Oxidant stress in rat liver after lipopolysaccharide administration: Effect of inducible nitric-oxide synthase inhibition

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 3, 2000, Pages 968-972

  Zhang, Chaojie ^a   Walker, Lisa M ^a   Hinson, Jack A ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; IMINOETHYL LYSINE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITOR INTERACTION; HISTOPATHOLOGY; LIVER METABOLISM; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BLOTTING, WESTERN; ENZYME INHIBITORS; GLUTATHIONE; LIPOPOLYSACCHARIDES; LIVER; MALE; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034131309     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bautista AP and Spitzer JJ (1990) Superoxide anion generation by in situ perfused rat liver: Effect of in vivo endotoxin. Am J Physiol 259:G907-G912.
2. Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS and Currie MG (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol 273:15-24.
3. Crespo E, Macias M, Pozo D, Escames G, Martin M, Vives F, Guerrero JM and Acuna-Castroviejo D (1999) Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. FASEB J 13:1537-1546.
4. Darley-Usmar V, Wiseman H and Halliwell B (1995) Nitric oxide and oxygen radicals: A question of balance. FEBS Lett 369:131-135.
5. Demling RH, Lalonde CJL-J, Ryan P and Fox R (1986) Endotoxemia causes increased lung tissue lipid peroxidation in unanesthetized sheep. J Appl Physiol 60:2094-2100.
6. Draper HH and Hadley MH (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421-431.
7. Duval DL, Miller DR, Collier J and Billings RE (1996) Characterization of hepatic nitric oxide synthase: Identification as the cytokine-inducible form primarily regulated by oxidants. Mol Pharmacol 50:277-284.
8. Eschwege P, Paradis V, Conti M, Holestege A, Richet F, Deteve J, Menager P, Legrand A, Jardin A, Bedossa P and Benoit G (1999) In situ detection of lipid peroxidation by-products as markers of renal ischemia injuries in rat kidneys. J Urol 162:553-557.
9. Esterbauer H, Schraur RJ and Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med 11:81-128.
10. Faas MM, Schuiling GA, Valkhof N, Baller JWF and Bakker WW (1998) Superoxide-mediated glomerulopathy in the endotoxin-treated pregnant rat. Kidney Blood Press Res 21:432-437.
11. Faraci WS, Nagel AA, Verdries KA, Vincent LA, Xu H, Nichols LE, Labasi JM, Salter ED and Pettipher ER (1996) 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br J Pharmacol 119:1101-1108.
12. Hinson JA, Pike SL, Pumford NR and Mayeux PR (1998) Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol 11:604-607.
13. Jaeschke H (1992) Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo. Am J Physiol 263:G60-G68.
14. Jaeschke H and Farhood A (1991) Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver in vivo. Am J Physiol 260:G355-G362.
15. Li J and Billiar JR (1999) Nitric oxide. IV. Determinants of nitric oxide protection and toxicity in liver. Am J Physiol 276:G1069-G1073.
16. Mayeux PR (1997) Pathobiology of lipopolysaccharide. J Toxicol Environ Health 51:415-435.
17. Mayeux PR, Garner HR, Gibson JD and Beanum VC (1995) Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules. Biochem Pharmacol 49:115-118.
18. Michael SL, Pumford NR, Mayeux PR, Niesman MR and Hinson JA (1999) Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology 30: 186-195.
19. Milligan SA, Hoeffel JM, Goldstein IM and Flick MR (1988) Effect of catalase on endotoxin-induced acute lung injury in unanesthetized sheep. Am Rev Respir Dis 137:420-428.
20. Pryor WA and Squadrito GL (1995) The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol 268:L699-L722.
21. Rockey DC and Chung JJ (1996) Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am J Physiol 271:G260-G267.
22. Roland CR, Naziruddin B, Mohanakumar T and Flye MW (1996) Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction. J Leukoc Biol 60:487-492.
23. Schwartz D, Mendonca M, Schwartz I, Xia Y, Satriano J, Wilson CB and Blantz RC (1997) Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rate. J Clin Invest 100:439-448.
24. Sies H, Sharov VS, Klotz L-O and Briviba K (1997) Glutathione peroxidase protects against peroxynitrite-mediated oxidations. J Biol Chem 272:27812-27817.
25. Stamler JS (1994) Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 78:931-936.
26. Stamler JS, Singel DJ and Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science (Wash DC) 258:1898-1902.
27. Szabo C, Day BJ and Salzman AL (1996) Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett 381:82-86.
28. Titheradge MA (1999) Nitric oxide in septic shock. Biochim Biophys Acta 1411:437-455.
29. Traylor LA and Mayeux PR (1997) Nitric oxide generation mediates lipid A-induced oxidant injury in renal proximal tubules. Arch Biochem Biophys 338:129-135.
30. Uchida K, Itakura K, Kawakishi S, Hiai H, Toyokuni S and Stadtman ER (1995) Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies. Arch Biochem Biophys 324:241-248.
31. Uchida K and Stadtman ER (1992) Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci USA 89:4544-4548.
32. Uchida K, Szweda LI, Chae H-Z and Stadtman ER (1993) Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proc Natl Acad Sci USA 90:8742-8746.
33. Wang JH, Redmond PH, Wu QD and Bouchier-Hayes D (1998a) Nitric oxide mediates hepatocyte injury. Am J Physiol 275:G1117-G1126.
34. Wang Y, Lawson JA and Jaeschke H (1998b) Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia. Shock 10:20-25.
35. Wenzel RP, Pinsky MR, Ulevitch RJ and Young L (1996) Current understandings of sepsis. Clin Infect Dis 22:407-413.
36. Wray GM, Millar CG, Hinds CJ and Thiemerman (1998) Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock 9:329-335.
37. Zainal TA, Weindruch R, Szweda LI and Oberley TD (1999) Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med 26:1181-1193.
38. Zhang C, Walker LM and Mayeux PR (2000) Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem Pharmacol 59:203-209.
39. Zurovsky Y and Gispaan I (1995) Antioxidants attenuate endotoxin-induced acute renal failure in rats. Am J Kidney Dis 25:51-57.