Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 2, 2009, Pages 641-648

  Lancel, Steve ^a   Hassoun, Sidi Mohamed ^a   Favory, Raphael ^a   Decoster, Brigitte ^a   Motterlini, Roberto ^b   Neviere, Remi ^a  

^a UNIV LILLE   (France)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CARBONYL DERIVATIVE; GLUTATHIONE; HYDROGEN PEROXIDE; INTERLEUKIN 10; MITOCHONDRIAL DNA; NITRATE; NITRITE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE; ORGANOMETALLIC COMPOUND; TRICARBONYLCHLORO(GLYCINATO)RUTHENIUM(II);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE FREE SURVIVAL; GENE NUMBER; HEART MITOCHONDRION; INFLAMMATION; INTESTINE PERFORATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PERITONITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECT; ENERGY METABOLISM; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; OXYGEN CONSUMPTION;

ANIMALS; CARBON MONOXIDE; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ENERGY METABOLISM; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED ICR; MITOCHONDRIA, HEART; NAD; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PERITONITIS; SEPSIS;

EID: 65649135789     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.148049     Document Type: Article

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