Low-dose candesartan improves renal blood flow and kidney oxygen tension in rats with endotoxin-induced acute kidney dysfunction

Shock

Volumn 30, Issue 2, 2008, Pages 166-172

  Nitescu, Nicoletta ^a,c   Grimberg, Elisabeth ^b   Guron, Gregor ^b  

^a Institute of Clinical Sciences   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acute kidney failure; Angiotensin II; Candesartan; Renal blood flow; Renal medulla; Renal oxygenation; Sepsis

Indexed keywords

CANDESARTAN; ENDOTOXIN; ANTIHYPERTENSIVE AGENT; BENZIMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; OXYGEN; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROL GROUP; CONTROLLED STUDY; ENDOTOXEMIA; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; KIDNEY; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; MALE; NONHUMAN; OXYGEN TENSION; RAT; RENAL PROTECTION; SEPSIS; SPRAGUE DAWLEY RAT; URINALYSIS; ACUTE KIDNEY FAILURE; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; KIDNEY CIRCULATION; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY FAILURE, ACUTE; LIPOPOLYSACCHARIDES; MALE; OXYGEN; OXYGEN CONSUMPTION; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; TETRAZOLES;

EID: 52149108072     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31815dd780     Document Type: Article

References (35)

1. Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med 351:159-169, 2004.
2. Boffa JJ, Arendshorst WJ: Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock. J Am Soc Nephrol 16:117-124, 2005.
3. Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, Schrier RW: Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice. Am J Physiol Renal Physiol 283:F583-F587, 2002.
4. Yamaguchi N, Jesmin S, Zaedi S, Shimojo N, Maeda S, Gando S, Koyama A, Miyauchi T: Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat. Peptides 27:2258-2270, 2006.
5. Boldt J, Papsdorf M, Kumle B, Piper S, Hempelmann G: Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelial-derived substances in the critically ill. Crit Care Med 26:1663-1670, 1998.
6. Tarpey SB, Bennett T, Randall MD, Gardiner SM: Differential effects of endotoxaemia on pressor and vasoconstrictor actions of angiotensin II and arginine vasopressin in conscious rats. Br J Pharmacol 123:1367-1374, 1998.
7. Schwobel J, Fischer T, Lanz B, Mohaupt M: Angiotensin II receptor subtypes determine induced NO production in rat glomerular mesangial cells. Am J Physiol Renal Physiol 279:F1092-F1100, 2000.
8. Dielis AW, Smid M, Spronk HM, Houben AJ, Hamulyak K, Kroon AA, Ten Cate H, Del PW: Changes in fibrinolytic activity after angiotensin II receptor blockade in therapy-resistant hypertensive patients. J Thromb Haemost 5:1509-1515, 2007.
9. Gardiner SM, Kemp PA, March JE, Bennett T: Temporal differences between the involvement of angiotensin II and endothelin in the cardiovascular responses to endotoxaemia in conscious rats. Br J Pharmacol 119:1619-1627, 1996.
10. Gardiner SM, March JE, Kemp PA, Bennett T: Influence of CGRP (8-37), but not adrenomedullin (22-52), on the haemodynamic responses to lipopolysaccharide in conscious rats. Br J Pharmacol 127:1611-1618, 1999.
11. Laesser M, Oi Y, Ewert S, Fandriks L, Aneman A: The angiotensin II receptor blocker candesartan improves survival and mesenteric perfusion in an acute porcine endotoxin model. Acta Anaesthesiol Scand 48:198-204, 2004.
12. Cervenka L, Wang CT, Navar LG: Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats. Am J Physiol Renal Physiol 274:F940-F945, 1998.
13. Cervenka L, Navar LG: Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan. J Am Soc Nephrol 11:S197-S201, 1999.
14. Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K: Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H- tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J Pharmacol Exp Ther 266:114-120, 1993.
15. Guron G, Marcussen N, Nilsson A, Sundelin B, Friberg P: Postnatal time frame for renal vulnerability to enalapril in rats. J Am Soc Nephrol 10:1550-1560, 1999.
16. Nitescu N, Grimberg E, Ricksten SE, Marcussen N, Nordlinder H, Guron G: Effects of thrombin inhibition with melagatran on renal hemodynamics and function and liver integrity during early endotoxemia. Am J Physiol Regul Integr Comp Physiol 292:R1117-R1124, 2007.
17. Nitescu N, Grimberg E, Ricksten SE, Guron G: Effects of N-acetyl-L-cysteine on renal haemodynamics and function in early ischaemia-reperfusion injury in rats. Clin Exp Pharmacol Physiol 33:53-57, 2006.
18. Smits GJ, Roman RJ, Lombard JH: Evaluation of laser-Doppler flowmetry as a measure of tissue blood flow. J Appl Physiol 61:666-672, 1986.
19. Liss P, Nygren A, Revsbech NP, Ulfendahl HR: Intrarenal oxygen tension measured by a modified Clark electrode at normal and low blood pressure and after injection of x-ray contrast media. Pflugers Arch 434:705-711, 1997.
20. Harrison-Bernard LM, Cook AK, Oliverio MI, Coffman TM: Renal segmental microvascular responses to ANG II in AT1A receptor null mice. Am J Physiol Renal Physiol 284:F538-F545, 2003.
21. 2+ activity and contraction of rat mesangial cells. Pflugers Arch 430:721-728, 1995.
22. Wang W, Jittikanont S, Falk SA, Li P, Feng L, Gengaro PE, Poole BD, Bowler RP, Day BJ, Crapo JD, et al.: Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am J Physiol Renal Physiol 284:F532-F537, 2003.
23. Wang W, Mitra A, Poole B, Falk S, Lucia MS, Tayal S, Schrier R: Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure. Am J Physiol Renal Physiol 287:F1044-F1048, 2004.
24. Welch WJ, Blau J, Xie H, Chabrashvili T, Wilcox CS: Angiotensin-induced defects in renal oxygenation: role of oxidative stress. Am J Physiol Heart Circ Physiol 288:H22-H28, 2005.
25. Piepot HA, Groeneveld AB, van Lambalgen AA, Sipkema P: Endotoxin impairs endothelium-dependent vasodilation more in the coronary and renal arteries than in other arteries of the rat. J Surg Res 110:413-418, 2003.
26. DiBona GF, Jones SY, Sawin LL: Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation. Am J Physiol Regul Integr Comp Physiol 271:R361-R367, 1996.
27. 2 receptors in the renal cortical and medullary circulations of anesthetized rabbits. Hypertension 42:200-205, 2003.
28. Joly E, Nonclercq D, Caron N, Mertens J, Flamion B, Toubeau G, Kramp R, Bouby N: Differential regulation of angiotensin II receptors during renal injury and compensatory hypertrophy in the rat. Clin Exp Pharmacol Physiol 32:241-248, 2005.
29. Lugon JR, Boim MA, Ramos OL, Ajzen H, Schor N: Renal function and glomerular hemodynamics in male endotoxemic rats. Kidney Int 36:570-575, 1989.
30. Pallone TL: Vasoconstriction of outer medullary vasa recta by angiotensin II is modulated by prostaglandin E2. Am J Physiol Renal Physiol 266:F850-F857, 1994.
31. Nishiyama A, Seth DM, Navar LG: Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension 39:129-134, 2002.
32. Silldorff EP, Yang S, Pallone TL: Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat. J Clin Invest 95:2734-2740, 1995.
33. Agmon Y, Peleg H, Greenfeld Z, Rosen S, Brezis M: Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat. J Clin Invest 94:1069-1075, 1994.
34. Xie YW, Shen W, Zhao G, Xu X, Wolin MS, Hintze TH: Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro. Implications for the development of heart failure. Circ Res 79:381-387, 1996.
35. Brezis M, Rosen S: Hypoxia of the renal medulla - its implications for disease. N Engl J Med 332:647-655, 1995.