Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury

Journal of the American Society of Nephrology

Volumn 18, Issue 6, 2007, Pages 1807-1815

  Wu, Liping ^a   Gokden, Neriman ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DIHYDRORHODAMINE 123; INDUCIBLE NITRIC OXIDE SYNTHASE; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE NITROGEN SPECIES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY; CAPILLARY FLOW; CONTROLLED STUDY; CREATININE BLOOD LEVEL; KIDNEY BLOOD VESSEL; KIDNEY TUBULE DAMAGE; MALE; MICROANGIOPATHY; MICROSCOPY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEPSIS; VIDEORECORDING;

EID: 34249884479     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006121402     Document Type: Article

References (47)

1. Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med 351: 159-169, 2004
2. Wan L, Bellomo R, Di Giantomasso D, Ronco C: The pathogenesis of septic acute renal failure. Curr Opin Crit Care 9: 496-502, 2003
3. Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S, Huang DT, Osborn T, Stevens D, Talan DA: Severe sepsis and septic shock: Review of the literature and emergency department management guidelines. Ann Emerg Med 48: 28-54, 2006
4. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310, 2001
5. Annane D, Bellissant E, Cavaillon JM: Septic shock. Lancet 365: 63-78, 2005
6. Dauphinee SM, Karsan A: Lipopolysaccharide signaling in endothelial cells. Lab Invest 86: 9-22, 2006
7. Yasuda H, Yuen PS, Hu X, Zhou H, Star RA: Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int 69: 1535-1542, 2006
8. Wu L, Tiwari MM, Messer KJ, Holthoff JH, Gokden N, Brock RW, Mayeux PR: Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am J Physiol Renal Physiol 292: F261-F268, 2007
9. Remick DG, Ward PA: Evaluation of endotoxin models for the study of sepsis. Shock 24[Suppl 1]: 7-11, 2005
10. Miyaji T, Hu X, Yuen PS, Muramatsu Y, Iyer S, Hewitt SM, Star RA: Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64: 1620-1631, 2003
11. Dear JW, Yasuda H, Hu X, Hieny S, Yuen PS, Hewitt SM, Sher A, Star RA: Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: Acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69: 832-836, 2006
12. Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PS, Star RA: Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. Kidney Int 70: 496-506, 2006
13. Fukuyama N, Takebayashi Y, Hida M, Isida H, Ichimori K, Nakazawa H: Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock. Free Radic Biol Med 22: 771-774, 1997
14. Bian K, Davis K, Kuret J, Binder L, Murad F: Nitrotyrosine formation with endotoxin-induced kidney injury detected by immunohistochemistry. Am J Physiol 177: F33-F40, 1999
15. Zhang C, Walker LM, Mayeux PR: Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem Pharmacol 59: 203-209, 2000
16. Wu F, Wilson JX, Tyml K: Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression. Free Radic Biol Med 37: 1282-1289, 2004
17. Tiwari MM, Brock RW, Kaushal GP, Mayeux PR: Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: Role of nitric oxide and caspases. Am J Physiol Renal Physiol 289: F1324-F1332, 2005
18. Moore WM, Webber RK, Jerome GM, Tjoeng FS, Misko TP, Currie MG: L-N6-(1-Iminoethly)lysine: A selective inhibitor of inducible nitric oxide synthase. J Med Chem 37: 3886-3888, 1994
19. Wang W, Faubel S, Ljubanovic D, Mitra A, Kim J, Tao Y, Soloviev A, Reznikov LL, Dinarello CA, Schrier RW, Edelstein CL: Endotoxemic acute renal failure (ARF) is attenuated in caspase-1 deficient mice. Am J Physiol Renal Physiol 288: F997-F1004, 2005
20. Halliwell B, Whiteman M: Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? Br J Pharmacol 142: 231-255, 2004
21. Ince C: The microcirculation is the motor of sepsis. Crit Care 9[Suppl 4]: S13-S19, 2005
22. Sutton TA, Mang HE, Campos SB, Sandoval RM, Yoder MC, Molitoris BA: Injury of the renal microvascular endothelium alters barrier function after ischemia. Am J Physiol Renal Physiol 285: F191-F198, 2003
23. Wolin MS: Interactions of oxidants with vascular signaling systems. Arterioscler Thromb Vasc Biol 20: 1430-1442, 2000
24. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620-1624, 1990
25. Brune B, Zhou J, von Knethen A: Nitric oxide, oxidative stress, and apoptosis. Kidney Int Suppl 63: S22-S24, 2003
26. Pryor WA, Squadrito GL: The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol 268: L699-L722, 1995
27. MacMillan-Crow LA, Crow JP, Kerby JK, Beckman JS: Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci USA 93: 11853-11858, 1996
28. Neumann P, Gertzberg N, Vaughan E, Weisbrot J, Woodburn R, Lambert W, Johnson A: Peroxynitrite mediates TNF-alpha-induced endothelial barrier dysfunction and nitration of actin. Am J Physiol Lung Cell Mol Physiol 290: L674-L684, 2006
29. Paxian M, Keller SA, Cross B, Huynh TT, Clemens MG: High-resolution visualization of oxygen distribution in the liver in vivo. Am J Physiol Gastrointest Liver Physiol 286: G37-G44, 2004
30. Wolin MS, Ahmad M, Gupte SA: The sources of oxidative stress in the vessel wall. Kidney Int 67: 1659-1661, 2005
31. Xie Y-W, Wolin MS: Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration: Involvement in response to hypoxia/reoxygenation. Circulation 94: 2580-2586, 1996
32. Yaqoob M, Edelstein CL, Wieder ED, Alkhunaizi AM, Gengaro PE, Nemenoff RA, Schrier RW: Nitric oxide kinetics during hypoxia in proximal tubules: Effects of acidosis and glycine. Kidney Int 49: 1314-1319, 1996
33. Noiri E, Peresleni T, Miller F, Goligorsky MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 97: 2377-2383, 1996
34. Chiao H, Kohda Y, McLeroy P, Craig L, Housini I, Star RA: alpha-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest 99: 1165-1172, 1997
35. Walker LM, Walker PD, Imam SZ, Ali SF, Mayeux PR: Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: Studies with the inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl)-lysine. J Pharmacol Exp Ther 295: 417-422, 2000
36. Kadoi Y, Goto F: Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats. Anesth Analg 99: 212-220, 2004
37. Hollenberg SM, Broussard M, Osman J, Parrillo JE: Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Cir Res 86: 774-778, 2000
38. Mayeux PR, Garner HR, Gibson JD, Beanum VC: Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules. Biochem Pharmacol 49: 115-118, 1995
39. Boer R, Ulrich WR, Klein T, Mirau B, Haas S, Baur I: The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 58: 1026-1034, 2000
40. Bultinck J, Sips P, Vakaet L, Brouckaert P, Cauwels A: Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: In vivo iNOS expression pattern in (septic) shock. FASEB J 20: 2363-2365, 2006
41. O'Riordan E, Chen J, Brodsky SV, Smirnova I, Li H, Goligorsky MS: Endothelial cell dysfunction: The syndrome in making. Kidney Int 67: 1654-1658, 2005
42. Yuan HT, Li XZ, Pitera JE, Long DA, Woolf AS: Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am J Pathol 163: 2289-2301, 2003
43. Molitoris BA, Sutton TA: Endothelial injury and dysfunction: Role in the extension phase of acute renal failure. Kidney Int 66: 496-499, 2004
44. Brodsky SV, Yamamoto T, Tada T, Kim B, Chen J, Kajiya F, Goligorsky MS: Endothelial dysfunction in ischemic acute renal failure: Rescue by transplanted endothelial cells. Am J Physiol Renal Physiol 282: F1140-F1149, 2002
45. Piepot HA, Groeneveld AB, van Lambalgen AA, Sipkema P: Endotoxin impairs endothelium-dependent vasodilation more in the coronary and renal arteries than in other arteries of the rat. J Surg Res 110: 413-418, 2003
46. Linas SL, Repine JE: Endothelial cells regulate proximal tubule epithelial cell sodium transport. Kidney Int 55: 1251-1258, 1999
47. Nangaku M: Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure. J Am Soc Nephrol 17: 17-25, 2006