SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 2, 2010, Pages 593-601

  Funk, Jason A ^a   Odejinmi, Sina ^a   Schnellmann, Rick G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL DNA; N [2 [3 (PIPERAZIN 1 YLMETHYL)IMIDAZO [2,1 B][1,3]THIAZOL 6 YL]PHENYL]QUINOXALINE 2 CARBOXAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SIRTUIN 1; SRT 1720; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL FUNCTION; CONTROLLED STUDY; DEACETYLATION; DRUG HALF LIFE; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; DNA, MITOCHONDRIAL; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KIDNEY TUBULES, PROXIMAL; MITOCHONDRIA; OXIDATIVE STRESS; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PPAR ALPHA; RABBITS;

EID: 77951049870     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.161992     Document Type: Article

References (44)

1. Barger PM, Browning AC, Garner AN, and Kelly DP (2001) p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 276:44495-44501. (Pubitemid 37391222)
2. Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, et al. (2008) SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 3:e1759. (Pubitemid 351903300)
3. Bonventre JV and Weinberg JM (2003) Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 14:2199-2210. (Pubitemid 36909930)
4. Bordone L and Guarente L (2005) Calorie restriction, SIRT1, and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6:298-305.
5. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, and Auwerx J (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:1056-1060.
6. Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, and Auwerx J (2008) The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α. Proc Natl Acad Sci USA 105:17187-17192.
7. Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, et al. (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297:H13-H20.
8. Czubryt MP, McAnally J, Fishman GI, and Olson EN (2003) Regulation of peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci USA 100:1711-1716. (Pubitemid 36254513)
9. Daitoku H, Yamagata K, Matsuzaki H, Hatta M, and Fukamizu A (2003) Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52:642-649. (Pubitemid 36323569)
10. Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, and Auwerx J (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8:347-358.
11. Feldkamp T, Kribben A, and Weinberg JM (2005) Assessment of mitochondrial membrane potential in proximal tubules after hypoxia-reoxygenation. Am J Physiol Renal Physiol 288:F1092-F1102. (Pubitemid 40677078)
12. Gleyzer N, Vercauteren K, and Scarpulla RC (2005) Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol 25:1354-1366. (Pubitemid 40204913)
13. Guarente L (2007) Sirtuins in aging and disease. Cold Spring Harb Symp Quant Biol 72:483-488.
14. Hardie DG, Scott JW, Pan DA, and Hudson ER (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546:113-120.
15. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:191-196. (Pubitemid 37150899)
16. Jäger S, Handschin C, St-Pierre J, and Spiegelman BM (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc Natl Acad Sci USA 104:12017-12022. (Pubitemid 47185622)
17. Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, and Muoio DM (2005) Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 280:33588-33598.
18. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122. (Pubitemid 44894520)
19. Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, Pillus L, and Sternglanz R (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci USA 97:5807-5811. (Pubitemid 30367480)
20. Lin J, Handschin C, and Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361-370. (Pubitemid 43960626)
21. Milne JC and Denu JM (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12:11-17.
22. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716. (Pubitemid 350207685)
23. Nemoto S, Fergusson MM, and Finkel T (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α. J Biol Chem 280:16456-16460. (Pubitemid 40616776)
24. Nowak G, Aleo MD, Morgan JA, and Schnellmann RG (1998) Recovery of cellular functions following oxidant injury. Am J Physiol Renal Physiol 274:F509-F515. (Pubitemid 28158353)
25. Pagel-Langenickel I, Bao J, Joseph JJ, Schwartz DR, Mantell BS, Xu X, Raghavachari N, and Sack MN (2008) PGC-1α integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem 283:22464-22472.
26. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, and Spiegelman BM (2001) Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1. Mol Cell 8:971-982. (Pubitemid 34031800)
27. Puigserver P and Spiegelman BM (2003) Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90. (Pubitemid 36223280)
28. Puigserver P, Wu Z, Park CW, Graves R, Wright M, and Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839. (Pubitemid 28155321)
29. 2+ induce PGC-1alpha degradation through calpain. Arch Biochem Biophys 478:130-135.
30. Rasbach KA and Schnellmann RG (2007a) PGC-1α overexpression promotes recovery from mitochondrial dysfunction and cell injury. Biochem Biophys Res Commun 355:734-739. (Pubitemid 46330214)
31. Rasbach KA and Schnellmann RG (2007b) Signaling of mitochondrial biogenesis following oxidant injury. J Biol Chem 282:2355-2362.
32. Rasbach KA and Schnellmann RG (2008) Isoflavones promote mitochondrial biogenesis. J Pharmacol Exp Ther 325:536-543.
33. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, and Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434:113-118. (Pubitemid 40349395)
34. Sano M, Tokudome S, Shimizu N, Yoshikawa N, Ogawa C, Shirakawa K, Endo J, Katayama T, Yuasa S, Ieda M, et al. (2007) Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor γ coactivator 1α. J Biol Chem 282:25970-25980. (Pubitemid 47372787)
35. Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, et al. (2009) Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol 3:31.
36. Teyssier C, Ma H, Emter R, Kralli A, and Stallcup MR (2005) Activation of nuclear receptor coactivator PGC-1α by arginine methylation. Genes Dev 19:1466-1473. (Pubitemid 41003013)
37. Wang H, Peiris TH, Mowery A, Le Lay J, Gao Y, and Greenbaum LE (2008) CCAAT/enhancer binding protein-β is a transcriptional regulator of peroxisomeproliferator-activated receptor-γ coactivator-1α in the regenerating liver. Mol Endocrinol 22:1596-1605. (Pubitemid 351920393)
38. Weinberg JM, Venkatachalam MA, Roeser NF, and Nissim I (2000) Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci USA 97:2826-2831.
39. Wenz T, Diaz F, Spiegelman BM, and Moraes CT (2008) Activation of the PPAR/PGC-1α pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab 8:249-256.
40. Wrutniak-Cabello C, Casas F, and Cabello G (2001) Thyroid hormone action in mitochondria. J Mol Endocrinol 26:67-77.
41. Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, and Williams RS (2002) Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296:349-352. (Pubitemid 34303690)
42. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124. (Pubitemid 29331201)
43. Yin W, Signore AP, Iwai M, Cao G, Gao Y, and Chen J (2008) Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. Stroke 39:3057-3063.
44. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, and Cohen RA (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor- deficient mice. Diabetes 55:2180-2191. (Pubitemid 44743614)