Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 5, 2006, Pages

  El Achkar, Tarek M ^a   Huang, Xiaoping ^a   Plotkin, Zoya ^a   Sandoval, Ruben M ^a   Rhodes, Georges J ^a   Dagher, Pierre C ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b Nephrology Division   (United States)

Author keywords

CD14; Cecal ligation and puncture; Lipopolysaccharide; Tamm Horsfall protein; TLR4

Indexed keywords

CD14 ANTIGEN; TAMM HORSFALL GLYCOPROTEIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GOLGI COMPLEX; IMMUNOFLUORESCENCE MICROSCOPY; INNATE IMMUNITY; KIDNEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEPSIS;

EID: 33646578794     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00414.2005     Document Type: Article

References (51)

1. Akira S and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4: 499-511, 2004.
2. Anders HJ, Banas B, and Schlondorff D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867, 2004.
3. Backhed F, Meijer L, Normark S, and Richter-Dahlfors A. TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14. Cell Microbiol 4: 493-501, 2002.
4. Backhed F, Soderhall M, Ekman P, Normark S, and Richter-Dahlfors A. Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract. Cell Microbiol 3: 153-158, 2001.
5. Basu S and Fenton MJ. Toll-like receptors: function and roles in lung disease. Am J Physiol Lung Cell Mol Physiol 286: L887-L892, 2004.
6. Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, and Kumar S. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int 65: 791-797, 2004.
7. Bussolati B, David S, Cambi V, Tobias PS, and Camussi G. Urinary soluble CD14 mediates human proximal tubular epithelial cell injury induced by LPS. Int J Mol Med 10: 441-449, 2002.
8. Chowdhury P, Sacks SH, and Sheerin NS. Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int 66: 1334-1344, 2004.
9. Cohen J. The immunopathogenesis of sepsis. Nature 420: 885-891, 2002.
10. Cunningham PN, Wang Y, Guo R, He G, and Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172: 2629-2635, 2004.
11. Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, and Molitoris BA. Functional studies of the kidney of living animals using multicolor two-photon microscopy. Am J Physiol Cell Physiol 283: C905-C916, 2002.
12. Dunzendorfer S, Lee HK, Soldau K, and Tobias PS. TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J Immunol 173: 1166-1170, 2004.
13. Fearns C, Kravchenko VV, Ulevitch RJ, and Loskutoff DJ. Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 181: 857-866, 1995.
14. Frendeus B, Wachtler C, Hedlund M, Fischer H, Samuelsson P, Svensson M, and Svanborg C. Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol Microbiol 40: 37-51, 2001.
15. Hedlund M, Frendeus B, Wachtler C, Hang L, Fischer H, and Svanborg C. Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells. Mol Microbiol 39: 542-552, 2001.
16. Heyman SN, Lieberthal W, Rogiers P, and Bonventre JV. Animal models of acute tubular necrosis. Curr Opin Crit Care 8: 526-534, 2002.
17. Hornef MW, Frisan T, Vandewalle A, Normark S, and Richter-Dahlfors A. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med 195: 559-570, 2002.
18. Kang YH, Falk MC, Bentley TB, and Lee CH. Distribution and role of lipopolysaccharide in the pathogenesis of acute renal proximal tubule injury. Shock 4: 441-449, 1995.
19. Kelly KJ, Plotkin Z, and Dagher PC. Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury. J Clin Invest 108: 1291-1298, 2001.
20. Kelly KJ, Plotkin Z, Vulgamott SL, and Dagher PC. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. J Am Soc Nephrol 14: 128-138, 2003.
21. Kelly KJ, Sandoval RM, Dunn KW, Molitoris BA, and Dagher PC. A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis. Am J Physiol Cell Physiol 284: C1309-C1318, 2003.
22. Kelly KJ, Sutton TA, Weathered N, Ray N, Caldwell EJ, Plotkin Z, and Dagher PC. Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury. Am J Physiol Renal Physiol 287: F760-F766, 2004.
23. Kim BS, Lim SW, Li C, Kim JS, Sun BK, Ahn KO, Han SW, Kim J, and Yang CW. Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation 79: 1370-1377, 2005.
24. Kitchens RL, Wang P, and Munford RS. Bacterial lipopolysaccharide can enter monocytes via two CD14-dependent pathways. J Immunol 161: 5534-5545, 1998.
25. Laestadius A, Soderblom T, Aperia A, and Richter-Dahlfors A. Developmental aspects of Escherichia coli-induced innate responses in rat renal epithelial cells. Pediatr Res 54: 536-541, 2003.
26. Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, and Espevik T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem 277: 47834-47843, 2002.
27. Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, and Florquin S. Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 115: 2894-2903, 2005.
28. Lim SW, Li C, Ahn KO, Kim J, Moon IS, Ahn C, Lee JR, and Yang CW. Cyclosporine-induced renal injury induces Toll-like receptor and maturation of dendritic cells. Transplantation 80: 691-699, 2005.
29. Michelsen KS, Doherty TM, Shah PK, and Arditi M. Role of Toll-like receptors in atherosclerosis. Circ Res 95: e96-e97, 2004.
30. Miyaji T, Hu X, Yuen PS, Muramatsu Y, Iyer S, Hewitt SM, and Star RA. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64: 1620-1631, 2003.
31. Morrissey J, Guo G, McCracken R, Tolley T, and Klahr S. Induction of CD14 in tubular epithelial cells during kidney disease. J Am Soc Nephrol 11: 1681-1690, 2000.
32. Musson RA, Morrison DC, and Ulevitch RJ. Distribution of endotoxin (lipopolysaccharide) in the tissues of lipopolysaccharide-responsive and -unresponsive mice. Infect Immun 21: 448-457, 1978.
33. Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, and Mann DL. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol 282: H2316-H2323, 2002.
34. Nishimura M and Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28: 886-892, 2005.
35. Pak J, Pu Y, Zhang ZT, Hasty DL, and Wu XR. Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. J Biol Chem 276: 9924-9930, 2001.
36. Phillips CL, Arend LJ, Filson AJ, Kojetin DJ, Clendenon JL, Fang S, and Dunn KW. Three-dimensional imaging of embryonic mouse kidney by two-photon microscopy. Am J Pathol 158: 49-55, 2001.
37. Pugin J, Schurer-Maly CC, Leturcq D, Moriarty A, Ulevitch RJ, and Tobias PS. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90: 2744-2748, 1993.
38. Riedemann NC, Guo RF, and Ward PA. The enigma of sepsis. J Clin Invest 112: 460-467, 2003.
39. Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, and Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev 204: 27-42, 2005.
40. Rothstein JL and Schreiber H. Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci USA 85: 607-611, 1988.
41. Sabroe I, Read RC, Whyte MK, Dockrell DH, Vogel SN, and Dower SK. Toll-like receptors in health and disease: complex questions remain. J Immunol 171: 1630-1635, 2003.
42. Saemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, Sobanov Y, Stulnig TM, Akira S, von Gabain A, von Ahsen U, Horl WH, and Zlabinger GJ. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 115: 468-475, 2005.
43. Samuelsson P, Hang L, Wullt B, Irjala H, and Svanborg C. Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect Immun 72: 3179-3186, 2004.
44. Schilling JD, Martin SM, Hung CS, Lorenz RG, and Hultgren SJ. Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc Natl Acad Sci USA 100: 4203-4208, 2003.
45. Serafini-Cessi F, Malagolini N, and Cavallone D. Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 42: 658-676, 2003.
46. Tsuboi N, Yoshikai Y, Matsuo S, Kikuchi T, Iwami K, Nagai Y, Takeuchi O, Akira S, and Matsuguchi T. Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol 169: 2026-2033, 2002.
47. Wichterman KA, Baue AE, and Chaudry IH. Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res 29: 189-201, 1980.
48. Wolfs TG, Buurman WA, van Schadewijk A, de Vries B, Daemen MA, Hiemstra PS, and van't Veer C. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated upregulation during inflammation. J Immunol 168: 1286 -1293, 2002.
49. Zarember KA and Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168: 554-561, 2002.
50. Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G, and Kupiec-Weglinski JW. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol 173: 7115-7119, 2004.
51. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, and Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526, 2004.