Activation of multiple pathways during photoreceptor apoptosis in the rd mouse

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 10, 2005, Pages 3530-3538

  Doonan, Francesca ^a   Donovan, Maryanne ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CALPASTATIN; CATHEPSIN D; N ACETYLLEUCYLLEUCYLNORLEUCINAL; REACTIVE OXYGEN METABOLITE; ACETYLLEUCYL LEUCYL NORLEUCINAL; ACETYLLEUCYL-LEUCYL-NORLEUCINAL; CALCIUM; LEUPEPTIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; FLOW CYTOMETRY; FLUORESCENCE; LASER; LIGHT SCATTERING; MEMBRANE DEPOLARIZATION; MITOCHONDRION; MOUSE; MOUSE STRAIN; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DEGENERATION; RETINITIS PIGMENTOSA; WESTERN BLOTTING; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL FREE SYSTEM; DRUG ANTAGONISM; DRUG EFFECT; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NICK END LABELING; ORGAN CULTURE TECHNIQUE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALPAIN; CATHEPSIN D; CELL-FREE SYSTEM; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; LEUPEPTINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PHOTORECEPTORS, VERTEBRATE; REACTIVE OXYGEN SPECIES; RETINAL DEGENERATION; SIGNAL TRANSDUCTION;

EID: 32944467645     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0248     Document Type: Article

References (42)

1. Donovan M, Carmody RJ, Cotter TG. Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J Biol Chem. 2001;276:23000-23008.
2. Doonan F, Donovan M, Cotter TG. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci. 2003;23:5723-5731.
3. Donovan M, Cotter TG. Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Cell Death Differ. 2002;9:1220-1231.
4. Zeiss CJ, Neal J, Johnson EA. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci. 2004;45:964-970.
5. Broker LE, Huisman C, Span SW, Rodriguez JA, Kruyt FA, Giaccone G. Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells. Cancer Res. 2004;64:27-30.
6. Tagliarino C, Pink JJ, Reinicke KE, et al. Mu-calpain activation in beta-lapachone-mediated apoptosis. Cancer Biol Ther. 2003;2:141-152.
7. Egger L, Schneider J, Rheme C, Tapernoux M, Hacki J, Borner C. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ. 2003;10:1188-1203.
8. Blink E, Maianski NA, Alnemri ES, Zervos AS, Roos D, Kuijpers TW. Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils. Cell Death Differ. 2004;11:937-939.
9. Rakoczy PE, Lai CM, Baines M, Di Grandi S, Fitton JH, Constable IJ. Modulation of cathepsin D activity in retinal pigment epithelial cells. Biochem J. 1997;324:935-940.
10. Rakoczy PE, Zhang D, Robertson T, et al. Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am J Pathol. 2002;161:1515-1524.
11. Jaattela M. Programmed cell death: many ways for cells to die decently. Ann Med. 2002;34:480-488.
12. Rohrer B, Pinto FR, Hulse KE, Lohr HR, Zhang L, Almeida JS. Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. J Biol Chem. 2004;279:41903-41910.
13. Sanvicens N, Gomez-Vicente V, Masip I, Messeguer A, Cotter TG. Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6. J Biol Chem. 2004;279:39268-39278.
14. Fain GL, Lisman JE. Light, Ca2+, and photoreceptor death: new evidence for the equivalent-light hypothesis from arrestin knockout mice. Invest Ophthalmol Vis Sci. 1999;40:2770-2772.
15. Stridh H, Gigliotti D, Orrenius S, Cotgreave I. The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis. Biochem Biophys Res Commun. 1999;266:460-465.
16. Fox DA, Poblenz AT, He L. Calcium overload triggers rod photoreceptor apoptotic cell death in chemical-induced and inherited retinal degenerations. Ann NY Acad Sci. 1999;893:282-285.
17. Lang-Rollin IC, Rideout HJ, Noticewala M, Stefanis L. Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation. J Neurosci. 2003;23:11015-11025.
18. Caffé AR, Visser H, Jansen HG, Sanyal S. Histotypic differentiation of neonatal mouse retina in organ culture. Curr Eye Res. 1989;8:1083-1092.
19. Young RW. Cell differentiation in the retina of the mouse. Anat Rec. 1985;212:199-205.
20. Wang KK, Posmantur R, Nath R, et al. Simultaneous degradation of alphaII- and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem. 1998;273:22490-22497.
21. Foghsgaard L, Wissing D, Manch D, et al. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol. 2001;153:999-1010.
22. 22: Hahn P, Lindsten T, Lyubarsky A, et al. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ. 2004;11:1192-1197.
23. Houde C, Banks KG, Coulombe N, et al. Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice. J Neurosci. 2004;24:9977-9984.
24. Hsu CD, Whaley MA, Frazer K, et al. Limited role of developmental programmed cell death pathways in Drosophila norpA retinal degeneration. J Neurosci. 2004;24:500-507.
25. Caffé AR, Soderpalm AK, Holmqvist I, van Veen T. A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal expiants. Invest Ophthalmol Vis Sci. 2001;42:275-282.
26. Lolley RN. The rd gene defect triggers programmed rod cell death: the Proctor Lecture. Invest Ophthalmol Vis Sci. 1994;35:4182-4191.
27. Fox DA, Poblenz AT, He L, Harris JB, Medrano CJ. Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection. Eur J Ophthalmol. 2003;13(suppl 3):S44-S56.
28. McGinnis KM, Gnegy ME, Park YH, Mukerjee N, Wang KK. Pro-caspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem Biophys Res Commun. 1999;263:94-99.
29. Saatman KE, Abai B, Grosvenor A, Vorwerk CK, Smith DH, Meaney DF. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. J Cereb Blood Flow Metab. 2003;23:34-42.
30. Sharma AK, Rohrer B. Calcium-induced calpain mediates apoptosis via caspase-3 in a mouse photoreceptor cell line. J Biol Chem. 2004;279:35564-35572.
31. Sakamoto YR, Nakajima TR, Fukiage CR, et al. Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina. Curr Eye Res. 2000;21:571-580.
32. Yakovlev AG, Wang G, Stoica BA, Simbulan-Rosenthal CM, Yoshihara K, Smulson ME. Role of DNAS1L3 in Ca2+- and Mg2+-dependent cleavage of DNA into oligonucleosomal and high molecular mass fragments. Nucleic Acids Res. 1999;27:1999-2005.
33. Roberg K, Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol. 1998;152:1151-1156.
34. Ollinger K. Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes. Arch Biochem Biophys. 2000;373:346-351.
35. Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem. 2002;277:21821-21828.
36. Foghsgaard L, Lademann U, Wissing D, Poulsen B, Jaattela M. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J Biol Chem. 2002;277:39499-39506.
37. Gobeil S, Boucher CC, Nadeau D, Poirier GG. Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ. 2001;8:588-594.
38. Rosenstock TR, Carvalho AC, Jurkiewicz A, Frussa-Filho R, Smaili SS. Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. J Neurochem. 2004;88:1220-1228.
39. Yamashima T, Tonchev AB, Tsukada T, et al. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. 2003;13:791-800.
40. Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med. 1999;5:1183-1187.
41. Pawlyk BS, Li T, Scimeca MS, Sandberg MA, Berson EL. Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse. Invest Ophthalmol Vis Sci. 2002;43:1912-1915.
42. Takano Y, Ohguro H, Dezawa M, et al. Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun. 2004;313:1015-1022.