Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 13, 2010, Pages 5961-5966

  Gorbatyuk, Marina S ^a   Knox, Tessa ^a   LaVail, Matthew M ^c   Gorbatyuk, Oleg S ^a   Noorwez, Syed M ^b   Hauswirth, William W ^b   Lin, Jonathan H ^d   Muzyczka, Nicholas ^a   Lewin, Alfred S ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adeno associated virus; Autosomal dominant retinitis pigmentosa; Endoplasmic reticulum stress; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BH3 PROTEIN; CASPASE 12; CASPASE 7; CELL EXTRACT; CELL PROTEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; RHODOPSIN;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL AGGREGATION; CELL MEMBRANE; CELL SURVIVAL; ELECTRORETINOGRAM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; HELA CELL; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSGENIC RAT; VISION;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BASE SEQUENCE; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; MUTATION, MISSENSE; PHOTORECEPTOR CELLS, VERTEBRATE; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECOMBINANT PROTEINS; RETINA; RETINITIS PIGMENTOSA; RHODOPSIN; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTOR CHOP; TRANSFECTION; UNFOLDED PROTEIN RESPONSE; VISION, OCULAR;

ADENO-ASSOCIATED VIRUS; ANIMALIA; RATTUS;

EID: 77950532428     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911991107     Document Type: Article

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