메뉴 건너뛰기




Volumn 145, Issue 3, 2007, Pages 1120-1129

Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration

Author keywords

antioxidants; neurodegeneration; photoreceptor degeneration; rd1 mouse; retinal degeneration; retinitis pigmentosa

Indexed keywords

ANTIOXIDANT; AVIDIN; EOSIN; GLUTATHIONE; HEMATOXYLIN; THIOCTIC ACID; XANTHOPHYLL; ZEAXANTHIN;

EID: 33947543601     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.12.034     Document Type: Article
Times cited : (112)

References (60)
  • 2
    • 14644401785 scopus 로고    scopus 로고
    • Decreased glutathione transferase levels in rd1/rd1 mouse retina: replenishment protects photoreceptors in retinal explants
    • Ahuja P., Caffé A.R., Ahuja S., Ekstrom P., and van Veen T. Decreased glutathione transferase levels in rd1/rd1 mouse retina: replenishment protects photoreceptors in retinal explants. Neuroscience 131 (2005) 935-943
    • (2005) Neuroscience , vol.131 , pp. 935-943
    • Ahuja, P.1    Caffé, A.R.2    Ahuja, S.3    Ekstrom, P.4    van Veen, T.5
  • 3
    • 33646866168 scopus 로고    scopus 로고
    • rd1 Mouse retina shows imbalance in cellular distribution and levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and sulfated glycosaminoglycans
    • Ahuja S., Ahuja P., Caffé A.R., Ekstrom P., Abrahamson M., and van Veen T. rd1 Mouse retina shows imbalance in cellular distribution and levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and sulfated glycosaminoglycans. Ophthalmic Res 38 (2006) 125-136
    • (2006) Ophthalmic Res , vol.38 , pp. 125-136
    • Ahuja, S.1    Ahuja, P.2    Caffé, A.R.3    Ekstrom, P.4    Abrahamson, M.5    van Veen, T.6
  • 4
    • 34247616816 scopus 로고    scopus 로고
    • Ahuja-Jensen P, Johnsen-Soriano S, Ahuja S, Bosch-Morell F, Sancho-Tello M, Romerob FJ, Abrahamson M, van Veen T (2007) Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport, in press.
  • 6
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: Age-Related Eye Disease Study Research Group Report No 8
    • Anonymous
    • Anonymous. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: Age-Related Eye Disease Study Research Group Report No 8. Arch Ophthalmol 119 (2001) 1417-1436
    • (2001) Arch Ophthalmol , vol.119 , pp. 1417-1436
  • 8
    • 33645356186 scopus 로고    scopus 로고
    • Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina
    • Azadi S., Paquet-Durand F., Medstrand P., van Veen T., and Ekstrom P.A. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31 (2006) 759-773
    • (2006) Mol Cell Neurosci , vol.31 , pp. 759-773
    • Azadi, S.1    Paquet-Durand, F.2    Medstrand, P.3    van Veen, T.4    Ekstrom, P.A.5
  • 9
    • 0142107431 scopus 로고    scopus 로고
    • Lipoic acid: a multifunctional antioxidant
    • Bast A., and Haenen G.R. Lipoic acid: a multifunctional antioxidant. Biofactors 17 (2003) 207-213
    • (2003) Biofactors , vol.17 , pp. 207-213
    • Bast, A.1    Haenen, G.R.2
  • 10
    • 33646128251 scopus 로고    scopus 로고
    • Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
    • Bazan N.G. Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 29 (2006) 263-271
    • (2006) Trends Neurosci , vol.29 , pp. 263-271
    • Bazan, N.G.1
  • 13
  • 14
    • 30944453898 scopus 로고    scopus 로고
    • Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence
    • Brown D.R. Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence. Folia Neuropathol 43 (2005) 229-243
    • (2005) Folia Neuropathol , vol.43 , pp. 229-243
    • Brown, D.R.1
  • 16
    • 0033134010 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of photoreceptor apoptosis in vitro
    • Carmody R.J., McGowan A.J., and Cotter T.G. Reactive oxygen species as mediators of photoreceptor apoptosis in vitro. Exp Cell Res 248 (1999) 520-530
    • (1999) Exp Cell Res , vol.248 , pp. 520-530
    • Carmody, R.J.1    McGowan, A.J.2    Cotter, T.G.3
  • 17
    • 0034027927 scopus 로고    scopus 로고
    • Oxidative stress induces caspase-independent retinal apoptosis in vitro
    • Carmody R.J., and Cotter T.G. Oxidative stress induces caspase-independent retinal apoptosis in vitro. Cell Death Differ 7 (2000) 282-291
    • (2000) Cell Death Differ , vol.7 , pp. 282-291
    • Carmody, R.J.1    Cotter, T.G.2
  • 18
    • 0017866791 scopus 로고
    • Differential effect of the rd mutation on rods and cones in the mouse retina
    • Carter-Dawson L.D., LaVail M.M., and Sidman R.L. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17 (1978) 489-498
    • (1978) Invest Ophthalmol Vis Sci , vol.17 , pp. 489-498
    • Carter-Dawson, L.D.1    LaVail, M.M.2    Sidman, R.L.3
  • 19
    • 0027521914 scopus 로고
    • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice
    • Chang G.Q., Hao Y., and Wong F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 11 (1993) 595-605
    • (1993) Neuron , vol.11 , pp. 595-605
    • Chang, G.Q.1    Hao, Y.2    Wong, F.3
  • 21
    • 26244433170 scopus 로고    scopus 로고
    • Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina
    • Delyfer M.N., Forster V., Neveux N., Picaud S., Leveillard T., and Sahel J.A. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol Vis 11 (2005) 688-696
    • (2005) Mol Vis , vol.11 , pp. 688-696
    • Delyfer, M.N.1    Forster, V.2    Neveux, N.3    Picaud, S.4    Leveillard, T.5    Sahel, J.A.6
  • 22
    • 32944467645 scopus 로고    scopus 로고
    • Activation of multiple pathways during photoreceptor apoptosis in the rd mouse
    • Doonan F., Donovan M., and Cotter T.G. Activation of multiple pathways during photoreceptor apoptosis in the rd mouse. Invest Ophthalmol Vis Sci 46 (2005) 3530-3538
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3530-3538
    • Doonan, F.1    Donovan, M.2    Cotter, T.G.3
  • 23
    • 0016295763 scopus 로고
    • Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina
    • Farber D.B., and Lolley R.N. Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina. Science 186 (1974) 449-451
    • (1974) Science , vol.186 , pp. 449-451
    • Farber, D.B.1    Lolley, R.N.2
  • 24
    • 31544453366 scopus 로고    scopus 로고
    • Glutathione-related enzymes and the eye
    • Ganea E., and Harding J.J. Glutathione-related enzymes and the eye. Curr Eye Res 31 (2006) 1-11
    • (2006) Curr Eye Res , vol.31 , pp. 1-11
    • Ganea, E.1    Harding, J.J.2
  • 26
    • 33644678324 scopus 로고    scopus 로고
    • Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments
    • Hauck S.M., Ekstrom P.A., Ahuja-Jensen P., Suppmann S., Paquet-Durand F., van Veen T., and Ueffing M. Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments. Mol Cell Proteomics 5 (2006) 324-336
    • (2006) Mol Cell Proteomics , vol.5 , pp. 324-336
    • Hauck, S.M.1    Ekstrom, P.A.2    Ahuja-Jensen, P.3    Suppmann, S.4    Paquet-Durand, F.5    van Veen, T.6    Ueffing, M.7
  • 27
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • Ishige K., Schubert D., and Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30 (2001) 433-446
    • (2001) Free Radic Biol Med , vol.30 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 28
    • 18844370917 scopus 로고    scopus 로고
    • Differential Akt activation in the photoreceptors of normal and rd1 mice
    • Johnson L.E., van Veen T., and Ekstrom P.A. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res 320 (2005) 213-222
    • (2005) Cell Tissue Res , vol.320 , pp. 213-222
    • Johnson, L.E.1    van Veen, T.2    Ekstrom, P.A.3
  • 29
    • 2942685882 scopus 로고    scopus 로고
    • Retinitis pigmentosa: understanding the clinical presentation, mechanisms and treatment options
    • Kalloniatis M., and Fletcher E.L. Retinitis pigmentosa: understanding the clinical presentation, mechanisms and treatment options. Clin Exp Optom 87 (2004) 65-80
    • (2004) Clin Exp Optom , vol.87 , pp. 65-80
    • Kalloniatis, M.1    Fletcher, E.L.2
  • 30
    • 33644928444 scopus 로고    scopus 로고
    • Delay of photoreceptor cell degeneration in rd mice by systemically administered phenyl-N-tert-butylnitrone
    • Kim J.H., Kim J.H., Yu Y.S., Jeong S.M., and Kim K.W. Delay of photoreceptor cell degeneration in rd mice by systemically administered phenyl-N-tert-butylnitrone. Korean J Ophthalmol 19 (2005) 288-292
    • (2005) Korean J Ophthalmol , vol.19 , pp. 288-292
    • Kim, J.H.1    Kim, J.H.2    Yu, Y.S.3    Jeong, S.M.4    Kim, K.W.5
  • 31
    • 33746773660 scopus 로고    scopus 로고
    • Antioxidants reduce cone cell death in a model of retinitis pigmentosa
    • Komeima K., Rogers B.S., Lu L., and Campochiaro P.A. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A 103 (2006) 11300-11305
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11300-11305
    • Komeima, K.1    Rogers, B.S.2    Lu, L.3    Campochiaro, P.A.4
  • 32
    • 9444224415 scopus 로고    scopus 로고
    • Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
    • Kowluru R.A., and Odenbach S. Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53 (2004) 3233-3238
    • (2004) Diabetes , vol.53 , pp. 3233-3238
    • Kowluru, R.A.1    Odenbach, S.2
  • 34
    • 33744913540 scopus 로고    scopus 로고
    • Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death
    • Lohr H.R., Kuntchithapautham K., Sharma A.K., and Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83 (2006) 380-389
    • (2006) Exp Eye Res , vol.83 , pp. 380-389
    • Lohr, H.R.1    Kuntchithapautham, K.2    Sharma, A.K.3    Rohrer, B.4
  • 35
    • 0028939390 scopus 로고
    • Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa
    • McLaughlin M.E., Ehrhart T.L., Berson E.L., and Dryja T.P. Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa. Proc Natl Acad Sci U S A 92 (1995) 3249-3253
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3249-3253
    • McLaughlin, M.E.1    Ehrhart, T.L.2    Berson, E.L.3    Dryja, T.P.4
  • 36
    • 0037704444 scopus 로고    scopus 로고
    • Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage
    • Okoye G., Zimmer J., Sung J., Gehlbach P., Deering T., Nambu H., Hackett S., Melia M., Esumi N., Zack D.J., and Campochiaro P.A. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci 23 (2003) 4164-4172
    • (2003) J Neurosci , vol.23 , pp. 4164-4172
    • Okoye, G.1    Zimmer, J.2    Sung, J.3    Gehlbach, P.4    Deering, T.5    Nambu, H.6    Hackett, S.7    Melia, M.8    Esumi, N.9    Zack, D.J.10    Campochiaro, P.A.11
  • 38
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • Packer L., Kraemer K., and Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17 (2001) 888-895
    • (2001) Nutrition , vol.17 , pp. 888-895
    • Packer, L.1    Kraemer, K.2    Rimbach, G.3
  • 39
    • 0031803334 scopus 로고    scopus 로고
    • alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury
    • Packer L. alpha-Lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Drug Metab Rev 30 (1998) 245-275
    • (1998) Drug Metab Rev , vol.30 , pp. 245-275
    • Packer, L.1
  • 42
    • 0034071816 scopus 로고    scopus 로고
    • Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina
    • Rapp L.M., Maple S.S., and Choi J.H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci 41 (2000) 1200-1209
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1200-1209
    • Rapp, L.M.1    Maple, S.S.2    Choi, J.H.3
  • 44
    • 2542432254 scopus 로고    scopus 로고
    • Double masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atropic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    • Richter S., Stilles W., Statkute L., Pulido J., Frankowski J., Rudy D., Pei K., Tsipursky M., and Nyland J. Double masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atropic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 75 (2004) 216-230
    • (2004) Optometry , vol.75 , pp. 216-230
    • Richter, S.1    Stilles, W.2    Statkute, L.3    Pulido, J.4    Frankowski, J.5    Rudy, D.6    Pei, K.7    Tsipursky, M.8    Nyland, J.9
  • 45
    • 4544326749 scopus 로고    scopus 로고
    • Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6
    • Sanvicens N., Gomez-Vicente V., Masip I., Messeguer A., and Cotter T.G. Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6. J Biol Chem 279 (2004) 39268-39278
    • (2004) J Biol Chem , vol.279 , pp. 39268-39278
    • Sanvicens, N.1    Gomez-Vicente, V.2    Masip, I.3    Messeguer, A.4    Cotter, T.G.5
  • 46
    • 16644394641 scopus 로고    scopus 로고
    • Nutrition and retina
    • Schmidt-Erfurth U. Nutrition and retina. Dev Ophthalmol 38 (2005) 120-147
    • (2005) Dev Ophthalmol , vol.38 , pp. 120-147
    • Schmidt-Erfurth, U.1
  • 49
    • 0028028103 scopus 로고
    • Selective development of one cone photoreceptor type in retinal organ culture
    • Söderpalm A., Szel A., Caffé A.R., and van Veen T. Selective development of one cone photoreceptor type in retinal organ culture. Invest Ophthalmol Vis Sci 35 (1994) 3910-3921
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 3910-3921
    • Söderpalm, A.1    Szel, A.2    Caffé, A.R.3    van Veen, T.4
  • 51
    • 20444409147 scopus 로고    scopus 로고
    • Bioactivity and protective effects of natural carotenoids
    • Stahl W., and Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 1740 (2005) 101-107
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 101-107
    • Stahl, W.1    Sies, H.2
  • 52
    • 0031984418 scopus 로고
    • Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues
    • Struthers L., Patel R., Clark J., and Thomas S. Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues. Anal Biochem 225 (1988) 20-31
    • (1988) Anal Biochem , vol.225 , pp. 20-31
    • Struthers, L.1    Patel, R.2    Clark, J.3    Thomas, S.4
  • 54
    • 0034815985 scopus 로고    scopus 로고
    • A PDE6A promoter fragment directs transcription predominantly in the photoreceptor
    • Taylor R.E., Shows K.H., Zhao Y., and Pittler S.J. A PDE6A promoter fragment directs transcription predominantly in the photoreceptor. Biochem Biophys Res Commun 282 (2001) 543-547
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 543-547
    • Taylor, R.E.1    Shows, K.H.2    Zhao, Y.3    Pittler, S.J.4
  • 55
    • 33749066763 scopus 로고    scopus 로고
    • Mitochondrial damage and intralysosomal degradation in cellular aging
    • Terman A., Gustafsson B., and Brunk U.T. Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med 27 (2006) 471-482
    • (2006) Mol Aspects Med , vol.27 , pp. 471-482
    • Terman, A.1    Gustafsson, B.2    Brunk, U.T.3
  • 57
    • 11144273817 scopus 로고    scopus 로고
    • Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration
    • Wenzel A., Grimm C., Samardzija M., and Reme C.E. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res 24 (2005) 275-306
    • (2005) Prog Retin Eye Res , vol.24 , pp. 275-306
    • Wenzel, A.1    Grimm, C.2    Samardzija, M.3    Reme, C.E.4
  • 60
    • 1542427168 scopus 로고    scopus 로고
    • Caspase-3 in postnatal retinal development and degeneration
    • Zeiss C.J., Neal J., and Johnson E.A. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45 (2004) 964-970
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 964-970
    • Zeiss, C.J.1    Neal, J.2    Johnson, E.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.