Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues

Molecular Vision

Volumn 7, Issue , 2001, Pages 154-163

  Karakousis, Petros C ^a   John, Sinoj K ^b   Behling, Kathryn C ^a   Surace, Enrico M ^a   Smith, Julie E ^b   Hendrickson, Anita ^c   Tang, Wai Xing ^b   Bennett, Jean ^a   Milam, Ann H ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MESSENGER RNA; MONOCLONAL ANTIBODY; PEPTIDE; PIGMENT EPITHELIUM DERIVED FACTOR; POLYCLONAL ANTIBODY;

ADULT; AGED; ANTIBODY LABELING; ANTIBODY SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CHOROID; CILIARY BODY; CONTROLLED STUDY; CORNEA; CORNEA ENDOTHELIUM; CORNEA EPITHELIUM; CYTOPLASM; EYE DEVELOPMENT; FETUS; GENE LOCATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOLOCALIZATION; IN SITU HYBRIDIZATION; IRIS; NEUROBLAST; PHOTORECEPTOR; PIGMENT EPITHELIUM; PROTEIN LOCALIZATION; RETINA; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA GANGLION CELL; RETINA ROD; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; EMBRYONIC AND FETAL DEVELOPMENT; EYE; EYE PROTEINS; FEMALE; HUMANS; IN SITU HYBRIDIZATION; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NERVE GROWTH FACTORS; PROTEINS; RNA, MESSENGER; SERPINS;

EID: 0347664084     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Ophthalmol Vis Sci 1989; 30:1700-7.
2. Tombran-Tink J, Chader GJ, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991; 53:411-4.
3. Steele FR, Chader GJ, Johnson LV, Tombran-Tink J. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci U S A 1993; 90:1526-30.
4. Wu YQ, Notario V, Chader GJ, Becerra SP. Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif 1995; 6:447-56.
5. Cayouette M, Smith SB, Becerra SP, Gravel C. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 1999; 6:523-32.
6. Taniwaki T, Becerra SP, Chader GJ, Schwartz JP. Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem 1995; 64:2509-17.
7. Taniwaki T, Hirashima N, Becerra SP, Chader GJ, Etcheberrigaray R, Schwartz JP. Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. J Neurochem 1997; 68:26-32.
8. Araki T, Taniwaki T, Becerra SP, Chader GJ, Schwartz JP. Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res 1998; 53:7-15.
9. DeCoster MA, Schabelman E, Tombran-Tink J, Bazan NG. Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons. J Neurosci Res 1999; 56:604-10.
10. Houenou LJ, D'Costa AP, Li L, Turgeon VL, Enyadike C, Alberdi E, Becerra SP. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. J Comp Neurol 1999; 412:506-14.
11. Bilak MM, Corse AM, Bilak SR, Lehar M, Tombran-Tink J, Kuncl RW. Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol 1999; 58:719-28.
12. Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci 2000; 20:7149-57.
13. Alberdi E, Aymerich MS, Becerra SP. Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem 1999; 274:31605-12.
14. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285:245-8.
15. Stellmach VV, Crawford SE, Zhou W, Bouck N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci U S A 2001; 98:2593-7.
16. Tombran-Tink J, Pawar H, Swaroop A, Rodriguez I, Chader GJ. Localization of the gene for pigment epithelium-derived factor (PEDF) to chromosome 17p13.1 and expression in cultured human retinoblastoma cells. Genomics 1994; 19:266-72.
17. Goliath R, Tombran-Tink J, Rodriquez IR, Chader G, Ramesar R, Greenberg J. The gene for PEDF, a retinal growth factor, is a prime candidate for retinitis pigmentosa and is tightly linked to the RP13 locus on chromosome 17p13.3. Mol Vis 1996; 2:5 .
18. Koenekoop R, Pina AL, Loyer M, Davidson J, Robitaille J, Maumenee I, Tombran-Tink J. Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis. Mol Vis 1999; 5:10 .
19. Becerra SP. Structure-function studies on PEDF. A noninhibitory serpin with neurotrophic activity. Adv Exp Med Biol 1997; 425:223-37.
20. Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. J Biol Chem 1995; 270:25992-9.
21. Perez-Mediavilla LA, Chew C, Campochiaro PA, Nickells RW, Notario V, Zack DJ, Becerra SP. Sequence and expression analysis of bovine pigment epithelium-derived factor. Biochim Biophys Acta 1998; 1398:203-14.
22. Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D. Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 1995; 15:4992-5003.
23. Ortego J, Escribano J, Becerra SP, Coca-Prados M. Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor. Invest Ophthalmol Vis Sci 1996; 37:2759-67.
24. Tombran-Tink J, Mazuruk K, Rodriguez IR, Chung D, Linker T, Englander E, Chader GJ. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol Vis 1996; 2:11 .
25. Li ZY, Kljavin IJ, Milam AH. Rod photoreceptor neurite sprouting in retinitis pigmentosa. J Neurosci 1995; 15:5429-38.
26. Frederick JM, Krasnoperova NV, Hoffmann K, Church-Kopish J, Ruther K, Howes K, Lem J, Baehr W. Mutant rhodopsin transgene expression on a null background. Invest Ophthalmol Vis Sci 2001; 42:826-33.
27. Samulski RJ, Chang LS, Shenk T. A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol 1987; 61:3096-101.
28. Surace EM, Angeletti B, Ballabio A, Marigo V. Expression pattern of the ocular albinism type I (Oa1) gene in the murine retinal pigment epithelium. Invest Ophthalmol Vis Sci 2000; 41:4333-7.
29. Wassle H, Dacey DM, Haun T, Haverkamp S, Grunert U, Boycott BB. The mosaic of horizontal cells in the macaque monkey retina: with a comment on biplexiform ganglion cells. Vis Neurosci 2000; 17:591-608.
30. John SK, Smith JE, Aguirre GD, Milam AH. Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. Mol Vis 2000; 6:204-15 .
31. Ahnelt PK, Kolb H. The mammalian photoreceptor mosaic-adaptive design. Prog Retin Eye Res 2000; 19:711-77.
32. Ishigooka H, Kitaoka T, Boutilier SB, Bost LM, Aotaki-Keen AE, Tablin F, Hjelmeland LM. Developmental expression of bFGF in the bovine retina. Invest Ophthalmol Vis Sci 1993; 34:2813-23.
33. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 1992; 12:3554-67.
34. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331:1480-7.
35. Chen C, Parangi S, Tolentino MJ, Folkman J. A strategy to discover circulating angiogenesis inhibitors generated by human tumors. Cancer Res 1995; 55:4230-3.
36. Behling KC, Surace EM, Milam AH, Bennett J. Endogenous and exogenous expression of pigment epithelium derived factor (PEDF) in the retina. Invest Ophthalmol Vis Sci 2001; 42:S771.
37. Chader GJ. PEDF: Raising both hopes and questions in controlling angiogenesis. Proc Natl Acad Sci U S A 2001; 98:2122-4.