Ciliary neurotrophic factor therapy for inherited retinal diseases: Pros and cons

Retina

Volumn 25, Issue 8 SUPPL., 2005, Pages

  Bok, Dean ^a,b  

^a JULES STEIN EYE INSTITUTE   (United States)

^b Retinal Cell Biology Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; RECOMBINANT CILIARY NEUROTROPHIC FACTOR;

ADENOVIRUS VECTOR; AMINO ACID SEQUENCE; BLINDNESS; CELL DEATH; CELL DIFFERENTIATION; CONFERENCE PAPER; CYTOMEGALOVIRUS; DOWN REGULATION; ELECTRORETINOGRAM; GENE MUTATION; MUELLER CELL; NONHUMAN; PHOTORECEPTOR CELL; PHOTOTRANSDUCTION; PIGMENT EPITHELIUM; POINT MUTATION; PROTEIN MODIFICATION; RETINA; RETINA CELL; RETINA DISEASE; RETINA ROD; ANIMAL; CELL SURVIVAL; DISEASE MODEL; GENETICS; HUMAN; MOUSE; RETINITIS PIGMENTOSA; REVIEW;

ANIMALS; CELL SURVIVAL; CILIARY NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; HUMANS; MICE; RETINITIS PIGMENTOSA;

EID: 33644874601     PISSN: 0275004X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006982-200512001-00010     Document Type: Conference Paper

References (3)

1. Bok D, Yasumura D, Matthes MT, et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 2002;74:719-735.
2. Caffe AR, Soderpalm AK, Holmqvist I, van Veen T. A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explants. Invest Ophthalmol Vis Sci 2001;42:275-282.
3. Beltran WA, Rohrer H, Aguirre GD. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFR alpha) in mammalian photoreceptor cells. Mol Vis 2005;11:232-244.