Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

Cell and Tissue Research

Volumn 286, Issue 2, 1996, Pages 191-207

  Nosrat, Christopher A ^a,b   Tomac, Andreas ^a   Lindqvist, Eva ^a   Lindskog, Sven ^b   Humpel, Christian ^c   Strömberg, Ingrid ^a   Ebendal, Ted ^d   Hoffer, Barry J ^e   Olson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d UPPSALA UNIVERSITY   (Sweden)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

Basal ganglia; Gastrointestinal tract; Glial cell line derived neurotrophic factor; In situ hybridization; Kidney; Pig; Prenatal and postnatal development; Rat (Sprague Dawley); Tooth development

Indexed keywords

MESSENGER RNA; NEURITE PROMOTING FACTOR;

ANIMAL TISSUE; ARTICLE; AUDITORY CANAL; BASAL GANGLION; CAROTID BODY; IN SITU HYBRIDIZATION; INNER EAR; LOCUS CERULEUS; NONHUMAN; NOSE CAVITY; OLFACTORY BULB; PEDUNCULAR ANSA; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; RAT; RETINA; THALAMUS NUCLEUS; TOOTH; VIBRISSA;

ANIMALS; CAROTID BODY; CELL PHYSIOLOGY; CENTRAL NERVOUS SYSTEM; CHICK EMBRYO; DIGESTIVE SYSTEM; DOPAMINE; EAR; EYE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; IN SITU HYBRIDIZATION; KIDNEY; MUSCLE, SKELETAL; NASAL CAVITY; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PERIPHERAL NERVOUS SYSTEM; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SWINE; TONGUE; TOOTH; VIBRISSAE;

ANIMALIA; SUS SCROFA;

EID: 0029801527     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050688     Document Type: Article

References (61)

1. Arenas E, Trupp M, Åkerud P, Ibáñez D (1995) GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15: 1465-1473
2. Ayer-LeLievre C, Olson L, Ebendal T, Seiger Å, Persson H (1988) Expression of the β-nerve growth factor gene in hippocampal neurons. Science 240: 1339-1341
3. Beck K, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen R, Rosenthal A, Hefti F (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373: 339-341
4. Beck K, Irwin I, Valverde J, Brennan T, Langston J, Hefti F (1996) GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Neuron 16: 665-673
5. Blum M, Weickert C (1995) GDNF mRNA expression in normal postnatal development, aging, and in Weaver mutant mice. Neurobiol Aging 16: 925-929
6. Bowenkamp K, Hoffmann A, Gerhardt G, Henry M, Biddle P, Hoffer B, Granholm A (1995) Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 355: 479-489
7. Buj-Bello A, Buchman V, Horton A, Rosenthal A, Davies A (1995) GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15: 821-828
8. Cheng H, Hoffer B, Strömberg I, Russell D, Olson L (1995) The effect of glial cell line-derived neurotrophic factor in fibrin glue on developing dopamine neurons. Exp Brain Res 104: 199-206
9. Choi-Lundberg DL, Bohn M (1995) Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Dev Brain Res 85: 80-88
10. Clarkson E, Zawada W, Freed C (1995) GDNF reduces apoptosis in dopaminergic neurons in vitro. Neuroreport 7: 145-149
11. Dagerlind Å, Friberg K, Bean A, Hökfelt T (1992) Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98: 39-49
12. Ebendal T (1989) Use of collagen gels to bioassay nerve growth factor activity. In: Rush R (eds) Nerve growth factors. IBRO Handbook series: methods in the neurosciences, vol 12. Wiley, Chichester, pp 81-93
13. Ebendal T, Tomac A, Hoffer B, Olson L (1995) Glial cell line-derived neurotrophic factor (GDNF) stimulates fibre formation and survival in cultured neurons from peripheral autonomic ganglia. J Neurosci Res 40: 276-284
14. Gash D, Zhang Z, Cass W, Ovadia A, Simmerman L, Martin D, Russell D, Collins F, Hoffer B, Gerhardt G (1995) Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J Comp Neurol 363: 345-358
15. Gash D, Zhang Z, Ovadia A, Cass W, Yi A, Simmerman L, Russell D, Martin D, Lapchak P, Collins F, Hoffer B, Gerhardt G (1996) Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380: 252-255
16. Gouin A, Bloch-Gallego E, Tanaka H, Rosenthal A, Henderson C (1996) Transforming growth factor-beta 3, glial cell line-derived neurotrophic factor, and fibroblast growth fuctor-2 act in different manners to promote motoneuron survival in vitro. J Neurosci Res 43: 454-464
17. Hellmich H, Kos L, Cho E, Mahou K, Zimmer A (1996) Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech Dev 54: 95-105
18. Henderson C, Phillips H, Pollock R, Davies A, Lemeulle C, Armanini M, Simpson L, Moffet B, Vandlen R, Koliatsos V, Rosenthal A (1994) GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266: 1062-1064
19. Hoffer B, Hoffman A, Bowenkamp K, Huettl P, Hudson J, Martin D, Lin L, Gerhardt G (1994) Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 182: 107-111
20. Hudson J, Granholm AC, Gerhard GA, Henry MA, Hoffman A, Biddle P, Leela NS, Mackerlova L, Lile JD, Collins F, Hoffer BJ (1995) Gliul cell line-derived neurotrophic factor augments midbrain dopaminengic circuits in vivo. Brain Res Bull 36: 425-133
21. Humpel C, Hoffer B, Strömberg I, Bektesh S, Collins F, Olson L (1994) Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in the response to kainate-induced excitation. Neuroscience 59: 791-795
22. Johansson M, Friedemann M, Hoffer B, Strömberg I (1995) Effects of GDNF on developing and mature mesencephalic grafts in oculo. Exp Neurol 134: 25-34
23. Kearns C, Gash D (1995) GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo. Brain Res 672: 104-111
24. + toxicity. EMBO J 14: 736-742
25. Li L, Wu W, Lind L-F, Lei M, Oppenheim R, Houenou L (1995) Rescue of adult mouse motoneurons from injury-induced cell death by dial cell line-derived neurotrophic factor. Proc Natl Acad Sci USA 92: 9771-9775
26. Lin L-F, Doherty D, Lile J, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132
27. Lindner M, Winn S, Baetge E, Hammang J, Gentile F, Doherty E, McDermott P, Frydel B, Ullman M, Schallert T, Emerich D (1995) Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms. Exp Neurol 132: 62-76
28. Lindqvist E, Tomac A, Luthman J, Hoffer B, Bektesh S, Olson L (1994) Distribution of glial cell line-derived neurotrophic factor (GDNF) during pre- and postnatal development in rat central and peripheral tissues. Soc Neurosci Abstr 20: 1101
29. Martin D, Miller G, Rosendahl M, Russell D (1995) Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat. Brain Res 683: 172-178
30. Mount H, Dean D, Albere J, Dreyfus C, Black I (1995) Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc Natl Acad Sci USA 92: 9092-9096
31. Nosrat C, Olson L (1995) Brain-derived neurotrophic factor mRNA is expressed in the developing taste bud-bearing tongue papillae of rat. J Comp Neurol 360: 698-704
32. Olson L, Seiger Å, Fuxe K (1972) Heterogeneity of striatal and limbic dopamine innervation: highly fluorescent islands in developing and adult rats. Brain Res 44: 283-288
33. Opacka-Juffry J, Ashworth S, Hume S, Martin D, Brooks D, Blunt S (1995) GDNF protects against 6-OHDA nigrostriatal lesion: in vivo study with microdialysis and PET. Neuroreport 7: 348-352
34. Oppenheim R, Houenou L, Johnson J, Lin L, Li L, Lo A, Newsome A, Prevette D, Wang S (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373: 344-346
35. Sauer H, Rosenblad C, Björklund A (1995) Glial cell line-derived neurotrophic factor but not transforming growth factor β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Natl Acad Sci USA 92: 8935-8939
36. Schaar DG, Sieber BA, Dreyfus CF, Black IB (1993) Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124: 368-371
37. Schaar D, Sieber B, Sherwood A, Dean D, Mendoza G (1994) Multiple astrocyte transcripts encode nigral trophic factors in rat and human. Exp Neurol 130: 387-393
38. Schmidt-Kastner R, Tomac A, Hoffer BJ, Bektesh S, Rosenzweig B, Olson L (1994) Glial cell line-derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Mol Brain Res 26: 325-330
39. Seiger Å, Olson L (1973) Late prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z Anat Entwickl Gesch 140: 281-318
40. Shults C, Kimber T, Martin D (1996) Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine. Neuroreport 7: 627-631
41. Springer J, Mu X, Bergmann L, Trojanowski J (1994) Expression of GDNF mRNA in rat and human nervous tissue. Exp Neurol 127: 167-170
42. Springer J, Seeburger J, He J, Gabrea A, Blankenhorn E, Bergman L (1995) cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Exp Neurol 131: 47-52
43. Strömberg I, Björklund L, Johansson M, Tomac A, Collins F, Olson L, Hoffer B, Humpel C (1993) Glial cell line-derived neurotrophic factor (GDNF) is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol 124: 401-412
44. Suter-Crazzolara C, Unsieker K (1994) GDNF is expressed in two forms in many tissues outside the CNS. Neuroreport 5: 2486-2488
45. Suvanto P, Hiltunen J, Arum'e U, Moshnyakov M, Sariola H, Sainio K, Saarma M (1996) Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. Eur J Neurosci 8: 816-822
46. Thesleff I, Vaahtokari A, Partanen AM (1995) Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs. Int J Dev Biol 39: 35-50
47. Tomac A, Lindqvist E, Lin L, Ögren S, Young D, Hoffer B, Olson L (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-339
48. Tomac A, Widenfalk J, Lin L, Kohno T, Ebendal T, Hoffer B, Olson L (1995b) Retrograde axonal transport of glial cell line-derived neurotrohic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci USA 92: 8274-8278
49. Trok K, Almström S, Olson L (1996a) A comparison of effects of glial cell line-derived neurotrophic factor on spinal cord and cortex cerebri grafts. J Pharmacol Exp Ther (in press)
50. Trok K, Hoffer B, L O (1996b) Glial cell line-derived neurotrophic factor enhances survival and growth of pre- and postnatal spinal cord transplants. Neuroscience 71: 231-241
51. Trupp M, Rydén M, Jörnvall H, Funakoshi H, Timmusk T, Arenäs E, Ibañez C (1995) Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130: 137-148
52. Unsicker K (1996) GDNF: a review. Cell Tissue Res (in press)
53. Vaahtokari A, Vainio S, Thesleff I (1991) Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 113: 985-94
54. Wetmore C, Ernfors P, Persson H, Olson L (1990) Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol 109: 141-152
55. Wetmore C, Cao YH, Pettersson RF, Olson L (1991) Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci USA 88: 9843-9847
56. Wetmore C, Cao Y, Pettersson R, Olson L (1993) Brain-derived neurotrophic factor (BDNF) peptide antibodies: charaeterization using a Vaccinia virus expression system. J Histochem Cytochem 41: 521-533
57. Wetmore C, Olson L, Bean A (1994) Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci 14: 1688-1700
58. Williams L, Inoue G, Cummins V, Pelleymounter M (1996) Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor. Exp Ther (in press)
59. Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T (1996) Expression of glial cell line-derived growth factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis. Neurosci Lett 204: 117-120
60. Yan Q, Matheson C, Lopez O (1995) In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373: 341-344
61. Zurn A, Baetge E, Hammang J, Tan S, Aebischer P (1994) Glial cell line-derived neurotrophic factor (GDNF). a new neurotrophic factor for motoneurones. Neuroreport 6: 113-118