572 , pp. 291-295
    • Barnstable, C.J.1    Tombran-Tink, J.2
  • 61
    • 0030796393 scopus 로고    scopus 로고
    • Brain-derived neurotrophicfactor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina
    • Cellerino A, Kohler K. Brain-derived neurotrophicfactor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina. J Comp Neurol 1997; 386: 149-160.
    • (1997) J Comp Neurol , vol.386 , pp. 149-160
    • Cellerino, A.1    Kohler, K.2
  • 62
    • 0033563292 scopus 로고    scopus 로고
    • Neurotrophins and other growth factors in the generation of retinal neurons
    • Frade JM, Bovolenta P, Rodriguez-Tebar A. Neurotrophins and other growth factors in the generation of retinal neurons. Microsc Res Tech 1999; 45: 243-251.
    • (1999) Microsc Res Tech , vol.45 , pp. 243-251
    • Frade, J.M.1    Bovolenta, P.2    Rodriguez-Tebar, A.3
  • 63
    • 33846018863 scopus 로고    scopus 로고
    • CNTF+BDNFtreatment and neuroprotective pathways in the rd1 mouse retina
    • Azadi S, Johnson LE, Paquet-Durand F, et al. CNTF+BDNFtreatment and neuroprotective pathways in the rd1 mouse retina. Brain Res 2007; 1129: 116-129.
    • (2007) Brain Res , vol.1129 , pp. 116-129
    • Azadi, S.1    Johnson, L.E.2    Paquet-Durand, F.3
  • 64
    • 0030826706 scopus 로고    scopus 로고
    • Survival of axoto mized retinal ganglion cells in adult mammals
    • Watanabe M, Sawai H, Fukuda Y. Survival of axoto mized retinal ganglion cells in adult mammals. Clin Neurosci 1997; 4: 233-239.
    • (1997) Clin Neurosci , vol.4 , pp. 233-239
    • Watanabe, M.1    Sawai, H.2    Fukuda, Y.3
  • 65
    • 0032816799 scopus 로고    scopus 로고
    • Effects of brainderivedneurotrophic factor on the development of NADPHdiaphorase/ nitric oxide synthase-positive amacrine cells in the rodent retina
    • Cellerino A, Arango-Gonzalez BA, Kohler K. Effects of brainderivedneurotrophic factor on the development of NADPHdiaphorase/ nitric oxide synthase-positive amacrine cells in the rodent retina. Eur J Neurosci 1999; 11: 2824-2834.
    • (1999) Eur J Neurosci , vol.11 , pp. 2824-2834
    • Cellerino, A.1    Arango-Gonzalez, B.A.2    Kohler, K.3
  • 66
    • 0037664250 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells
    • Cellerino A, Arango-Gonzalez B, Pinzon-Duarte G, Kohler K. Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells. J Comp Neurol 2003; 467:97-104.
    • (2003) J Comp Neurol , vol.467 , pp. 97-104
    • Cellerino, A.1    Arango-Gonzalez, B.2    Pinzon-Duarte, G.3    Kohler, K.4
  • 67
    • 62649174867 scopus 로고    scopus 로고
    • Exogenous brainderived neurotrophic factor (BDNF) reverts phenotypic changes in the retinas of transgenic mice lacking the BDNF gene
    • Arango-Gonzalez B, Cellerino A, Kohler K. Exogenous brainderived neurotrophic factor (BDNF) reverts phenotypic changes in the retinas of transgenic mice lacking the BDNF gene. Invest Ophthalmol Vis Sci 2009; 50: 1416-1422.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1416-1422
    • Arango-Gonzalez, B.1    Cellerino, A.2    Kohler, K.3
  • 68
    • 0033571532 scopus 로고    scopus 로고
    • Parvalbumin immunoreactivity is enhanced bybrain-derived neurotrophic factor in organotypic cultures of rat retina
    • Rickman DW. Parvalbumin immunoreactivity is enhanced bybrain-derived neurotrophic factor in organotypic cultures of rat retina. J Neurobiol 1999; 41: 376-384.
    • (1999) J Neurobiol , vol.41 , pp. 376-384
    • Rickman, D.W.1
  • 69
    • 18744433956 scopus 로고    scopus 로고
    • Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Muller glia cells in the developing retina
    • Pinzon-Duarte G, Arango-Gonzalez B, Guenther E, Kohler K. Effects of brain-derived neurotrophic factor on cell survival, differentiation and patterning of neuronal connections and Muller glia cells in the developing retina. Eur J Neurosci 2004; 19: 1475-1484.
    • (2004) Eur J Neurosci , vol.19 , pp. 1475-1484
    • Pinzon-Duarte, G.1    Arango-Gonzalez, B.2    Guenther, E.3    Kohler, K.4
  • 70
    • 0031937530 scopus 로고    scopus 로고
    • Protection of mouse photoreceptors by survival factors in retinal degenerations
    • LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 1998; 39: 592-602.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 592-602
    • Lavail, M.M.1    Yasumura, D.2    Matthes, M.T.3
  • 71
    • 0037704444 scopus 로고    scopus 로고
    • Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage
    • Okoye G, Zimmer J, Sung J, et al. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci 2003; 23: 4164-4172.
    • (2003) J Neurosci , vol.23 , pp. 4164-4172
    • Okoye, G.1    Zimmer, J.2    Sung, J.3
  • 72
    • 0041842695 scopus 로고    scopus 로고
    • Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha)
    • Beltran WA, Zhang Q, Kijas JW, et al. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Invest Ophthalmol Vis Sci 2003; 44: 3642-3649.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3642-3649
    • Beltran, W.A.1    Zhang, Q.2    Kijas, J.W.3
  • 73
    • 25444470057 scopus 로고    scopus 로고
    • Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells
    • Beltran WA, Rohrer H, Aguirre GD. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. Mol Vis 2005; 11: 232-244.
    • (2005) Mol Vis , vol.11 , pp. 232-244
    • Beltran, W.A.1    Rohrer, H.2    Aguirre, G.D.3
  • 74
    • 0035179374 scopus 로고    scopus 로고
    • Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa
    • Liang FQ, Aleman TS, Dejneka NS, et al. Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther 2001; 4: 461-472.
    • (2001) Mol Ther , vol.4 , pp. 461-472
    • Liang, F.Q.1    Aleman, T.S.2    Dejneka, N.S.3
  • 75
    • 0036784819 scopus 로고    scopus 로고
    • Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    • Tao W, Wen R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002; 43: 3292-3298.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3292-3298
    • Tao, W.1    Wen, R.2    Goddard, M.B.3
  • 76
    • 33644875055 scopus 로고    scopus 로고
    • Survival factors for treatment of retinaldegenerative disorders: Preclinical gains and issues for translation into clinical studies
    • LaVail MM. Survival factors for treatment of retinaldegenerative disorders: preclinical gains and issues for translation into clinical studies. Retina 2005; 25: S25-S26.
    • (2005) Retina , vol.25
    • Lavail, M.M.1
  • 77
    • 0026462896 scopus 로고
    • Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
    • LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA 1992; 89: 11249-11253.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11249-11253
    • Lavail, M.M.1    Unoki, K.2    Yasumura, D.3    Matthes, M.T.4    Yancopoulos, G.D.5    Steinberg, R.H.6
  • 78
    • 0036349623 scopus 로고    scopus 로고
    • Effects of adenoassociated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
    • Bok D, Yasumura D, Matthes MT, et al. Effects of adenoassociated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 2002; 74: 719-735.
    • (2002) Exp Eye Res , vol.74 , pp. 719-735
    • Bok, D.1    Yasumura, D.2    Matthes, M.T.3
  • 79
    • 79953304523 scopus 로고    scopus 로고
    • Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration
    • Xia X, Li Y, Huang D, et al. Oncostatin M protects rod and cone photoreceptors and promotes regeneration of cone outer segment in a rat model of retinal degeneration. PLoS ONE 2011; 6: e18282.
    • (2011) PLoS ONE , vol.6
    • Xia, X.1    Li, Y.2    Huang, D.3
  • 80
    • 34047246836 scopus 로고    scopus 로고
    • Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa
    • Rhee KD, Ruiz A, Duncan JL, et al. Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2007; 48: 1389-400.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 1389-1400
    • Rhee, K.D.1    Ruiz, A.2    Duncan, J.L.3
  • 81
    • 0037352472 scopus 로고    scopus 로고
    • Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration
    • Schlichtenbrede FC, MacNeil A, Bainbridge JW, et al. Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Ther 2003; 10: 523-52.
    • (2003) Gene Ther , vol.10 , pp. 523-552
    • Schlichtenbrede, F.C.1    Macneil, A.2    Bainbridge, J.W.3
  • 82
    • 0031914627 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor blocks rod photoreceptor differentiation from postmitotic precursor cells in vitro
    • Kirsch M, Schulz-Key S, Wiese A, Fuhrmann S, Hofmann H. Ciliary neurotrophic factor blocks rod photoreceptor differentiation from postmitotic precursor cells in vitro. Cell Tissue Res 1998; 291: 207-216.
    • (1998) Cell Tissue Res , vol.291 , pp. 207-216
    • Kirsch, M.1    Schulz-Key, S.2    Wiese, A.3    Fuhrmann, S.4    Hofmann, H.5
  • 84
    • 33644874601 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor therapy for inherited retinaldiseases: Pros and cons
    • Bok D. Ciliary neurotrophic factor therapy for inherited retinaldiseases: pros and cons. Retina 2005; 25: S27-S28.
    • (2005) Retina , vol.25
    • Bok, D.1
  • 85
    • 9444282118 scopus 로고    scopus 로고
    • Integration between abutting retinas: Role of glial structuresand associated molecules at the interface
    • Zhang Y, Kardaszewska AK, van VT, Rauch U, Perez MT. Integration between abutting retinas: role of glial structuresand associated molecules at the interface. Invest Ophthalmol Vis Sci 2004; 45: 4440-4449.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 4440-4449
    • Zhang, Y.1    Kardaszewska, A.K.2    Van, V.T.3    Rauch, U.4    Perez, M.T.5
  • 86
    • 79953134852 scopus 로고    scopus 로고
    • Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    • Talcott KE, Ratnam K, Sundquist SM, et al. Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment. Invest Ophthalmol Vis Sci 2011; 52: 2219-2226.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2219-2226
    • Talcott, K.E.1    Ratnam, K.2    Sundquist, S.M.3
  • 87
    • 0029025831 scopus 로고
    • Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity
    • Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D. Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 1995; 15: 4992-5003.
    • (1995) J Neurosci , vol.15 , pp. 4992-5003
    • Tombran-Tink, J.1    Shivaram, S.M.2    Chader, G.J.3    Johnson, L.V.4    Bok, D.5
  • 88
    • 0032537459 scopus 로고    scopus 로고
    • Sequence and expression analysis of bovine pigment epithelium-derived factor
    • Perez-Mediavilla LA, Chew C, Campochiaro PA, et al. Sequence and expression analysis of bovine pigment epithelium-derived factor. Biochim Biophys Acta 1998; 1398: 203-214.
    • (1998) Biochim Biophys Acta , vol.1398 , pp. 203-214
    • Perez-Mediavilla, L.A.1    Chew, C.2    Campochiaro, P.A.3
  • 89
    • 0029347070 scopus 로고
    • Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes
    • Wu YQ, Notario V, Chader GJ, Becerra SP. Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif 1995; 6: 447-456.
    • (1995) Protein Expr Purif , vol.6 , pp. 447-456
    • Wu, Y.Q.1    Notario, V.2    Chader, G.J.3    Becerra, S.P.4
  • 90
    • 0036211549 scopus 로고    scopus 로고
    • Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization
    • Ogata N, Wada M, Otsuji T, Jo N, Tombran-Tink J, Matsumura M. Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2002; 43: 1168-1175.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 1168-1175
    • Ogata, N.1    Wada, M.2    Otsuji, T.3    Jo, N.4    Tombran-Tink, J.5    Matsumura, M.6
  • 91
    • 0036974050 scopus 로고    scopus 로고
    • Pigment epitheliumderivedfactor expression in the developing mouse eye
    • Behling KC, Surace EM, Bennett J. Pigment epitheliumderivedfactor expression in the developing mouse eye. Mol Vis 2002; 8: 449-454.
    • (2002) Mol Vis , vol.8 , pp. 449-454
    • Behling, K.C.1    Surace, E.M.2    Bennett, J.3
  • 92
    • 0347664084 scopus 로고    scopus 로고
    • Localization ofpigment epithelium derived factor (PEDF) in developing and adult human ocular tissues
    • Karakousis PC, John SK, Behling KC, et al. Localization ofpigment epithelium derived factor (PEDF) in developing and adult human ocular tissues. Mol Vis 2001; 7: 154-163.
    • (2001) Mol Vis , vol.7 , pp. 154-163
    • Karakousis, P.C.1    John, S.K.2    Behling, K.C.3
  • 93
    • 0030476601 scopus 로고    scopus 로고
    • Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor
    • Ortego J, Escribano J, Becerra SP, Coca-Prados M. Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor. Invest Ophthalmol Vis Sci 1996; 37: 2759-2767.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 2759-2767
    • Ortego, J.1    Escribano, J.2    Becerra, S.P.3    Coca-Prados, M.4
  • 94
    • 38949121725 scopus 로고    scopus 로고
    • Neuro trophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuro protectin D1
    • Bazan NG. Neuro trophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuro protectin D1. Adv Exp Med Biol 2008; 613: 39-44.
    • (2008) Adv Exp Med Biol , vol.613 , pp. 39-44
    • Bazan, N.G.1
  • 96
    • 0034307757 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal
    • Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci 2000; 20: 7149-7157.
    • (2000) J Neurosci , vol.20 , pp. 7149-7157
    • Jablonski, M.M.1    Tombran-Tink, J.2    Mrazek, D.A.3    Iannaccone, A.4
  • 97
    • 0029801527 scopus 로고    scopus 로고
    • Cellular expressionof GDNF mRNA suggests multiple functions inside andoutside the nervous system
    • Nosrat CA, Tomac A, Lindqvist E, et al. Cellular expressionof GDNF mRNA suggests multiple functions inside andoutside the nervous system. Cell Tissue Res 1996; 286: 191-207.
    • (1996) Cell Tissue Res , vol.286 , pp. 191-207
    • Nosrat, C.A.1    Tomac, A.2    Lindqvist, E.3
  • 98
    • 26244460046 scopus 로고    scopus 로고
    • Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?
    • Delyfer MN, Simonutti M, Neveux N, Leveillard T, Sahel JA. Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST? Mol Vis 2005; 11: 677-687.
    • (2005) Mol Vis , vol.11 , pp. 677-687
    • Delyfer, M.N.1    Simonutti, M.2    Neveux, N.3    Leveillard, T.4    Sahel, J.A.5
  • 99
    • 0032829894 scopus 로고    scopus 로고
    • Glial cell linederived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
    • Frasson M, Picaud S, Leveillard T, et al. Glial cell linederived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 1999; 40: 2724-2734.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2724-2734
    • Frasson, M.1    Picaud, S.2    Leveillard, T.3
  • 100
    • 0035664438 scopus 로고    scopus 로고
    • Glial cell line derived neuro trophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa
    • McGee Sanftner LH, Abel H, Hauswirth WW, Flannery JG. Glial cell line derived neuro trophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa. Mol Ther 2001; 4: 622-629.
    • (2001) Mol Ther , vol.4 , pp. 622-629
    • McGee, S.L.H.1    Abel, H.2    Hauswirth, W.W.3    Flannery, J.G.4
  • 101
    • 0346096976 scopus 로고    scopus 로고
    • Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats
    • Lawrence JM, Keegan DJ, Muir EM, et al. Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci 2004; 45: 267-274.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 267-274
    • Lawrence, J.M.1    Keegan, D.J.2    Muir, E.M.3
  • 102
    • 84871849885 scopus 로고    scopus 로고
    • Non-viral gene therapy for GDNF production in RCS rat: The crucial role of the plasmid dose
    • Epub ahead of print)
    • Touchard E, Heiduschka P, Berdugo M, et al. Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose. Gene Ther 2011 (Epub ahead of print).
    • (2011) Gene Ther
    • Touchard, E.1    Heiduschka, P.2    Berdugo, M.3
  • 103
    • 84856975718 scopus 로고    scopus 로고
    • Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9
    • Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Ther 2011, 19: 176-181.
    • (2011) Gene Ther , vol.19 , pp. 176-181
    • Dalkara, D.1    Byrne, L.C.2    Lee, T.3    Hoffmann, N.V.4    Schaffer, D.V.5    Flannery, J.G.6
  • 104
    • 75649107243 scopus 로고    scopus 로고
    • Muller-cell-derived neurotrophic factors, a road to neuroprotective therapy in the retina
    • Hauck SM, Ueffing M. Muller-cell-derived neurotrophic factors, a road to neuroprotective therapy in the retina. Arch Soc Esp Oftalmol 2009; 84: 423-425.
    • (2009) Arch Soc Esp Oftalmol , vol.84 , pp. 423-425
    • Hauck, S.M.1    Ueffing, M.2
  • 105
    • 79952653281 scopus 로고    scopus 로고
    • GDNFinduced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration
    • Del Rio P, Irmler M, Arango-Gonzalez B, et al. GDNFinduced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration. Glia 2011; 59: 821-832.
    • (2011) Glia , vol.59 , pp. 821-832
    • del Rio, P.1    Irmler, M.2    Arango-Gonzalez, B.3
  • 106
    • 39549108935 scopus 로고    scopus 로고
    • Chronicintravitreous infusion of ciliary neurotrophic factor modulates electrical retinal stimulation thresholds in the RCS rat
    • Kent TL, Glybina IV, Abrams GW, Iezzi R. Chronicintravitreous infusion of ciliary neurotrophic factor modulates electrical retinal stimulation thresholds in the RCS rat. Invest Ophthalmol Vis Sci 2008; 49: 372-379.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 372-379
    • Kent, T.L.1    Glybina, I.V.2    Abrams, G.W.3    Iezzi, R.4
  • 107
    • 77949751399 scopus 로고    scopus 로고
    • CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration
    • Li Y, Tao W, Luo L, et al. CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS ONE 2010; 5: e9495.
    • (2010) PLoS ONE , vol.5
    • Li, Y.1    Tao, W.2    Luo, L.3
  • 108
    • 0035183596 scopus 로고    scopus 로고
    • Mouse retina explants after long-term culture in serum free medium
    • Caffé AR, Ahuja P, Holmqvist B, et al. Mouse retina explants after long-term culture in serum free medium. J Chem Neuroanat 2001; 22: 263-273.
    • (2001) J Chem Neuroanat , vol.22 , pp. 263-273
    • Caffé, A.R.1    Ahuja, P.2    Holmqvist, B.3
  • 109
    • 0034052318 scopus 로고    scopus 로고
    • Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture
    • Ogilvie JM, Speck JD, Lett JM. Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture. Exp Neurol 2000; 161: 676-685.
    • (2000) Exp Neurol , vol.161 , pp. 676-685
    • Ogilvie, J.M.1    Speck, J.D.2    Lett, J.M.3
  • 110
    • 0025062946 scopus 로고
    • Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
    • Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 1990; 347: 83-86.
    • (1990) Nature , vol.347 , pp. 83-86
    • Faktorovich, E.G.1    Steinberg, R.H.2    Yasumura, D.3    Matthes, M.T.4    Lavail, M.M.5
  • 111
    • 0026666404 scopus 로고
    • Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat
    • Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 1992; 12: 3554-3567.
    • (1992) J Neurosci , vol.12 , pp. 3554-3567
    • Faktorovich, E.G.1    Steinberg, R.H.2    Yasumura, D.3    Matthes, M.T.4    Lavail, M.M.5
  • 112
    • 0032533962 scopus 로고    scopus 로고
    • Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
    • Cayouette M, Behn D, Sendtner M, Lachapelle P, Gravel C. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 1998; 18: 9282-9293.
    • (1998) J Neurosci , vol.18 , pp. 9282-9293
    • Cayouette, M.1    Behn, D.2    Sendtner, M.3    Lachapelle, P.4    Gravel, C.5
  • 113
    • 0032925488 scopus 로고    scopus 로고
    • Repeated injections of a ciliary neurotrophicfactor analogue leading to long-term photoreceptor survivalin hereditary retinal degeneration
    • Chong NH, Alexander RA, Waters L, Barnett KC, Bird AC, Luthert PJ. Repeated injections of a ciliary neurotrophicfactor analogue leading to long-term photoreceptor survivalin hereditary retinal degeneration. Invest Ophthalmol Vis Sci 1999; 40: 1298-1305.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1298-1305
    • Chong, N.H.1    Alexander, R.A.2    Waters, L.3    Barnett, K.C.4    Bird, A.C.5    Luthert, P.J.6
  • 114
    • 0032881941 scopus 로고    scopus 로고
    • Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
    • Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 1999; 5: 1183-1187.
    • (1999) Nat Med , vol.5 , pp. 1183-1187
    • Frasson, M.1    Sahel, J.A.2    Fabre, M.3    Simonutti, M.4    Dreyfus, H.5    Picaud, S.6
  • 115
    • 0031969285 scopus 로고    scopus 로고
    • Neuro trophins in the developing and regenerating visual system
    • von Bartheld CS. Neuro trophins in the developing and regenerating visual system. Histol Histopathol 1998; 13: 437-459.
    • (1998) Histol Histopathol , vol.13 , pp. 437-459
    • von Bartheld, C.S.1
  • 116
    • 15244345579 scopus 로고    scopus 로고
    • Effect of exogenous administration of nerve growth factorin the retina of rats with inherited retinitis pigmentosa
    • Lenzi L, Coassin M, Lambiase A, Bonini S, Amendola T, Aloe L. Effect of exogenous administration of nerve growth factorin the retina of rats with inherited retinitis pigmentosa. Vision Res 2005; 45: 1491-1500.
    • (2005) Vision Res , vol.45 , pp. 1491-1500
    • Lenzi, L.1    Coassin, M.2    Lambiase, A.3    Bonini, S.4    Amendola, T.5    Aloe, L.6
  • 118
    • 0029059248 scopus 로고
    • Serine 133- phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals
    • Bonni A, Ginty DD, Dudek H, Greenberg ME. Serine 133- phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol Cell Neurosci 1995; 6: 168-183.
    • (1995) Mol Cell Neurosci , vol.6 , pp. 168-183
    • Bonni, A.1    Ginty, D.D.2    Dudek, H.3    Greenberg, M.E.4
  • 119
    • 33645356186 scopus 로고    scopus 로고
    • Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina
    • Azadi S, Paquet-Durand F, Medstrand P, van Veen T, Ekstrom PA. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 2006; 31:759-77
    • (2006) Mol Cell Neurosci , vol.31 , pp. 759-777
    • Azadi, S.1    Paquet-Durand, F.2    Medstrand, P.3    van Veen, T.4    Ekstrom, P.A.5
  • 120
    • 0034633619 scopus 로고    scopus 로고
    • Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Longterm survival and late-stage therapy
    • LaVail MM, Yasumura D, Matthes MT, et al. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: longterm survival and late-stage therapy. Proc Natl Acad Sci USA 2000; 97: 11488-11493.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11488-11493
    • Lavail, M.M.1    Yasumura, D.2    Matthes, M.T.3
  • 122
    • 65949122960 scopus 로고    scopus 로고
    • Ex vivo gene therapy using intravitreal injection of GDNFsecreting mouse embryonic stem cells in a rat model of retinal degeneration
    • Gregory-Evans K, Chang F, Hodges MD, Gregory-Evans CY. Ex vivo gene therapy using intravitreal injection of GDNFsecreting mouse embryonic stem cells in a rat model of retinal degeneration. Mol Vis 2009; 15: 962-973.
    • (2009) Mol Vis , vol.15 , pp. 962-973
    • Gregory-Evans, K.1    Chang, F.2    Hodges, M.D.3    Gregory-Evans, C.Y.4
  • 123
    • 0036297886 scopus 로고    scopus 로고
    • Regression of ocular neovascularization in response toincreased expression of pigment epithelium-derived factor
    • Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA. Regression of ocular neovascularization in response toincreased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 2002; 43: 2428-2434.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2428-2434
    • Mori, K.1    Gehlbach, P.2    Ando, A.3    McVey, D.4    Wei, L.5    Campochiaro, P.A.6
  • 124
    • 59149107151 scopus 로고    scopus 로고
    • Neuro trophic support and oxidative stress: Converging effects in the normal and diseased nervous system
    • Gardiner J, Barton D, Overall R, Marc J. Neuro trophic support and oxidative stress: converging effects in the normal and diseased nervous system. Neuroscientist 2009; 15: 47-61.
    • (2009) Neuroscientist , vol.15 , pp. 47-61
    • Gardiner, J.1    Barton, D.2    Overall, R.3    Marc, J.4
  • 125
    • 3042526482 scopus 로고    scopus 로고
    • Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat
    • Yu DY, Cringle S, Valter K, Walsh N, Lee D, Stone J. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Invest Ophthalmol Vis Sci 2004; 45: 2013-2019.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2013-2019
    • Yu, D.Y.1    Cringle, S.2    Valter, K.3    Walsh, N.4    Lee, D.5    Stone, J.6
  • 126
    • 77952543205 scopus 로고    scopus 로고
    • Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice
    • Kong L, Zhou X, Li F, Yodoi J, McGinnis J, Cao W. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiol Dis 2010; 38: 446-455.
    • (2010) Neurobiol Dis , vol.38 , pp. 446-455
    • Kong, L.1    Zhou, X.2    Li, F.3    Yodoi, J.4    McGinnis, J.5    Cao, W.6
  • 127
    • 77952299343 scopus 로고    scopus 로고
    • Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system
    • Bhatt L, Groeger G, McDermott K, Cotter TG. Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system. Mol Vis 2010; 16: 283-293.
    • (2010) Mol Vis , vol.16 , pp. 283-293
    • Bhatt, L.1    Groeger, G.2    McDermott, K.3    Cotter, T.G.4
  • 128
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006; 127: 397-408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3
  • 129
    • 20444400860 scopus 로고    scopus 로고
    • Retinal degeneration and local oxygen metabolism
    • Yu DY, Cringle SJ. Retinal degeneration and local oxygen metabolism. Exp Eye Res 2005; 80: 745-751.
    • (2005) Exp Eye Res , vol.80 , pp. 745-751
    • Yu, D.Y.1    Cringle, S.J.2
  • 130
    • 34247616816 scopus 로고    scopus 로고
    • Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases
    • Ahuja-Jensen P, Johnsen-Soriano S, Ahuja S, et al. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 2007; 18: 797-801.
    • (2007) Neuroreport , vol.18 , pp. 797-801
    • Ahuja-Jensen, P.1    Johnsen-Soriano, S.2    Ahuja, S.3
  • 131
    • 70349172938 scopus 로고    scopus 로고
    • Apoptosis and glutathione: Beyondan antioxidant
    • Franco R, Cidlowski JA. Apoptosis and glutathione: beyondan antioxidant. Cell Death Differ 2009; 16: 1303-1314.
    • (2009) Cell Death Differ , vol.16 , pp. 1303-1314
    • Franco, R.1    Cidlowski, J.A.2
  • 132
    • 33750110882 scopus 로고    scopus 로고
    • Reactive oxygen species and vascular remodelling in hypertension: Still alive
    • Xu S, Touyz RM. Reactive oxygen species and vascular remodelling in hypertension: still alive. Can J Cardiol 2006; 22: 947-951.
    • (2006) Can J Cardiol , vol.22 , pp. 947-951
    • Xu, S.1    Touyz, R.M.2
  • 133
    • 0033134010 scopus 로고    scopus 로고
    • Reactive oxygenspecies as mediators of photoreceptor apoptosis in vitro
    • Carmody RJ, McGowan AJ, Cotter TG. Reactive oxygenspecies as mediators of photoreceptor apoptosis in vitro. Exp Cell Res 1999; 248: 520-530.
    • (1999) Exp Cell Res , vol.248 , pp. 520-530
    • Carmody, R.J.1    McGowan, A.J.2    Cotter, T.G.3
  • 134
    • 67349177794 scopus 로고    scopus 로고
    • Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa
    • Usui S, Komeima K, Lee SY, et al. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Mol Ther 2009; 17: 778-786.
    • (2009) Mol Ther , vol.17 , pp. 778-786
    • Usui, S.1    Komeima, K.2    Lee, S.Y.3
  • 135
    • 67650505494 scopus 로고    scopus 로고
    • NADPH oxidase plays acentral role in cone cell death in retinitis pigmentosa
    • Usui S, Oveson BC, Lee SY, et al. NADPH oxidase plays acentral role in cone cell death in retinitis pigmentosa. J Neurochem 2009; 110: 1028-1037.
    • (2009) J Neurochem , vol.110 , pp. 1028-1037
    • Usui, S.1    Oveson, B.C.2    Lee, S.Y.3
  • 136
    • 35248831880 scopus 로고    scopus 로고
    • Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa
    • Komeima K, Rogers BS, Campochiaro PA. Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa. J Cell Physiol 2007; 213: 809-815.
    • (2007) J Cell Physiol , vol.213 , pp. 809-815
    • Komeima, K.1    Rogers, B.S.2    Campochiaro, P.A.3
  • 137
    • 33748677104 scopus 로고    scopus 로고
    • Oxidative stress in glaucomatousneurodegeneration: Mechanisms and consequences
    • Tezel G. Oxidative stress in glaucomatousneurodegeneration: mechanisms and consequences. Prog Retin Eye Res 2006; 25: 490-513.
    • (2006) Prog Retin Eye Res , vol.25 , pp. 490-513
    • Tezel, G.1
  • 138
    • 80255131319 scopus 로고    scopus 로고
    • Neuro protective effects of tempol acyl esters against retinal ganglion cell death in a rat partial optic nerve crush model
    • Thaler S, Fiedorowicz M, Grieb P, et al. Neuro protective effects of tempol acyl esters against retinal ganglion cell death in a rat partial optic nerve crush model. Acta Ophthalmol 2011; 89: e555-e560.
    • (2011) Acta Ophthalmol , vol.89
    • Thaler, S.1    Fiedorowicz, M.2    Grieb, P.3
  • 139
    • 34548847441 scopus 로고    scopus 로고
    • Excessiveactivation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinaldegeneration 1 mouse
    • Paquet-Durand F, Silva J, Talukdar T, et al. Excessiveactivation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinaldegeneration 1 mouse. J Neurosci 2007; 27: 10311-10319.
    • (2007) J Neurosci , vol.27 , pp. 10311-10319
    • Paquet-Durand, F.1    Silva, J.2    Talukdar, T.3
  • 140
    • 0033524924 scopus 로고    scopus 로고
    • Photo-oxidative stress down-modulates the activity of nuclear factor-kappaB via involvement of caspase-1, leading to apoptosis of photoreceptor cells
    • Krishnamoorthy RR, Crawford MJ, Chaturvedi MM, et al. Photo-oxidative stress down-modulates the activity of nuclear factor-kappaB via involvement of caspase-1, leading to apoptosis of photoreceptor cells. J Biol Chem 1999; 274: 3734-3743.
    • (1999) J Biol Chem , vol.274 , pp. 3734-3743
    • Krishnamoorthy, R.R.1    Crawford, M.J.2    Chaturvedi, M.M.3
  • 141
    • 4744338189 scopus 로고    scopus 로고
    • Multi destructive pathways triggered in photoreceptor celldeath of the rd mouse as determined through gene expression profiling
    • Rohrer B, Pinto FR, Hulse KE, Lohr HR, Zhang L, Almeida JS. Multi destructive pathways triggered in photoreceptor celldeath of the rd mouse as determined through gene expression profiling. J Biol Chem 2004; 279: 41903-41910.
    • (2004) J Biol Chem , vol.279 , pp. 41903-41910
    • Rohrer, B.1    Pinto, F.R.2    Hulse, K.E.3    Lohr, H.R.4    Zhang, L.5    Almeida, J.S.6
  • 142
    • 33751239138 scopus 로고    scopus 로고
    • Apoptosis in retinal degeneration involves cross-talk between apoptosisinducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors
    • Sanges D, Comitato A, Tammaro R, Marigo V. Apoptosis in retinal degeneration involves cross-talk between apoptosisinducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proc Natl Acad Sci USA 2006; 103: 17366-17371.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17366-17371
    • Sanges, D.1    Comitato, A.2    Tammaro, R.3    Marigo, V.4
  • 143
    • 32944467645 scopus 로고    scopus 로고
    • Activation of multiple pathways during photoreceptor apoptosis in the rd mouse
    • Doonan F, Donovan M, Cotter TG. Activation of multiple pathways during photoreceptor apoptosis in the rd mouse. Invest Ophthalmol Vis Sci 2005; 46: 3530-3538.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3530-3538
    • Doonan, F.1    Donovan, M.2    Cotter, T.G.3
  • 144
    • 0027537949 scopus 로고
    • Retinitis pigmentosa. The Friedenwald Lecture
    • Berson EL. Retinitis pigmentosa. The Friedenwald Lecture. Invest Ophthalmol Vis Sci 1993; 34: 1659-1676.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 1659-1676
    • Berson, E.L.1
  • 145
    • 0036733063 scopus 로고    scopus 로고
    • Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: A 3-year followup study
    • Pasantes-Morales H, Quiroz H, Quesada O. Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year followup study. Metab Brain Dis 2002; 17: 183-197.
    • (2002) Metab Brain Dis , vol.17 , pp. 183-197
    • Pasantes-Morales, H.1    Quiroz, H.2    Quesada, O.3
  • 146
    • 72649084334 scopus 로고    scopus 로고
    • Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism
    • Miranda M, Arnal E, Ahuja S, et al. Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism. Free Radic Biol Med 2010; 48: 216-222.
    • (2010) Free Radic Biol Med , vol.48 , pp. 216-222
    • Miranda, M.1    Arnal, E.2    Ahuja, S.3
  • 147
    • 14644401785 scopus 로고    scopus 로고
    • Decreased glutathione transferase levels in rd1/rd1 mouse retina: Replenishment protects photoreceptors in retinal explants
    • Ahuja P, Caffe AR, Ahuja S, Ekstrom P, van Veen T. Decreased glutathione transferase levels in rd1/rd1 mouse retina: replenishment protects photoreceptors in retinal explants. Neuroscience 2005; 131: 935-943.
    • (2005) Neuroscience , vol.131 , pp. 935-943
    • Ahuja, P.1    Caffe, A.R.2    Ahuja, S.3    Ekstrom, P.4    van Veen, T.5
  • 148
    • 67650697532 scopus 로고    scopus 로고
    • The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina
    • Fridlich R, Delalande F, Jaillard C, et al. The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina. Mol Cell Proteomics 2009; 8: 1206-1218.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 1206-1218
    • Fridlich, R.1    Delalande, F.2    Jaillard, C.3
  • 149
    • 77953621101 scopus 로고    scopus 로고
    • The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress
    • Cronin T, Raffelsberger W, Lee-Rivera I, et al. The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ 2010; 17: 1199-1210.
    • (2010) Cell Death Differ , vol.17 , pp. 1199-1210
    • Cronin, T.1    Raffelsberger, W.2    Lee-Rivera, I.3
  • 150
    • 0034087064 scopus 로고    scopus 로고
    • Etiology, pathogenesis, and experimental treatment of retinitis pigmentosa
    • Baumgartner WA. Etiology, pathogenesis, and experimental treatment of retinitis pigmentosa. Med Hypotheses 2000; 54: 814-824.
    • (2000) Med Hypotheses , vol.54 , pp. 814-824
    • Baumgartner, W.A.1
  • 152
    • 77950866700 scopus 로고    scopus 로고
    • Age-related macular degeneration: Current and novel therapies
    • Prasad PS, Schwartz SD, Hubschman JP. Age-related macular degeneration: current and novel therapies. Maturitas 2010; 66: 46-50.
    • (2010) Maturitas , vol.66 , pp. 46-50
    • Prasad, P.S.1    Schwartz, S.D.2    Hubschman, J.P.3
  • 153
    • 0036634250 scopus 로고    scopus 로고
    • Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells
    • Fiscus RR. Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells. Neurosignals 2002; 11: 175-190.
    • (2002) Neurosignals , vol.11 , pp. 175-190
    • Fiscus, R.R.1
  • 154
    • 17044363529 scopus 로고    scopus 로고
    • Mechanisms of cell death in rhodopsin retinitis pigmentosa: Implications for therapy
    • Mendes HF, van der SJ, Chapple JP, Cheetham ME. Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy. Trends Mol Med 2005; 11: 177-185.
    • (2005) Trends Mol Med , vol.11 , pp. 177-185
    • Mendes, H.F.1    van der, S.J.2    Chapple, J.P.3    Cheetham, M.E.4
  • 155
    • 78650918670 scopus 로고    scopus 로고
    • Restoration ofcone vision in the CNGA3(-/-) mouse model of congenital complete lack of cone photoreceptor function
    • Michalakis S, Muhlfriedel R, Tanimoto N, et al. Restoration ofcone vision in the CNGA3(-/-) mouse model of congenital complete lack of cone photoreceptor function. Mol Ther 2010; 18: 2057-2063.
    • (2010) Mol Ther , vol.18 , pp. 2057-2063
    • Michalakis, S.1    Muhlfriedel, R.2    Tanimoto, N.3
  • 156
    • 4644256599 scopus 로고    scopus 로고
    • Leber congenital amaurosis linked to AIPL1: A mouse model reveals destabilization of cGMP phosphodiesterase
    • Ramamurthy V, Niemi GA, Reh TA, Hurley JB. Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase. ProcNatl Acad Sci USA 2004; 101: 13897-13902.
    • (2004) ProcNatl Acad Sci USA , vol.101 , pp. 13897-13902
    • Ramamurthy, V.1    Niemi, G.A.2    Reh, T.A.3    Hurley, J.B.4
  • 157
    • 38949202376 scopus 로고    scopus 로고
    • Involvement of guanylatecyclases in transport of photoreceptor peripheral membrane proteins
    • Karan S, Frederick JM, Baehr W. Involvement of guanylatecyclases in transport of photoreceptor peripheral membrane proteins. Adv Exp Med Biol 2008; 613: 351-359.
    • (2008) Adv Exp Med Biol , vol.613 , pp. 351-359
    • Karan, S.1    Frederick, J.M.2    Baehr, W.3
  • 158
    • 4444329802 scopus 로고    scopus 로고
    • A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1)associated with auto somal dominant cone degeneration
    • Nishiguchi KM, Sokal I, Yang L, et al. A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1)associated with auto somal dominant cone degeneration. Invest Ophthalmol Vis Sci 2004; 45: 3863-3870.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3863-3870
    • Nishiguchi, K.M.1    Sokal, I.2    Yang, L.3
  • 159
    • 0036193892 scopus 로고    scopus 로고
    • Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic link to human retinal degeneration
    • Olshevskaya EV, Ermilov AN, Dizhoor AM. Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic link to human retinal degeneration. Mol Cell Biochem 2002; 230: 139-147.
    • (2002) Mol Cell Biochem , vol.230 , pp. 139-147
    • Olshevskaya, E.V.1    Ermilov, A.N.2    Dizhoor, A.M.3
  • 160
    • 85119550172 scopus 로고    scopus 로고
    • Chickens carry the same GC1 null allele (GUCY1*)
    • Semple-Rowland SL, Cheng KM. Chickens carry the same GC1 null allele (GUCY1*). Exp Eye Res 1999; 69: 575-581.
    • (1999) Exp Eye Res , vol.69 , pp. 575-581
    • Semple-Rowland, S.L.1    Cheng, K.M.2
  • 161
    • 79551610546 scopus 로고    scopus 로고
    • RNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa
    • Tosi J, Davis RJ, Wang NK, Naumann M, Lin CS, Tsang SH. RNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. J Cell Mol Med 2010; 15: 1778-1787.
    • (2010) J Cell Mol Med , vol.15 , pp. 1778-1787
    • Tosi, J.1    Davis, R.J.2    Wang, N.K.3    Naumann, M.4    Lin, C.S.5    Tsang, S.H.6
  • 162
    • 19944428767 scopus 로고    scopus 로고
    • Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
    • Huttl S, Michalakis S, Seeliger M, et al. Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J Neurosci 2005; 25: 130-138.
    • (2005) J Neurosci , vol.25 , pp. 130-138
    • Huttl, S.1    Michalakis, S.2    Seeliger, M.3
  • 164
    • 0026713642 scopus 로고
    • Programmed cell death: Its possible contribution to neurotoxicity mediated by calcium channel antagonists
    • Koh JY, Cotman CW. Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res 1992; 587: 233-240.
    • (1992) Brain Res , vol.587 , pp. 233-240
    • Koh, J.Y.1    Cotman, C.W.2
  • 165
    • 33751182616 scopus 로고    scopus 로고
    • Diltiazem protects human NT-2 neurons against excitotoxic damage in a model of simulated ischemia
    • Paquet-Durand F, Gierse A, Bicker G. Diltiazem protects human NT-2 neurons against excitotoxic damage in a model of simulated ischemia. Brain Res 2006; 1124: 45-54.
    • (2006) Brain Res , vol.1124 , pp. 45-54
    • Paquet-Durand, F.1    Gierse, A.2    Bicker, G.3
  • 166
    • 67349217830 scopus 로고    scopus 로고
    • Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture
    • Podrygajlo G, Tegenge MA, Gierse A, et al. Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture. Cell Tissue Res 2009; 336: 439-452.
    • (2009) Cell Tissue Res , vol.336 , pp. 439-452
    • Podrygajlo, G.1    Tegenge, M.A.2    Gierse, A.3
  • 167
    • 0033389181 scopus 로고    scopus 로고
    • Calcium overload triggers rodphotoreceptor apoptotic cell death in chemical-induced and inherited retinal degenerations
    • Fox DA, Poblenz AT, He L. Calcium overload triggers rodphotoreceptor apoptotic cell death in chemical-induced and inherited retinal degenerations. Ann N Y Acad Sci 1999; 893: 282-285.
    • (1999) Ann N Y Acad Sci , vol.893 , pp. 282-285
    • Fox, D.A.1    Poblenz, A.T.2    He, L.3
  • 168
    • 25844486601 scopus 로고    scopus 로고
    • Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors
    • Vallazza-Deschamps G, Cia D, Gong J, et al. Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors. Eur J Neurosci 2005; 22: 1013-1022.
    • (2005) Eur J Neurosci , vol.22 , pp. 1013-1022
    • Vallazza-Deschamps, G.1    Cia, D.2    Gong, J.3
  • 169
    • 36749103711 scopus 로고    scopus 로고
    • Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds)mouse
    • Takeuchi K, Nakazawa M, Mizukoshi S. Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds)mouse. Exp Eye Res 2008; 86: 60-69.
    • (2008) Exp Eye Res , vol.86 , pp. 60-69
    • Takeuchi, K.1    Nakazawa, M.2    Mizukoshi, S.3
  • 170
    • 0346949036 scopus 로고    scopus 로고
    • Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa
    • Pearce-Kelling SE, Aleman TS, Nickle A, et al. Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of retinitis pigmentosa. Mol Vis 2001; 7: 42-47.
    • (2001) Mol Vis , vol.7 , pp. 42-47
    • Pearce-Kelling, S.E.1    Aleman, T.S.2    Nickle, A.3
  • 172
    • 9144222598 scopus 로고    scopus 로고
    • Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse
    • Takano Y, Ohguro H, Dezawa M, et al. Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun 2004; 313: 1015-1022.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 1015-1022
    • Takano, Y.1    Ohguro, H.2    Dezawa, M.3
  • 173
    • 0027404913 scopus 로고
    • Intracellular cyclic GMP receptor proteins
    • Lincoln TM, Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J 1993; 7: 328-33
    • (1993) FASEB J , vol.7 , pp. 328-333
    • Lincoln, T.M.1    Cornwell, T.L.2
  • 174
    • 2542619027 scopus 로고    scopus 로고
    • Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells
    • Deguchi A, Thompson WJ, Weinstein IB. Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells. Cancer Res 2004; 64: 3966-3973.
    • (2004) Cancer Res , vol.64 , pp. 3966-3973
    • Deguchi, A.1    Thompson, W.J.2    Weinstein, I.B.3
  • 175
    • 33746877160 scopus 로고    scopus 로고
    • Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells
    • Canzoniero LM, Adornetto A, Secondo A, et al. Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells. J Neurosci Res 2006; 84: 692-697.
    • (2006) J Neurosci Res , vol.84 , pp. 692-697
    • Canzoniero, L.M.1    Adornetto, A.2    Secondo, A.3
  • 176
    • 0037821818 scopus 로고    scopus 로고
    • Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase
    • Canals S, Casarejos MJ, de BS, Rodriguez-Martin E, Mena MA. Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. J Biol Chem 2003; 278: 21542-21549.
    • (2003) J Biol Chem , vol.278 , pp. 21542-21549
    • Canals, S.1    Casarejos, M.J.2    De, B.S.3    Rodriguez-Martin, E.4    Mena, M.A.5
  • 177
    • 34250016231 scopus 로고    scopus 로고
    • Inhibition of resting potassium conductances by long-term activation of the NO/cGMP/protein kinase G pathway: A new mechanism regulating neuronal excitability
    • Gonzalez-Forero D, Portillo F, Gomez L, Montero F, Kasparov S, Moreno-Lopez B. Inhibition of resting potassium conductances by long-term activation of the NO/cGMP/protein kinase G pathway: a new mechanism regulating neuronal excitability. J Neurosci 2007; 27: 6302-3612.
    • (2007) J Neurosci , vol.27 , pp. 3612-6302
    • Gonzalez-Forero, D.1    Portillo, F.2    Gomez, L.3    Montero, F.4    Kasparov, S.5    Moreno-Lopez, B.6
  • 178
    • 78549296353 scopus 로고    scopus 로고
    • Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes
    • Castro LR, Schittl J, Fischmeister R. Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes. Circ Res 2010; 107: 1232-1240.
    • (2010) Circ Res , vol.107 , pp. 1232-1240
    • Castro, L.R.1    Schittl, J.2    Fischmeister, R.3
  • 179
    • 0034623769 scopus 로고    scopus 로고
    • Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1
    • Chang HY, Ready DF. Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. Science 2000; 290: 1978-1980.
    • (2000) Science , vol.290 , pp. 1978-1980
    • Chang, H.Y.1    Ready, D.F.2
  • 180
    • 67249123818 scopus 로고    scopus 로고
    • Depleting Rac1 in mouse rod photoreceptors protects them from photooxidative stress without affecting their structure or function
    • Haruta M, Bush RA, Kjellstrom S, et al. Depleting Rac1 in mouse rod photoreceptors protects them from photooxidative stress without affecting their structure or function. Proc Natl Acad Sci USA 2009; 106: 9397-9402.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9397-9402
    • Haruta, M.1    Bush, R.A.2    Kjellstrom, S.3
  • 181
    • 77952544284 scopus 로고    scopus 로고
    • ENA/VASP down regulation triggers cell death by impairing axonal maintenance in hippo campal neurons
    • Franco DL, Rezaval C, Caceres A, Schinder AF, Ceriani MF. ENA/VASP down regulation triggers cell death by impairing axonal maintenance in hippo campal neurons. Mol Cell Neurosci 2010; 44: 154-164.
    • (2010) Mol Cell Neurosci , vol.44 , pp. 154-164
    • Franco, D.L.1    Rezaval, C.2    Caceres, A.3    Schinder, A.F.4    Ceriani, M.F.5
  • 185
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
    • Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10: 32-42.
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 187
    • 77952656234 scopus 로고    scopus 로고
    • Histone H4deacetylation plays a critical role in early gene silencing during neuronal apoptosis
    • Pelzel HR, Schlamp CL, Nickells RW. Histone H4deacetylation plays a critical role in early gene silencing during neuronal apoptosis. BMC Neurosci 2010; 11: 62.
    • (2010) BMC Neurosci , vol.11 , pp. 62
    • Pelzel, H.R.1    Schlamp, C.L.2    Nickells, R.W.3
  • 188
    • 77955795723 scopus 로고    scopus 로고
    • Bmi1distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development
    • Chatoo W, Abdouh M, Duparc RH, Bernier G. Bmi1distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development. Stem Cells 2010; 28: 1412-1423.
    • (2010) Stem Cells , vol.28 , pp. 1412-1423
    • Chatoo, W.1    Abdouh, M.2    Duparc, R.H.3    Bernier, G.4
  • 189
    • 77955435095 scopus 로고    scopus 로고
    • The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors
    • Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle 2010; 9: 2663-2673.
    • (2010) Cell Cycle , vol.9 , pp. 2663-2673
    • Bommi, P.V.1    Dimri, M.2    Sahasrabuddhe, A.A.3    Khandekar, J.4    Dimri, G.P.5
  • 190
    • 58149389397 scopus 로고    scopus 로고
    • HDAC4 regulates neuronal survival in normal and diseased retinas
    • Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 2009; 323: 256-259.
    • (2009) Science , vol.323 , pp. 256-259
    • Chen, B.1    Cepko, C.L.2
  • 191
    • 38149045693 scopus 로고    scopus 로고
    • DNA oxidation astriggered by H3K9me2 demethylation drives estrogeninduced gene expression
    • Perillo B, Ombra MN, Bertoni A, et al. DNA oxidation astriggered by H3K9me2 demethylation drives estrogeninduced gene expression. Science 2008; 319: 202-206.
    • (2008) Science , vol.319 , pp. 202-206
    • Perillo, B.1    Ombra, M.N.2    Bertoni, A.3
  • 192
    • 24144462170 scopus 로고    scopus 로고
    • LSD1 demethylates repressive histone marks to promote androgen-receptordependent transcription
    • Metzger E, Wissmann M, Yin N, et al. LSD1 demethylates repressive histone marks to promote androgen-receptordependent transcription. Nature 2005; 437: 436-439.
    • (2005) Nature , vol.437 , pp. 436-439
    • Metzger, E.1    Wissmann, M.2    Yin, N.3
  • 194
    • 34247508686 scopus 로고    scopus 로고
    • Cell cycle regulation in the postmitoticneuron: Oxymoron or new biology?
    • Herrup K, Yang Y. Cell cycle regulation in the postmitoticneuron: oxymoron or new biology? Nat Rev Neurosci 2007; 8: 368-378.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 368-378
    • Herrup, K.1    Yang, Y.2
  • 196
    • 18944390248 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
    • Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 2005; 4: 421-440.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 421-440
    • Jagtap, P.1    Szabo, C.2
  • 197
    • 0038727723 scopus 로고    scopus 로고
    • Poly(ADP-Ribose) polymerase-1 in acuteneuronal death and inflammation: A strategy for neuroprotection
    • Skaper SD. Poly(ADP-Ribose) polymerase-1 in acuteneuronal death and inflammation: a strategy for neuroprotection. Ann N Y Acad Sci 2003; 993: 217-228.
    • (2003) Ann N Y Acad Sci , vol.993 , pp. 217-228
    • Skaper, S.D.1
  • 198
    • 67649888368 scopus 로고    scopus 로고
    • Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
    • Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO. Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res 2009; 37: 3723-3738.
    • (2009) Nucleic Acids Res , vol.37 , pp. 3723-3738
    • Altmeyer, M.1    Messner, S.2    Hassa, P.O.3    Fey, M.4    Hottiger, M.O.5
  • 199
    • 67649526000 scopus 로고    scopus 로고
    • Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
    • Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 2009; 218:193-202.
    • (2009) Exp Neurol , vol.218 , pp. 193-202
    • Wang, Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 200
    • 57649233085 scopus 로고    scopus 로고
    • Mitochondrial and nuclear cross talk in cell death: Parthanatos
    • Andrabi SA, Dawson TM, Dawson VL. Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann N Y Acad Sci 2008; 1147: 233-241.
    • (2008) Ann N Y Acad Sci , vol.1147 , pp. 233-241
    • Andrabi, S.A.1    Dawson, T.M.2    Dawson, V.L.3
  • 201
    • 78649510331 scopus 로고    scopus 로고
    • PARP1 gene knockout increases resistance to retinal degeneration without affecting retinal function
    • Sahaboglu A, Tanimoto N, Kaur J, et al. PARP1 gene knockout increases resistance to retinal degeneration without affecting retinal function. PLoS ONE 2010; 5: e15495.
    • (2010) PLoS ONE , vol.5
    • Sahaboglu, A.1    Tanimoto, N.2    Kaur, J.3
  • 202
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADPribose) polymerase inhibitors
    • Virag L, Szabo C. The therapeutic potential of poly(ADPribose) polymerase inhibitors. Pharmacol Rev 2002; 54: 375-429.
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 203
    • 33748068133 scopus 로고    scopus 로고
    • Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina
    • Goebel DJ, Winkler BS. Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina. J Neurochem 2006; 98: 1732-1745.
    • (2006) J Neurochem , vol.98 , pp. 1732-1745
    • Goebel, D.J.1    Winkler, B.S.2
  • 204
    • 77649211292 scopus 로고    scopus 로고
    • Novel neuroprotective strategies in ischemic retinal lesions
    • Szabadfi K, Mester L, Reglodi D, et al. Novel neuroprotective strategies in ischemic retinal lesions. Int J Mol Sci 2010; 11: 544-561.
    • (2010) Int J Mol Sci , vol.11 , pp. 544-561
    • Szabadfi, K.1    Mester, L.2    Reglodi, D.3
  • 205
    • 31344471292 scopus 로고    scopus 로고
    • Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADPribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition
    • Uehara N, Miki K, Tsukamoto R, Matsuoka Y, Tsubura A. Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADPribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition. Exp Eye Res 2006; 82: 488-495.
    • (2006) Exp Eye Res , vol.82 , pp. 488-495
    • Uehara, N.1    Miki, K.2    Tsukamoto, R.3    Matsuoka, Y.4    Tsubura, A.5
  • 206
    • 4143051586 scopus 로고    scopus 로고
    • Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line
    • Sharma AK, Rohrer B. Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line. J Biol Chem 2004; 279: 35564-35572.
    • (2004) J Biol Chem , vol.279 , pp. 35564-35572
    • Sharma, A.K.1    Rohrer, B.2
  • 207
    • 1542427168 scopus 로고    scopus 로고
    • Caspase-3 in postnatal retinal development and degeneration
    • Zeiss CJ, Neal J, Johnson EA. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 2004; 45: 964-970.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 964-970
    • Zeiss, C.J.1    Neal, J.2    Johnson, E.A.3
  • 208
    • 0037707639 scopus 로고    scopus 로고
    • Caspase-independentphotoreceptor apoptosis in mouse models of retinal degeneration
    • Doonan F, Donovan M, Cotter TG. Caspase-independentphotoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 2003; 23: 5723-5731.
    • (2003) J Neurosci , vol.23 , pp. 5723-5731
    • Doonan, F.1    Donovan, M.2    Cotter, T.G.3
  • 211
    • 41949112698 scopus 로고    scopus 로고
    • Rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C
    • Ahuja S, Ahuja-Jensen P, Johnson LE, et al. Rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 2008; 49: 1089-1096.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1089-1096
    • Ahuja, S.1    Ahuja-Jensen, P.2    Johnson, L.E.3
  • 213
    • 5644280075 scopus 로고    scopus 로고
    • Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus
    • Hood JL, Brooks WH, Roszman TL. Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus. J Biol Chem 2004; 279: 43126-43135.
    • (2004) J Biol Chem , vol.279 , pp. 43126-43135
    • Hood, J.L.1    Brooks, W.H.2    Roszman, T.L.3
  • 214
    • 3543024505 scopus 로고    scopus 로고
    • Comparison ofelectrical stimulation thresholds in normal and retinal degenerated mouse retina
    • Suzuki S, Humayun MS, Weiland JD, et al. Comparison ofelectrical stimulation thresholds in normal and retinal degenerated mouse retina. Jpn J Ophthalmol 2004; 48: 345-349.
    • (2004) Jpn J Ophthalmol , vol.48 , pp. 345-349
    • Suzuki, S.1    Humayun, M.S.2    Weiland, J.D.3
  • 215
    • 40749157087 scopus 로고    scopus 로고
    • The role of calcium-activated protease calpain in experimental retinal pathology
    • Azuma M, Shearer TR. The role of calcium-activated protease calpain in experimental retinal pathology. Surv Ophthalmol 2008; 53: 150-163.
    • (2008) Surv Ophthalmol , vol.53 , pp. 150-163
    • Azuma, M.1    Shearer, T.R.2
  • 217
    • 58149397537 scopus 로고    scopus 로고
    • Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration:Neuroprotection by CAST overexpression
    • Rao MV, Mohan PS, Peterhoff CM, et al. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration:neuroprotection by CAST overexpression. J Neurosci 2008;28: 12241-1225
    • (2008) J Neurosci , vol.28 , pp. 1225-12241
    • Rao, M.V.1    Mohan, P.S.2    Peterhoff, C.M.3
  • 218
    • 38549153790 scopus 로고    scopus 로고
    • Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs
    • Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y. Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J 2008; 27: 421-432.
    • (2008) EMBO J , vol.27 , pp. 421-432
    • Oka, S.1    Ohno, M.2    Tsuchimoto, D.3    Sakumi, K.4    Furuichi, M.5    Nakabeppu, Y.6
  • 219
    • 53749096967 scopus 로고    scopus 로고
    • Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration
    • Vosler PS, Brennan CS, Chen J. Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol Neurobiol 2008; 38: 78-100.
    • (2008) Mol Neurobiol , vol.38 , pp. 78-100
    • Vosler, P.S.1    Brennan, C.S.2    Chen, J.3
  • 221
    • 33748087835 scopus 로고    scopus 로고
    • Involvement of calpain activation in neurodegenerative processes
    • Camins A, Verdaguer E, Folch J, Pallas M. Involvement of calpain activation in neurodegenerative processes. CNS Drug Rev 2006; 12: 135-148.
    • (2006) CNS Drug Rev , vol.12 , pp. 135-148
    • Camins, A.1    Verdaguer, E.2    Folch, J.3    Pallas, M.4
  • 222
    • 4644250807 scopus 로고    scopus 로고
    • Higher calpastatin levels correlate with resistance to calpainmediated proteolysis and neuronal apoptosis in juvenile rats after spinal cord injury
    • Wingrave JM, Sribnick EA, Wilford GG, et al. Higher calpastatin levels correlate with resistance to calpainmediated proteolysis and neuronal apoptosis in juvenile rats after spinal cord injury. J Neurotrauma 2004; 21: 1240-1254.
    • (2004) J Neurotrauma , vol.21 , pp. 1240-1254
    • Wingrave, J.M.1    Sribnick, E.A.2    Wilford, G.G.3
  • 223
    • 17644393902 scopus 로고    scopus 로고
    • Distinct mechanisticroles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
    • Higuchi M, Tomioka M, Takano J, et al. Distinct mechanisticroles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem 2005; 280: 15229-1527.
    • (2005) J Biol Chem , vol.280 , pp. 1527-15229
    • Higuchi, M.1    Tomioka, M.2    Takano, J.3
  • 225
    • 21744460556 scopus 로고    scopus 로고
    • Multiple death pathways in retina-derived 661W cells following growth factor deprivation: Crosstalk between caspases and calpains
    • Gomez-Vicente V, Donovan M, Cotter TG. Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains. Cell Death Differ 2005; 12: 796-804.
    • (2005) Cell Death Differ , vol.12 , pp. 796-804
    • Gomez-Vicente, V.1    Donovan, M.2    Cotter, T.G.3
  • 226
    • 3242806710 scopus 로고    scopus 로고
    • Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers
    • Araujo CL, Sampaio NM, Hokoc JN, Blanco Martinez AM. Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers. J Neurosci Res 2004; 77: 410-419.
    • (2004) J Neurosci Res , vol.77 , pp. 410-419
    • Araujo, C.L.1    Sampaio, N.M.2    Hokoc, J.N.3    Blanco, M.A.M.4
  • 227
    • 33646405190 scopus 로고    scopus 로고
    • Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx
    • Das A, Garner DP, Del Re AM, et al. Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx. Brain Res 2006; 1084: 146-157.
    • (2006) Brain Res , vol.1084 , pp. 146-157
    • Das, A.1    Garner, D.P.2    del Re, A.M.3
  • 228
    • 33646345845 scopus 로고    scopus 로고
    • Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension
    • Oka T, Tamada Y, Nakajima E, Shearer TR, Azuma M. Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension. J Neurosci Res 2006; 83: 1342-1351.
    • (2006) J Neurosci Res , vol.83 , pp. 1342-1351
    • Oka, T.1    Tamada, Y.2    Nakajima, E.3    Shearer, T.R.4    Azuma, M.5
  • 229
    • 0033765620 scopus 로고    scopus 로고
    • A survey of calpain inhibitors
    • Donkor IO. A survey of calpain inhibitors. Curr Med Chem 2000; 7: 1171-11788.
    • (2000) Curr Med Chem , vol.7 , pp. 1171-11788
    • Donkor, I.O.1
  • 230
    • 0031437175 scopus 로고    scopus 로고
    • Calpain-induced light scattering by crystallins from three rodent species
    • Fukiage C, Azuma M, Nakamura Y, Tamada Y, Shearer TR.Calpain-induced light scattering by crystallins from three rodent species. Exp Eye Res 1997; 65: 757-770.
    • (1997) Exp Eye Res , vol.65 , pp. 757-770
    • Fukiage, C.1    Azuma, M.2    Nakamura, Y.3    Tamada, Y.4    Shearer, T.R.5
  • 231
    • 0034680918 scopus 로고    scopus 로고
    • Theubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutarylcoenzyme A reductase
    • Ravid T, Doolman R, Avner R, Harats D, Roitelman J. Theubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutarylcoenzyme A reductase. J Biol Chem 2000; 275: 35840-35847.
    • (2000) J Biol Chem , vol.275 , pp. 35840-35847
    • Ravid, T.1    Doolman, R.2    Avner, R.3    Harats, D.4    Roitelman, J.5
  • 232
    • 0024844775 scopus 로고
    • Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene
    • Maki M, Bagci H, Hamaguchi K, Ueda M, Murachi T, Hatanaka M. Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J Biol Chem 1989; 264: 18866-18869.
    • (1989) J Biol Chem , vol.264 , pp. 18866-18869
    • Maki, M.1    Bagci, H.2    Hamaguchi, K.3    Ueda, M.4    Murachi, T.5    Hatanaka, M.6
  • 233
    • 0025156879 scopus 로고
    • Characterization of a functional domain of human calpastatin
    • Uemori T, Shimojo T, Asada K, et al. Characterization of a functional domain of human calpastatin. Biochem Biophys Res Commun 1990; 166: 1485-1493.
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 1485-1493
    • Uemori, T.1    Shimojo, T.2    Asada, K.3
  • 234
    • 33947328548 scopus 로고    scopus 로고
    • Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration
    • Sharma AK, Rohrer B. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res 2007; 32: 259-269.
    • (2007) Curr Eye Res , vol.32 , pp. 259-269
    • Sharma, A.K.1    Rohrer, B.2
  • 235
    • 77958560768 scopus 로고    scopus 로고
    • Photoreceptor rescue and toxicity induced by different calpain inhibitors
    • Paquet-Durand F, Sanges D, McCall J, et al. Photoreceptor rescue and toxicity induced by different calpain inhibitors. J Neurochem 2010; 115: 930-940.
    • (2010) J Neurochem , vol.115 , pp. 930-940
    • Paquet-Durand, F.1    Sanges, D.2    McCall, J.3
  • 236
    • 0034116930 scopus 로고    scopus 로고
    • Disruption of the murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division
    • Arthur JS, Elce JS, Hegadorn C, Williams K, Greer PA. Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol 2000; 20: 4474-4481.
    • (2000) Mol Cell Biol , vol.20 , pp. 4474-4481
    • Arthur, J.S.1    Elce, J.S.2    Hegadorn, C.3    Williams, K.4    Greer, P.A.5
  • 237
    • 33745826605 scopus 로고    scopus 로고
    • Ubiquitous calpains promoteboth apoptosis and survival signals in response to different cell death stimuli
    • Tan Y, Wu C, De VT, Greer PA. Ubiquitous calpains promoteboth apoptosis and survival signals in response to different cell death stimuli. J Biol Chem 2006; 281: 17689-17698.
    • (2006) J Biol Chem , vol.281 , pp. 17689-17698
    • Tan, Y.1    Wu, C.2    De, V.T.3    Greer, P.A.4
  • 239
  • 240
    • 62549102021 scopus 로고    scopus 로고
    • Eyecup scope-- optical recordings of light stimulus-evoked fluorescence signals in the retina
    • Euler T, Hausselt SE, Margolis DJ, et al. Eyecup scope-- optical recordings of light stimulus-evoked fluorescence signals in the retina. Pflugers Arch 2009; 457: 1393-1414.
    • (2009) Pflugers Arch , vol.457 , pp. 1393-1414
    • Euler, T.1    Hausselt, S.E.2    Margolis, D.J.3
  • 241
    • 77956369812 scopus 로고    scopus 로고
    • Imaging multiple phases of neurodegeneration: A novel approach to assessing cell death in vivo
    • Cordeiro MF, Guo L, Coxon KM, et al. Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo. Cell Death Dis 2010; 1: e3.
    • (2010) Cell Death Dis , vol.1
    • Cordeiro, M.F.1    Guo, L.2    Coxon, K.M.3
  • 242
    • 70349515367 scopus 로고    scopus 로고
    • Approaching clinicalproteomics: Current state and future fields of application in cellular proteomics
    • Apweiler R, Aslanidis C, Deufel T, et al. Approaching clinicalproteomics: current state and future fields of application in cellular proteomics. Cytometry A 2009; 75: 816-832.
    • (2009) Cytometry A , vol.75 , pp. 816-832
    • Apweiler, R.1    Aslanidis, C.2    Deufel, T.3
  • 243
    • 77955983759 scopus 로고    scopus 로고
    • Activity-based protein profiling for biochemical pathway discovery in cancer
    • Nomura DK, Dix MM, Cravatt BF. Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer 2010; 10: 630-638.
    • (2010) Nat Rev Cancer , vol.10 , pp. 630-638
    • Nomura, D.K.1    Dix, M.M.2    Cravatt, B.F.3
  • 245
    • 33744913540 scopus 로고    scopus 로고
    • Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death
    • Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 2006; 83: 380-389.
    • (2006) Exp Eye Res , vol.83 , pp. 380-389
    • Lohr, H.R.1    Kuntchithapautham, K.2    Sharma, A.K.3    Rohrer, B.4
  • 246


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.