A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation

Shock

Volumn 35, Issue 2, 2011, Pages 178-183

  Inoue, Yoshiaki ^a,b   Tanaka, Hiroshi ^b   Sumi, Yuka ^a   Woehrle, Tobias ^a   Chen, Yu ^a   Hirsh, Mark I ^a   Junger, Wolfgang G ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JUNTENDO UNIVERSITY   (Japan)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

A3 adenosine receptor antagonist; acute lung injury; hypertonic saline; neutrophil elastase; Polymorphonuclear neutrophils; sepsis

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; SODIUM CHLORIDE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; INHIBITION KINETICS; LIGATION; MALE; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PUNCTURE; RESUSCITATION; SEPSIS;

ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; CELL MEMBRANE; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG; MALE; MICE; NEUTROPHIL INFILTRATION; NEUTROPHILS; RECEPTOR, ADENOSINE A3; RESUSCITATION; SALINE SOLUTION, HYPERTONIC; SEPSIS; TIME FACTORS;

EID: 78751626386     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181f221fb     Document Type: Article

References (33)

1. Botha AJ, Moore FA, Moore EE, Sauaia A, Banerjee A, Peterson VM: Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. J Trauma 39:411-417, 1995.
2. Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med 342:1334-1349, 2000.
3. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874, 1992.
4. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG: ATP release guides neutrophil chemotaxis via P2-2 and A3 receptors. Science 314:1792-1795, 2006.
5. Velasco IT, Pontieri V, Rocha e Silva M Jr, Lopes OU: Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol 239:H664YH673, 1980.
6. Velasco IT, Rocha e Silva M, Oliveira MA, Oliveira MA, Silva RI: Hypertonic and hyperoncotic resuscitation from severe hemorrhagic shock in dogs: a comparative study. Crit Care Med 17:262-264, 1989.
7. Younes RN, Aun F, Tomida RM, Birolini D: The role of lung innervation in the hemodynamic response to hypertonic sodium chloride solutions in hemorrhagic shock. Surgery 98:900-9061, 1985.
8. Junger WG, Hoyt DB, Davis RE, Herdon-Remelius C, Namiki S, Junger H, Loomis W, Altman A: Hypertonicity regulates the function of human neu-trophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest 101:2768-2779, 1998.
9. Angle N, Hoyt DB, Coimbra R, Liu F, Herdun-Remelius C, Loomis W, Junger WG: Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock 9:164-170, 1998.
10. Angle N, Hoyt DB, Coimbra R, Liu F, Herdon-Remelius C, Loomis W, Junger WG: Hypertonic saline enhances cellular immune function. Circ Shock 42:190-196, 1994.
11. Junger WG, Coimbra R, Liu FC, Herdon-Remelius C, Junger W, Junger H, Loomis W, Hoyt DB, Altman A: Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock 8:235-241, 1997.
12. Rizoli SB, Kapus A, Fan J, Li YH, Marshall JC, Rotstein OD: Immunomodu-latory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. J Immunol 161:6288-6296, 1998.
13. Rotstein OD: Novel strategies for immunomodulation after trauma: revisiting hypertonic saline as a resuscitation strategy for hemorrhagic shock. J Trauma 49:580-583, 2000.
14. Angle N, Hoyt DB, Cabello-Passini R, Herdon-Remelius C, Loomis W, Junger WG: Hypertonic resuscitation reduces neutrophil margination by suppressing neutrophil L selectin expression. J Trauma 45:7-13, 1998. (Pubitemid 28335149)
15. Murao Y, Hoyt DB, Loomis W, Namiki S, Patel N, Wolf P, Junger WG: Does the timing of hypertonic saline resuscitation affect its potential to prevent lung damage? Shock 14:18-23, 2000.
16. Murao Y, Loomis W, Wolf P, Hoyt DB, Junger WG: Effect of dose of hyper-tonic saline on its potential to prevent lung tissue damage in a mouse model of hemorrhagic shock. Shock 20:29-34, 2003.
17. Inoue Y, Chen Y, Hirsh MI, Yip L, Junger WG: A3 and P2-2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis. Shock 30:173-177, 2008.
18. Ciesla DJ, Moore EE, Zallen G, Biffl WL, Silliman CC: Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything. J Trauma 48:388-395, 2000.
19. Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet 363:1988-1996, 2004.
20. Inoue Y, Chen Y, Pauzenberger R, Hirsh MI, Junger WG: Hypertonic saline up-regulates A3 adenosine receptors expression of activated neutrophils and increases acute lung injury after sepsis. Crit Care Med 36:2569-2575, 2008.
21. Chen Y, Hashiguchi N, Yip L, Junger WG: Hypertonic saline enhances neu-trophil elastase release through activation of P2 and A3 receptors. Am J Physiol Cell Physiol 290:C1051YC1059, 2006.
22. Orlic T, Loomis WH, Shreve A, Namiki S, Junger WG: Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms. Am J Physiol Cell Physiol 282:C1261YC1269, 2002.
23. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG: A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol 76:245-253, 2004.
24. Mattox K, Maningas PA, Moore EE, Mateer JR, Marx JA, Aprahamian C, Burch JM, Pepe PE: Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. multicenter trial. 1. Ann Surg 213:482-491, 1991.
25. Nick JA, Avdi NJ, Young SK, Knall C, Gerwins P, Johnson GL, Worthen GS: Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J Clin Invest 99:975-986, 1997.
26. Hinschen AK, Rose'Meyer RB, Headrick JP: Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol 41: 73-80, 2003.
27. Liu GS, Richards SC, Olsson RA, Mullane K, Walsh RS, Downey JM: Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. Cardiovasc Res 28:1057-1061, 1994.
28. Headrick JP, Peart J: A3 adenosine receptor-mediated protection of the ische-mic heart. Vascul Pharmacol 42:271-279, 2005.
29. Young HW, Molina JG, Dimina D, Zhong H, Jacobson M, Chan LN, Chan TS, Lee JJ, Blackburn MR: A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol 173:1380-1389, 2004.
30. Young HW, Sun CX, Evans CM, Dickey BF, Blackburn MR: A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge. Am J Respir Cell Mol Biol 35:549-558, 2006.
31. Zhao Z, Kapoian T, Shepard M, Lianos EA: Adenosine-induced apoptosis in glomerular mesangial cells. Kidney Int 61:1276-1285, 2002.
32. Durham RM, Moran JJ, Mazuski JE, Shapiro MJ, Baue AE, Flint LM: Multiple organ failure in trauma patients. J Trauma 55:608-616, 2003.
33. Inoue Y, Seiyama A, Tanaka H, Ukai I, Akimau P, Nishino M, Shimazu T, Sugimoto H: Protective effects of a selective neutrophil elastase inhibitor (Sivelestat) on LPS-induced acute dysfunction of the pulmonary microcir-culation. Crit Care Med 33:1814-1822, 2005.