Sepsis and acute kidney injury

Journal of the American Society of Nephrology

Volumn 22, Issue 6, 2011, Pages 999-1006

  Zarjou, Abolfazl ^a   Agarwal, Anupam ^a  

^a and Clinical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAZANAVIR; BIOLOGICAL MARKER; CARBON MONOXIDE; CHLOROQUINE; CYSTATIN C; ERITORAN; FATTY ACID BINDING PROTEIN; GHRELIN; INTERLEUKIN 18; KIDNEY INJURY MOLECLUE 1; L TYPE FATTY ACID BINDING PROTEIN; NETRIN 1; NEUTRALIZING ANTIBODY; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL MODEL; CONTROLLED STUDY; DRUG TARGETING; GRAFT SURVIVAL; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SHORT SURVEY;

EID: 79957693494     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010050484     Document Type: Short Survey

References (92)

1. Bone RC, Sprung CL, Sibbald WJ: Definitions for sepsis and organ failure. Crit Care Med 20: 724-726, 1992
2. Vincent JL: Clinical sepsis and septic shock: Definition, diagnosis and management principles. Langenbecks Arch Surg 393: 817-824, 2008
3. Strijack B, Mojica J, Sood M, Komenda P, Bueti J, Reslerova M, Roberts D, Rigatto C: Outcomes of chronic dialysis patients admitted to the intensive care unit. J Am Soc Nephrol 20: 2441-2447, 2009
4. Rangel-Frausto, MS: The epidemiology of bacterial sepsis. Infect Dis Clin North Am 13: 299-312, vii, 1999
5. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16: 3365-3370, 2005 (Pubitemid 46179340)
6. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310, 2001 (Pubitemid 32641789)
7. Lafrance JP, Miller DR: Acute kidney injury associates with increased long-term mortality. J Am Soc Nephrol 21: 345-352, 2010
8. Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 20: 223-228, 2009
9. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C: Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 294: 813-818, 2005 (Pubitemid 41175724)
10. Murugan R, Karajala-Subramanyam V, Lee M, Yende S, Kong L, Carter M, Angus DC, Kellum JA: Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int 77: 527-535, 2010
11. Silvester W, Bellomo R, Cole L: Epidemiology, management, and outcome of severe acute renal failure of critical illness in Australia. Crit Care Med 29: 1910-1915, 2001
12. Zappitelli M: Epidemiology and diagnosis of acute kidney injury. Semin Nephrol 28: 436-446, 2008
13. Bagshaw SM, Lapinsky S, Dial S, Arabi Y, Dodek P, Wood G, Ellis P, Guzman J, Marshall J, Parrillo JE, Skrobik Y, Kumar A: Acute kidney injury in septic shock: Clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med 35: 871-881, 2009
14. Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo R: Pathophysiology of septic acute kidney injury: What do we really know? Crit Care Med 36: S198-S203, 2008
15. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150, 2003 (Pubitemid 36056721)
16. Munford RS, Pugin J: Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 163: 316-321, 2001 (Pubitemid 32158505)
17. Martins PS, Brunialti MK, da Luz Fernandes M, Martos LS, Gomes NE, Rigato O, Salomao R: Bacterial recognition and induced cell activation in sepsis. Endocr Metab Immune Disord Drug Targets 6: 183-191, 2006 (Pubitemid 43881031)
18. Tracey KJ, Beutler B, Lowry SF, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fahey TJ, 3rd, Zentella A, Albert JD, Shires GT, Cerami A: Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474, 1986 (Pubitemid 17181429)
19. Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA: Interleukin 1 induces a shock-like state in rabbits: Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest 81: 1162-1172, 1988
20. Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH: IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 19: 1106-1115, 2008
21. Monneret G, Venet F, Pachot A, Lepape A: Monitoring immune dysfunctions in the septic patient: A new skin for the old ceremony. Mol Med 14: 64-78, 2008 (Pubitemid 351356886)
22. Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H: The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19: 547-558, 2008 (Pubitemid 351355398)
23. De Vriese AS, Bourgeois M: Pharmacologic treatment of acute renal failure in sepsis. Curr Opin Crit Care 9: 474-480, 2003 (Pubitemid 37518646)
24. Rittirsch D, Hoesel LM, Ward PA: The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol 81: 137-143, 2007 (Pubitemid 46021262)
25. Sharfuddin AA, Sandoval RM, Berg DT, McDougal GE, Campos SB, Phillips CL, Jones BE, Gupta A, Grinnell BW, Molitoris BA: Soluble thrombomodulin protects ischemic kidneys. J Am Soc Nephrol 20: 524-534, 2009
26. Bengatta S, Arnould C, Letavernier E, Monge M, de Preneuf HM, Werb Z, Ronco P, Lelongt B: MMP9 and SCF protect from apoptosis in acute kidney injury. J Am Soc Nephrol 20: 787-797, 2009
27. Kumar H, Kawai T, Akira S: Toll-like receptors and innate immunity. Biochem Biophys Res Commun 388: 621-625, 2009
28. Anders HJ: Toll-like receptors and danger signaling in kidney injury. J Am Soc Nephrol 21: 1270-1274, 2010
29. Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB: TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol 19: 923-932, 2008
30. Tsujimoto H, Ono S, Hiraki S, Majima T, Kawarabayashi N, Sugasawa H, Kinoshita M, Hiraide H, Mochizuki H: Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock. J Endotoxin Res 10: 229-237, 2004 (Pubitemid 39481012)
31. Armstrong L, Medford AR, Hunter KJ, Uppington KM, Millar AB: Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis. Clin Exp Immunol 136: 312-319, 2004 (Pubitemid 38543451)
32. Tsujimoto H, Ono S, Majima T, Kawarabayashi N, Takayama E, Kinoshita M, Seki S, Hiraide H, Moldawer LL, Mochizuki H: Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 23: 39-44, 2005
33. Wan L, Bellomo R, Di Giantomasso D, Ronco C: The pathogenesis of septic acute renal failure. Curr Opin Crit Care 9: 496-502, 2003 (Pubitemid 37518649)
34. Langenberg C, Wan L, Bagshaw SM, Egi M, May CN, Bellomo R: Urinary biochemistry in experimental septic acute renal failure. Nephrol Dial Transplant 21: 3389-3397, 2006 (Pubitemid 44817086)
35. Bellomo R, Bagshaw S, Langenberg C, Ronco C: Pre-renal azotemia: A flawed paradigm in critically ill septic patients? Contrib Nephrol 156: 1-9, 2007
36. Bagshaw SM, Langenberg C, Haase M, Wan L, May CN, Bellomo R: Urinary biomarkers in septic acute kidney injury. Intensive Care Med 33: 1285-1296, 2007 (Pubitemid 47036892)
37. Waikar SS, Bonventre JV: Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 20: 672-679, 2009
38. Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah S: Improving outcomes from acute kidney injury. J Am Soc Nephrol 18: 1992-1994, 2007
39. Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, Star RA: Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol 20: 1217-1221, 2009
40. Zhang Z, Humphreys BD, Bonventre JV: Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region. J Am Soc Nephrol 18: 2704-2714, 2007 (Pubitemid 47531197)
41. Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA: Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol 20: 1823-1832, 2009
42. Bagshaw SM, Bennett M, Haase M, Haase- Fielitz A, Egi M, Morimatsu H, D'Amico G, Goldsmith D, Devarajan P, Bellomo R: Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 36: 452-461, 2010
43. Srisawat N, Murugan R, Wen X, Singbartl K, Clermont G, Eiam-Ong S, Kellum JA: Recovery from acute kidney injury: Determinants and predictors. Contrib Nephrol 165: 284-291, 2010
44. Coca SG, Yalavarthy R, Concato J, Parikh CR: Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review. Kidney Int 73: 1008-1016, 2008 (Pubitemid 351543898)
45. Nakamura T, Sugaya T, Koide H: Urinary liver-type fatty acid-binding protein in septic shock: Effect of polymyxin B-immobilized fiber hemoperfusion. Shock 31: 454-459, 2009
46. Basnakian AG: Netrin-1: A potential universal biomarker for acute kidney injury. Am J Physiol Renal Physiol 294: F729-F730, 2008
47. Reeves WB, Kwon O, Ramesh G: Netrin-1 and kidney injury: II. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol 294: F731-F738, 2008
48. Doi K, Leelahavanichkul A, Yuen PS, Star RA: Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 119: 2868-2878, 2009
49. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 9: 1-11, 1998
50. Nemzek JA, Hugunin KM, Opp MR: Modeling sepsis in the laboratory: Merging sound science with animal well-being. Comp Med 58: 120-128, 2008
51. Beutler B, Rehli M: Evolution of the TIR, tolls and TLRs: Functional inferences from computational biology. Curr Top Microbiol Immunol 270: 1-21, 2002 (Pubitemid 35448150)
52. Richmond JM, Walker JF, Avila A, Petrakis A, Finley RJ, Sibbald WJ, Linton AL: Renal and cardiovascular response to nonhypotensive sepsis in a large animal model with peritonitis. Surgery 97: 205-214, 1985 (Pubitemid 15037894)
53. Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D: A model of ovine endotoxemia characterized by an increased cardiac output. Circ Shock 17: 103-108, 1985 (Pubitemid 16221440)
54. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 49: 186-196, 1990 (Pubitemid 20241651)
55. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S: Renal blood flow in sepsis. Crit Care 9: R363-R374, 2005
56. Bagshaw SM, Langenberg C, Wan L, May CN, Bellomo R: A systematic review of urinary findings in experimental septic acute renal failure. Crit Care Med 35: 1592-1598, 2007 (Pubitemid 46809325)
57. Licari E, Calzavacca P, Ronco C, Bellomo R: Fluid resuscitation and the septic kidney: The evidence. Contrib Nephrol 156: 167-177, 2007
58. Bradley VE, Shier MR, Lucas CE, Rosenberg IK: Renal hemodynamic response to furosemide in septic and injured patients. Surgery 79: 549-554, 1976
59. Brenner M, Schaer GL, Mallory DL, Suffredini AF, Parrillo JE: Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest 98: 170-179, 1990 (Pubitemid 20223686)
60. Parker MM, Shelhamer JH, Natanson C, Alling DW, Parrillo JE: Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 15: 923-929, 1987 (Pubitemid 18055700)
61. Langenberg C, Wan L, Egi M, May CN, Bellomo R: Renal blood flow in experimental septic acute renal failure. Kidney Int 69: 1996-2002, 2006
62. Langenberg C, Wan L, Egi M, May CN, Bellomo R: Renal blood flow and function during recovery from experimental septic acute kidney injury. Intensive Care Med 33: 1614-1618, 2007 (Pubitemid 47312480)
63. Ravikant T, Lucas CE: Renal blood flow distribution in septic hyperdynamic pigs. J Surg Res 22: 294-298, 1977 (Pubitemid 8079209)
64. Reinhart K, Karzai W: Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned. Crit Care Med 29: S121-S125, 2001 (Pubitemid 32681594)
65. Fiedler VB, Loof I, Sander E, Voehringer V, Galanos C, Fournel MA: Monoclonal antibody to tumor necrosis factor-alpha prevents lethal endotoxin sepsis in adult rhesus monkeys. J Lab Clin Med 120: 574-588, 1992
66. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ: Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol 168: 5817-5823, 2002 (Pubitemid 34556169)
67. Iglesias J, Marik PE, Levine JS: Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Am J Kidney Dis 41: 62-75, 2003 (Pubitemid 36043352)
68. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher, CJ Jr: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344: 699-709, 2001 (Pubitemid 32204987)
69. Togel F, Cohen A, Zhang P, Yang Y, Hu Z, Westenfelder C: Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev 18: 475-485, 2009
70. Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, Collino F, Morando L, Busca A, Falda M, Bussolati B, Tetta C, Camussi G: Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20: 1053-1067, 2009
71. Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E: Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15: 42-49, 2009
72. Tracz MJ, Alam J, Nath KA: Physiology and pathophysiology of heme: Implications for kidney disease. J Am Soc Nephrol 18: 414-420, 2007 (Pubitemid 46193307)
73. Chung SW, Liu X, Macias AA, Baron RM, Perrella MA: Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest 118: 239-247, 2008
74. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA: High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol 41: 129-135, 2009
75. Lin YT, Chen YH, Yang YH, Jao HC, Abiko Y, Yokoyama K, Hsu, C: Heme oxygenase-1 suppresses the infiltration of neutrophils in rat liver during sepsis through inactivation of P38 Mapk. Shock 34: 615-621, 2010
76. Devarajan P: Proteomics for the investigation of acute kidney injury. Contrib Nephrol 160: 1-16, 2008
77. Wheeler DS, Devarajan P, Ma Q, Harmon K, Monaco M, Cvijanovich N, Wong HR: Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med 36: 1297-1303, 2008 (Pubitemid 351482681)
78. Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P: Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 5: 395-401, 2010
79. Lotze MT, Tracey KJ: High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol 5: 331-342, 2005 (Pubitemid 40516158)
80. Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6: 813-822, 2006 (Pubitemid 44631650)
81. Roger T, Froidevaux C, Le Roy D, Reymond MK, Chanson AL, Mauri D, Burns K, Riederer BM, Akira S, Calandra T: Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci U S A 106: 2348-2352, 2009
82. Plitas G, Burt BM, Nguyen HM, Bamboat ZM, DeMatteo RP: Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. J Exp Med 205: 1277-1283, 2008 (Pubitemid 351831485)
83. Yasuda H, Leelahavanichkul A, Tsunoda S, Dear JW, Takahashi Y, Ito S, Hu X, Zhou H, Doi K, Childs R, Klinman DM, Yuen PS, Star RA: Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 294: F1050-F1058, 2008
84. Doi K, Leelahavanichkul A, Hu X, Sidransky KL, Zhou H, Qin Y, Eisner C, Schnermann J, Yuen PS, Star RA: Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int 74: 1017-1025, 2008
85. Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC: Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med 203: 1447-1458, 2006 (Pubitemid 43877607)
86. Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM: Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis. Crit Care Med 35: 1955-1960, 2007
87. Huber-Lang M, Sarma VJ, Lu KT, McGuire SR, Padgaonkar VA, Guo RF, Younkin EM, Kunkel RG, Ding J, Erickson R, Curnutte JT, Ward PA: Role of C5a in multiorgan failure during sepsis. J Immunol 166: 1193-1199, 2001 (Pubitemid 32060279)
88. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA: Functional roles for C5a receptors in sepsis. Nat Med 14: 551-557, 2008 (Pubitemid 351655216)
89. Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L: Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 10: 1216-1221, 2004 (Pubitemid 39540438)
90. Doi K, Hu X, Yuen PS, Leelahavanichkul A, Yasuda H, Kim SM, Schnermann J, Jonassen TE, Frokiaer J, Nielsen S, Star RA: AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int 73: 1266-1274, 2008 (Pubitemid 351693164)
91. Chorny A, Anderson P, Gonzalez-Rey E, Delgado M: Ghrelin protects against experimental sepsis by inhibiting high-mobility group box 1 release and by killing bacteria. J Immunol 180: 8369-8377, 2008
92. Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, Keys EM, Allen-Vercoe E, Devinney R, Doig CJ, Green FH, Kubes P: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13: 463-469, 2007 (Pubitemid 46559832)