Early microvascular changes in sepsis and severe sepsis

Shock

Volumn 33, Issue 4, 2010, Pages 387-391

  Spanos, Angeliki ^a   Jhanji, Shaman ^a   Vivian Smith, Amanda ^a   Harris, Tim ^b   Pearse, Rupert M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

Author keywords

Microcirculation; Sepsis

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; MALE; MICROCIRCULATION; OBSERVATIONAL STUDY; SEPSIS; BLOOD FLOW; MORTALITY; MOUTH; PATHOLOGY; PATHOPHYSIOLOGY; VASCULARIZATION;

ADULT; FEMALE; HUMANS; MALE; MICROCIRCULATION; MOUTH FLOOR; REGIONAL BLOOD FLOW; SEPSIS;

EID: 77954734108     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181c6be04     Document Type: Article

References (32)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310, 2001.
2. Harrison D, Welch C, Eddleston J: The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 10:R42, 2006.
3. Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, Sicignano A, Palazzo M, Moreno R, Boulme R, et al.: Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 28:108-121, 2002.
4. Brun-Buisson C, Meshaka P, Pinton P, Vallet B: EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 30:580-588, 2004.
5. Levy MM, Macias WL, Vincent JL, Russell JA, Silva E, Trzaskoma B, Williams MD: Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 33:2194-2201, 2005.
6. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368-1377, 2001.
7. Landry DW, Oliver JA: The pathogenesis of vasodilatory shock. N Engl J Med 345:588-595, 2001.
8. Marik PE, Varon J: The hemodynamic derangements in sepsis: implications for treatment strategies. Chest 114:854-860, 1998.
9. DeBacker D, Creteur J, Preiser JC, Dubois MJ, Vincent JL: Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98-104, 2002.
10. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL: Persistent micro-circulatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32:1825-1831, 2004.
11. van Eijk LT, Nooteboom A, Hendriks T, Sprong T, Netea MG, Smits P, van der Hoeven JG, Pickkers P: Plasma obtained during human endotoxemia increases endothelial albumin permeability in vitro. Shock 25:358-362, 2006.
12. Jonkam CC, Lange M, Traber DL, Maybauer DM, Maybauer MO, Bansal K, Hamahata A, Zhu Y, Esechie A, Traber LD, et al.: Cardiovascular collapse and vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis. Shock 32:621-625, 2009.
13. Croner RS, Hoerer E, Kulu Y, Hackert T, Gebhard MM, Herfarth C, Klar E: Hepatic platelet and leukocyte adherence during endotoxemia. Crit Care 10:R15, 2006.
14. Ellis CG, Bateman RM, Sharpe MD, Sibbald WJ, Gill R: Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis. Am J Physiol Heart Circ Physiol 282:H156-H164, 2002.
15. 2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am J Physiol Heart Circ Physiol 290:H2277-H2285, 2006.
16. Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL, Arnold RC, Colilla S, Zanotti S, Hollenberg SM: Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 49:88-98, 98 e81-82, 2007.
17. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34: 2210-2217, 2008.
18. Lamontagne F, Meade M, Ondiveeran HK, Lesur O, Robichaud AE: Nitric oxide donors in sepsis: a systematic review of clinical and in vivo preclinical data. Shock 30:653-659, 2008.
19. De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL: The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 34: 403-408, 2006.
20. Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF: Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 360:1395-1396, 2002.
21. De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL: Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 34:1918-1924, 2006.
22. Contaldo C, Elsherbiny A, Lindenblatt N, Plock JA, Trentz O, Giovanoli P, Menger MD, Wanner GA: Erythropoietin enhances oxygenation in critically perfused tissue through modulation of nitric oxide synthase. Shock 31: 599-606, 2009.
23. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655, 1992.
24. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32:858-873, 2004.
25. Ince C: The microcirculation is the motor of sepsis. Crit Care 9:S13-S19, 2005.
26. Jhanji S, Lee C, Watson D, Hinds C, Pearse RM: Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med 35:671-677, 2009.
27. De Backer D, Hollenberg S, Boerma C, Goedhart P, Buchele G, Ospina-Tascon G, Dobbe I, Ince C: How to evaluate the microcirculation: report of a round table conference. Crit Care 11:R101, 2007.
28. Jhanji S, Dawson J, Pearse RM: Cardiac output monitoring: basic science and clinical application. Anaesthesia 63:172-181, 2008.
29. Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM: The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 37:1961-1966, 2009.
30. Boerma EC, van der Voort PH, Spronk PE, Ince C: Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med 35:1055-1060, 2007.
31. Creteur J, De Backer D, Sakr Y, Koch M, Vincent JL: Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 32: 516-523, 2006.
32. Kelly RI, Pearse R, Bull RH, Leveque JL, de Rigal J, Mortimer PS: The effects of aging on the cutaneous microvasculature. J Am Acad Dermatol 33:749-756, 1995.