DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression

Science

Volumn 319, Issue 5860, 2008, Pages 202-206

  Perillo, Bruno ^a   Ombra, Maria Neve ^a   Bertoni, Alessandra ^b   Cuozzo, Concetta ^c   Sacchetti, Silvana ^c   Sasso, Annarita ^b   Chiariotti, Lorenzo ^b   Malorni, Antonio ^a   Abbondanza, Ciro ^d   Avvedimento, Enrico V ^b  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLTRANSFERASE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ESTROGEN; ESTROGEN RECEPTOR; HISTONE H3; LYSINE; RNA POLYMERASE II;

DNA; ENZYME; GENE EXPRESSION; OXIDATION;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN; CONFORMATIONAL TRANSITION; DEMETHYLATION; DNA CONFORMATION; DNA DAMAGE; ESTROGEN RESPONSIVE ELEMENT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; METHYLATION; OXIDATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MODIFICATION;

CELL LINE, TUMOR; CELLS, CULTURED; CHROMATIN; DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; GENES, BCL-2; GUANINE; HISTONES; HUMANS; HYDROGEN PEROXIDE; LYSINE; METHYLATION; NUCLEIC ACID CONFORMATION; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS (GENETICS); RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

EID: 38149045693     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1147674     Document Type: Article

References (26)

1. S. F. Doisneau-Sixou et al., Endocr. Relat. Cancer 10, 179 (2003).
2. B. Perillo, A. Sasso, C. Abbondanza, G. Palumbo, Mol. Cell. Biol. 20, 2890 (2000).
3. D. J. Mangelsdorf et al., Cell 83, 835 (1995).
4. Y. Shang, X. Hu, J. DiRenzo, M. A. Lazar, M. Brown, Cell 103, 843 (2000).
5. R. Metivier et al., Cell 115, 751 (2003).
6. B. D. Strahl, C. D. Allis, Nature 403, 41 (2000).
7. T. Jenuwein, C. D. Allis, Science 293, 1074 (2001).
8. M. Shanmugam et al., Mol. Cell. Endocrinol. 148, 109 (1999).
9. R. L. Young, S. J. Korsmeyer, Mol. Cell. Biol. 13, 3686 (1993).
10. A. Ansari, M. Hampsey, Genes Dev. 19, 2969 (2005).
11. H. Wang et al., Mol. Cell 8, 1207 (2001).
12. O. Vaute, E. Nicolas, L. Vandel, D. Tronche, Nucleic Acids Res. 30, 475 (2002).
13. E. Metzger et al., Nature 437, 436 (2005).
14. Y. Shi et al., Cell 119, 941 (2004).
15. I. Garcia-Bassets et al., Cell 128, 505 (2007).
16. F. Forneris, C. Binda, M. A. Vanoni, A. Mattevi, E. Battaglioli, FEBS Lett. 579, 2203 (2005).
17. A. P. Grollman, M. Moriya, Trends Genet. 9, 246 (1993).
18. N. Rajapakse, M. Butterworth, A. Kortenkamp, Environ. Mol. Mutagen. 45, 397 (2005).
19. T. Roldan-Arjona et al., Proc. Natl. Acad. Sci. U.S.A. 94, 8016 (1997).
20. B.-G. Ju et al., Science 312, 1798 (2006).
21. M. T. Russo et al., Cancer Res. 64, 4411 (2004).
22. S. S. David, V. L. O'Shea, S. Kundu, Nature 447, 941 (2007).
23. P. E. Kroeger, N. Osheroff, T. C. Rowe, J. Biol. Chem. 268, 16449 (1993).
24. H. Zhang et al., EMBO J. 25, 4223 (2006).
25. Q. Felty et al., Biochemistry 44, 6900 (2005).
26. This work has been supported by the Ministero dell'Università e delle Ricerca (MUIR), RBNE0157EH, by Associazone Italiana per la Ricerca sul Cancro (AIRC), and by Federazione Italiana per la Ricerca sul Cancro (FIRC), NOGEC (Naples Oncogenomic Center), CEINGE. We are grateful to the memory of G. Salvatore, S. Varrone, and J. Guardiola.