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Volumn 31, Issue 2, 2003, Pages 353-358

Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase

Author keywords

Endothelial cells; Mitochondria; Nitric oxide; Peroxynitrite; Poly(ADP ribose) synthase; Septic shock

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3 AMINOBENZAMIDE; ADENOSINE TRIPHOSPHATE; LACTIC ACID; N(G) METHYLARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE;

EID: 0037324056     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000050074.82486.B2     Document Type: Article
Times cited : (118)

References (42)
  • 1
    • 0023875712 scopus 로고
    • Cellular oxygen metabolism during sepsis and shock
    • Rackow EC, Astiz M, Weil M: Cellular oxygen metabolism during sepsis and shock. JAMA 1988; 259:1989-1993
    • (1988) JAMA , vol.259 , pp. 1989-1993
    • Rackow, E.C.1    Astiz, M.2    Weil, M.3
  • 2
    • 0032790876 scopus 로고    scopus 로고
    • Microcirculatory oxygenation and shunting in sepsis and shock
    • Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369-1377
    • (1999) Crit Care Med , vol.27 , pp. 1369-1377
    • Ince, C.1    Sinaasappel, M.2
  • 3
    • 0028796672 scopus 로고
    • Microvascular function and rheologic changes in hyperdynamic sepsis
    • Astiz M, DeGent G, Lin R, et al: Microvascular function and rheologic changes in hyperdynamic sepsis. Crit Care Med. 1995; 23:265-271
    • (1995) Crit Care Med , vol.23 , pp. 265-271
    • Astiz, M.1    DeGent, G.2    Lin, R.3
  • 4
    • 0028053865 scopus 로고
    • Microvascular perfusion is impaired in a rat model of normotensive sepsis
    • Lam C, Tyml K, Martin C, et al: Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 1994; 94:2077-2083
    • (1994) J Clin Invest , vol.94 , pp. 2077-2083
    • Lam, C.1    Tyml, K.2    Martin, C.3
  • 5
    • 4243815580 scopus 로고    scopus 로고
    • Microcirculatory alterations in cardiogenic and septic shock
    • DeBacker D, Creuter J, Vincent JL: Microcirculatory alterations in cardiogenic and septic shock. Intensive Care Med 2000; 26:S334
    • (2000) Intensive Care Med , vol.26
    • DeBacker, D.1    Creuter, J.2    Vincent, J.L.3
  • 6
    • 0031799256 scopus 로고    scopus 로고
    • Abnormalities of gastric mucosal oxygenation in septic shock: Partial responsiveness to dopexamine
    • Temmesfeld-Wollbruck B, Szalay A, Mayer K, et al: Abnormalities of gastric mucosal oxygenation in septic shock: Partial responsiveness to dopexamine. Am J Respir Crit Care Med. 1998; 157(5 Pt 1):1586-1592
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.5 PART 1 , pp. 1586-1592
    • Temmesfeld-Wollbruck, B.1    Szalay, A.2    Mayer, K.3
  • 7
    • 0016768378 scopus 로고
    • Cellular metabolism in shock
    • Schumer W, Erve P: Cellular metabolism in shock. Circ Shock 1975:109-127
    • (1975) Circ Shock , pp. 109-127
    • Schumer, W.1    Erve, P.2
  • 8
    • 0018509261 scopus 로고
    • Physiologic and metabolic correlations in human sepsis
    • Siegel J, Cerra F, Coleman B, et al: Physiologic and metabolic correlations in human sepsis. Surgery 1979; 86:163-193
    • (1979) Surgery , vol.86 , pp. 163-193
    • Siegel, J.1    Cerra, F.2    Coleman, B.3
  • 9
    • 0035115951 scopus 로고    scopus 로고
    • Cytopathic hypoxia: Mitochondrial dysfunction as a mechanism contributing to organ dysfunction in sepsis
    • Fink MP: Cytopathic hypoxia: Mitochondrial dysfunction as a mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 2001; 17:219-237
    • (2001) Crit Care Clin , vol.17 , pp. 219-237
    • Fink, M.P.1
  • 10
    • 0027390508 scopus 로고
    • Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate
    • Ronco J, Fenwick J, Wiggs B, et al: Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate. Am Rev Respir Dis 1993; 147:25-31
    • (1993) Am Rev Respir Dis , vol.147 , pp. 25-31
    • Ronco, J.1    Fenwick, J.2    Wiggs, B.3
  • 11
    • 0028273158 scopus 로고
    • Skeletal muscle partial pressure of oxygen in patients with sepsis
    • Boekstegers P, Weidenhofer S, Kaspner T, et al: Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 1994; 22:640-650
    • (1994) Crit Care Med , vol.22 , pp. 640-650
    • Boekstegers, P.1    Weidenhofer, S.2    Kaspner, T.3
  • 12
    • 0014803148 scopus 로고
    • Effect of endotoxemia on live mitochondria in man
    • Schumer W, Dasgupta T, Moss G, et al: Effect of endotoxemia on live mitochondria in man. Ann Surg 1970:875-882
    • (1970) Ann Surg , pp. 875-882
    • Schumer, W.1    Dasgupta, T.2    Moss, G.3
  • 13
    • 0013421156 scopus 로고
    • Defective oxidative metabolism of rat mitochondria in hemorrhagic and endotoxic shock
    • Mela L, Bacalzao V, Miller L: Defective oxidative metabolism of rat mitochondria in hemorrhagic and endotoxic shock. Am J Physiol 1971; 220:517-577
    • (1971) Am J Physiol , vol.220 , pp. 517-577
    • Mela, L.1    Bacalzao, V.2    Miller, L.3
  • 14
    • 0029934194 scopus 로고    scopus 로고
    • Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite
    • Szabo C, Zingarelli B, Salzman A: Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 1996; 78:1051-1063
    • (1996) Circ Res , vol.78 , pp. 1051-1063
    • Szabo, C.1    Zingarelli, B.2    Salzman, A.3
  • 15
    • 0030783158 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates lipopolysaccharide-induced gut mucosal barrier dysfunction in rats
    • Unno N, Wang H, Menconi M, et al: Inhibition of inducible nitric oxide synthase ameliorates lipopolysaccharide-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997; 113:1246-1252
    • (1997) Gastroenterology , vol.113 , pp. 1246-1252
    • Unno, N.1    Wang, H.2    Menconi, M.3
  • 16
    • 0032760428 scopus 로고    scopus 로고
    • Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine
    • King CJ, Tygat S, Delude R, et al: Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 1999; 27:2518-2524
    • (1999) Crit Care Med , vol.27 , pp. 2518-2524
    • King, C.J.1    Tygat, S.2    Delude, R.3
  • 17
    • 0029998238 scopus 로고    scopus 로고
    • Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport
    • Cassina A, Radi R: Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 1996; 328:309-316
    • (1996) Arch Biochem Biophys , vol.328 , pp. 309-316
    • Cassina, A.1    Radi, R.2
  • 18
    • 0032947296 scopus 로고    scopus 로고
    • Nitric oxide and mitochondrial respiration
    • Brown GC: Nitric oxide and mitochondrial respiration. Biochem Biophys Acta 1999; 1411:351-359
    • (1999) Biochem Biophys Acta , vol.1411 , pp. 351-359
    • Brown, G.C.1
  • 19
    • 0030000690 scopus 로고    scopus 로고
    • DNA strand breakage, activation of poly-(ADP-ribose) synthetase, and cellular energy depletion are involve in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
    • Szabo C, Zingarelli B, O'Connor M, et al: DNA strand breakage, activation of poly-(ADP-ribose) synthetase, and cellular energy depletion are involve in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Nat Acad Sci U S A 1996; 93:1753-1758
    • (1996) Proc Nat Acad Sci U S A , vol.93 , pp. 1753-1758
    • Szabo, C.1    Zingarelli, B.2    O'Connor, M.3
  • 20
    • 0029934194 scopus 로고    scopus 로고
    • Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite
    • Szabo C, Zingarelli B, Salzman A: Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 1996; 78:1051-1063
    • (1996) Circ Res , vol.78 , pp. 1051-1063
    • Szabo, C.1    Zingarelli, B.2    Salzman, A.3
  • 21
    • 0024848871 scopus 로고
    • Nanogram nitrite and nitrate determination in environmental and biological materials by vandium (III) reduction with chemiluminescence detection
    • Braman RS, Hendrix SA: Nanogram nitrite and nitrate determination in environmental and biological materials by vandium (III) reduction with chemiluminescence detection. Anal Chem 1989; 61:2715-2758
    • (1989) Anal Chem , vol.61 , pp. 2715-2758
    • Braman, R.S.1    Hendrix, S.A.2
  • 22
    • 26144455600 scopus 로고
    • Quantification of adherent and nonadherent cell cultured in 96-well plates using the supravital stain neutral red
    • Lowik CW, Alblas MJ, van de Ruit M, et al: Quantification of adherent and nonadherent cell cultured in 96-well plates using the supravital stain neutral red. Anal Chem 1989; 61:2715-2758
    • (1989) Anal Chem , vol.61 , pp. 2715-2758
    • Lowik, C.W.1    Alblas, M.J.2    Van De Ruit, M.3
  • 23
    • 0014071250 scopus 로고
    • Abnormal vascular tone, defective oxygen transport and myocardial failure in human septic shock
    • Siegel J, Greenspan M, delGuercio L: Abnormal vascular tone, defective oxygen transport and myocardial failure in human septic shock. Ann Surg 1967; 165:504-517
    • (1967) Ann Surg , vol.165 , pp. 504-517
    • Siegel, J.1    Greenspan, M.2    DelGuercio, L.3
  • 24
  • 25
    • 0015831523 scopus 로고
    • Hemodynamic and metabolic studies on shock associated with Gram negative bacteremia
    • Nishijima H, Weil M, Shubin H, et al: Hemodynamic and metabolic studies on shock associated with Gram negative bacteremia. Medicine 1973; 52:287-293
    • (1973) Medicine , vol.52 , pp. 287-293
    • Nishijima, H.1    Weil, M.2    Shubin, H.3
  • 26
    • 0023815459 scopus 로고
    • Early impairment of oxidative metabolism and energy production in severe sepsis
    • Astiz M, Rackow EC, Weil MH, et al: Early impairment of oxidative metabolism and energy production in severe sepsis. Circ Shock 1988; 26:311-316
    • (1988) Circ Shock , vol.26 , pp. 311-316
    • Astiz, M.1    Rackow, E.C.2    Weil, M.H.3
  • 27
    • 0028132781 scopus 로고
    • Altered mitochondrial redox response in gram negative septic shock in primates
    • Simonson S, Welty-Wolf K, Huang Y, et al: Altered mitochondrial redox response in gram negative septic shock in primates. Circ Shock 1994; 43:34-43
    • (1994) Circ Shock , vol.43 , pp. 34-43
    • Simonson, S.1    Welty-Wolf, K.2    Huang, Y.3
  • 28
    • 0031572226 scopus 로고    scopus 로고
    • Oxidative metabolism in rat hepatocytes and mitochondria during sepsis
    • Kantrow S, Taylor D, Carraway M, et al: Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. Arch Biochem Biophys 1997; 345:278-288
    • (1997) Arch Biochem Biophys , vol.345 , pp. 278-288
    • Kantrow, S.1    Taylor, D.2    Carraway, M.3
  • 30
    • 0032547535 scopus 로고    scopus 로고
    • Interpretation of blood lactate concentration in patients with sepsis
    • Kirshchenbaum LA, Astiz ME, Rackow EC: Interpretation of blood lactate concentration in patients with sepsis. Lancet 1998; 352:921-922
    • (1998) Lancet , vol.352 , pp. 921-922
    • Kirshchenbaum, L.A.1    Astiz, M.E.2    Rackow, E.C.3
  • 31
    • 0030069775 scopus 로고
    • Lactic acidosis in sepsis: A commentary
    • Gutierrez G, Wulf M: Lactic acidosis in sepsis: A commentary. Intensive Care Med 1666; 22:6-16
    • (1666) Intensive Care Med , vol.22 , pp. 6-16
    • Gutierrez, G.1    Wulf, M.2
  • 32
    • 0031968240 scopus 로고    scopus 로고
    • Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction
    • Levraut J, Ciebiera JP, Chave S, et al: Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 1999; 157:1021-1026
    • (1999) Am J Respir Crit Care Med , vol.157 , pp. 1021-1026
    • Levraut, J.1    Ciebiera, J.P.2    Chave, S.3
  • 33
    • 0028820955 scopus 로고
    • Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release
    • Ertel W, Morrison H, Ayala A, et al: Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release. Am J Physiol 1995; 265: R160-R166
    • (1995) Am J Physiol , vol.265
    • Ertel, W.1    Morrison, H.2    Ayala, A.3
  • 34
    • 0036121596 scopus 로고    scopus 로고
    • Role of mitochondrial oxidant injury in endothelial cells response to hypoxia
    • Pearlstein DP, Mir H, Mungai P, et al: Role of mitochondrial oxidant injury in endothelial cells response to hypoxia. Arterioscl Thromb Vasc Biol 2002; 22:566-573
    • (2002) Arterioscl Thromb Vasc Biol , vol.22 , pp. 566-573
    • Pearlstein, D.P.1    Mir, H.2    Mungai, P.3
  • 35
    • 0026735208 scopus 로고
    • Negative inotropic effects of cytokines on the heart mediated by nitric oxide
    • Fischer M, Oddis C, Jacobs T, et al: Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992; 257:387-389
    • (1992) Science , vol.257 , pp. 387-389
    • Fischer, M.1    Oddis, C.2    Jacobs, T.3
  • 36
    • 0032891779 scopus 로고    scopus 로고
    • The role of nitric oxide and cyclic GMP in human septic serum-induced depression of cardiac myocyte contractility
    • Kumar A, Brar R, Wang P, et al: The role of nitric oxide and cyclic GMP in human septic serum-induced depression of cardiac myocyte contractility. Am J Physiol 1999; 276: R265-R276
    • (1999) Am J Physiol , vol.276
    • Kumar, A.1    Brar, R.2    Wang, P.3
  • 37
    • 0030969327 scopus 로고    scopus 로고
    • Differential induction of constitutive and inducible nitric oxide synthases by distinct inflammatory stimuli in bovine aortic endothelial cells
    • Kaku Y, Nanri H, Sakimura T, et al: Differential induction of constitutive and inducible nitric oxide synthases by distinct inflammatory stimuli in bovine aortic endothelial cells. Biochem Biophys Acta 1997; 1356:43-52
    • (1997) Biochem Biophys Acta , vol.1356 , pp. 43-52
    • Kaku, Y.1    Nanri, H.2    Sakimura, T.3
  • 38
    • 0035186047 scopus 로고    scopus 로고
    • Regulation of the nitric oxide synthase-nitric oxide-cGMP pathway in rat mesenteric endothelial cells
    • Papapetropoulos A, Andreopoulos S, Go Yhoque A, et al: Regulation of the nitric oxide synthase-nitric oxide-cGMP pathway in rat mesenteric endothelial cells. J Appl Physiol 2001; 91:2553-2560
    • (2001) J Appl Physiol , vol.91 , pp. 2553-2560
    • Papapetropoulos, A.1    Andreopoulos, S.2    Go Yhoque, A.3
  • 39
    • 0029836410 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells
    • Rockey D, Chung J: Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am J Physiol 1996; 271:G260-G267
    • (1996) Am J Physiol , vol.271
    • Rockey, D.1    Chung, J.2
  • 40
    • 0030203367 scopus 로고    scopus 로고
    • The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia- reperfusion injury
    • Szabo C: The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia- reperfusion injury. Shock 1996; 6:79-88
    • (1996) Shock , vol.6 , pp. 79-88
    • Szabo, C.1
  • 41
    • 0021998114 scopus 로고
    • Shock-induced damage to mitochondrial function and some cellular antioxidant mechanism in humans
    • Corbucci G, Gasparetto A, Candiani A, et al: Shock-induced damage to mitochondrial function and some cellular antioxidant mechanism in humans. Circ Shock 1985; 15:15-26
    • (1985) Circ Shock , vol.15 , pp. 15-26
    • Corbucci, G.1    Gasparetto, A.2    Candiani, A.3
  • 42
    • 0035422607 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis
    • Adrie C, Bachelt M, Vayssier-Taussat M, et al: Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. Am J Respir Crit Care Med 2001; 164:389-395
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 389-395
    • Adrie, C.1    Bachelt, M.2    Vayssier-Taussat, M.3


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