Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Journal of Clinical Investigation

Volumn 108, Issue 5, 2001, Pages 689-701

  Garcia, Joe G N ^a,e   Liu, Feng ^a   Verin, Alexander D ^a   Birukova, Anna ^a   Dechert, Melissa A ^b   Gerthoffer, William T ^b   Bamburg, James R ^c   English, Denis ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

^d METHODIST RESEARCH INSTITUTE   (United States)

^e JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFILIN; GUANOSINE TRIPHOSPHATASE; PROTEIN P21; PROTEIN TYROSINE KINASE; RAC PROTEIN; REGULATOR PROTEIN; RHO KINASE; SPHINGOSINE 1 PHOSPHATE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CATTLE; CONTROLLED STUDY; CYTOSKELETON; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LUNG ARTERY; LUNG BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL;

EID: 0034799675     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12450     Document Type: Article

References (63)

1. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium
2. Effects of platelet transfusions: Plug formation and maintenance of vascular integrity
3. Vasoactive agonists prevent erythrocyte extravasation in thrombocytopenic hamsters
4. Role of platelets in maintenance of pulmonary vascular permeability to protein
5. Platelets reduce coronary microvascular permeability to macromolecules
6. Platelet-released phospholipids link haemostasis and angiogenesis
7. Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro
8. Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer permeability by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis
9. Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells
10. Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells
11. Induction of endothelial monolayer permeability by phosphatidate
12. Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
13. High efficiency transient transfection of endothelial cells for functional analysis
14. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
15. Sphingosine 1-phosphate stimulates cell migration through a Gi-coupled cell surface receptor. Potential involvement in angiogenesis
16. Sphingosine 1-phosphate as a ligand for the G-protein-coupled receptor Edg-1
17. Mechanisms of angiogenesis and arteriogenesis
18. Edg-1, the G protein-coupled receptor for sphingosine 1-phosphate, is essential for vascular maturation
19. Leakage-resistant blood vessels in mice transgenically over-expressing angiopoietin-1
20. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
21. Induction and suppression of apoptosis by sphingolipids: A possible in vitro model for cell-cell interactions between platelets and endothelial cells
22. Sphingosine 1-phosphate-induced cell proliferation, survival and related signaling events mediated by G protein-coupled receptors Edg-3 and Edg-5
23. An abundant transcript induced in differentiating human endothelial cells encodes a poly peptide with structural similarities to G-protein-coupled receptors
24. Sphingosine-1-phosphate signaling through the G-protein-coupled receptor Edg-1
25. Molecular cloning of the Edg-2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
26. Sphingosine 1-phosphate signaling in mammalian cells
27. iα2-linked Rho kinase activity
28. Thrombin-induced prostacyclin biosynthesis in human endothelium: Role of guanine nucleotide regulatory proteins in stimulus/coupling responses
29. A morphological biosensor for mammalian cells
30. Mechanisms of ionomycin-induced endothelial cell barrier dysfunction
31. Electrical method for detection of endothelial cell shape change in real time: Assessment of endothelial barrier function
32. Diperoxovanadate alters endothelial cell focal contacts and increases permeability: Role of tyrosine phosphorylation
33. i-coupled signal transduction
34. Sphingosine 1-phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical vein endothelial cells
35. i protein-linked phospholipase C pathway
36. Sphingosine-1-phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical vein endothelial cells
37. 2+ mobilization, barrier dysfunction, prostaglandin synthesis and platelet-derived growth factor mRNA expression in cultured endothelium
38. Role of Ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction
39. Regulation of endothelial cell gap formation and paracellular permeability
40. EB2000 symposium report: Mechanisms regulating endothelial cell barrier function
41. Regulation of endothelial cell gap formation and barrier dysfunction. Role of myosin light chain phosphorylation
42. Myosin light chain kinase in endothelium: Molecular cloning and regulation
43. Activation of LIM-kinase by PAK-1 couples Rac/Cdc43 GTPase signaling to actin cytoskeletal dynamics
44. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
45. Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate
46. Sphingosine 1-phosphate: Signaling inside and out
47. Mechanisms of pertussis toxin-induced barrier dysfunction in bovine pulmonary artery endothelial cell monolayers
48. i-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: Possible involvement in cell motility, enhancement in cooperation with Rho-mediated pathways
49. Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells
50. Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets
51. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
52. Phosphorylation and activation of myosin light chain by p21-activated kinase (γ-PAK)
53. Regulation of human leukocyte p21-activated kinases through G-protein-coupled receptors
54. A GTPase-independent mechanism of p21-activated kinase activation
55. Inhibition of myosin light chain kinase by p21-activated kinase
56. Differential regulation by tyrosine phosphorylation of alternatively spliced endothelial cell MLCK isoforms
57. Temporal and spatial distribution of activated Pak1 in fibroblasts
58. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin
59. LIM-kinase 1
60. Cofilin is an essential component of the yeast cortical cytoskeleton
61. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
62. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
63. Increase in neurite outgrowth mediated by over-expression of actin depolymerizing factor