Levosimendan for resuscitating the microcirculation in patients with septic shock: A randomized controlled study

Critical Care

Volumn 14, Issue 6, 2010, Pages

  Morelli, Andrea ^a   Donati, Abele ^b   Ertmer, Christian ^c   Rehberg, Sebastian ^c   Lange, Matthias ^c   Orecchioni, Alessandra ^a   Cecchini, Valeria ^a   Landoni, Giovanni ^d   Pelaia, Paolo ^b   Pietropaoli, Paolo ^a   Van Aken, Hugo ^c   Teboul, Jean Louis ^e   Ince, Can ^f,g   Westphal, Martin ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e BICÊTRE HOSPITAL   (France)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; LEVOSIMENDAN; HYDRAZONE DERIVATIVE; PYRIDAZINE DERIVATIVE; SIMENDAN;

ADULT; AGED; ARTICLE; BLOOD FLOW; BLOOD VOLUME; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GENETIC HETEROGENEITY; HEART CATHETERIZATION; HEMODYNAMICS; HUMAN; INTENSIVE CARE UNIT; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MICROVASCULATURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESUSCITATION; SEPTIC SHOCK; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; TONGUE; VASCULARIZATION;

AGED; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDRAZONES; MALE; MICROCIRCULATION; MIDDLE AGED; PROSPECTIVE STUDIES; PYRIDAZINES; RESUSCITATION; SHOCK, SEPTIC; TONGUE;

EID: 78650368315     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9387     Document Type: Article

References (35)

1. Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, Hollenberg SM, . Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008, 15:399-413. 10.1111/j.1553-2712.2008.00109.x, 2727641, 18439194, Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators.
2. De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, Vincent JL. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006, 34:403-408. 10.1097/01.CCM.0000198107.61493.5A, 16424721.
3. Buwalda M, Ince C. Opening the microcirculation: can vasodilators be useful in sepsis?. Intensive Care Med 2002, 28:1208-1217. 10.1007/s00134-002-1407-2, 12209267.
4. Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360:1395-1396. 10.1016/S0140-6736(02)11393-6, 12423989.
5. Boerma EC, Koopmans M, Konijn A, Kaiferova K, Bakker AJ, van Roon EN, Buter H, Bruins N, Egbers PH, Gerritsen RT, Koetsier PM, Kingma WP, Kuiper MA, Ince C. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med 2010, 38:93-100. 10.1097/CCM.0b013e3181b02fc1, 19730258.
6. Noto A, Giacomini M, Palandi A, Stabile L, Reali-Forster C, Iapichino G. Levosimendan in septic cardiac failure. Intensive Care Med 2005, 31:164-165. 10.1007/s00134-004-2502-3, 15580334.
7. Morelli A, De Castro S, Teboul JL, Singer M, Rocco M, Conti G, De Luca L, Di Angelantonio E, Orecchioni A, Pandian NG, Pietropaoli P. Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 2005, 31:638-644. 10.1007/s00134-005-2619-z, 15812624.
8. Morelli A, Teboul JL, Maggiore SM, Vieillard-Baron A, Rocco M, Conti G, De Gaetano A, Picchini U, Orecchioni A, Carbone I, Tritapepe L, Pietropaoli P, Westphal M. Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. Crit Care Med 2006, 34:2287-2293. 10.1097/01.CCM.0000230244.17174.4F, 16791109.
9. Powell BP, De Keulenaer BL. Levosimendan in septic shock: a case series. Br J Anaesth 2007, 99:447-448. 10.1093/bja/aem225, 17702832.
10. Pinto BB, Rheberg S, Ertmer C, Westphal M. Role of levosimendan in sepsis and septic shock. Curr Opin Anaesthesiol 2008, 21:168-177. 10.1097/ACO.0b013e3282f43c56, 18443483.
11. Toller WG, Stranz C. Levosimendan, a new inotropic and vasodilator agent. Anesthesiology 2006, 104:556-569. 10.1097/00000542-200603000-00024, 16508404.
12. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Muhl H, Boost KA, Hofstetter C. Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med 2009, 35:1412-1419. 10.1007/s00134-009-1481-9, 19367398.
13. Antoniades C, Tousoulis D, Koumallos N, Marinou K, Stefanadis C. Levosimendan: beyond its simple inotropic effect in heart failure. Pharmacol Ther 2007, 114:184-197. 10.1016/j.pharmthera.2007.01.008, 17363065.
14. Rehberg S, Ertmer C, Vincent JL, Spiegel HU, Köhler G, Erren M, Lange M, Morelli A, Seisel J, Su F, Van Aken H, Traber DL, Westphal M. Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock. Crit Care Med 2010, 38:2016-2023.
15. Dubin A, Murias G, Sottile JP, Pozo MO, Barán M, Edul VS, Canales HS, Etcheverry G, Maskin B, Estenssoro E. Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. Intensive Care Med 2007, 33:485-494. 10.1007/s00134-006-0519-5, 17262190.
16. García-Septiem J, Lorente JA, Delgado MA, de Paula M, Nin N, Moscoso A, Sánchez-Ferrer A, Perez-Vizcaino F, Esteban A. Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock. Shock 2010, 34:275-280.
17. De Backer D, Hollenberg S, Boerma C, Goedhart P, Büchele G, Ospina-Tascon G, Dobbe I, Ince C. How to evaluate the microcirculation? Report of a round table conference. Crit Care 2007, 11:R101-111. 10.1186/cc6118, 2556744, 17845716.
18. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL, et al. International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock 2008. Crit Care Med 2008, 36:296-327. 10.1097/01.CCM.0000298158.12101.41, 18158437, International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases.
19. Kaiser L. Adjusting for baseline: change or percentage change. Stat Med 1989, 8:1183-1190. 10.1002/sim.4780081002, 2682909.
20. Erbüyün K, Vatansever S, Tok D, Ok G, Türköz E, Aydede H, Erhan Y, Tekin I. Effects of levosimendan and dobutamine on experimental acute lung injury in rats. Acta Histochem 2009, 111:404-414.
21. Barraud D, Faivre V, Damy T, Welschbillig S, Gayat E, Heymes C, Payen D, Shah AM, Mebazaa A. Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. Crit Care Med 2007, 35:1376-1382. 10.1097/01.CCM.0000261889.18102.84, 17414729.
22. Cunha-Goncalves D, Perez-de-Sa V, Dahm P, Grins E, Thörne J, Blomquist S. Cardiovascular effects of levosimendan in the early stages of endotoxemia. Shock 2007, 28:71-77. 10.1097/shk.0b013e31804d18f6, 17510599.
23. Dubin A, Maskin B, Murias G, Pozo MO, Sottile JP, Barán M, Edul VS, Canales HS, Estenssoro E. Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. Resuscitation 2006, 69:277-286. 10.1016/j.resuscitation.2005.08.002, 16458408.
24. Faivre V, Kaskos H, Callebert J, Losser MR, Milliez P, Bonnin P, Payen D, Mebazaa A. Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits. Anesthesiology 2005, 103:514-521. 10.1097/00000542-200509000-00014, 16129976.
25. Oldner A, Konrad D, Weitzberg E, Rudehill A, Rossi P, Wanecek M. Effect of levosimendan a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 2001, 29:2185-2193. 10.1097/00003246-200111000-00022, 11700420.
26. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Muhl H, Boost KA, Hofstetter C. Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury. Crit Care Med 2008, 36:1979-1981. 10.1097/CCM.0b013e318176aae9, 18520665.
27. Ramaswamykanive H, Bihari D, Solano TR. Myocardial depression associated with pneumococcal septic shock reversed by levosimendan. Anaesth Intensive Care 2007, 35:409-413.
28. Matejovic M, Krouzecky A, Radej J, Novak I. Successful reversal of resistent hypodynamic septic shock with levosimendan. Acta Anaesthesiol Scand 2005, 49:127-128. 10.1111/j.1399-6576.2005.00541.x, 15676005.
29. Schwarte LA, Picker O, Bornstein SR, Fournell A, Scheeren TW. Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med 2005, 33:135-142. 10.1097/01.CCM.0000150653.89451.6F, 15644660.
30. Fries M, Ince C, Rossaint R, Bleilevens C, Bickenbach J, Rex S, Mik EG. Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. Crit Care Med 2008, 36:1886-1891. 10.1097/CCM.0b013e31817cede9, 18496356.
31. Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 2001, 345:588-595. 10.1056/NEJMra002709, 11529214.
32. Duranteau J, Sitbon P, Teboul JL, Vicaut E, Anguel N, Richard C, Samii K. Effects of epinephrine, norepinephrine or combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 1999, 27:893-900. 10.1097/00003246-199905000-00021, 10362410.
33. Levy B, Nace L, Bollaert PE, Dousset B, Mallie JP, Larcan A. Comparison of systemic and regional effects of dobutamine and dopexamine in norepinephrine-treated septic shock. Intensive Care Med 1999, 25:942-948. 10.1007/s001340050986, 10501749.
34. Creteur J, De Backer D, Vincent JL. A dobutamine test can disclose hepatosplanchnic hypoperfusion in septic patients. Am J Respir Crit Care Med 1999, 160:839-845.
35. Lebuffe G, Levy B, Nevière R, Chagnon JL, Perrigault PF, Duranteau J, Edouard A, Teboul JL, Vallet B. Dobutamine and gastric-to-arterial carbon dioxide gap in severe sepsis without shock. Intensive Care Med 2002, 28:265-271. 10.1007/s00134-001-1198-x, 11904654.