In vitro model of sepsis-induced renal epithelial reactive nitrogen species generation

Toxicological Sciences

Volumn 115, Issue 2, 2010, Pages 475-481

  Pathak, Elina ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cecal ligation and puncture; iNOS; L N6 (1 iminoethyl) lysine; mIMCD 3; NO; Renal tubular epithelial cells; RNS

Indexed keywords

5 CARBOXY 2,7' DICHLORODIHYDROFLUORESCEIN DIACETATE; 6 CARBOXY 2,7' DICHLORODIHYDROFLUORESCEIN DIACETATE; CYTOKINE; DICHLORODIHYDROFLUORESCEIN; DIHYDRORHODAMINE 123; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CECAL LIGATION; CECAL PUNCTURE; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY EPITHELIUM; KIDNEY INJURY; LIGATION; MALE; MOUSE; NONHUMAN; OXIDATION; PATHOGENESIS; PATHOPHYSIOLOGY; PUNCTURE; SEPSIS;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KIDNEY TUBULES; LYSINE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE NITROGEN SPECIES; RNA, MESSENGER; SEPSIS;

MURINAE; MUS;

EID: 77954074637     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq058     Document Type: Article

References (33)

1. Abraham, E., and Singer, M. (2007). Mechanisms of sepsis-induced organ dysfunction. Crit. Care Med. 35, 2408-2416.
2. Ahn, K. Y., Mohaupt, M. G., Madsen, K. M., and Kone, B. C. (1994). In situ hybridization localization of mRNA encoding inducible nitric oxide synthase in rat kidney. Am. J. Physiol. 267, F748-F57.
3. Bultinck, J., Sips, P., Vakaet, L., Brouckaert, P., and Cauwels, A. (2006). Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock. FASEB J. 20, 2363-2365.
4. Chiao, C. W., Lee, S. S., Wu, C. C., and Su, M. J. (2006). N-Allylsecoboldine as a novel agent prevents acute renal failure during endotoxemia. Eur. J. Pharmacol. 535, 291-300.
5. Cruthirds, D. L., Saba, H., and MacMillan-Crow, L. A. (2005). Overexpression of manganese superoxide dismutase protects against ATP depletion-mediated cell death of proximal tubule cells. Arch. Biochem. Biophys. 437, 96-105.
6. Doi, K., Leelahavanichkul, A., Yuen, P. S., and Star, R. A. (2009). Animal models of sepsis and sepsis-induced kidney injury. J. Clin. Invest. 119, 2868-2878.
7. Du, C., Guan, Q., Diao, H., Yin, Z., and Jevnikar, A. M. (2006). Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8. Am. J. Physiol. Renal Physiol. 290, F1044-F1054.
8. Gomes, A., Fernandes, E., and Lima, J. L. (2006). Use of fluorescence probes for detection of reactive nitrogen species: a review. J. Fluoresc. 16, 119-139.
9. Hagar, H., Ueda, N., and Shah, S. V. (1996). Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Am. J. Physiol. 271, F209-F215.
10. Handa, O., Stephen, J., and Cepinskas, G. (2008). Role of endothelial nitric oxide synthase-derived nitric oxide in activation and dysfunction of cerebrovascular endothelial cells during early onsets of sepsis. Am. J. Physiol. Heart Circ. Physiol. 295, H1712-H1719.
11. Heemskerk, S., Masereeuw, R., Russel, F. G., and Pickkers, P. (2009). Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat. Rev. Nephrol. 5, 629-640.
12. Heemskerk, S., Pickkers, P., Bouw, M. P., Draisma, A., van der Hoeven, J. G., Peters, W. H., Smits, P., Russel, F. G., and Masereeuw, R. (2006). Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury. Clin. J. Am. Soc. Nephrol. 1, 853-862.
13. Holmqvist, B., Olsson, C. F., Svensson, M. L., Svanborg, C., Forsell, J., and Alm, P. (2005). Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4. J. Mol. Hist. 36, 499-516.
14. Liaw, W. J., Chen, T. H., Lai, Z. Z., Chen, S. J., Chen, A., Tzao, C., Wu, J. Y., and Wu, C. C. (2005). Effects of a membrane-permeable radical scavenger, Tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock 23, 88-96.
15. Markewitz, B. A., Michael, J. R., and Kohan, D. E. (1993). Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells. J. Clin. Invest. 91, 2138-2143.
16. Miyaji, T., Hu, X., Yuen, P. S., Muramatsu, Y., Iyer, S., Hewitt, S. M., and Star, R. A. (2003). Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int. 64, 1620-1631.
17. Mohaupt, M. G., Schwobel, J., Elzie, J. L., Kannan, G. S., and Kone, B. C. (1995). Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells. Am. J. Physiol. 268, F770-F777.
18. Morrissey, J. J., McCracken, R., Kaneto, H., Vehaskari, M., Montani, D., and Klahr, S. (1994). Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int. 45, 998-1005.
19. Peluffo, G., Calcerrada, P., Piacenza, L., Pizzano, N., and Radi, R. (2009). Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am. J. Physiol. Heart Circ. Physiol. 296, H1781-H1792.
20. Radi, R., Cassina, A. M., Hodara, R., Quijano, C., and Castro, L. (2002). Peroxynitrite reactions and formation in mitochondria. Free Rad. Biol. Med. 33, 1451-1464.
21. Rauchman, M. I., Nigam, S. K., Delpire, E., and Gullans, S. R. (1993). An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am. J. Physiol. 265, F416-F424.
22. Remick, D. G. (2007). Pathophysiology of sepsis. Am. J. Pathol. 170, 1435-1444.
23. Russell, J. A. (2006). Management of sepsis. N. Engl. J. Med. 355, 1699-1713.
24. Schrier, R. W., and Wang, W. (2004). Acute renal failure and sepsis. N. Engl. J. Med. 351, 159-169.
25. Sobreira, C., Davidson, M., King, M. P., and Miranda, A. F. (1996). Dihydrorhodamine 123 identifies impaired mitochondrial respiratory chain function in cultured cells harboring mitochondrial DNA mutations. J. Histochem. Cytochem. 44, 571-579.
26. Tarpey, M. M., Wink, D. A., and Grisham, M. B. (2004). Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R431-R444.
27. Tiwari, M. M., Brock, R. W., Kaushal, G. P., and Mayeux, P. R. (2005). Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases. Am. J. Physiol. Renal Physiol. 289, F1324-F1332.
28. Tiwari, M. M., Messer, K. J., and Mayeux, P. R. (2006). Inducible nitric oxide synthase and apoptosis in murine proximal tubule epithelial cells. Toxicol. Sci. 91, 493-500.
29. Wang, W., Jittikanont, S., Falk, S. A., Li, P., Feng, L., Gengaro, P. E., Poole, B. D., Bowler, R. P., Day, B. J., Crapo, J. D., et al. (2003). Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am. J. Physiol. 284, F532-F537.
30. Wu, L., Gokden, N., and Mayeux, P. R. (2007a). Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury. J. Am. Soc. Nephrol. 18, 1807-1815.
31. Wu, L., and Mayeux, P. R. (2007). Effects of the inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl)-lysine on microcirculation and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. J. Pharmacol. Exp. Ther. 320, 1061-1067.
32. Wu, L., Tiwari, M. M., Messer, K. J., Holthoff, J. H., Gokden, N., Brock, R. W., and Mayeux, P. R. (2007b). Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am. J. Physiol. Renal Physiol. 292, F261-F268.
33. Zhang, C., Walker, L. M., and Mayeux, P. R. (2000). Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem. Pharmacol. 59, 203-209.