Neurotrophic support and oxidative stress: Converging effects in the normal and diseased nervous system

Neuroscientist

Volumn 15, Issue 1, 2009, Pages 47-61

  Gardiner, John ^a   Barton, Deborah ^a   Overall, Robyn ^a   Marc, Jan ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cytoskeleton; Neurological disease; Neurotrophic support; Oxidative stress

Indexed keywords

ANTIOXIDANT; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; CENTRAL NERVOUS SYSTEM; DISEASE COURSE; DOWN REGULATION; DYSAUTONOMIA; FEEDBACK SYSTEM; FRIEDREICH ATAXIA; HEARING; HEARING LOSS; HUMAN; HUNTINGTON CHOREA; MACHADO JOSEPH DISEASE; MENTAL DISEASE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SMELLING; SPINOCEREBELLAR DEGENERATION; UPREGULATION; VISION; WILSON DISEASE;

ANIMALS; HUMANS; NERVE GROWTH FACTORS; NERVOUS SYSTEM DISEASES; OXIDATIVE STRESS;

EID: 59149107151     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858408325269     Document Type: Review

References (148)

1. Amantea D., Russo R., Bagetta G., Corasaniti MT 2005. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52: 119-32.
2. Anderson SL, Coli R., Daly IW, Kichula EA, Rork MJ, Volpi SA, and others. 2001. Familial dysautonomia is caused by mutations of the IKAP gene. Am J Hum Genet 68: 753-8.
3. Bahmad F. Jr, Merchant SN, Nadol JB Jr, Tranebjaerg L. 2007. Otopathology in Mohr-Tranebjaerg syndrome. Laryngoscope 117: 1202-8.
4. Baquet ZC, Bickford PC, Jones KB 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25: 6251-9.
5. Braas KM, Schutz KC, Bond JP, Vizzard MA, Girard BM, May V. 2007. Microarray analyses of pituitary adenylate cyclise activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons. Peptides 28: 1856-70.
6. Briscoe TA, Tolcos M., Dieni S., Loeliger M., Rees SM 2006. Prenatally compromised neurons respond to brain-derived neurotrophic factor treatment in vitro. Neuroreport 17: 1385-9.
7. Buckland ME, Cunningham AM 1999. Alterations in expression of the neurotrophic factors glial cell line-derived neurotrophic factor, ciliary neurotrophic factor and brain-derived neurotrophic factor, in the target-deprived olfactory neuroepithelium. Neuroscience 90: 333-47.
8. Caleo M., Medini P., von Bartheld CS, Maffel L. 2003. Provision of brain-derived neurotrophic factor via anterograde transport from the eye preserves the physiological responses of axotomized geniculate neurons. J Neurosci 23: 287-96.
9. Castellani RJ, Honda K., Zhu X., Cash AD, Nunomura A., Perry G., Smith MA 2004. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Res Rev 3: 319-26.
10. Chao CC, Lee EHY. 1999. Neuroprotective mechanisms of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation. Neuropharmacol 38: 913-16.
11. Charon I., Zuin-Kornmann G., Bataille S., Schorderet M. 1999. Protective effects of neurotrophic factors, neuropoietic cytokines and dibutyryl cyclic amp on hydrogen peroxide-induced cytotoxicity on PC 12 cells: a possible link with the state of differentiation. Neurochem Int 33: 497-505.
12. Chauhan NB, Stegel GJ, Lee JM 2001. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J Chem Neuroanat 21: 277-88.
13. Cheng A., Wang S., Cai J., Rao MS, Mattson MP 2003. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol 258: 319-33.
14. Cuthbert JA 1995. Wilson's disease: a new gene and an animal model for an old disease. J Investig Med 43: 323-36.
15. Darrat I., Ahmad N., Seidman K., Seidman MD 2007. Auditory research involving antioxidants. Curr Opin Otolaryngol Head Neck Surg 15: 358-63.
16. Deckner ML, Frisen J., Verge VM, Hokfelt T., Risling M. 1993. Localization of neurotrophin receptors in olfactory epithelium and bulb. Neuroreport 5: 301-4.
17. Dluzen DE, Story GM, Xu K., Kucera J., Walro JM 1999. Alterations in nigrostriatal dopaminergic function within BDNF mutant mice. Exp Neurol 160: 500-7.
18. Dolcet X., Soler RM, Gould TW, Egea J., Oppenheim RW, Comella KX 2001. Cytokines promote motorneuron survival through the Janus-kinase dependent activation of the phosphatidyl 3-kinase pathway. Mol Cell Neurosci 18: 619-31.
19. Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, Humbert S., Saudou F. 2007. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 27: 3571-81.
20. Donovan MH, Yamaguchi M., Eisch AJ 2008. Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus (epub ahead of print).
21. Dugan LL, Creedon DJ, Johnson EM Jr, Holtzman DM 1997. Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94: 4086-91.
22. Evert BO, Vogt IR, Vieiera-Saecker AM, Ozimek L., de Vos RA, Brunt ER, and others. 2003. Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3. J Neuropathol Exp Neurol 62: 1006-18.
23. Farooqui T. 2007. Octopamine mediated neuronal plasticity in honeybees: implications for olfactory dysfunction in humans. Neuroscientist 13: 304-22.
24. Fernandez-Ruiz J., Diaz R., Hall-Haro C., Vergara P., Fiorentini A., Nunez L., and others. 2003. Olfactory dysfunction in hereditary ataxia and basal ganglia disorders. Neuroreport 14: 1339-41.
25. Fox JH, Kama JA, Lieberman G., Chopra R., Dorsey K., Chopra V., and others. 2007. Mechanisms of copper ion mediated Huntington's disease progression. PLoS ONE 2: e334.
26. Frank L., Wiegand SJ, Siuciak JA, Lindsay RM, Rudge JS 1997. Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain. Exp Neurol 145: 62-70.
27. Frechilla D., Garcia-Osta A., Palacios S., Cenarruzabeitia E., Del Rio J. 2001. BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons. Neuroreport 12: 919-23.
28. Fujiwara M., Iso H., Kitanaka N., Eguchi H., Ookawara T., Ozawa K, and others. 2006. Effects of copper metabolism on neurological functions in Wistar and Wilson's disease model rats. Biochem Biophys Res Commun 349: 1079-86.
29. Fukui H., Moraes CT 2007. Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Hum Mol Genet 16: 783-97.
30. Gabaizadeh R., Staecker H., Liu W., Kopke RD, Malgrange B., Lefebvre PP, Van De Water TR 1997. Protection of both auditory hair cells and auditory neurons from cisplatin induced damage. Acta Otolaryngol (Stockh) 117: 232-8.
31. Gardiner J., Barton D., Marc J., Overall R. 2007. Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Traffic 8: 1145-9.
32. Gauthier LR, Charrin BC, Borrell- Pages M., Dompierre JP, Rangone H., Cordelieres FP, and others. 2004. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118: 127-38.
33. Germani E., Lesma E., Di Giulio AM, Gorio A. 1999. Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by prenatal diabetes: protective action of antioxidant treatment. J Neurosci Res 57: 521-8.
34. Gibson TJ, Koonin EV, Musco G., PastoreA, Bork P. 1996. Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction. Trends Neurosci 19: 465-8.
35. Giuliano P., De Cristofaro T., Affaitati A., Pizzulo GM, Feliciello A., Criscuolo C, and others. 2003. DNA damage induced by polyglutamine-expanded proteins. Hum Mol Genet 12: 2301-19.
36. Gong L., Wyatt RJ, Baker I., Masserano JM 1999. Brain-derived and glial cell line-derived neurotrophic factors protect a catecholaminergic cell line from dopamine-induced cell death. Neurosci Lett 263: 153-6.
37. Grant MM, Barber VS, Griffiths HR 2005. The presence of ascorbate induces expression of brain-derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival. Proteomics 5: 534-40.
38. Gu M., Cooper JM, Butler P., Walker AP, Mistry PK, Dooley JS, SchapiraAH. 2000. Oxidative-phosphorylation defects in liver of patients with Wilson's disease. Lancet 356: 469-74.
39. Guo ZH, Mattson MP 2000. Neurotrophic factors protect cortical synaptic terminals against amyloid- and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cerebral Cortex 10: 50-7.
40. Guthrie KM, Gall CM 1991. Differential expression of mRNAs for the NGF family of neurotrophic factors in the adult rat central olfactory system. J Comp Neurol 313: 95-102.
41. Heaton MB, Paiva M., Madorsky I., Shaw G. 2003. Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods. Brain Res Dev Brain Res 145: 249-62.
42. Holcomb JD, Mumm JS, Calof AL 1995. Apoptosis in the neuronal lineage of the mouse olfactory epithelium: regulation in vivo and in vitro. Dev Biol 172: 307-23.
43. Howells DW, Porritt MJ, Wong JY, Batchelor PE, Kalnins R., Hughes AJ, Donnan GA 2000. Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp Neurol 166: 127-35.
44. Hu D., Hou X., Hui Y. 2002. Effect of adenovirally delivered brain-derived neurotrophic factor on superoxide dismutase within the retina of experimentally injured optic nerve of rat eyes. Yan Ke Xue Bao 18: 249-52.
45. Hyman C., Hoter M., Barde YA, Juhasz M., Yancopoulos GD, Squinto SP, Lindsay RM 1991. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230-2.
46. Iwata E., Asabuna M., Nishibayashi S., Kondo Y., Ogawa N. 1997. Different effects of oxidative stress on activation of transcription factors in primary cultured rat neuronal and glial cells. Brain Res Mol Brain Res 50: 213-20.
47. Jensen JL, Kuczera K., Roy S., Schoneich C. 2000. Metal- catalyzed oxidation of brain-derived neurotrophic factor (BDNF): selectivity and conformational consequences of histidine modification. Cell Mol Biol (Noisy-le-grand) 46: 685-96.
48. Jiang H., Talaska AE, Schacht J., Sha SH 2007. Oxidative imbalance in the aging inner ear. Neurobiol Aging 28: 1605-12.
49. Johansen LD, Naumanen T., Knudsen A., Westerlund N., Gromova I., Junttila M, and others. 2008. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci 121: 854-64.
50. Joosten EA, Houweling DA 2004. Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects. Neuroreport 15: 1163-6.
51. Kaur N., Lu B., Monroe RK, Ward SM, Halvorsen SW 2005. Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signalling in neurons. J Neurochem 92: 1521-30.
52. Kew JNC, Smith DW, Sofroniew MV 1996. Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons in vitro: protection by cyclic AMP analogue and high potassium. Neuroscience 70: 329-39.
53. Kim YT, Shin SM, Lee WY, Kim GM, Jin DK 2004. Expression of expanded polyglutamine protein induces behavioural changes in Drosophila. Cell Mol Neurobiol 24: 109-22.
54. Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF 1996. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res 713: 178-85.
55. Klepac N., Relja M., Klepac R. Hecimovic S., Babic T., Trkulja V. 2007. Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: a cross-sectional study. J Neurol 254: 1676-83.
56. Landi S., Sale A., Berardi N., Viegi A., Maffel L., Cenni MC 2007. Retinal function is sensitive to environmental enrichment: a role for BDNF. FASEB J 21: 130-9.
57. Lastres- Becker I., Rüb U., Auburger G. 2008. Spinocerebellar ataxia 2 (SCA2). Cerebellum (epub ahead of print).
58. Lech T., Hydzik P., Kosowski B. 2007. Significance of copper determination in late onset Wilson's disease. Clin Toxicol (Phila) 45: 688-94.
59. Lefebvre PP, Malgrange B., Lallemend F., Staecker H., Moonen G., Van De Water TR 2002. Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiology Neuro-Otology 7: 165-70.
60. Lee CF, Liu CY, Hsieh RH, Wei YH 2005. Oxidative stress-induced depolymerisation of microtubules and alteration of mitochondrial mass in human cells. Ann N Y Acad Sci 1042: 246-54.
61. Levivier M., Przedborski S., Bencsics C., Kang UJ 1995. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 15: 7810-20.
62. Liberman MC, Tartaglini E., Fleming JC, Neufeld EJ 2006. Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype. J Assoc Res Otolaryngol 7: 211-17.
63. Liu L., Trimarchi JR, Keefe DL 2000. Involvement of mitochondria in oxidative stress-induced cell death in mouse zygotes. Biol Repro 62: 1745-53.
64. Liu- Snyder P., McNally H., Shi R., Borgens RB 2006. Acrolein-mediated mechanisms of neuronal death. J Neurosci Res 84: 209-18.
65. Llorens JV, Navarro JA, Martinez-Sebastian MJ, Baylies MK, Schneuwly S., Botella JA, Molto MD 2007. Causative role of oxidative stress in a Drosophila model of Friedreich ataxia. FASEB J 21: 333-44.
66. Lobner D., Golner S., Hjelmhaug J. 2003. Neurotrophic factor effects on oxidative stress-induced neuronal death. Neurochem Res 28: 749-56.
67. Lonsdale D. 2007. Dysautonomia, a heuristic approach to a revised model for etiology of disease. Evidence-based Comp Alt Med. Avail able from: http://ecam.oxfordjournals.org/cgi/content/abstract/nem064
68. Lu C., Chan SL, Haughey N., Lee WT, Mattson MP 2001. Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-D-aspartate channels. J Neurochem 78: 577-89.
69. Madeddu F., Naska S., Bozzi Y. 2004. BDNF down-regulates the caspase 3 pathway in injured geniculo-cortical neurones. Neuroreport 15: 2045-9.
70. Maksimovic ID, Jovanovic MD, Malicevic Z., Colic M., Ninkovic M. 2002. Effects of nerve and fibroblast growth factors on the production of nitric oxide in experimental model of Huntington's disease. Vojnosanit Pregl 59: 119-23.
71. Markham A., Cameron I., Franklin P., Spedding M. 2004. BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II. Eur J Neurosci 20: 1189-96.
72. Martinowich K., Lu B. 2008. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33: 73-83.
73. Maruyama J., Yamagata T., Ulfendahl M., Brednerg G., Alyschuler RA, Miller JM 2007. Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs. Neurobiol Dis 25: 309-18.
74. Masana Y., Wanaka A., Kato H., Asai T., Tohyama M. 1993. Localization of trkB mRNA in postnatal brain development. J Neurosci Res 35: 468-79.
75. Mattson MP 2003. Will caloric restriction and folate protect against AD and PD ? Neurology 60: 690-5.
76. Mattson MP, Duan W., Guo Z. 2003. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem 84: 417-31.
77. Mattson MP, Lovell MA, Furukawa K., Markesbery WR 1995. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 65: 1740-51.
78. Mcdonald JW, Stefovska VG, Liu XZ, Shin H., Liu S., Choi DW 2002. Neurotrophin potentiation of iron-induced spinal cord injury. Neuroscience 115: 931-9.
79. McGuinness SL, Shepherd RK 2005. Exogenous BDNF rescues rat spiral ganglion neurons in vivo. Otol Neurotol 26: 1064-72.
80. McLean JH, Darby-King A., Bonnell WS 2001. Neonatal olfactory sensory deprivation decreases BDNF in the olfactory bulb of the rat. Brain Res Dev Brain Res 128: 17-24.
81. Mogi M., Togari A., Kondo T., Mizuno Y., Komure 0, Kuno S., and others. 1999. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci Lett 270: 45-8.
82. Moretti P., Blazo M., Garcia L., Armstrong D., Lewis RA, Roa B., Scaglia F. 2003. Spinocerebellar ataxia type 2 (SCA2) presenting with opthalmoplegia and developmental delay in infancy. Am J Med Gen A 124A: 392-6.
83. Mueller A., Reuner U., Landis B., Kitzler H., Reichmann H., Hummel T. 2006. Extrapyramidal symptoms in Wilson's disease are associated with olfactory dysfunction. Mov Disord 21: 1311-16.
84. Narita M., Miyagawa K., Narita M., Mizuo K., Miyatake M., Tsutomu S. 2005. The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection. Nihon Shinkei Seishin Yakungaku Zasshi 25: 91-104.
85. Neely MD, Boutte A., Milatovic D., Montine TJ 2005. Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction. Brain Res 1037: 90-8.
86. Nef S., Lush ME, Shipman TE, Parada LF 2001. Neurotrophins are not required for normal embryonic development of olfactory neurons. Dev Biol 234: 80-92.
87. Nehru B., Verma R., Khanna P., Sharma SK 2008. Behavioral alterations in rotenone model of Parkinson's disease: attenuation by co-treatment with centrophenoxine. Brain Res (epub ahead of print).
88. Ng F., Berk M., Dean 0, Bush AI. 2008. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol epub ahead of print.
89. Nunomura A., Moreira PI, Lee HG, Zhu X., Castellani RJ, Smith MA, Perry G. 2007. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets 6: 411-23.
90. Nunomura A., Moreira PI, Zhu X., Cash AD, Smith MA, Perry G. 2008. Role of oxidative insult and neuronal survival in Alzheimer's and Parkinson's diseases. In: Fisher A, Memo M, Stocchi F, Hanin I, editors. Advances in Alzheimer's and Parkinson's disease. New York, New York: Springer. p 133-48.
91. OldendorfWH, Kitano M. 1965. Increased brain radiocopper uptake in Wilson's disease. Arch Neurol 13: 533-40.
92. Olivieri G., Otten U., Meier F., Baysang G., Dimitriades-Schmutz B., Muller- Spahn F., Savaskan E. 2003. Beta-amyloid modulates tyrosine kinase P receptor expression in SHSY5Y neuroblastoma cells: influence of the antioxidant melatonin. Neuroscience 120: 659-65.
93. Onyango IG, Tuttle JB, Bennett JP Jr. 2005. Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signalling pathways to protect PD cybrids from H202-induced neuronal death. Neurobiol Dis 20: 141-54.
94. Parain K., Murer MG, Yan Q., Faucheux B., Agid Y., Hirsch E., Raisman- Vozari R. 1999. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 10: 557-61.
95. Petersen AA, Larsen KE, Behr GG, Romero N., Przedborski S., Brundin P., Sulzer D. 2001. Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain Res Bull 56: 331-5.
96. Phillips HS, Hains JM, Laramee GR, Rosenthal A., Winslow JW 1990. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science 250: 290-4.
97. Polla BS, Bonventre JV, Krane SM 1988. 1,25 dihydroxyvitamin D3 increases the toxicity of hydrogen peroxide in the human monocytic line U937: the role of calcium and heat shock. J Cell Biol 107: 373-80.
98. Ponten SC, Kwee ML, Wolters ECh, Zijlmans JC 2007. First case of ataxia with isolated vitamin E deficiency in the Netherlands. Parkinsonism Relat Disord 13: 315-16.
99. Pugazhenthi S., Phansalkar K., Audesirk G., West A., Cabell L. 2006. Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. Free Radic Biol Med 40: 21-34.
100. Puranam KL, Wu G., Strittmatter WJ, Burke JR 2006. Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria. Biochem Biophys Res Commun 341: 607-13.
101. Radak Z., Toldy A., Szabo Z., Siamilis S., Nyakas C., Silye G, and others. 2006. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int 49: 387-92.
102. Rao JS, Ertley RN, Lee HJ, DeMar JC Jr, Arnold JT, Rapoport SI, Bazinet RP 2007. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 12: 36-46.
103. Rossi L., Lombardo MF, Ciriolo MR, Rotillo G. 2004. Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance. Neurochem Res 29: 493-504.
104. Rub U., Brunt ER, Deller T. 2008. New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease). Curr Opin Neurol 21: 111-16.
105. Ruttiger L., Panford- Walsh R., Schimmang T., Tan J., Zimmermann U., Rohbock K., and others. 2007. BDNF mRNA expression and protein localization are changed in age-related hearing loss. Neurobiol Aging 28: 586-601.
106. Salazar-Colocho P., Del Río J., Frechilla D. 2008. Neuroprotective effects of serotonin 5-HT(lA) receptor activation against ischemic cell damage in gerbil hippocampus: involvement of NMDA receptor NR1 subunit and BDNF. Brain Res 1199: 159-66.
107. Samuele A., Mangiagalli A., Armentero MT, Fancellu R., Bazzini E., Vairetti M, and others. 2005. Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease. Biochim Biophys Acta 1741: 325-30.
108. Santa- Maria I., Smith MA, Perry G., Hernandez F., Avila J., Moreno FJ 2005. Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations inAlzheimer's disease. Biochim Biophys Acta 1740: 472-80.
109. Sasahara K., Shikimi H., Haraguchi S., Sakamoto H., Honda S., Harada N., Tsutsui K. 2007. Mode of action and functional significance of estrogen-inducing dendritic growth, spinogenesis, and synaptogenesis in the developing Purkinje cell. J Neurosci 27: 7408-17.
110. Sato T., Doi K., Taniguchi M., Yamashita T., Kubo T., Tohyama M. 2006. Progressive hearing loss in mice carrying a mutation in the p75 gene. Brain Res 1091: 224-34.
111. Sayre LM, Perry G., Smith MA 2008. Oxidative stress and neurotoxicity. Chem Res Toxicol 21: 172-88.
112. Schindowski K., Belarbi K., Buee L. 2008. Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav 7: 43-56.
113. Schimmang T., Tan J., Muller M., Zimmermann U., Rohbock K., Kopschall I., and others. 2003. Lack of BDNF and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervations along the tonotopic axis and hearing loss. Development 130: 4741-50.
114. Schulz JB, Bremen D., Reed JC, Lommatzsch J., Takayama S., Weller M. 1997. Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J Neurochem 69: 2075-86.
115. Sebastiani M., Giordano C., Nediani C., Travaglini C., Borchi E., Zani M, and others. 2007. Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies. J Am Coll Cardiol 50: 1362-9.
116. Seyb KI, Ansar S., Bean J., Michaelis ML 2006. Beta-amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton. J Mol Neurosci 28: 111-23.
117. Shinohara T., Bredberg G., Ulfendahl M., Pyykko I., Olivius NP, Kaksonen R, and others. 2002. Neurotrophic factor intervention restores auditory function in deafened animals. Proc Natl Acad Sci USA 99: 1657-60.
118. Sinha S., Christopher R., Arundaya GR, Prashanth LK, Gopinath G., Swamy HS, Taly AB 2005. Is low serum tocopherol in Wilson's disease a significant symptom ? J Neurol Sci 228: 121-3.
119. Skaper SD, Floreani M., Negro A., Facci L., Giusti P. 1998. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death. Selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated kinase pathway. J Neurochem 5: 1859-68.
120. Spina MB, Squinto SP, Miller J., Lindsay RM, Hyman C. 1992. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridium ion toxicity: involvement of the glutathione system. J Neurochem 59: 99-106.
121. Stone EA, Lin Y., Quartermain D. 2008. A common pathway for depression? Progress toward a general conceptual framework. Neurosci Biobehav Rev 32: 508-24.
122. Suzuki T., Sekido H., Kato N., Nakayama Y., Yabe-Nishimura C. 2004. Neurotrophin-3 induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathway. J Neuochem 91: 1430-8.
123. Tabuchi A., Funaji K., Nakatsubo J., Fukuchi M., Tsuchiya T., Tsuda M. 2003. Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J Neurosci Res 71: 504-15.
124. Takeda H., Tsuji M., Yamada T., Masuya J., Matsushita K., Tahara M, and others. 2006. Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice. Eur J Pharmacol 534: 115-21.
125. Tan J., Widjaja S., Xu J., Shepherd RK 2007. Cochlear implants stimulate activity-dependent CREB pathway in the deaf auditory cortex: implications for molecular plasticity induced by neural prosthetic devices. Cerebral Cortex (epub ahead of print).
126. Tang LL, Wang R., Tang XC 2005. Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. Eur J Pharmacol 519: 9-15.
127. Thornalley PJ 2005. The potential role of thiamine (vitamin B(l)) in diabetic complications. Curr Diabetes Rev 1: 287-98.
128. Tyurina YY, Nylander KD, Mirnics ZK, Portugal C., Yan C., Zaccaro C., and others. 2005. The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidative stress. Aging Cell 4: 187-96.
129. Vaudry D., Hamelink C., Damadzic R., Eskay RL, Gonzalez B., Eiden LE 2005. Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Peptides 26: 2518-24.
130. Vaudry D., Pamantung TF, Basille M., Rouselle C., Fournier A., Vaudry H., and others. 2002. PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis. Eur J Neurosci 15: 1451-60.
131. Vaynman S., Ying Z., Wu A., Gomez-Pinilla F. 2006. Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor mediated synaptic plasticity. Neuroscience 139: 1221-34.
132. Velazquez-Perez L., Pernandez-Ruiz J., Diaz R., Gonzalez RP, Ochoa NC, Cruz GS, and others. 2006. Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases. J Neurol 253: 1165-9.
133. Vellucci SV, Parrott RF, Mimmack ML 2002. Chronic dexamethasone-treatment alters mineralcorticoid receptor, truncated trkB and selected glutamate receptor subunit mRNA expression in the porcine hippocampus. Neuropeptides 36: 291-8.
134. Wahle P., Di Cristo G., Schwerdtfeger G., Engelhardt M., Berardi N., Maffel L. 2003. Differential effects of cortical neurotrophic factors on development of lateral geniculate nucleus and superior colliculus neurons: anterograde and retrograde actions. Development 130: 611-22.
135. Walker UA, Schon EA 1998. Neurotrophin-4 is up-regulated in ragged-red fibers associated with pathogenic mitochondrial DNA mutations. Ann Neurol 43: 536-40.
136. Wang H., Yuan G., Prabhakar NR, Boswell M., Katz DM 2006. Secretion of brain-derived neurotrophic factor from PC 12 cells in response to oxidative stress requires autocrine dopamine signalling. J Neuochem 96: 694-705.
137. Wen FC, Li YH, Tsai HF, Lin CH, Li C., Lii CK, and others. 2003. Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3. FEBS Lett 546: 307-14.
138. Wilson RB 2006. Iron dysregulation in Friedreich ataxia. Semin Pediatr Neurol 13: 166-75.
139. Wilson RB, Kunchithapauthan K., Rohrer B. 2007. Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Invest Ophthalmol Vis Sci 48: 2877-86.
140. Wrathall JR 1986. Reduced neuronotrophic activity of fibroblasts from individuals with dysautonomia in cultures of newborn mouse sensory ganglion cells. Brain Res 364: 23-9.
141. Wu A., Ying Z., Gomez-Pinilla F. 2004 a. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19: 1699-707.
142. Wu A., Ying Z., Gomez-Pinilla F. 2004 b. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 21: 1457-67.
143. Yamamoto-Sasaki M., Ozawa H., Saito T., Rösler M., Riederer P. 1999. Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res 824: 300-3.
144. Yamasoba T., Pourbakht A., Sakamoto T., Suzuki M. 2005. Ebselen prevents noise-induced excitotoxicity and temporary threshold shift. Neurosci Lett 380: 234-8.
145. Yasuno H., Fukazawa K., Fukuoka T., Kondo E., Sakagami M., Noguchi K. 2000. Nerve growth factor applied onto the olfactory epithelium alleviates degenerative changes of the olfactory receptor neurons following axotomy. Brain Res 887: 53-62.
146. Zhu X., Raina AK, Perry G., Smith MA 2004. Alzheimer's disease: the two-hit hypothesis. Lancet Neurol 3: 219-26.
147. Zigova T., Pencea V., Wiegand SJ, Luskin MB 1998. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci 11: 234-45.
148. Zink M., Otto C., Zorner B., Zacher C., Schutz G., Henn FA, Gass P. 2004. Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclise activating polypeptide type-I-receptor. Neurosci Lett 360: 106-8.