HDAC4 regulates neuronal survival in normal and diseased retinas

Science

Volumn 323, Issue 5911, 2009, Pages 256-259

  Chen, Bo ^a   Cepko, Constance L ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 4; HYPOXIA INDUCIBLE FACTOR 1;

APOPTOSIS; EYE; NERVOUS SYSTEM; PHOTORECEPTION;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CYTOPLASM; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA BIPOLAR GANGLION CELL; RETINA DEVELOPMENT; RETINA NERVE CELL;

ACETYLATION; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; CYTOPLASM; ELECTROPORATION; HISTONE DEACETYLASES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MUTATION; RETINA; RETINAL DEGENERATION; RETINAL NEURONS; RETINAL ROD PHOTORECEPTOR CELLS; RHODOPSIN; TRANSFECTION;

EID: 58149389397     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1166226     Document Type: Article

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24. We thank J. R. Lu for providing HDAC4, HDAC5, and HDAC6 expression constructs; T. P. Yao for providing HDAC4-3SA mutant; X. J. Yang for providing HDAC4-L175A mutant; G. L. Semenza for providing dnHIF1α constructs and K. W. Kim for providing HIF1α and HIF1αK532R constructs; and T. Matsuda for assistance with various techniques. Supported by NIH grant EYO 14466, the Foundation for Retinal Research, a gift from Merck, and the Howard Hughes Medical Institute (HHMI). C.L.C. is an Investigator of HHMI and B.C. is a postdoctoral fellow of HHMI. C.L.C. and B.C. have filed a U.S. patent application, 61/088,455, based on the work in this paper.