Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion

Journal of Hepatology

Volumn 56, Issue 1, 2012, Pages 137-145

  Shi, Yanjun ^a   Rehman, Hasibur ^a   Ramshesh, Venkat K ^a,b   Schwartz, Justin ^a   Liu, Qinlong ^a   Krishnasamy, Yasodha ^a   Zhang, Xun ^a   Lemasters, John J ^a,b   Smith, Charles D ^a,c   Zhong, Zhi ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c APOGEE BIOTECHNOLOGY CORPORATION   (United States)

Author keywords

Inflammation; Ischemia reperfusion; Liver; Mitochondrial permeability transition; Sphingosine kinase; Sphingosine 1 phosphate

Indexed keywords

ABC 294640; CALCEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHOSPHOTRANSFERASE INHIBITOR; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INHIBITION; FEEDING; HEPATIC ISCHEMIA REPERFUSION; INFLAMMATION; LIVER; LIVER CELL; LIVER INJURY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL PERMEABILITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION; SURVIVAL;

ADAMANTANE; ANIMALS; CELL DEATH; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; INFLAMMATION; LIVER; LYSOPHOSPHOLIPIDS; MALE; MICE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PYRIDINES; REPERFUSION INJURY; RNA, MESSENGER; RNA, SMALL INTERFERING; SPHINGOSINE;

EID: 83555173697     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.05.025     Document Type: Article

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