The microcirculation is the motor of sepsis

Critical Care

Volumn 9, Issue SUPPL. 4, 2005, Pages

  Ince, Can ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACTIVATED PROTEIN C; GLYCERYL TRINITRATE; INDUCIBLE NITRIC OXIDE SYNTHASE; STEROID; VASOPRESSIN;

DISEASE COURSE; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEMODYNAMIC MONITORING; HEMODYNAMICS; HUMAN; HYPOXIA; INFLAMMATION; ISCHEMIA; MICROCIRCULATION; NONHUMAN; OXYGEN TRANSPORT; PATHOGENESIS; PERFUSION; POLARIZATION MICROSCOPY; PRIORITY JOURNAL; RESUSCITATION; REVIEW; SEPSIS; TISSUE OXYGENATION;

ANIMALS; FLUID THERAPY; HUMANS; MICROCIRCULATION; MITOCHONDRIAL DISEASES; OXYGEN; RESUSCITATION; SEPSIS; SHOCK; VASODILATOR AGENTS;

EID: 27144553471     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc3753     Document Type: Review

References (74)

1. Spronk PE, Zandstra DF, Ince C: Bench-to-bedside review: Sepsis is a disease of the microcirculation. Crit Care 2004, 8:462-468.
2. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831.
3. Meakins JL, Marshall JC: The gastrointestinal tract: the 'motor' of MOF. Arch Surg 1986, 121:197-204.
4. Vallet B: Endothelial cell dysfunction and abnormal tissue perfusion. Crit Care Med 2002, 30(suppl 5):S229-S234.
5. Lidington D, Tyml K, Ouellette Y: Lipopolysaccharide-induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin. J Cell Physiol 2002, 193:373-379.
6. Bateman RM, Sharpe MD, Ellis CG: Bench-to-bedside review: Microvascular dysfunction in sepsis - hemodynamics, oxygen transport, and nitric oxide. Crit Care 2003, 7:359-373.
7. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL: Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166:98-104.
8. Lam C, Tyml K, Martin C, Sibbald W: Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 1994, 94:2077-2083.
9. Nakijima Y, Baudry N, Durante J, Vicaut E: Microcirculation in intestinal villi: a comparison between hemorrhagic and endotoxin shock. Am J Respir Crit Care Med 2001, 164:1526-1530.
10. Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF: Nitroglycerin promotes microvascular recruitment in septic shock after intravascular volume resuscitation. Lancet 2002, 360:1395-1396.
11. Goldman D, Bateman RM, Ellis CG: Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model. Am J Physiol Heart Circ Physiol 2004, 287:H2535-H2544.
12. Ince C, Sinaappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999, 27:1369-1377.
13. Sinaasappel, M, van Iterson M, Ince C: Microvascular oxygen pressure measurements in the intestine during hemorrhagic shock and resuscitation. J Physiol (Lond) 1999, 514:245-253.
14. Schwarte LA, Fournell A, van Bommel J, Ince C: Redistribution of intestinal microcirculatory oxygenation during acute hemodilution in pigs. J Appl Physiol 2005, 98:1070-1075.
15. Morin MJ, Unno N, Hodin RA, Fink MP: Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med 1998, 26:1258-1264.
16. Revelly JP, Ayuse T, Brienza N, Fessier HE, Robotham JL: Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 1996, 24:1345-1351.
17. Baker CH, Wilmoth FR: Microvascular responses to E. coli endotoxin with altered adrenergic activity. Circ Shock 1984, 12:165-176.
18. Price SA, Spain DA, Wilson MA, Harris PD, Garrison RN: Subacute sepsis impairs vascular smooth muscle contractile machinery and alters vasoconstrictor and dilator mechanisms. J Surg Res 1999, 83:75-80.
19. Baskurt OK, Temiz A, Meiselman HJ: Red blood cell aggregation in experimental sepsis. J Lab Clin Med 1997, 130:183-190.
20. Piagnerelli M, Boudjeltia KZ, Vanhaeverbeek M, Vincent JL: Red blood cell rheology in sepsis. Intensive Care Med 2003, 29:1052-1061.
21. Siegemund M, Hardeman MR, van Bommel J, Stegenga ME, Lind A, Ince C: Red blood cell deformability in two different doses of LPS in a porcine model of endotoxemia. Intensive Care Med 1999, 25:821.
22. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, et al.: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003, 9:1498-1505.
23. Singel DJ, Stamler JS: Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. Annu Rev Physiol 2005, 67:99-145.
24. Cerwinka WH, Cooper D, Krieglstein CF, Ross CR, McCord JM, Granger DN: Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. Am J Physiol Heart Circ Physiol 2003, 284:H535-H541.
25. Martins PS, Kallas EG, Neto MC, Dalboni MA, Blecher S, Salomao R: Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock. Shock 2003, 20:208-212.
26. Victor VM, Rocha M, De la Fuente M: Immune cells: free radicals and antioxidants in sepsis. Int Immunopharmacol 2004, 4:327-347.
27. Fink MP: Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness. Curr Opin Crit Care 2003, 9:143-151.
28. van den Berg BM, Vink H, Spaan JA: The endothelial glycocalyx protects against myocardial edema. Circ Res 2003, 92:592-594.
29. Fink MP: Cytopathic hypoxia in sepsis. Acta Anaesthesiol Scand Suppl 1997, 110:87-95.
30. Ince C: Microcirculatory weak units: an alternative explanation. Crit Care Med 2000, 28:3128-3129.
31. Avontuur JAM, Bruining HA, Ince C: Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 1995, 76:418-425.
32. Eerbeek O, Milstein DMJ, Ince C: Microcirculatory dysfunction in Langendorff endotoxemic rat hearts. Shock 2004, 21:81.
33. Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Singer M: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360:219-223.
34. Dubois MJ, de Backer D, Creteur J, Anane S, Vincent JL: Effect of vasopressin on sublingual microcirculation in a patient with distributive shock. Intensive Care Med 2003, 29:1020-1023.
35. Spronk PE, Kanoore-Edul VS, Ince C: Microcirculatory and mitochondrial distress syndrome (MMDS): a new look at sepsis. In Functional Hemodynamic Monitoring. Edited by Pinsky MR, Payen D. Berlin: Springer-Verlag; 2004.
36. Update in Intensive Care Emergency Medicine 2004, 42:47-69.
37. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
38. Siegemund, M, van Bommel J, Ince C: Assessment of regional tissue oxygenation. Intensive Care Med 1999, 25:1044-1060.
39. 2 in patients with septic shock. Crit Care Med Suppl 2004, 31:419.
40. Guzman JA, Dikin MS, Kruse JA: Lingual, splanchnic, and systemic hemodynamic and carbon dioxide tension changes during endotoxic shock and resuscitation. J Appl Physiol 2005, 98:108-113.
41. Venkatesh B, Morgan TJ, Hall J, Willgoss EZ: Subcutaneous gas tensions closely track ileal mucosal gas tensions in a model of endotoxemia without anaerobism. Intensive Care Med 2005, 31:447-454.
42. Weil MH, Nakagawa Y, Tang W, Sato Y, Ercoli F, Finegan R, Grayman G, Bisera J: Sublingual capnometry: a new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med 1999, 27:1225-1229.
43. Buise MP, Ince C, Tilanus HW, Gommers D, van Bommel J: The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction. Anesth Analg 2005, 100:1107-1111.
44. Atasever B, van der Veen A, Goedhart P, de Mo B, Ince C: Sublingual NIRS and reflectance spectrophotometry: new methods to monitor sublingual oxygen availability. Crit Care 2005, 8(suppl 1):P73.
45. Mathura KR, Voilebrecht KC, Boer K, de Graaf JC, Ubbink DT, Ince C: Comparison of OPS imaging to intravital capillarosopy of nail fold microcirculation. J Appl Physiol 2001, 91:74-78.
46. Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, Nadeau R: Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999, 5:1209-1212.
47. Mathura KR, Alic L, Ince C: Initial clinical experience with OPS imaging. In Yearbook of Intensive Care and Emergency Medicine. Edited by Vincent JL Berlin: Springer-Verlag; 2001:233-244.
48. Mathura KR, Bouma GJ, Ince C: Abnormal microcirculation in brain tumours during surgery. Lancet 2001, 358:1698-1699.
49. Pennings F, Bouma GJ, Ince C: Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility. Stroke 2004, 35:1284-1288.
50. Ince C: Sidestream dark field (SDF) imaging: an improved technique to observe sublingual microcirculation. Crit Care 2005, 8(suppl 1):P72.
51. Siegmund M, van Bommel J, Schwarte LA, Emons M, Rademacher P, Ince C: Selective blockade of iNOS by 1400W restores the gut oxygenation in a pig model of low-dose endotoxaemia. Intensive Care Med 31:985-992.
52. Van Iterson, M Siegemund, K Burhop, Ince C: Heart and gut microvascular oxygenation in pigs after resuscitation from hemorrhage by different doses of a hemoglobin based oxygen carrier. J Trauma 2003, 55:1111-1124.
53. Anning PB, Finney SJ, Singh S, Winlove CP, Evans TW: Fluids reverse the early lipopolysaccharide-induced albumin leakage in rodent mesenteric venules. Intensive Care Med 2004, 30:1944-1949.
54. Raat NJ, Verhoeven AJ, Mik EG, Gouwerok CW, Verhaar R, Goedhart PT, de Korte D, Ince C: The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model. Crit Care Med 2005, 33:39-45.
55. Van Iterson M, Ince C: Resuscitation of the microcirculation with haemoglobin based oxygen carriers following hemorrhage. In Yearbook of Intensive Care and Emergency Medicine. Edited by Vincent JL Berlin: Springer-Verlag; 2004:762-779.
56. Avontuur JA, Bruining HA, Ince C: Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. Cardiovasc Res 1997, 35:368-376.
57. Groeneveld AB, van Lambalgen AA, van den Bos GC, Bronsveld W, Nauta JJ, Thijs LG: Maldistribution of heterogeneous coronary blood flow during canine endotoxin shock. Cardiovasc Res 1991, 25:80-88.
58. Hollenberg SM, Broussard M, Osman J, Parillo JE: Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 2000, 86:774-779.
59. Pittner A, Nalos M, Asfar P, Yang Y, Ince C, Georgieff M, Bruckner UB, Radermacher P, Froba G: Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Intensive Care Med 2003, 29:312-316.
60. Wang le F, Patel M, Razavi HM, Weicker S, Joseph MG, McCormack DG, Mehta S: Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis. Am J Respir Crit Care Med 2002, 165:1634-1639.
61. Duma D, Silva-Santos JE, Assreuy J: Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. Crit Care Med 2005, 32:2304-2310.
62. Keh D, Sprung CL: Use of corticosteroid therapy in patients with sepsis and septic shock: an evidence-based review. Crit Care Med 2004, 32:5527-5533.
63. Buwalda M, Ince C: Opening the microcirculation: can vasodilators be useful in sepsis? Intensive Care Med 2002, 28:1208-1217.
64. Siegemund M, van Bommel J, Voilebrecht K, Dries J, Ince C: Influence of NO donor SIN-1 on the gut oxygenation in a normodynamic, porcine model of low-dose endotoxaemia. Intensive Care Med 2000, 26:5362.
65. Boerma EC, van der Voort PHJ, Ince C: Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock. Acta Anaesth Scand 2005, doi: 1011/j/1399-6576.2005.00752.x
66. Albert M, Losser MR, Hayon D, Faivre V, Payen D: Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits. Crit Care Med 2001, 32: 1891-1898.
67. Westphal M, Freise H, Kehe BE, Bone HG, van Aken H, Seilenkamp AW: Argenine vasopressin compromises gut mucosal microcirculation in septic rats. Crit Care Med 2004, 32:194-200.
68. Bernard GR, Vincent JL, Laterre P, Larosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Heiterbrand JD, Ely EW, Fisher CJ Jr, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709.
69. Isobe H, Okajima K, Uchiba M, Mizutani A, Harada N, Nagasaki A, Okabe K: Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation 2001, 104:1171-1175.
70. Brueckmann M, Hoffmann U, Dvortsak E, Lang S, Kaden JJ, Borggrefe M, Haase KK: Drotrecogin alfa (activated) inhibits NF-kappa B activation and MIP-1-alpha release from isolated mononuclear cells of patients with severe sepsis. Inflamm Res 2004, 53:528-533.
71. Yamaji K, Wang Y, Liu Y, Abeyama K, Hashiguchi T, Uchimura T, Krishna Biswas K, Iwamoto H, Maruyama I: Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation. Thromb Res 2005, 115:319-325.
72. Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Fertmann J, Schildberg FW, Menger MD: Microhemodynamic and cellular mechanisms of activated protein action during endotoxemia. Crit Care Med 2004, 32:1011-1017.
73. Iba T, Kidokoro A, Fukunaga M, Nagakari K, Shirahama A, Ida Y: Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med 2005, 33:368-372.
74. Ince C: The microcirculation in distress: a new resuscitation end-point? Crit Care Med 2004, 32:1963-1964.