-
1
-
-
0036478899
-
Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors
-
Al-Tassan N, Chmiel NH, Maynard J, Fleming N, Livingston AL, Williams GT, Hodges AK, Davies DR, David SS, Sampson JR, Cheadle JP (2002) Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors. Nat Genet 30: 227-232
-
(2002)
Nat Genet
, vol.30
, pp. 227-232
-
-
Al-Tassan, N.1
Chmiel, N.H.2
Maynard, J.3
Fleming, N.4
Livingston, A.L.5
Williams, G.T.6
Hodges, A.K.7
Davies, D.R.8
David, S.S.9
Sampson, J.R.10
Cheadle, J.P.11
-
2
-
-
0037443884
-
Human mitochondrial DNA is packaged with TFAM
-
Alam TI, Kanki T, Muta T, Ukaji K, Abe Y, Nakayama H, Takio K, Hamasaki N, Kang D (2003) Human mitochondrial DNA is packaged with TFAM. Nucleic Acids Res 31: 1640-1645
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 1640-1645
-
-
Alam, T.I.1
Kanki, T.2
Muta, T.3
Ukaji, K.4
Abe, Y.5
Nakayama, H.6
Takio, K.7
Hamasaki, N.8
Kang, D.9
-
3
-
-
0027171266
-
Oxidants, antioxidants, and the degenerative diseases of aging
-
Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90: 7915-7922
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7915-7922
-
-
Ames, B.N.1
Shigenaga, M.K.2
Hagen, T.M.3
-
4
-
-
33847616097
-
Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease
-
Arai T, Fukae J, Hatano T, Kubo S, Ohtsubo T, Nakabeppu Y, Mori H, Mizuno Y, Hattori N (2006) Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol 112: 139-145
-
(2006)
Acta Neuropathol
, vol.112
, pp. 139-145
-
-
Arai, T.1
Fukae, J.2
Hatano, T.3
Kubo, S.4
Ohtsubo, T.5
Nakabeppu, Y.6
Mori, H.7
Mizuno, Y.8
Hattori, N.9
-
5
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434: 658-662
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
Robbins, J.11
Molkentin, J.D.12
-
6
-
-
0242384898
-
In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: Implication of a calpain-mediated cleavage of active caspase-3
-
Bizat N, Hermel JM, Humbert S, Jacquard C, Creminon C, Escartin C, Saudou F, Krajewski S, Hantraye P, Brouillet E (2003) In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3. J Biol Chem 278: 43245-43253
-
(2003)
J Biol Chem
, vol.278
, pp. 43245-43253
-
-
Bizat, N.1
Hermel, J.M.2
Humbert, S.3
Jacquard, C.4
Creminon, C.5
Escartin, C.6
Saudou, F.7
Krajewski, S.8
Hantraye, P.9
Brouillet, E.10
-
7
-
-
0034192265
-
The human OGG1 gene: Structure, functions, and its implication in the process of carcinogenesis
-
Boiteux S, Radicella JP (2000) The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys 377: 1-8
-
(2000)
Arch Biochem Biophys
, vol.377
, pp. 1-8
-
-
Boiteux, S.1
Radicella, J.P.2
-
9
-
-
0023058907
-
Menadione- (2-methyl-1,4- naphthoquinone-) dependent enzymatic redox cycling and calcium release by mitochondria
-
Frei B, Winterhalter KH, Richter C (1986) Menadione- (2-methyl-1,4- naphthoquinone-) dependent enzymatic redox cycling and calcium release by mitochondria. Biochemistry 25: 4438-4443
-
(1986)
Biochemistry
, vol.25
, pp. 4438-4443
-
-
Frei, B.1
Winterhalter, K.H.2
Richter, C.3
-
10
-
-
23844465238
-
Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders
-
Fukae J, Takanashi M, Kubo S, Nishioka K, Nakabeppu Y, Mori H, Mizuno Y, Hattori N (2005) Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta Neuropathol 109: 256-262
-
(2005)
Acta Neuropathol
, vol.109
, pp. 256-262
-
-
Fukae, J.1
Takanashi, M.2
Kubo, S.3
Nishioka, K.4
Nakabeppu, Y.5
Mori, H.6
Mizuno, Y.7
Hattori, N.8
-
12
-
-
0036942993
-
Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain
-
Iida T, Furuta A, Nishioka K, Nakabeppu Y, Iwaki T (2002) Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain. Acta Neuropathol 103: 20-25
-
(2002)
Acta Neuropathol
, vol.103
, pp. 20-25
-
-
Iida, T.1
Furuta, A.2
Nishioka, K.3
Nakabeppu, Y.4
Iwaki, T.5
-
13
-
-
0028980982
-
Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria
-
Kang D, Nishida J, Iyama A, Nakabeppu Y, Furuichi M, Fujiwara T, Sekiguchi M, Takeshige K (1995) Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J Biol Chem 270: 14659-14665
-
(1995)
J Biol Chem
, vol.270
, pp. 14659-14665
-
-
Kang, D.1
Nishida, J.2
Iyama, A.3
Nakabeppu, Y.4
Furuichi, M.5
Fujiwara, T.6
Sekiguchi, M.7
Takeshige, K.8
-
14
-
-
0021769722
-
Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents
-
Kasai H, Nishimura S (1984) Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res 12: 2137-2145
-
(1984)
Nucleic Acids Res
, vol.12
, pp. 2137-2145
-
-
Kasai, H.1
Nishimura, S.2
-
15
-
-
0036948404
-
Origins of spontaneous mutations: Specificity and directionality of base-substitution, frameshift, and sequence-substitution mutageneses
-
Maki H (2002) Origins of spontaneous mutations: specificity and directionality of base-substitution, frameshift, and sequence-substitution mutageneses. Annu Rev Genet 36: 279-303
-
(2002)
Annu Rev Genet
, vol.36
, pp. 279-303
-
-
Maki, H.1
-
16
-
-
17644436794
-
Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA
-
Miyako K, Takamatsu C, Umeda S, Tajiri T, Furuichi M, Nakabeppu Y, Sekiguchi M, Hamasaki N, Takeshige K, Kang D (2000) Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA. J Biol Chem 275: 12326-12330
-
(2000)
J Biol Chem
, vol.275
, pp. 12326-12330
-
-
Miyako, K.1
Takamatsu, C.2
Umeda, S.3
Tajiri, T.4
Furuichi, M.5
Nakabeppu, Y.6
Sekiguchi, M.7
Hamasaki, N.8
Takeshige, K.9
Kang, D.10
-
17
-
-
0029882525
-
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: A role in nerve cell death?
-
Mouatt-Prigent A, Karlsson JO, Agid Y, Hirsch EC (1996) Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience 73: 979-987
-
(1996)
Neuroscience
, vol.73
, pp. 979-987
-
-
Mouatt-Prigent, A.1
Karlsson, J.O.2
Agid, Y.3
Hirsch, E.C.4
-
18
-
-
33745485302
-
Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids
-
Nakabeppu Y, Sakumi K, Sakamoto K, Tsuchimoto D, Tsuzuki T, Nakatsu Y (2006) Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids. Biol Chem 387: 373-379
-
(2006)
Biol Chem
, vol.387
, pp. 373-379
-
-
Nakabeppu, Y.1
Sakumi, K.2
Sakamoto, K.3
Tsuchimoto, D.4
Tsuzuki, T.5
Nakatsu, Y.6
-
20
-
-
0032945268
-
Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
-
Nishioka K, Ohtsubo T, Oda H, Fujiwara T, Kang D, Sugimachi K, Nakabeppu Y (1999) Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol Biol Cell 10: 1637-1652
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1637-1652
-
-
Nishioka, K.1
Ohtsubo, T.2
Oda, H.3
Fujiwara, T.4
Kang, D.5
Sugimachi, K.6
Nakabeppu, Y.7
-
21
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60: 759-767
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
22
-
-
0034654256
-
Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
-
Ohtsubo T, Nishioka K, Imaiso Y, Iwai S, Shimokawa H, Oda H, Fujiwara T, Nakabeppu Y (2000) Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 28: 1355-1364
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 1355-1364
-
-
Ohtsubo, T.1
Nishioka, K.2
Imaiso, Y.3
Iwai, S.4
Shimokawa, H.5
Oda, H.6
Fujiwara, T.7
Nakabeppu, Y.8
-
23
-
-
34547105083
-
MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis
-
Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K, Egashira A, Kura S, Yao T, Tsuneyoshi M, Maki H, Nakabeppu Y, Tsuzuki T (2007) MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis. Cancer Res 67: 6599-6604
-
(2007)
Cancer Res
, vol.67
, pp. 6599-6604
-
-
Sakamoto, K.1
Tominaga, Y.2
Yamauchi, K.3
Nakatsu, Y.4
Sakumi, K.5
Yoshiyama, K.6
Egashira, A.7
Kura, S.8
Yao, T.9
Tsuneyoshi, M.10
Maki, H.11
Nakabeppu, Y.12
Tsuzuki, T.13
-
24
-
-
0027474051
-
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: A potential molecular basis for neuronal degeneration
-
Saito K, Elce JS, Hamos JE, Nixon RA (1993) Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 90: 2628-2632
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2628-2632
-
-
Saito, K.1
Elce, J.S.2
Hamos, J.E.3
Nixon, R.A.4
-
25
-
-
0032709404
-
Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease
-
Shimura-Miura H, Hattori N, Kang D, Miyako K, Nakabeppu Y, Mizuno Y (1999) Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease. Ann Neurol 46: 920-924
-
(1999)
Ann Neurol
, vol.46
, pp. 920-924
-
-
Shimura-Miura, H.1
Hattori, N.2
Kang, D.3
Miyako, K.4
Nakabeppu, Y.5
Mizuno, Y.6
-
26
-
-
0030870794
-
Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition
-
Simbula G, Glascott PA Jr, Akita S, Hoek JB, Farber JL (1997) Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition. Am J Physiol 273: 479-488
-
(1997)
Am J Physiol
, vol.273
, pp. 479-488
-
-
Simbula, G.1
Glascott Jr, P.A.2
Akita, S.3
Hoek, J.B.4
Farber, J.L.5
-
27
-
-
0032840464
-
Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein
-
Slupska MM, Luther WM, Chiang JH, Yang H, Miller JH (1999) Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J Bacteriol 181: 6210-6213
-
(1999)
J Bacteriol
, vol.181
, pp. 6210-6213
-
-
Slupska, M.M.1
Luther, W.M.2
Chiang, J.H.3
Yang, H.4
Miller, J.H.5
-
28
-
-
22244476422
-
Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction
-
Stuart JA, Mayard S, Hashiguchi K, Souza-Pinto NC, Bohr VA (2005) Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction. Nucleic Acids Res 33: 3722-3732
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3722-3732
-
-
Stuart, J.A.1
Mayard, S.2
Hashiguchi, K.3
Souza-Pinto, N.C.4
Bohr, V.A.5
-
29
-
-
2942696205
-
MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain
-
Tominaga Y, Ushijima Y, Tsuchimoto D, Mishima M, Shirakawa M, Hirano S, Sakumi K, Nakabeppu Y (2004) MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain. Nucleic Acids Res 32: 3198-3211
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 3198-3211
-
-
Tominaga, Y.1
Ushijima, Y.2
Tsuchimoto, D.3
Mishima, M.4
Shirakawa, M.5
Hirano, S.6
Sakumi, K.7
Nakabeppu, Y.8
-
30
-
-
0035369734
-
Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen
-
Tsuchimoto D, Sakai Y, Sakumi K, Nishioka K, Sasaki M, Fujiwara T, Nakabeppu Y (2001) Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen. Nucleic Acids Res 29: 2349-2360
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2349-2360
-
-
Tsuchimoto, D.1
Sakai, Y.2
Sakumi, K.3
Nishioka, K.4
Sasaki, M.5
Fujiwara, T.6
Nakabeppu, Y.7
-
31
-
-
0037415380
-
Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney
-
Tsuruya K, Furuichi M, Tominaga Y, Shinozaki M, Tokumoto M, Yoshimitsu T, Fukuda K, Kanai H, Hirakata H, Iida M, Nakabeppu Y (2003) Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. DNA Repair 2: 211-229
-
(2003)
DNA Repair
, vol.2
, pp. 211-229
-
-
Tsuruya, K.1
Furuichi, M.2
Tominaga, Y.3
Shinozaki, M.4
Tokumoto, M.5
Yoshimitsu, T.6
Fukuda, K.7
Kanai, H.8
Hirakata, H.9
Iida, M.10
Nakabeppu, Y.11
-
32
-
-
33644953588
-
MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Yamaguchi H, Kajitani K, Dan Y, Furuichi M, Ohno M, Sakumi K, Kang D, Nakabeppu Y (2006) MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Cell Death Differ 13: 551-563
-
(2006)
Cell Death Differ
, vol.13
, pp. 551-563
-
-
Yamaguchi, H.1
Kajitani, K.2
Dan, Y.3
Furuichi, M.4
Ohno, M.5
Sakumi, K.6
Kang, D.7
Nakabeppu, Y.8
-
33
-
-
3342900223
-
Ca2+-dependent proteases in ischemic neuronal death: A conserved 'calpain-cathepsin cascade' from nematodes to primates
-
Yamashima T (2004) Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell Calcium 36: 285-293
-
(2004)
Cell Calcium
, vol.36
, pp. 285-293
-
-
Yamashima, T.1
-
34
-
-
0141733067
-
An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
-
Yoshimura D, Sakumi K, Ohno M, Sakai Y, Furuichi M, Iwai S, Nakabeppu Y (2003) An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J Biol Chem 278: 37965-37973
-
(2003)
J Biol Chem
, vol.278
, pp. 37965-37973
-
-
Yoshimura, D.1
Sakumi, K.2
Ohno, M.3
Sakai, Y.4
Furuichi, M.5
Iwai, S.6
Nakabeppu, Y.7
-
35
-
-
33845317242
-
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
-
Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103: 18314-18319
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18314-18319
-
-
Yu, S.W.1
Andrabi, S.A.2
Wang, H.3
Kim, N.S.4
Poirier, G.G.5
Dawson, T.M.6
Dawson, V.L.7
-
36
-
-
0037067317
-
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
-
Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297: 259-263
-
(2002)
Science
, vol.297
, pp. 259-263
-
-
Yu, S.W.1
Wang, H.2
Poitras, M.F.3
Coombs, C.4
Bowers, W.J.5
Federoff, H.J.6
Poirier, G.G.7
Dawson, T.M.8
Dawson, V.L.9
|