Vascular dysfunction in sepsis: Effects of the peroxynitrite decomposition catalyst MnTMPyP

Shock

Volumn 36, Issue 2, 2011, Pages 156-161

  Nin, Nicolás ^a   El Assar, Mariam ^a   Sánchez, Carolina ^a   Ferruelo, Antonio ^a   Sánchez Ferrer, Alberto ^a   Martínez Caro, Leticia ^a   Rojas, Yeny ^a   Paula, Marta De ^a   Hurtado, Javier ^b   Esteban, Andrés ^a   Lorente, José A ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^b HOSPITAL DE CLÍNICAS   (Uruguay)

Author keywords

antioxidants; free radicals; Nitric oxide; peroxynitrite; sepsis; vascular dysfunction; vascular reactivity

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; COPPER ZINC SUPEROXIDE DISMUTASE; HYDROETHIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE DERIVATIVE; MANGANESE TETRAKIS; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; NORADRENALIN; PEROXYNITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; RNA; SUPEROXIDE DISMUTASE; TEMPOL; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CATALYST; CONTROLLED STUDY; DECOMPOSITION; EX VIVO STUDY; FLUORESCENCE; HYPOTHESIS; ISOMETRIC TENSION RECORDING; LIGATION; MALE; MESENTERY BLOOD VESSEL; MICROVASCULATURE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SEPSIS; SEPSIS VASCULAR DYSFUNCTION; SHAM PROCEDURE; VASCULAR CONTRACTION; VASCULAR DISEASE; VASCULAR RELAXATION; VASCULAR TISSUE;

ACETYLCHOLINE; ANIMALS; AORTA; MALE; METALLOPORPHYRINS; MICROVESSELS; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NOREPINEPHRINE; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; VASODILATOR AGENTS;

EID: 80051544053     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31821e50de     Document Type: Article

References (33)

1. Esteban A, Frutos-Vivar F, Ferguson ND, Peñuelas O, Lorente JA, Gordo F, Honrubia T, Algora A, Bustos A, García G, et al.: Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med 35(5):1284-1289, 2007. (Pubitemid 46642655)
2. Landín L, Lorente JA, Renes E, Cañas P, Jorge P, Liste D: Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 106(1):250-256, 1994.
3. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32(9):1825-1831, 2004. (Pubitemid 39202356)
4. Ospina-Tascon G, Neves AP, Occhipinti G, Donadello K, Büchele G, Simion D, Chierego ML, Silva TO, Fonseca A, Vincent JL, et al.: Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med 36(11):949-955, 2010.
5. Traber DL: Presence and absence of nitric oxide synthase in sepsis. Crit Care Med 24(7):1102-1103, 1996. (Pubitemid 26249356)
6. Nelson S, Steward RH, Traber L, Traber D: Endotoxin-induced alterations in contractility of isolated blood vessels from sheep. Am J Physiol 260(2): H1790-H1794, 1991.
7. Lorente JA, Landín L, Renes E, De Pablo R, Jorge P, Ródena E, Liste D: Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 21(5): 759-767, 1993.
8. Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315-424, 2007. (Pubitemid 46217686)
9. Lange M, Connelly R, Traber DL, Hamahata A, Nakano Y, Esechie A, Jonkam C, von Borzyskowski S, Traber LD, Schmalstieg FC, et al.: Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model. Critical Care 14(4):R129, 2010.
10. Cuzzocrea S, Costantino G, Mazzon E, Caputi AP: Protective effect of Nacetylcysteine on multiple organ failure induced by zymosan in the rat. Crit Care Med 27(8):1524-1532, 1999. (Pubitemid 29406943)
11. el-Dwairi Q, Comtois A, Guo Y, Hussain SN: Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases. Am J Physiol 3(3 Pt 1):C770-C779, 1998.
12. Nin N, Cassina A, Boggia J, Alfonso E, Botti H, Peluffo G, Trostchansky A, Batthyány C, Radi R, Rubbo H, et al.: Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. Intensive Care Med 30(12):2271-2278, 2004. (Pubitemid 40174266)
13. Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabo C: The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 120(7):259-267, 1997. (Pubitemid 27039275)
14. Cuzzocrea S, Mazzon E, Di Paola R, Esposito E, Macarthur H, Matuschak GM, Salvemini D: A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock. J Pharmacol Exp Ther 319(1):73-81, 2006. (Pubitemid 44455112)
15. d'Emmanuele di Villa Bianca R, Marzocco S, Di Paola R, Autore G, Pinto A, Cuzzocrea S, Sorrentino R: Melatonin prevents lipopolysaccharide-induced hyporeactivity in rat. J Pineal Res 36(39):146-154, 2004. (Pubitemid 38429279)
16. Soriano FG, Liaudet L, Szabo E, Virag L, Mabley JG, Pacher P, Szabo C: Resistance to acute septic peritonitis in poly(ADPribose) polymerase-1-deficient mice. Shock 17(4):286-292, 2002.
17. Zingarelli B, Salzman AL, Szabo C: Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP-ribosyl synthetase. Shock 5(4):258-264, 1996. (Pubitemid 126727686)
18. Salvemini D, Wang ZQ, Stern MK, Currie MG, Misko TP: Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology. Proc Natl Acad Sci USA 95(5):2659-2663, 1998.
19. Crow JP, Spruell C, Chen J, Gunn C, Ischiropoulos H, Tsai M, Smith CD, Radi R, Koppenol WH, Beckman JS: On the pH-dependent yield of hydroxyl radical products from peroxynitrite. Free Radic Biol Med 16(3):331-338, 1994. (Pubitemid 24122878)
20. Gryglewski RJ, Palmer RM, Moncada S: Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320(6961): 454-456, 1986. (Pubitemid 16097810)
21. Saba H, Batinic-Haberle I, Munusamy S, Mitchell T, Lichti C, Megyesi J, MacMillan-Crow LA: Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radic Biol Med 42(10): 1571-1578, 2007. (Pubitemid 46591998)
22. Szabó C, Cuzzocrea S, Zingarelli B, O'Connor M, Saltzman AL: Endothelial dysfunction in a rat model of endotoxic shock. J Clin Invest 100(3):723-735, 1997.
23. Szabó C, Zingarelli B, Salzman AL: Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res 78(6):1051-1063, 1996. (Pubitemid 26168580)
24. Tse HM, Milton MJ, Piganelli JD: Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity. Free Radic Biol Med 36(2):233-247, 2004. (Pubitemid 38117241)
25. Offer T, Russo A, Samuni A: The pro-oxidative activity of SOD and nitroxide SOD mimics. FASEB J 14(9):1215-1223, 2000. (Pubitemid 30350403)
26. Reid MB, Khawli FA, Moody MR: Reactive oxygen in skeletal muscle: III. Contractility of unfatigued muscle. J Appl Physiol 75(3):1081-1087, 1993. (Pubitemid 23289594)
27. Novials A, Rodriguez-Mañas L, Chico A, El Assar M, Casas S, Gomis R: Amylin and hypertension: association of an amylin-G132A gene mutation and hypertension in humans and amylin-induced endothelium dysfunction in rats. J Clin Endocrinol Metab 92(4):1446-1450, 2007. (Pubitemid 46556424)
28. Szabó C, Ischiropoulos H, Radi R: Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 6(8):662-680, 2009. (Pubitemid 47207751)
29. Thiemermann C, McDonald MC, Cuzzocrea S: The stable nitroxide, tempol, attenuates the effects of peroxynitrite and oxygen-derived free radicals. Crit Care Med 29(1):223-224, 2001. (Pubitemid 32125811)
30. Cuzzocrea S, McDonald MC, Mazzon E, Siriwardena D, Costantino G, Fulia F, Cucinotta G, Gitto E, Cordaro S, Barberi I, et al.: Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury. Brain Res 875(1-2):96-106, 2000.
31. Szabó C, Csáki C, Benyó Z, Reivich M, Kovách AG: Role of the L-arginineYnitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion. Circ Shock 37(4):307-316, 1992.
32. MacKenzie A, Martin W: Loss of endothelium-derived nitric oxide in rabbit aorta by oxidant stress: restoration by superoxide dismutase mimetics. Br J Pharmacol 124(4):719-728, 1998. (Pubitemid 28276809)
33. Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, Maeda H: Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32(3):827-832, 1993. (Pubitemid 23059363)