Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: Feasibility and outcome in seven patients

British Journal of Ophthalmology

Volumn 92, Issue 10, 2008, Pages 1361-1368

  Besch, D ^a   Sachs, H ^b   Szurman, P ^a   Gulicher D ^c   Wilke, R ^a   Reinert, S ^c   Zrenner, E ^a   Bartz Schmidt, K U ^a   Gekeler, F ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POLYIMIDE; SILICONE;

ARTICLE; CLINICAL ARTICLE; ENERGY RESOURCE; EYE SURGERY; FUNCTIONAL ASSESSMENT; HUMAN; MALE; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETINITIS PIGMENTOSA; TEMPORALIS MUSCLE; TREATMENT OUTCOME; VISUAL PROSTHESIS;

BIOMEDICAL ENHANCEMENT; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; FEASIBILITY STUDIES; FLUORESCEIN ANGIOGRAPHY; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSTHESIS DESIGN; PROSTHESIS IMPLANTATION; RETINA; RETINITIS PIGMENTOSA; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 53649104645     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2007.131961     Document Type: Article

References (26)

1. Rizzo JF III, Wyatt J, Humayun M, et al. Retinal prosthesis: An encouraging first decade with major challenges ahead. Ophthalmology 2001;108:13-14.
2. Zrenner E, Will retinal implants restore vision? Science 2002;295:1022-5.
3. Santos A, Humayun MS, de Juan EJ, et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol 1997;115:511-15.
4. Stone JL, Barlow WE, Humayun MS, et al. Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol 1992;110:1634-9.
5. Zrenner E, Miliczek K-D, Gabel V-P, et al. The development of subretinal microphotodiodes for replacement of degenerated photoreceptors [see comments]. Ophthalmic Res 1997;29:269-80.
6. Zrenner E, Stett A, Weiss S, et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res 1999;39:2555-67.
7. Schwahn HN, Gekeler F, Kohler K, et al. Studies on the feasibility of a subretinal visual prosthesis: data from Yucatan micropig and rabbit. Graefes Arch Clin Exp Ophthalmol 2001;239:961-7.
8. Zrenner E, The subretinal implant: can microphotodiode arrays replace degenerated retinal photoreceptors to restore vision? Ophthalmologica 2002;216:8-20.
9. Stett A, Kohler K, Weiss S, et al. Electrical stimulation of degenerated retina of RCS rats by distally applied spatial voltage patterns. Invest Ophthalmol Vis Sci 1998;39:902S.
10. Stett A, Barth W, Haemmerle H, et al. Network activity of the chicken retina electrically evoked by distally applied spatial voltage patterns. In: Eisner N, Wehner R, eds. Proceedings of the 26th Goettingen Neurobiology Conference. Stuttgart: Georg Thieme, 1998:437.
11. Stett A, Tepfenhart M, Kohler K, et al. Charge sensitivity of electrically stimulated chicken and RCS rat retinae. Invest Ophthalmol Vis Sci 1999;40:734S.
12. Stett A, Barth W, Weiss S, et al. Electrical multisite stimulation of the isolated chicken retina. Vision Res 2000;40:1785-95.
13. Gekeler F, Kobuch K, Schwahn HN, et al. Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays. Graefes Arch Clin Exp Ophthalmol 2004;242:587-96.
14. Gekeler F, Szurman P, Grisanti S, et al. Compound subretinal prostheses with extraocular parts designed for human trials: successful long-term implantation in pigs. Graefes Arch Clin Exp Ophthalmol 2007;245:230-41.
15. Sachs HG, Gabel VP. Retinal replacement-the development of microelectronic retinal prostheses-experience with subretinal implants and new aspects. Graefes Arch Clin Exp Ophthalmol 2004;242:717-23.
16. Sachs HG, Schanze T, Brunner U, et al. Transscleral implantation and neurophysiological testing of subretinal polyimide film electrodes in the domestic pig in visual prosthesis development. J Neural Eng 2005;2:57-64S.
17. Sachs HG, Gekeler F, Schwahn H, et al. Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development. Eur J Ophthalmol 2005;15:493-9.
18. Sachs HG, Schanze T, Wilms M, et al. Subretinal implantation and testing of polyimide film electrodes in cats. Grsefes Arch Clin Exp Ophthalmol 2005;243:464-8.
19. Gekeler F, Messias A, Ottinger M, et al. Phosphenes electrically evoked with DTL electrodes: a study in patients with retinitis pigmentosa, glaucoma, and homonymous visual field loss and normal subjects. Invest Ophthalmol Vis Sci 2006;47:4966-74.
20. Gekeler F, Sachs H, Szurman P, et al. Fluorescein angiographic findings in blind patients treated by an active subretinal implant. Invest Ophthalmol Vis Sci 2007;48:2567.
21. Humayun MS, Weiland JD, Fujii GY, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res 2003;43:2573-81.
22. Rizzo JF III, Chen J, Shire D, et al. Implantation of a wirelessly powered retinal prosthesis using an ab externo surgical technique. Invest Ophthalmol Vis Sci 2008;49:3027.
23. Alteheld N, Roessler G, Walter P. Towards the bionic eye-the retina implant: surgical, opthalmological and histopathological perspectives. Acta Neurochir Suppl 2007;97:487-93.
24. Sachs HG, Bartz-Schmidt U, Brunner U, et al. Subretinal chronic active visual prostheses in blind patients: the transchoroidal surgical procedure. Invest Ophthalmol Vis Sci 2006;47:3207.
25. Walter P, Schnakenberg U, vom Bögel G, et al. Development of a completely encapsulated intraocular pressure sensor. Ophthalmic Res 2000;32:278-84.
26. Sailer H, Shinoda K, Blatsios G, et al. Investigation of thermal effects of infrared lasers on the rabbit retina: a study in the course of the development of an active subretinal prosthesis. Graefes Arch Clin Exp Ophthalmol 2007;745:1169-78.