Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 6, 2008, Pages

  Leelahavanichkul, Asada ^a   Yasuda, Hideo ^a,b   Doi, Kent ^a,c   Hu, Xuzhen ^a   Zhou, Hua ^a   Yuen, Peter S T ^a   Star, Robert A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Apoptosis; Cecal ligation puncture; Chloroquine; Nuclear factor B; Spleen

Indexed keywords

ANTIINFLAMMATORY AGENT; CHLOROQUINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; METHYL 2 ACETAMIDOACRYLATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD1 MOUSE; CONTROLLED STUDY; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LIVER INJURY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN; SPLEEN CELL; SPLENECTOMY; SURVIVAL;

EID: 57549087975     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90442.2008     Document Type: Article

References (57)

1. Campbell KJ, Perkins ND. Regulation of NF-kappaB function. Biochem Soc Symp: 165-180, 2006.
2. Dear JW, Kobayashi H, Jo SK, Holly MK, Hu X, Yuen PST, Brechbiel MW, Star RA. Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice. Kidney Int 67: 2159-2167, 2005.
3. Dear JW, Leelahavanichkul A, Aponte A, Hu X, Constant SL, Hewitt SM, Yuen PST, Star RA. Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure. Crit Care Med 35: 2319-2328, 2007.
4. Dear JW, Yasuda H, Hu X, Hieny S, Yuen PST, Hewitt SM, Sher A, Star RA. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69: 832-836, 2006.
5. Doi K, Hu X, Yuen PST, Leelahavanichkul A, Yasuda H, Kim SM, Schnermann J, Jonassen TEN, Frokiaer J, Nielsen S, Star RA. AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int 73: 1266-1274, 2008.
6. Epperly M, Jin S, Nie S, Cao S, Zhang X, Franicola D, Wang H, Fink MP, Greenberger JS. Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. Radiat Res 168: 552-559, 2007.
7. Ertel W, Morrison MH, Ayala A, Chaudry IH. Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis. Arch Surg 127: 70-75; discussion 75-76, 1992.
8. Fink MP. Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Curr Opin Clin Nutr Metab Care 5: 167-174, 2002.
9. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time. Crit Care Med 26: 2078-2086, 1998.
10. Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro- versus antiinflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 181: 176-180, 2000.
11. Han Y, Englert JA, Yang R, Delude RL, Fink MP. Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther 312: 1097-1105, 2005.
12. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745, 2000.
13. Hiramatsu M, Hotchkiss RS, Karl IE, Buchman TG. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7: 247-253, 1997.
14. Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev 210: 171-186, 2006.
15. Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PST, Star RA. Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. Kidney Int 70: 496-506, 2006.
16. Hong Z, Jiang Z, Liangxi W, Guofu D, Ping L, Yongling L, Wendong P, Minghai W. Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release. Int Immunopharmacol 4: 223-234, 2004.
17. Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE. Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci USA 100: 6724-6729, 2003.
18. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6: 813-822, 2006.
19. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25: 1298-1307, 1997.
20. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27: 1230-1251, 1999.
21. Hotchkiss RS, Tinsley KW, Karl IE. Role of apoptotic cell death in sepsis. Scand J Infect Dis 35: 585-592, 2003.
22. Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, Karl IE. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 96: 14541-14546, 1999.
23. Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LW 3rd, Bland KI, Chaudry IH. Cecal ligation and puncture. Shock 24, Suppl 1: 52-57, 2005.
24. Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, Pavlov VA, Gallowitsch-Puerta M, Ashok M, Czura CJ, Foxwell B, Tracey KJ, Ulloa L. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 203: 1623-1628, 2006.
25. Johansson AS, Johansson-Haque K, Okret S, Palmblad J. Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway. Br J Pharmacol 154: 1318-1326, 2008.
26. Joshi AR, Chung CS, Song GY, Lomas J, Priester RA, Ayala A. NF-kappaB activation has tissue-specific effects on immune cell apoptosis during polymicrobial sepsis. Shock 18: 380-386, 2002.
27. Kang SC, Choudhry MA, Matsutani T, Schwacha MG, Rue LW, Bland KI, Chaudry IH. Splenectomy differentially influences immune responses in various tissue compartments of the body. Cytokine 28: 101-108, 2004.
28. Klenzak J, Himmelfarb J. Sepsis and the kidney. Crit Care Clin 21: 211-222, 2005.
29. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434: 1138-1143, 2005.
30. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA. Possible new role for NF-kappaB in the resolution of inflammation. Nat Med 7: 1291-1297, 2001.
31. Liang Y, Zhou Y, Shen P. NF-kappaB and its regulation on the immune system. Cell Mol Immunol 1: 343-350, 2004.
32. Liu SF, Malik AB. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290: L622-L645, 2006.
33. Miyaji T, Hu X, Yuen PST, Muramatsu Y, Iyer S, Hewitt SM, Star RA. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 64: 1620-1631, 2003.
34. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273: 117-123, 1995.
35. Reade MC, Fink MP. Bench-to-bedside review: amelioration of acute renal impairment using ethyl pyruvate. Crit Care 9: 556-560, 2005.
36. Riedemann NC, Guo RF, Ward PA. Novel strategies for the treatment of sepsis. Nat Med 9: 517-524, 2003.
37. Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.
38. Sappington PL, Cruz RJ Jr, Harada T, Yang R, Han Y, Englert JA, Ajami AA, Killeen ME, Delude RL, Fink MP. The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. Biochem Pharmacol 70: 1579-1592, 2005.
39. Shishodia S, Aggarwal BB. Nuclear factor-kappaB activation: a question of life or death. J Biochem Mol Biol 35: 28-40, 2002.
40. Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP. Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med 29: 1513-1518, 2001.
41. Smith JW, Gamelli RL, Jones SB, Shankar R. Immunologic responses to critical injury and sepsis. J Intensive Care Med 21: 160-172, 2006.
42. Tawadrous ZS, Delude RL, Fink MP. Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock 17: 473-477, 2002.
43. Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC, Karl IE, Hotchkiss RS. Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol 171: 909-914, 2003.
44. Tsung A, Kaizu T, Nakao A, Shao L, Bucher B, Fink MP, Murase N, Geller DA. Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis. Transplantation 79: 196-204, 2005.
45. Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP, Tracey KJ. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci USA 99: 12351-12356, 2002.
46. Volk HD, Reinke P, Docke WD. Clinical aspects: from systemic inflammation to 'immunoparalysis.' Chem Immunol 74: 162-177, 2000.
47. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248-251, 1999.
48. Wang LZ, Sun WC, Zhu XZ. Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis. Eur J Pharmacol 508: 57-68, 2005.
49. Wang TS, Deng JC. Molecular and cellular aspects of sepsis-induced immunosuppression. J Mol Med 86: 495-506, 2008.
50. Woo YJ, Taylor MD, Cohen JE, Jayasankar V, Bish LT, Burdick J, Pirolli TJ, Berry MF, Hsu V, Grand T. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg 127: 1262-1269, 2004.
51. Yang R, Gallo DJ, Baust JJ, Uchiyama T, Watkins SK, Delude RL, Fink MP. Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 283: G212-G221, 2002.
52. Yang R, Uchiyama T, Alber SM, Han X, Watkins SK, Delude RL, Fink MP. Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med 32: 1453-1459, 2004.
53. Yang S, Chung CS, Ayala A, Chaudry IH, Wang P. Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse. Shock 17: 55-60, 2002.
54. Yasuda H, Leelahavanichkul A, Tsunoda S, Dear JW, Takahashi Y, Ito S, Hu X, Zhou H, Doi K, Childs R, Klinman DM, Yuen PST, Star RA. Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 294: F1050-F1058, 2008.
55. Yasuda H, Yuen PST, Hu X, Zhou H, Star RA. Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int 69: 1535-1542, 2006.
56. Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7: 454-465, 2007.
57. Yuen PST, Dunn SR, Miyaji T, Yasuda H, Sharma K, Star RA. A simplified method for HPLC determination of creatinine in mouse serum. Am J Physiol Renal Physiol 286: F1116-F1119, 2004.