S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death

Science

Volumn 297, Issue 5584, 2002, Pages 1186-1190

  Gu, Zezong ^a   Kaul, Marcus ^a   Yan, Boxu ^a   Kridel, Steven J ^a   Cui, Jiankun ^a   Strongin, Alex ^a   Smith, Jeffrey W ^a   Liddington, Robert C ^a   Lipton, Stuart A ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; DISEASES; ENZYMES; MASS SPECTROMETRY; PATHOLOGY;

PROTEOLYSIS;

CELLS;

GELATINASE B; MATRIX METALLOPROTEINASE; NITRIC OXIDE SYNTHASE; TISSUE INHIBITOR OF METALLOPROTEINASE;

BIOLOGY; NERVOUS SYSTEM DISORDER; NEUROLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; IMMUNOFLUORESCENCE TEST; MOUSE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STROKE; ZYMOGRAPHY;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CELL LINE; CELLS, CULTURED; CEREBRAL CORTEX; CYSTEINE; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, MOLECULAR; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; PHENYLMERCURIC ACETATE; RATS; RECOMBINANT PROTEINS; REPERFUSION; S-NITROSOTHIOLS; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA;

EID: 0037119624     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1073634     Document Type: Article

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32. We thank C. Ju for cerebrocortical cultures, G. del Zoppo for helpful discussions, and W. Li and K. Gramatikoff for modeling and illustration of the MMP-9 crystal structure. Z.G. and S.J.K. were supported by NIH grants NRSA T32 AG00252 and AR08505, respectively; M.K. was supported by the American Foundation for AIDS Research; J.W.S., R.C.L., and S.A.L. were supported in part by NIH grants P01 HD29587, R01 EY09024, R01 EY05477, R01 NS41207, R01 AR42750, and R01 CA 69306, and the American Heart Association.