Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture

Experimental Neurology

Volumn 161, Issue 2, 2000, Pages 676-685

  Ogilvie, Judith Mosinger ^a,b   Speck, Judith D ^a,b   Lett, Jaclynn M ^a  

^a CENTRAL INSTITUTE FOR THE DEAF   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BDNF; CNTF; FGF; GDNF; Photoreceptor rescue; Trophic factors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEURTURIN; PERSEPHIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; ORGAN CULTURE; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DYSTROPHY;

EID: 0034052318     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7291     Document Type: Article

References (54)

1. Arce V. P. R., Philippe J. M., Pennica D., Henderson C. E., deLapeyriere O. Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1). J. Neurosci. 18:1998;1440-1448.
2. Bowes C., Li T., Dancinger M., Baxter L. C., Applebury M. L., Farber D. B. Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase. Nature. 347:1990;677-680.
3. Caffé A. R., Söderpalm A., van Veen T. Photoreceptor-specific protein expression of mouse retina in organ culture and retardation of rd degeneration in vitro by a combination of basic fibroblast and nerve growth factors. Curr. Eye Res. 12:1993;719-726.
4. Cao W., Wen R., Li F., LaVail M., Steinberg R. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp. Eye Res. 65:1997;241-248.
5. Carter-Dawson L. D., LaVail M. M., Sidman R. L. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest. Ophthalmol. Vis. Sci. 17:1978;489-498.
6. Carwile M. E., Culbert R. B., Sturdivant R. L., Kraft T. W. Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF. Exp. Eye Res. 66:1998;791-805.
7. Cayouette M., Behn D., Sendtner M., Lachapelle P., Gravel C. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J. Neurosci. 18:1998;9282-9293.
8. Cayouette M., Gravel C. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum. Gene Ther. 8:1997;423-430.
9. Chong N. V., Alexander R. A., Waters L., Barnett K. C., Bird A. C., Luthert P. J. Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Invest. Ophthalmol. Vis. Sci. 40:1999;1298-1305.
10. Creedon D. J., Tansey M. G., Baloh R. H., Osborne P. A., Lampe P. A., Fahrner T. J., Heuckeroth R. O., Milbrandt J., Johnson E. M. Jr. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc. Natl. Acad. Sci. USA. 94:1997;7018-7023.
11. DeChiara T., Vejsada R., Poueymirou W., Acheson A., Suri C., Conover J., Friedman B., McClain J., Pan L., Stahl N. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 83:1995;313-322.
12. Ezzeddine Z. D., Yang X., DeChiara T., Yancopoulos G., Cepko C. L. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development. 124:1997;1055-1067.
13. Faktorovich E. G., Steinberg R. H., Yasumura D., Matthes M. T., LaVail M. M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 347:1990;83-86.
14. Faktorovich E. G., Steinberg R. H., Yasumura D., Matthes M. T., LaVail M. M. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J. Neurosci. 12:1992;3554-3567.
15. Farber D. B., Flannery J. G., Bowes-Rickman C. The rd mouse story: Seventy years of research on an animal model of inherited retinal degeneration. Prog. Ret. Eye Res. 13:1994;31-64.
16. Fayein N., Courtois Y., Jeanny J. Ontogeny of basic fibroblast growth factor binding sites in mouse ocular tissues. Exp. Cell Res. 188:1990;75-88.
17. Fontaine V., Kinkl N., Sahel J., Dreyfus H., Hicks D. Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2. J. Neurosci. 18:1998;9662-9672.
18. Fuhrmann S., Kirsch M., Hofmann H.-D. Ciliary neurotrophic factor promotes chick photoreceptor development in vitro. Development. 121:1995;2695-2706.
19. Gao H., Hollyfield J. Basic fibroblast growth factor (bFGF) immunolocalization in the rodent outer retina demonstrated with an anti-rodent bFGF antibody. Brain Res. 585:1992;355-360.
20. Gao H., Hollyfield J. G. Basic fibroblast growth factor in retinal development: Differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev. Biol. 169:1995;168-184.
21. Guillonneau X., Régnier-Ricard F., Laplace O., Jonet L., Bryckaert M., Courtois Y., Mascarelli F. Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration. Mol. Cell. Biol. 9:1998;2785-2802.
22. Hackett S., Friedman Z., Freund J., Schoenfeld C., Curtis R., DiStefano P., Campochiaro P. A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics. Brain Res. 789:1998;201-212.
23. Hackett S., Schoenfeld C., Freund J., Gottsch J., Bhargave S., Campochiaro P. Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells. Exp. Eye Res. 64:1997;865-873.
24. Ikeda S., Hawes N. L., Chang B., Avery C. S., Smith R. S., Nishina P. M. Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice. Invest. Ophthalmol. Vis. Sci. 40:1999;1874-1878.
25. Inglehearn C. Molecular genetics of human retinal dystrophies. Eye. 12:1998;571-579.
26. Jing S., Wen D., Yu Y., Holst P. L., Luo Y., Fang M., Tamir R., Antonio L., Hu Z., Cupples R., Louis J.-C., Hu S., Altrock B. W., Fox G. M. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell. 85:1996;1113-1124.
27. Jomary C., Thomas M., Grist J., Milbrandt J., Neal M. J., Jones S. E. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest. Ophthalmol. Vis. Sci. 40:1999;568-574.
28. Kirsch M., Fuhrmann S., Wiese A., Hofmann H.-D. CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors. NeuroReport. 7:1996;697-700.
29. Kirsch M., Lee M., Meyer V., Wiese A., Hofmann H. Evidence for multiple, local functions of ciliary neurotrophic factor (CNTF) in retinal development: Expression of CNTF and its receptors and in vitro effects on target cells. J. Neurochem. 68:1997;979-990.
30. Kirsch M., Schulz-Key S., Wiese A., Fuhrmann S., Hofmann H.-D. Ciliary neurotrophic factor blocks rod photoreceptor differentiation from postmitotic precursor cells in vitro. Cell Tissue Res. 291:1998;207-216.
31. Koide T., Takahashi J. B., Hoshimaru M., Kojima M., Otsuka T., Asahi M., Kikuchi H. Localization of trkB and low-affinity nerve growth factor receptor mRNA in the developing rat retina. Neurosci. Lett. 185:1995;183-186.
32. Lambiase A., Aloe L. Nerve growth factor delays retinal degeneration in C3H mice. Graefe's Arch. Clin. Exp. Ophthalmol. 234:1996;S96-S100.
33. LaVail M. M., Unok K., Yasumura D., Matthes M. T., Yancopoulos G. D., Steinberg R. H. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. USA. 89:1992;11249-11253.
34. LaVail M. M., Yasumura D., Matthes M. T., Lau-Villacorta C., Unoki K., Sung C.-H., Steinberg R. H. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest. Ophthalmol. Vis. Sci. 39:1998;592-602.
35. Lindsay R. Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases. Ciba Found. Symp. 196:1996;39-48.
36. Liu C., Peng M., Laties A., Wen R. Preconditioning with bright light evokes a protective response against light damage in the rat retina. J. Neurosci. 18:1998;1337-1344.
37. Llamosas M., Cernuda-Cernuda R., Huerta J., Vega J., García-Fernández J. Neurotrophin receptors expression in the developing mouse retina: An immunohistochemical study. Anat. Embryol. 195:1997;337-344.
38. Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature. 365:1993;27-32.
39. Masuda K., Watanabe I., Unoki K., Ohba N., Muramatsu T. Functional rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat. Invest. Ophthalmol. Vis. Sci. 36:1995;2142-2146.
40. Meyer-Franke A., Kaplan M. R., Pfrieger F. W., Barres B. A. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron. 15:1995;805-819.
41. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J., Wong V., Lindsay R. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science. 265:1994;1107-1110.
42. Mosinger Ogilvie J., Speck J. D., Lett J. M., Fleming T. T. A reliable method for organ culture of neonatal mouse retina with long-term survival. J. Neurosci. Methods. 87:1999;57-65.
43. Noji S., Matsuo T., Koyama E., Yamaai T., Nohno T., Matsuo N., Taniguchi S. Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes. Biochem. Biophys. Res. Commun. 168:1990;343-349.
44. Pearce-Kelling S., Acland G., Laties A., Cearbaum J., Aguirre G. Survival factors slow inherited retinal degeneration in the rcd1 and erd dog models. Invest. Ophthalmol. Vis. Sci. 39:1998;S571.
45. Perez M.-T. R., Caminos E. Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina. Neurosci. Lett. 183:1995;96-99.
46. Pittler S. J., Baehr W. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse. Proc. Natl. Acad. Sci. USA. 88:1991;8322-8326.
47. Rickman D. W., Brecha N. C. Expression of the proto-oncogene, trk, receptors in the developing rat retina. Vis. Neurosci. 12:1995;215-222.
48. Sanyal S., Bal A. K. Comparative light and electron microscopic study of retinal histogenesis in normal and rd mutant mice. Z. Anat. Entwickl.-Gesch. 142:1973;219-238.
49. Ugolini G., Cremisi F., Maffei L. TrkA, TrkB, and p75 mRNA expression is developmentally regulated in the rat retina. Brain Res. 704:1995;121-124.
50. Vecino E., Caminos E., Ugarte M., Martin-Zanca D., Osborne N. N. Immunohistochemical distribution of neurotrophins and their receptors in the rat retina and the effects of ischemia and reperfusion. Gen. Pharmacol. 30:1998;305-314.
51. Wen R., Cheng T., Song Y., Matthes M. T., Yasumura D., LaVail M. M., Steinberg R. H. Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina. Curr. Eye Res. 17:1998;494-500.
52. Wen R., Song Y., Cheng T., Matthes M., Yasumura D., LaVail M., Steinberg R. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J. Neurosci. 15:1995;7377-7385.
53. Wong V., Arriaga R., Ip N., Lindsay R. The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons. Eur. J. Neurosci. 5:1993;466-474.
54. Yan Q., Wang J., Matheson C. R., Urich J. L. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: Comparison to and combination with brain-derived neurotrophic factor (BDNF). J. Neurobiol. 38:1999;382-390.