Erythropoietin ameliorates renal dysfunction during endotoxaemia

Nephrology Dialysis Transplantation

Volumn 22, Issue 8, 2007, Pages 2349-2353

  Mitra, Amit ^a   Bansal, Shweta ^a   Wang, Wei ^a   Falk, Sandor ^a   Zolty, Einath ^a   Schrier, Robert W ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute renal failure; Lipopolysaccharide; Sepsis; Super oxide dismutase

Indexed keywords

C REACTIVE PROTEIN; ENDOTOXIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; RECOMBINANT ERYTHROPOIETIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; ENDOTOXEMIA; ENZYME ACTIVITY; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY DYSFUNCTION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RENAL PROTECTION; WILD TYPE;

ANIMALS; CYTOKINES; ENDOTOXEMIA; ERYTHROPOIETIN; GLOMERULAR FILTRATION RATE; INFLAMMATION; KIDNEY; KIDNEY DISEASES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34547851709     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm216     Document Type: Article

References (29)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-1310
2. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J Clin Invest 2003; 112: 460-467
3. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. Jama 1995; 273: 117-123
4. Abdelrahman M, Sharples EJ, McDonald MC et al. Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock 2004; 22: 63-69
5. Sharples EJ, Patel N, Brown P et al. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 2004; 15: 2115-2124
6. Patel NS, Sharples EJ, Cuzzocrea S et al. Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo. Kidney Int 2004; 66: 983-989
7. Westenfelder C, Biddle DL, Baranowski RL. Human, rat, and mouse kidney cells express functional erythropoietin receptors. Kidney Int 1999; 55: 808-820
8. Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med 2004; 351: 159-169
9. Knotek M, Rogachev B, Wang W et al. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 2001; 59: 2243-2249
10. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ. Acute renal failure in endotoxaemia is caused by TNF acting directly on TNF receptor-1 in kidney. J Immunol 2002; 168: 5817-5823
11. Zager RA, Johnson AC, Hanson SY, Lund S. Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-alpha generation and systemic release. Am J Physiol Renal Physiol 2005; 289: F289-F297
12. Zager RA, Johnson AC, Hanson SY, Lund S. Acute nephrotoxic and obstructive injury primes the kidney to endotoxin-driven cytokine/ chemokine production. Kidney Int 2006; 69: 1181-1188
13. Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, Schrier RW. Protective effect of renal denervation on normotensive endotoxaemia- induced acute renal failure in mice. Am J Physiol Renal Physiol 2002; 283: F583-F587
14. Puren AJ, Fantuzzi G, Gu Y, Su MS, Dinarello CA. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14 + human blood mononuclear cells. J Clin Invest 1998; 101: 711-721
15. Gobe G, Zhang XJ, Willgoss DA, Schoch E, Hogg NA, Endre ZH. Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol 2000; 11: 454-467
16. Wang W, Faubel S, Ljubanovic D et al. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol 2005; 288: F997-F1004
17. Lacombe C, Mayeux P. Biology of erythropoietin. Haematologica 1998; 83: 724-732
18. Siren AL, Fratelli M, Brines M et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 2001; 98: 4044-4049
19. Junk AK, Mammis A, Savitz SI et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA 2002; 99: 10659-10664
20. Squadrito F, Altavilla D, Squadrito G et al. Recombinant human erythropoietin inhibits iNOS activity and reverts vascular dysfunction in splanchnic artery occlusion shock. Br J Pharmacol 1999; 127: 482-488
21. Frede S, Fandrey J, Pagel H, Hellwig T, Jelkmann W. Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats. Am J Physiol 1997; 273: R1067-R1071
22. Hotchkiss RS, Swanson PE, Freeman BD et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27: 1230-1251
23. Novelli GP. Role of free radicals in septic shock. J Physiol Pharmacol 1997; 48: 517-527
24. Wang W, Jittikanont S, Falk SA et al. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxaemia-related acute renal failure. Am J Physiol Renal Physiol 2003; 284: F532-F537
25. Inal M, Kanbak G, Sen S, Akyuz F, Sunal E. Antioxidant status and lipid peroxidation in hemodialysis patients undergoing erythropoietin and erythropoietin-vitamin E combined therapy. Free Radic Res 1999; 31: 211-216
26. Wang W, Zolty E, Falk S, Basava V, Reznikov L, Schrier R. Pentoxifylline protects against endotoxin-induced acute renal failure in mice. Am J Physiol Renal Physiol 2006; 291: F1090-F1095
27. Calvillo L, Latini R, Kajstura J et al. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci USA 2003; 100: 4802-4806
28. Xia D, Samols D. Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxaemia. Proc Natl Acad Sci USA 1997; 94: 2575-2580
29. Mold C, Rodriguez W, Rodic-Polic B, Du Clos TW. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol 2002; 169: 7019-7025