Repair of injured proximal tubule does not involve specialized progenitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 22, 2011, Pages 9226-9231

  Humphreys, Benjamin D ^a,b   Czerniak, Suzanne ^a   DiRocco, Derek P ^a   Hasnain, Wirasat ^a   Cheema, Rabia ^a   Bonventre, Joseph V ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; DNA REPLICATION; IN VIVO STUDY; KIDNEY CORTEX; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY PAPILLA; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; STEM CELL; TISSUE REPAIR;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DNA; KI-67 ANTIGEN; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; STEM CELLS; STOCHASTIC PROCESSES; THYMIDINE; TIME FACTORS;

EID: 79959336759     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100629108     Document Type: Article

References (36)

1. Messier B, Leblond CP (1960) Cell proliferation and migration as revealed by radio-autography after injection of thymidine-H3 into male rats and mice. Am J Anat 106:247-285.
2. Venkatachalam MA, Bernard DB, Donohoe JF, Levinsky NG (1978) Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2, and S3 segments. Kidney Int 14(1):31-49.
3. Witzgall R, Brown D, Schwarz C, Bonventre JV (1994) Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 93:2175-2188.
4. Little MH, Bertram JF (2009) Is there such a thing as a renal stem cell? J Am Soc Nephrol 20:2112-2117.
5. Elger M, et al. (2003) Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea. J Am Soc Nephrol 14:1506-1518. (Pubitemid 36687052)
6. Zhou W, Boucher RC, Bollig F, Englert C, Hildebrandt F (2010) Characterization of mesonephric development and regeneration using transgenic zebrafish. Am J Physiol Renal Physiol 299:F1040-F1047.
7. Humphreys BD, et al. (2008) Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2:284-291. (Pubitemid 351298594)
8. Oliver JA, Maarouf O, Cheema FH, Martens TP, Al-Awqati Q (2004) The renal papilla is a niche for adult kidney stem cells. J Clin Invest 114:795-804. (Pubitemid 39578738)
9. Oliver JA, et al. (2009) Proliferation and migration of label-retaining cells of the kidney papilla. J Am Soc Nephrol 20:2315-2327.
10. Maeshima A, Sakurai H, Nigam SK (2006) Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. J Am Soc Nephrol 17(1):188-198.
11. Kitamura S, et al. (2005) Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney. FASEB J 19:1789-1797. (Pubitemid 41598763)
12. Gupta S, et al. (2006) Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol 17:3028-3040. (Pubitemid 44707763)
13. Appel D, et al. (2009) Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 20:333-343.
14. Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS (2009) NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol 20: 311-321.
15. Singh SR, Liu W, Hou SX (2007) The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell 1:191-203. (Pubitemid 47215591)
16. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12:817-826. (Pubitemid 46667754)
17. Bersell K, Arab S, Haring B, Kühn B (2009) Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138:257-270.
18. Vogetseder A, Palan T, Bacic D, Kaissling B, Le Hir M (2007) Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am J Physiol Cell Physiol 292:C807-C813.
19. Cairns J (1975) Mutation selection and the natural history of cancer. Nature 255: 197-200.
20. Vogetseder A, Karadeniz A, Kaissling B, Le Hir M (2005) Tubular cell proliferation in the healthy rat kidney. Histochem Cell Biol 124(2):97-104. (Pubitemid 41429764)
21. Kiel MJ, et al. (2007) Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature 449:238-242. (Pubitemid 47402371)
22. Ichimura T, et al. (1998) Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 273:4135-4142. (Pubitemid 28103282)
23. Ichimura T, et al. (2008) Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 118:1657-1668. (Pubitemid 351632370)
24. Imgrund M, et al. (1999) Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice 1. Kidney Int 56:1423-1431. (Pubitemid 29451249)
25. Villanueva S, Céspedes C, Vio CP (2006) Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am J Physiol Regul Integr Comp Physiol 290:R861-R870.
26. Maeshima A, Maeshima K, Nojima Y, Kojima I (2002) Involvement of Pax-2 in the action of activin A on tubular cell regeneration. J Am Soc Nephrol 13:2850-2859. (Pubitemid 35386904)
27. Zuk A, Bonventre JV, Brown D, Matlin KS (1998) Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 275:C711-C731.
28. Kuehn EW, Park KM, Somlo S, Bonventre JV (2002) Kidney injury molecule-1 expression in murine polycystic kidney disease. Am J Physiol Renal Physiol 283: F1326-F1336. (Pubitemid 35332662)
29. Zhang J, et al. (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425:836-841. (Pubitemid 37351467)
30. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-1337.
31. Welm BE, et al. (2002) Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Dev Biol 245(1):42-56. (Pubitemid 34461802)
32. Urbanek K, et al. (2006) Stem cell niches in the adult mouse heart. Proc Natl Acad Sci USA 103:9226-9231. (Pubitemid 43902560)
33. Shapiro GI, Edwards CD, Ewen ME, Rollins BJ (1998) p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18:378-387. (Pubitemid 28021049)
34. Adams DC, Oxburgh L (2009) The long-term label retaining population of the renal papilla arises through divergent regional growth of the kidney. Am J Physiol Renal Physiol 297:F809-F815.
35. Wojtowicz JM, Kee N (2006) BrdU assay for neurogenesis in rodents. Nat Protoc 1: 1399-1405.
36. Aten JA, Bakker PJ, Stap J, Boschman GA, Veenhof CH (1992) DNA double labelling with IdUrd and CldUrd for spatial and temporal analysis of cell proliferation and DNA replication. Histochem J 24:251-259.