Pharmacological targets in the renal peritubular microenvironment: Implications for therapy for sepsis-induced acute kidney injury

Pharmacology and Therapeutics

Volumn 134, Issue 2, 2012, Pages 139-155

  Mayeux, Philip R ^a   MacMillan Crow, Lee Ann ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Acute kidney injury; Microcirculation; Oxidative stress; Peritubular capillary; Sepsis; Tubular epithelium

Indexed keywords

5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; ACTINONIN; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; AP 214; BOSENTAN; DOXYCYCLINE; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; HYPERTENSIVE FACTOR; INOTROPIC AGENT; LEVOSIMENDAN; MANGANESE SUPEROXIDE DISMUTASE; MANGANESE TETRAKIS(1 METHYL 4 PYRIDYL)PORPHYRIN TETRATOSYLATE HYDROXIDE; METHYL 2 ACETAMIDOACRYLATE; MITOQUINONE; N6 (1 IMINOETHYL)LYSINE; PEROXYNITRITE; PYRUVIC ACID ETHYL ESTER; RESVERATROL; SCAVENGER; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; TEZOSENTAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE KIDNEY FAILURE; BLOOD VESSEL PERMEABILITY; CAPILLARY LEAK SYNDROME; CARDIOVASCULAR AUTOREGULATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; HENLE LOOP; HUMAN; KIDNEY BLOOD FLOW; KIDNEY COLLECTING TUBULE; KIDNEY CORTEX; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY MEDULLA; KIDNEY TUBULE; KIDNEY TUBULE BASEMENT MEMBRANE; LIVER INJURY; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MICROENVIRONMENT; MITOCHONDRIAL ENERGY TRANSFER; MOLECULAR INTERACTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RENAL PROTECTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASODILATATION;

ACUTE KIDNEY INJURY; ANIMALS; CELLULAR MICROENVIRONMENT; HUMANS; KIDNEY TUBULES; RENAL CIRCULATION; SEPSIS;

EID: 84859163198     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.01.004     Document Type: Review

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